目的超声引导下髋关节囊周围神经(PENG)阻滞联合硬膜外麻醉对股骨头置换术老年患者麻醉效果、术后认知功能及免疫功能的影响。方法选取2021年6月至2024年7月成都市中西医结合医院收治的120例行股骨头置换术的老年患者,采用随机数字表法...目的超声引导下髋关节囊周围神经(PENG)阻滞联合硬膜外麻醉对股骨头置换术老年患者麻醉效果、术后认知功能及免疫功能的影响。方法选取2021年6月至2024年7月成都市中西医结合医院收治的120例行股骨头置换术的老年患者,采用随机数字表法将患者分为对照组(n=60)和研究组(n=60),年龄>60岁,美国麻醉医师协会(ASA)分级Ⅰ或Ⅱ级,研究组接受超声引导下PENG阻滞联合硬膜外麻醉,对照组仅行硬膜外麻醉。比较两组患者的血流动力学指标(心率、平均动脉压)、免疫功能[CD4^(+)、CD4^(+)/CD8^(+)、调节性T细胞(CD4^(+)CD25^(+))]、简易智力状态检查评分(MMSE)、术后认知功能障碍(POCD)发生率、视觉模拟评分法(VAS)。结果研究组麻醉后心率、平均动脉压波动低于对照组(P<0.05);研究组术后6、24、72 h的CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD4^(+)CD25^(+)低于对照组(P<0.05);研究组术后6 h、术后24 h、术后48 h MMSE评分明显高于对照组(P<0.05);与对照组比较,研究组术后6、24 h POCD发生率明显降低(P<0.05);研究组术后30 min、2 h VAS评分低于对照组(P<0.05);术后24 h两组VAS评分差异无统计学意义(P>0.05)。结论超声引导下PENG阻滞联合硬膜外麻醉效果更佳,镇痛效果好,有利于降低对血流动力学和免疫功能的影响,更快恢复认知,降低POCD发生率。展开更多
OBJECTIVE: To evaluate the influence of the Tibetan medicine Ru Peng15 powder(RPP15) on uric acid levels, and explore its possible mechanisms of action in hyperuricemic animal models.METHODS: Hyperuricemic mice were g...OBJECTIVE: To evaluate the influence of the Tibetan medicine Ru Peng15 powder(RPP15) on uric acid levels, and explore its possible mechanisms of action in hyperuricemic animal models.METHODS: Hyperuricemic mice were generated by orally administering yeast extract paste twice daily(30 g/kg) for 8 days, to mimic human hyperuricemia induced by high-protein diets. Hyperuricemic rats were generated by intraperitoneal injection of 250 mg/kg potassium oxonate to each animal 1 h before the last oral administration of test compounds, which raised the serum uric acid level by inhibiting the decomposition of uric acid. Levels of uric acid and creatinine in serum and urine were detected by the phosphotungstic acid and picric acid methods respectively, and the activity of xanthine oxidase(XOD) was assayed using a commercial test kit.RESULTS: RPP15(0.4, 0.8, 1.2 g/kg) significantly decreased the level of serum uric acid in healthy rats(P < 0.05). Furthermore, hyperuricemic rats treated with RPP15(0.4, 0.8, 1.2 g/kg) had lower serum uric acid levels(P < 0.05), accompanied by lower urine uric acid(P < 0.05). For the hyperuricemic mice, the levels of uric acid in the serum decreased significantly(P < 0.05) and the activity of XOD in the liver was restored to normal levels after treatment with RPP15(P < 0.05).CONCLUSION: RPP15(0.4, 0.8, 1.2 g/kg) demonstrated an anti-hyperuricemic effect on both healthy and hyperuricemic animals, and the mechanism is most likely associated with inhibiting the activity of XOD.展开更多
The stabilization of the world population and the achievement of sustained development depend not only on the endeavours of governments of nations,but also on further strengthening and promotion of international coope...The stabilization of the world population and the achievement of sustained development depend not only on the endeavours of governments of nations,but also on further strengthening and promotion of international cooperation,The developed countries should make eforts to improve the international economic environment,increase funds for population and development programmes and transfer technology at preferable conditions.展开更多
The Peng Co ophiolite is located to the west of Peng lake in the area of lakes in north Tibet, which belongs to the Baila-Yilashan sub-belt of the the middle Bangong Co-Nujiang ophiolitic belt. The Peng Co ophiolite i...The Peng Co ophiolite is located to the west of Peng lake in the area of lakes in north Tibet, which belongs to the Baila-Yilashan sub-belt of the the middle Bangong Co-Nujiang ophiolitic belt. The Peng Co ophiolite is mainly composed of mantle peridotites, cumulates, diabase dikes. About 70 percent peridotites are harzburgites and 30 percent are lherzolites. Mineral chemistry of the Peng Co lherzolitesare characterized by low Fo contents(88.85–90.33) of olivine and high Al2O3 content(4.26%–7.25%) in pyroxenes. Compared to the primitive mantle, the Peng Co peridotites have relatively higher MgO contents, lower CaO, Al2O3 and TiO2 contents. The total rare-earth element(REE) contents of the lherzolites are 1.11–1.53 ppm, which are lower than those of the primitive mantle. The chondritenormalized REE patterns of the Peng Co peridotites display slight loss in LREE. In the primitive mantle-normalized spider diagram, the Peng Co peridotites exhibit negative Rb and Zr anomalies and intensively positive U, Ta, Sr anomalies. The PGE contents of Peng Co lherzolites are between 22.9–27 ppb. The chondrite-normalized PGE patterns of the Peng Co lherzolites are consistent with that of the primitive mantle. Mineral and whole-rock geochemistry characteristics of the Peng Co lherzolites show an affinity to abyssal peridotites, indicating that it may have formed in the mid-ocean ridge setting. Through quantitative modeling, we conclude that the Peng Co lherzolites formed after 5%–10% degree of partial melting of the spinelphase lherzolite mantle source. The sharp increase of Cr#(56.74–60.84)in Spinel of harzburgites and relatively high Pd/Ir and Rh/Ir ratios suggest that they have experienced melt-rock reaction. The crystallization sequence of Peng Co cumulate is olivine-clinopyroxene-plagioclase. The Mg# value of clinopyroxene in cumulate peridotite ranges from 86.92 to 89.93, and the mean value of Fo is 84.45, which is obviously higher than that of MOR-type ophiolite cumulates. The mineral composition, sequence of magmatic crystallization and mineral components of Peng Co cumulate are similar to those of the cumulate formed by the SSZ-type ophiolite in the subduction zone. Therefore, we can draw a preliminary conclusion that Peng Co lherzolites were formed in an environment of mid oceanic ridge and were remnants of the spinel lherzolite zone which experienced a partial melting of no more than 10%. In the later period, due to the intra-oceanic subduction, it experienced the rock-meltinteraction, and thus formed the SSZ-type cumulate and harzburgite of high Cr value.展开更多
■Since April,all Magazine has examined five artist couples working in China.This month we lookatthe youngest of the artistic duos,Peng Yu and Sun Yuan,whose
文摘目的超声引导下髋关节囊周围神经(PENG)阻滞联合硬膜外麻醉对股骨头置换术老年患者麻醉效果、术后认知功能及免疫功能的影响。方法选取2021年6月至2024年7月成都市中西医结合医院收治的120例行股骨头置换术的老年患者,采用随机数字表法将患者分为对照组(n=60)和研究组(n=60),年龄>60岁,美国麻醉医师协会(ASA)分级Ⅰ或Ⅱ级,研究组接受超声引导下PENG阻滞联合硬膜外麻醉,对照组仅行硬膜外麻醉。比较两组患者的血流动力学指标(心率、平均动脉压)、免疫功能[CD4^(+)、CD4^(+)/CD8^(+)、调节性T细胞(CD4^(+)CD25^(+))]、简易智力状态检查评分(MMSE)、术后认知功能障碍(POCD)发生率、视觉模拟评分法(VAS)。结果研究组麻醉后心率、平均动脉压波动低于对照组(P<0.05);研究组术后6、24、72 h的CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD4^(+)CD25^(+)低于对照组(P<0.05);研究组术后6 h、术后24 h、术后48 h MMSE评分明显高于对照组(P<0.05);与对照组比较,研究组术后6、24 h POCD发生率明显降低(P<0.05);研究组术后30 min、2 h VAS评分低于对照组(P<0.05);术后24 h两组VAS评分差异无统计学意义(P>0.05)。结论超声引导下PENG阻滞联合硬膜外麻醉效果更佳,镇痛效果好,有利于降低对血流动力学和免疫功能的影响,更快恢复认知,降低POCD发生率。
基金This work has supported in part by the Natural Science Foundation of Shandong Province(No.ZR2009AL015)the Youth Foundation of Qufu Normal University(No.XJ201111)
基金Supported by the National Natural Sciences Foundation of China(A Study on the Anti-gout Effects and Related Mechanisms of Tibetan Medicine Rupeng15 Powder,No.81160410)
文摘OBJECTIVE: To evaluate the influence of the Tibetan medicine Ru Peng15 powder(RPP15) on uric acid levels, and explore its possible mechanisms of action in hyperuricemic animal models.METHODS: Hyperuricemic mice were generated by orally administering yeast extract paste twice daily(30 g/kg) for 8 days, to mimic human hyperuricemia induced by high-protein diets. Hyperuricemic rats were generated by intraperitoneal injection of 250 mg/kg potassium oxonate to each animal 1 h before the last oral administration of test compounds, which raised the serum uric acid level by inhibiting the decomposition of uric acid. Levels of uric acid and creatinine in serum and urine were detected by the phosphotungstic acid and picric acid methods respectively, and the activity of xanthine oxidase(XOD) was assayed using a commercial test kit.RESULTS: RPP15(0.4, 0.8, 1.2 g/kg) significantly decreased the level of serum uric acid in healthy rats(P < 0.05). Furthermore, hyperuricemic rats treated with RPP15(0.4, 0.8, 1.2 g/kg) had lower serum uric acid levels(P < 0.05), accompanied by lower urine uric acid(P < 0.05). For the hyperuricemic mice, the levels of uric acid in the serum decreased significantly(P < 0.05) and the activity of XOD in the liver was restored to normal levels after treatment with RPP15(P < 0.05).CONCLUSION: RPP15(0.4, 0.8, 1.2 g/kg) demonstrated an anti-hyperuricemic effect on both healthy and hyperuricemic animals, and the mechanism is most likely associated with inhibiting the activity of XOD.
文摘The stabilization of the world population and the achievement of sustained development depend not only on the endeavours of governments of nations,but also on further strengthening and promotion of international cooperation,The developed countries should make eforts to improve the international economic environment,increase funds for population and development programmes and transfer technology at preferable conditions.
基金granted by National Natural Science Foundation of China(41720104009)China Geology Survey Project(DD20160023-01)Foundation of MLR(201511022)
文摘The Peng Co ophiolite is located to the west of Peng lake in the area of lakes in north Tibet, which belongs to the Baila-Yilashan sub-belt of the the middle Bangong Co-Nujiang ophiolitic belt. The Peng Co ophiolite is mainly composed of mantle peridotites, cumulates, diabase dikes. About 70 percent peridotites are harzburgites and 30 percent are lherzolites. Mineral chemistry of the Peng Co lherzolitesare characterized by low Fo contents(88.85–90.33) of olivine and high Al2O3 content(4.26%–7.25%) in pyroxenes. Compared to the primitive mantle, the Peng Co peridotites have relatively higher MgO contents, lower CaO, Al2O3 and TiO2 contents. The total rare-earth element(REE) contents of the lherzolites are 1.11–1.53 ppm, which are lower than those of the primitive mantle. The chondritenormalized REE patterns of the Peng Co peridotites display slight loss in LREE. In the primitive mantle-normalized spider diagram, the Peng Co peridotites exhibit negative Rb and Zr anomalies and intensively positive U, Ta, Sr anomalies. The PGE contents of Peng Co lherzolites are between 22.9–27 ppb. The chondrite-normalized PGE patterns of the Peng Co lherzolites are consistent with that of the primitive mantle. Mineral and whole-rock geochemistry characteristics of the Peng Co lherzolites show an affinity to abyssal peridotites, indicating that it may have formed in the mid-ocean ridge setting. Through quantitative modeling, we conclude that the Peng Co lherzolites formed after 5%–10% degree of partial melting of the spinelphase lherzolite mantle source. The sharp increase of Cr#(56.74–60.84)in Spinel of harzburgites and relatively high Pd/Ir and Rh/Ir ratios suggest that they have experienced melt-rock reaction. The crystallization sequence of Peng Co cumulate is olivine-clinopyroxene-plagioclase. The Mg# value of clinopyroxene in cumulate peridotite ranges from 86.92 to 89.93, and the mean value of Fo is 84.45, which is obviously higher than that of MOR-type ophiolite cumulates. The mineral composition, sequence of magmatic crystallization and mineral components of Peng Co cumulate are similar to those of the cumulate formed by the SSZ-type ophiolite in the subduction zone. Therefore, we can draw a preliminary conclusion that Peng Co lherzolites were formed in an environment of mid oceanic ridge and were remnants of the spinel lherzolite zone which experienced a partial melting of no more than 10%. In the later period, due to the intra-oceanic subduction, it experienced the rock-meltinteraction, and thus formed the SSZ-type cumulate and harzburgite of high Cr value.
文摘■Since April,all Magazine has examined five artist couples working in China.This month we lookatthe youngest of the artistic duos,Peng Yu and Sun Yuan,whose
