I am a Ph.D.candidate at the University of Almeria in Spain,majoring in sinology and sociolinguistics.Fascinated with Chinese culture,I went to live in China for two years as part of an exchange program at Beijing Nor...I am a Ph.D.candidate at the University of Almeria in Spain,majoring in sinology and sociolinguistics.Fascinated with Chinese culture,I went to live in China for two years as part of an exchange program at Beijing Normal University.展开更多
Background:Tetralogy of Fallot(TOF),the predominant cyanotic congenital heart defect,arisesfrom multifactorial gene-envirorment interactions disrup ting cardiac developmental networks.This studyinvestiga ted TOF-speci...Background:Tetralogy of Fallot(TOF),the predominant cyanotic congenital heart defect,arisesfrom multifactorial gene-envirorment interactions disrup ting cardiac developmental networks.This studyinvestiga ted TOF-specific transcriptional alterations and identified high-confidence candidate genes.Methods:Based on GSE36761 transcriptome data,a weighted gene co-exp ression network analysis(WGCNA)andprotein-protein interaction(PPI)network were conducted to identify TOF-related sub-netrwork and Hub genes.The potentialbiological functions among these genes were revealed by enrichment analysis.Genetic,epigeneticand transcriptional alteration in the Fub genes were analyzed with leveraged public resources:a methylationdataset(CSE62629)and two single-cell datasets(EGAS00001003996 and GSE126128),Results:Eight Hub geneswere identified using the WGCNA network and PPl network,and functional errichment analysis revealedthatGJA1,RUNX2,FTK7,PRICKLE1,and SPRP1 were involved in the morphogenesis of an epithelium,anddysregulation of the signaling were also found in the other two TOF datasets,Furthermore,the study foundthat the promoters of GJA1,RUNX2,FTK7,and PRICKLE1 genes were hypermethylated and that GJA1 andSFRP1 are highly expressed in mouse second heart field cells and neural crest cells,and the la tter is expressedin human embry onic outflow tract cells.Since RUNX2 was not expressed in human and mouse embryonichearts,GJA1,FTK7,PRICKLE1,and SPRP1 were ultimately identified as TOF candidate genes.Conclusion:Based on the WGCNA network and various bioinformatics analysis approaches,we screened 4 TOF candidatepathogenic genes,and found that the signaling pathways related to the morphogenesis of an epithelium maybe involved in the pathogenesis of TOF.展开更多
Yongduan Song (PhD,PE,Fellow IEEE,AAIA,CAA) received the Ph.D.degree in electrical and computer engineering from Tennessee Technological University,USA,in 1992.He held a tenured Full Professor with North Carolina A&am...Yongduan Song (PhD,PE,Fellow IEEE,AAIA,CAA) received the Ph.D.degree in electrical and computer engineering from Tennessee Technological University,USA,in 1992.He held a tenured Full Professor with North Carolina A&T State University,USA,from 1993 to 2008 and a Langley Distinguished Professor with the National Institute of Aerospace,USA,from 2005 to 2008.He is currently the Chair Professor with School of Automation,Chongqing University.展开更多
Frank L.Lewis(Life Fellow,IEEE)received the Ph.D.degree from the Georgia Institute of Technology.He is currently a member of the National Academy of Inventors and the Moncrief-O'Donnell Chair with The University o...Frank L.Lewis(Life Fellow,IEEE)received the Ph.D.degree from the Georgia Institute of Technology.He is currently a member of the National Academy of Inventors and the Moncrief-O'Donnell Chair with The University of Texas at Arlington Research Institute.He is the author of seven U.S.patents,numerous journal special issues and journal articles,and 20 books.展开更多
Frank L.Lewis(Life Fellow,IEEE)received the Ph.D.degree from the Georgia Institute of Technology.He iscurrently a member of the National Academy of Inventorsand the Moncrief-O'Donnell Chair with The University ofT...Frank L.Lewis(Life Fellow,IEEE)received the Ph.D.degree from the Georgia Institute of Technology.He iscurrently a member of the National Academy of Inventorsand the Moncrief-O'Donnell Chair with The University ofTexas at Arlington Research Institute.He is the author ofseven U.s.patents,numerous journal special issues andjournal articles,and 20 books.展开更多
Frank L.Lewis (Life Fellow,IEEE) received the Ph.D.degree from the Georgia Institute of Technology.He is currently a member of the National Academy of Inventors and the Moncrief-O'Donnell Chair with The University...Frank L.Lewis (Life Fellow,IEEE) received the Ph.D.degree from the Georgia Institute of Technology.He is currently a member of the National Academy of Inventors and the Moncrief-O'Donnell Chair with The University of Texas at Arlington Research Institute.He is the author of seven U.S.patents,numerous journal special issues and journal articles,and 20 books.He received the Fulbright Research Award,the NSF Research Initiation Grant,the ASEE Terman Award,the International Neural Network Society Gabor Award,the U.K.Institute of Measurement and Control Honeywell Field Engineering Medal,the IEEE Computational Intelligence Society Neural Networks Pioneer Award,the AIAA Intelligent Systems Award,andthe AACC Ragazzini Award.展开更多
Frank L.Lewis (Life Fellow,IEEE) received the Ph.D.degree from the Georgia Institute of Technology.He is currently a member of the National Academy of Inventors and the Moncrief-O'Donnell Chair with The University...Frank L.Lewis (Life Fellow,IEEE) received the Ph.D.degree from the Georgia Institute of Technology.He is currently a member of the National Academy of Inventors and the Moncrief-O'Donnell Chair with The University of Texas at Arlington Research Institute.He is the author of seven U.S.patents,numerous journal special issues and journal articles,and 20 books.He received the Fulbright Research Award,the NSF Research Initiation Grant,the ASEE Terman Award,the International Neural Network Society Gabor Award,the U.K.Institute of Measurement and Control Honeywell Field Engineering Medal,the IEEE Computational Intelligence Society Neural Networks Pioneer Award,the AIAA Intelligent Systems Award,and the AACC Ragazzini Award.展开更多
文摘I am a Ph.D.candidate at the University of Almeria in Spain,majoring in sinology and sociolinguistics.Fascinated with Chinese culture,I went to live in China for two years as part of an exchange program at Beijing Normal University.
基金supported by the National Natural Science Found ation of China(No.8230045i for Zhen Wang,82302230 for jiawei Shi,82202194 for Jing Wang and 82171961 for Haiyan Cao).
文摘Background:Tetralogy of Fallot(TOF),the predominant cyanotic congenital heart defect,arisesfrom multifactorial gene-envirorment interactions disrup ting cardiac developmental networks.This studyinvestiga ted TOF-specific transcriptional alterations and identified high-confidence candidate genes.Methods:Based on GSE36761 transcriptome data,a weighted gene co-exp ression network analysis(WGCNA)andprotein-protein interaction(PPI)network were conducted to identify TOF-related sub-netrwork and Hub genes.The potentialbiological functions among these genes were revealed by enrichment analysis.Genetic,epigeneticand transcriptional alteration in the Fub genes were analyzed with leveraged public resources:a methylationdataset(CSE62629)and two single-cell datasets(EGAS00001003996 and GSE126128),Results:Eight Hub geneswere identified using the WGCNA network and PPl network,and functional errichment analysis revealedthatGJA1,RUNX2,FTK7,PRICKLE1,and SPRP1 were involved in the morphogenesis of an epithelium,anddysregulation of the signaling were also found in the other two TOF datasets,Furthermore,the study foundthat the promoters of GJA1,RUNX2,FTK7,and PRICKLE1 genes were hypermethylated and that GJA1 andSFRP1 are highly expressed in mouse second heart field cells and neural crest cells,and the la tter is expressedin human embry onic outflow tract cells.Since RUNX2 was not expressed in human and mouse embryonichearts,GJA1,FTK7,PRICKLE1,and SPRP1 were ultimately identified as TOF candidate genes.Conclusion:Based on the WGCNA network and various bioinformatics analysis approaches,we screened 4 TOF candidatepathogenic genes,and found that the signaling pathways related to the morphogenesis of an epithelium maybe involved in the pathogenesis of TOF.
文摘Yongduan Song (PhD,PE,Fellow IEEE,AAIA,CAA) received the Ph.D.degree in electrical and computer engineering from Tennessee Technological University,USA,in 1992.He held a tenured Full Professor with North Carolina A&T State University,USA,from 1993 to 2008 and a Langley Distinguished Professor with the National Institute of Aerospace,USA,from 2005 to 2008.He is currently the Chair Professor with School of Automation,Chongqing University.
文摘Frank L.Lewis(Life Fellow,IEEE)received the Ph.D.degree from the Georgia Institute of Technology.He is currently a member of the National Academy of Inventors and the Moncrief-O'Donnell Chair with The University of Texas at Arlington Research Institute.He is the author of seven U.S.patents,numerous journal special issues and journal articles,and 20 books.
文摘Frank L.Lewis(Life Fellow,IEEE)received the Ph.D.degree from the Georgia Institute of Technology.He iscurrently a member of the National Academy of Inventorsand the Moncrief-O'Donnell Chair with The University ofTexas at Arlington Research Institute.He is the author ofseven U.s.patents,numerous journal special issues andjournal articles,and 20 books.
文摘Frank L.Lewis (Life Fellow,IEEE) received the Ph.D.degree from the Georgia Institute of Technology.He is currently a member of the National Academy of Inventors and the Moncrief-O'Donnell Chair with The University of Texas at Arlington Research Institute.He is the author of seven U.S.patents,numerous journal special issues and journal articles,and 20 books.He received the Fulbright Research Award,the NSF Research Initiation Grant,the ASEE Terman Award,the International Neural Network Society Gabor Award,the U.K.Institute of Measurement and Control Honeywell Field Engineering Medal,the IEEE Computational Intelligence Society Neural Networks Pioneer Award,the AIAA Intelligent Systems Award,andthe AACC Ragazzini Award.
文摘Frank L.Lewis (Life Fellow,IEEE) received the Ph.D.degree from the Georgia Institute of Technology.He is currently a member of the National Academy of Inventors and the Moncrief-O'Donnell Chair with The University of Texas at Arlington Research Institute.He is the author of seven U.S.patents,numerous journal special issues and journal articles,and 20 books.He received the Fulbright Research Award,the NSF Research Initiation Grant,the ASEE Terman Award,the International Neural Network Society Gabor Award,the U.K.Institute of Measurement and Control Honeywell Field Engineering Medal,the IEEE Computational Intelligence Society Neural Networks Pioneer Award,the AIAA Intelligent Systems Award,and the AACC Ragazzini Award.
