Hepatocellular carcinoma(HCC)is a pressing global health problem and is the sixth most common cancer and the third leading cause of cancer mortality worldwide.Despite continuous advances in treatment modalities,the 5-...Hepatocellular carcinoma(HCC)is a pressing global health problem and is the sixth most common cancer and the third leading cause of cancer mortality worldwide.Despite continuous advances in treatment modalities,the 5-year survival rate is low with a high propensity for recurrence and metastasis1.This clinical challenge in treating HCC is largely attributed to the heterogeneity and intrinsic therapy resistance of cancer stem cells(CSCs),which are a subpopulation of cells with self-renewal capability and multidirectional differentiation potential to induce tumorigenicity2.The behavior and maintenance of CSCs are not autonomous but critically dependent on the complex bidirectional crosstalk between CSCs and the tumor immune microenvironment(TIME)1.In this review we first summarize the recent progress in characterizing CSCs and the interactions between CSCs and the TIME in HCC.Next,we discuss the emerging therapeutic strategies targeting CSC populations with the ongoing challenges.Finally,we give our perspectives on the future directions in HCC CSC research.展开更多
Allogeneic hematopoietic cell transplantation(allo-HCT) remains a cornerstone therapy for severe hematologic malignancies, offering a potential cure when conventional therapies are ineffective. However, not all patien...Allogeneic hematopoietic cell transplantation(allo-HCT) remains a cornerstone therapy for severe hematologic malignancies, offering a potential cure when conventional therapies are ineffective. However, not all patients are suitable recipients of allo-HCT, particularly the elderly patients and those with high comorbidity burdens.Furthermore, patients who develop relapse or graft failure after initial transplantation encounter additional challenges when evaluated for a second transplant.展开更多
Hardship The Double Take column looks at a single topic from an African and Chinese perspective.This month,we explore whether enduring hardship is still a necessary path to growth in a changing world.
The transverse incision with longitudinal ligation(TILL)procedure is a new method for treating circumferential prolapsed hemorrhoids.A study by Song et al found TILL to be better than the traditional Milligan-Morgan h...The transverse incision with longitudinal ligation(TILL)procedure is a new method for treating circumferential prolapsed hemorrhoids.A study by Song et al found TILL to be better than the traditional Milligan-Morgan hemorrhoidectomy for short-term results,showing less pain,quicker healing,and lower risk of anal stenosis.TILL reduces tissue tension and controls blood supply,allowing effective removal of diseased tissue while maintaining anal function and structure.However,the study's limitations,including its retrospective,single-center design,small sample size,and short follow-up,restrict the findings'generalizability and ability to assess long-term outcomes like recurrence.Larger,multicenter trials are needed for a thorough evaluation and wider clinical adoption of TILL.展开更多
Sodium-sulfur(Na-S)batteries are considered as a promising successor to the next-generation of high-capacity,low-cost and environmentally friendly sulfur-based battery systems.However,Na-S batteries still suffer from ...Sodium-sulfur(Na-S)batteries are considered as a promising successor to the next-generation of high-capacity,low-cost and environmentally friendly sulfur-based battery systems.However,Na-S batteries still suffer from the“shuttle effect”and sluggish ion transport kinetics due to the dissolution of sodium polysulfides and poor conductivity of sulfur.MXenes,as 2D transition metal carbides/nitrides,have exhibited excellent conductivity,diverse structure and tunable surface groups,particularly playing a crucial role in inhibiting polysulfide shuttle and sodium dendrite growth.In this review,achievements and advancements of MXene-based Na-S batteries are discussed,including applications of a sulfur cathode,separator,interlayer between separator and cathode,and sodium anode.In the end,perspectives and challenges on the future development of MXene-based materials in Na-S batteries are proposed.展开更多
Atomically precise metal nanoclusters are an emerging type of nanomaterial which has diverse interfacial metal-ligand coordination motifs that can significantly affect their physicochemical properties and functionalit...Atomically precise metal nanoclusters are an emerging type of nanomaterial which has diverse interfacial metal-ligand coordination motifs that can significantly affect their physicochemical properties and functionalities.Among that,Cu nanoclusters have been gaining continuous increasing research attentions,thanks to the low cost,diversified structures,and superior catalytic performance for various reactions.In this review,we first summarize the recent progress regarding the synthetic methods of atomically precise Cu nanoclusters and the coordination modes between Cu and several typical ligands and then discuss the catalytic applications of these Cu nanoclusters with some explicit examples to explain the atomical-level structure-performance relationship.Finally,the current challenges and future research perspectives with some critical thoughts are elaborated.We hope this review can not only provide a whole picture of the current advances regarding the synthesis and catalytic applications of atomically precise Cu nanoclusters,but also points out some future research visions in this rapidly booming field.展开更多
Laparoscopic and endoscopic cooperative surgery(LECS)is a hybrid minimally invasive technique originally developed for treatment of gastric submucosal tumors.Several modifications of LECS—including inverted LECS,non-...Laparoscopic and endoscopic cooperative surgery(LECS)is a hybrid minimally invasive technique originally developed for treatment of gastric submucosal tumors.Several modifications of LECS—including inverted LECS,non-exposed endoscopic wall-inversion surgery,and closed LECS have evolved over a period of time to address the earlier concerns about peritoneal contamination and tumor seeding.These innovations have led to the application of combined laparoendoscopic techniques to several gastrointestinal(GI)lesions such as the duodenum,colon,and rectum.This minireview explores the evolution,current applications,and future potential of laparoendoscopic surgery in GI diseases.展开更多
To meet the demand for enhanced energy density and improved safety in batteries,anode-free aqueous zinc metal batteries(AF-AZMBs)have garnered significant research interest and attention.Compared with conventional aqu...To meet the demand for enhanced energy density and improved safety in batteries,anode-free aqueous zinc metal batteries(AF-AZMBs)have garnered significant research interest and attention.Compared with conventional aqueous Zn batteries,AF-AZMBs provide higher theoretical energy density,a more simplified structural design,and improved cost-effectiveness.However,AF-AZMBs are confronted with severe capacity degradation and lifespan reduction due to the absence of an excess zinc inventory.In recent years,extensive research efforts have been devoted to addressing these challenges,resulting in significant advancements.Therefore,there is highly warranted for a comprehensive discussion on AF-AZMBs.Herein,this review provides a thorough analysis and in-depth investigation of recent developments in AF-AZMBs from the perspectives of current collectors,electrolytes,and cathodes.Specifically,the working mechanisms and advantageous features of AF-AZMBs are summarized.The major scientific issues affecting capacity degradation and lifespan reduction are discussed,including inhomogeneous Zn deposition/stripping kinetics,unstable SEI layer,and irreversible cathode material loss.Furthermore,the corresponding strategies to address these issues are highlighted,such as anodic current collector design,electrolyte engineering,and cathodic modification.Finally,several promising directions are explored for the future advancement of AF-AZMBs,including developing high-performance Zn-rich cathodes,regulating solid-state electrolytes,and designing dual-electrode-free zinc-metal batteries.Additionally,exploring advanced characterization and analysis techniques and optimizing pouch cells under practical operating conditions are also mentioned,highlighting the urgent need for further research to address existing bottlenecks.展开更多
基金supported by the Hong Kong Research Grants Council Theme-based Research Scheme(Grant No.T12-716/22-R)Innovation and Technology Commission grant for State Key Laboratory of Liver Research(Grant No.ITC PD/17-9)University Development Fund of The University of Hong Kong,and Loke Yew Endowed Professorship award.I.O.L.Ng is Loke Yew Professor in Pathology.
文摘Hepatocellular carcinoma(HCC)is a pressing global health problem and is the sixth most common cancer and the third leading cause of cancer mortality worldwide.Despite continuous advances in treatment modalities,the 5-year survival rate is low with a high propensity for recurrence and metastasis1.This clinical challenge in treating HCC is largely attributed to the heterogeneity and intrinsic therapy resistance of cancer stem cells(CSCs),which are a subpopulation of cells with self-renewal capability and multidirectional differentiation potential to induce tumorigenicity2.The behavior and maintenance of CSCs are not autonomous but critically dependent on the complex bidirectional crosstalk between CSCs and the tumor immune microenvironment(TIME)1.In this review we first summarize the recent progress in characterizing CSCs and the interactions between CSCs and the TIME in HCC.Next,we discuss the emerging therapeutic strategies targeting CSC populations with the ongoing challenges.Finally,we give our perspectives on the future directions in HCC CSC research.
基金supported by National Natural Science Foundation of China (No. 82370215).
文摘Allogeneic hematopoietic cell transplantation(allo-HCT) remains a cornerstone therapy for severe hematologic malignancies, offering a potential cure when conventional therapies are ineffective. However, not all patients are suitable recipients of allo-HCT, particularly the elderly patients and those with high comorbidity burdens.Furthermore, patients who develop relapse or graft failure after initial transplantation encounter additional challenges when evaluated for a second transplant.
文摘Hardship The Double Take column looks at a single topic from an African and Chinese perspective.This month,we explore whether enduring hardship is still a necessary path to growth in a changing world.
文摘The transverse incision with longitudinal ligation(TILL)procedure is a new method for treating circumferential prolapsed hemorrhoids.A study by Song et al found TILL to be better than the traditional Milligan-Morgan hemorrhoidectomy for short-term results,showing less pain,quicker healing,and lower risk of anal stenosis.TILL reduces tissue tension and controls blood supply,allowing effective removal of diseased tissue while maintaining anal function and structure.However,the study's limitations,including its retrospective,single-center design,small sample size,and short follow-up,restrict the findings'generalizability and ability to assess long-term outcomes like recurrence.Larger,multicenter trials are needed for a thorough evaluation and wider clinical adoption of TILL.
基金supported by the National Natural Science Foundation of China(Nos.51972198 and 61633015)the Natural Science Foundation of Shandong Province(No.ZR2020JQ19)+1 种基金Taishan Scholars Program of Shandong Province(No.ts20190908)Shenzhen Fundamental Research Program(No.JCYJ20190807093405503).
文摘Sodium-sulfur(Na-S)batteries are considered as a promising successor to the next-generation of high-capacity,low-cost and environmentally friendly sulfur-based battery systems.However,Na-S batteries still suffer from the“shuttle effect”and sluggish ion transport kinetics due to the dissolution of sodium polysulfides and poor conductivity of sulfur.MXenes,as 2D transition metal carbides/nitrides,have exhibited excellent conductivity,diverse structure and tunable surface groups,particularly playing a crucial role in inhibiting polysulfide shuttle and sodium dendrite growth.In this review,achievements and advancements of MXene-based Na-S batteries are discussed,including applications of a sulfur cathode,separator,interlayer between separator and cathode,and sodium anode.In the end,perspectives and challenges on the future development of MXene-based materials in Na-S batteries are proposed.
基金supported by the open funds of Key Laboratory of Functional Inorganic Material Chemistry (Heilongjiang University), Ministry of Education, Chinathe funding from Guangdong Natural Science Funds (No. 2023A0505050107)。
文摘Atomically precise metal nanoclusters are an emerging type of nanomaterial which has diverse interfacial metal-ligand coordination motifs that can significantly affect their physicochemical properties and functionalities.Among that,Cu nanoclusters have been gaining continuous increasing research attentions,thanks to the low cost,diversified structures,and superior catalytic performance for various reactions.In this review,we first summarize the recent progress regarding the synthetic methods of atomically precise Cu nanoclusters and the coordination modes between Cu and several typical ligands and then discuss the catalytic applications of these Cu nanoclusters with some explicit examples to explain the atomical-level structure-performance relationship.Finally,the current challenges and future research perspectives with some critical thoughts are elaborated.We hope this review can not only provide a whole picture of the current advances regarding the synthesis and catalytic applications of atomically precise Cu nanoclusters,but also points out some future research visions in this rapidly booming field.
文摘Laparoscopic and endoscopic cooperative surgery(LECS)is a hybrid minimally invasive technique originally developed for treatment of gastric submucosal tumors.Several modifications of LECS—including inverted LECS,non-exposed endoscopic wall-inversion surgery,and closed LECS have evolved over a period of time to address the earlier concerns about peritoneal contamination and tumor seeding.These innovations have led to the application of combined laparoendoscopic techniques to several gastrointestinal(GI)lesions such as the duodenum,colon,and rectum.This minireview explores the evolution,current applications,and future potential of laparoendoscopic surgery in GI diseases.
基金supported by the National Natural Science Foundation of China(22209006)the Fundamental Research Funds for the Central Universities(buctrc202307)the Natural Science Foundation of Shandong Province(ZR2022QE009)。
文摘To meet the demand for enhanced energy density and improved safety in batteries,anode-free aqueous zinc metal batteries(AF-AZMBs)have garnered significant research interest and attention.Compared with conventional aqueous Zn batteries,AF-AZMBs provide higher theoretical energy density,a more simplified structural design,and improved cost-effectiveness.However,AF-AZMBs are confronted with severe capacity degradation and lifespan reduction due to the absence of an excess zinc inventory.In recent years,extensive research efforts have been devoted to addressing these challenges,resulting in significant advancements.Therefore,there is highly warranted for a comprehensive discussion on AF-AZMBs.Herein,this review provides a thorough analysis and in-depth investigation of recent developments in AF-AZMBs from the perspectives of current collectors,electrolytes,and cathodes.Specifically,the working mechanisms and advantageous features of AF-AZMBs are summarized.The major scientific issues affecting capacity degradation and lifespan reduction are discussed,including inhomogeneous Zn deposition/stripping kinetics,unstable SEI layer,and irreversible cathode material loss.Furthermore,the corresponding strategies to address these issues are highlighted,such as anodic current collector design,electrolyte engineering,and cathodic modification.Finally,several promising directions are explored for the future advancement of AF-AZMBs,including developing high-performance Zn-rich cathodes,regulating solid-state electrolytes,and designing dual-electrode-free zinc-metal batteries.Additionally,exploring advanced characterization and analysis techniques and optimizing pouch cells under practical operating conditions are also mentioned,highlighting the urgent need for further research to address existing bottlenecks.
