摘要
采用质谱(MS)和核磁共振谱(NMR)对原料苯氧乙醇进行定性分析,优化并建立了液相色谱法及气相色谱法测定苯氧乙醇,纯度为99.3%。以甲醇为基体溶液,采用重量-容量法制备苯氧乙醇标准物质。以液相色谱(紫外法、示差法)两种方法进行定值,并做了均匀性检验和稳定性跟踪。建立不确定度评定方法,标准物质特性值为99.3(±1.1)μg/mL(k=2)。苯氧乙醇标准物质具有溯源性和准确性,对于化妆品中防腐剂苯氧乙醇含量的准确测定及监控具有重要意义。
GC-MS and NMR were used to confirm the structure of phenoxyethanol.HPLC and GC were used to determine the purity of phenoxyethanol,and the purity was revealed to be 99.3%.Phenoxyethanol reference was prepared in methanol according to weight-capacity method.Ultraviolet and differential spectrophotometry were used for certificating the value,the homogeneity and stability.The uncertainty of this evaluation method was established.The property value of phenoxyethanol was 99.3（± 1.1）μg/mL（k=2）.The standard phenoxyethanol reference prepared in this study was traceable and accurate,and it can be used as a standard reference for preservative analysis of cosmetics.
作者
顾玲玲
田玉平
吴建军
朱丽娜
刘悦
GU Ling-ling TIAN Yu- ping WU Jian-jun ZHU Li-na LIU-Yue(Shanghai Institute of Measurement and Testing Technology, Shanghai 201203, China)
出处
《化学试剂》
CAS
北大核心
2017年第3期281-284,320,共5页
Chemical Reagents
基金
上海市技术性贸易措施应对专项项目(12TBT003)
国家质量监督检验检疫总局资助项目(2011QK094)
关键词
苯氧乙醇
标准物质
均匀性
稳定性
不确定度
phenoxyethanol
certified reference material
homogeneity
stability
uncertainty
