Objective To analyze the technical information in the field of tumor cell therapy in China,and to provide reference for identifying technical trends and predicting technical opportunities.Methods Based on the patent d...Objective To analyze the technical information in the field of tumor cell therapy in China,and to provide reference for identifying technical trends and predicting technical opportunities.Methods Based on the patent data in the field of tumor cell therapy in China,the patent map method was used to construct a scientific technical information analysis model.Then,the technical status of new drug research and development in this field was explored to identify technical opportunities.Results and Conclusion Studies have found that China’s tumor immunotherapy is in the growth stage.The technical innovation regions are mainly distributed in the east and innovative entities are enterprises.Technology hotspots are concentrated in areas such as A61P35,C12N5,and the patented technical efficacy is high.Besides,the technical research and development opportunities identified are closely related to the background in this field.To better promote the development of the industry,enterprises and research institutions should strengthen cooperation in technological innovation Meanwhile,they should pay attention to technical efficacy analysis to identify more technical opportunities,thereby effectively guiding innovation strategic decisions.展开更多
Objective To study the patent map and the relevant theories of the patent development of biopharmaceutical industry for conducting a comprehensive and in-depth analysis of the problems in patent application in Liaonin...Objective To study the patent map and the relevant theories of the patent development of biopharmaceutical industry for conducting a comprehensive and in-depth analysis of the problems in patent application in Liaoning biopharmaceutical industry.Methods Literature review,information visualization method,empirical analysis method and comparative analysis method were used to research the problems in the patent application.Results and Conclusion While developing biopharmaceutical industry,Liaoning provincial government should strengthen the protection of pharmaceutical patents,creating a new R&D mode of“university+research institutes+enterprises+individuals”to broaden the scope of technical fields.Then,its biopharmaceutical industry will be developed in an all-round way.Besides,it should closely follow the national development direction so that the biopharmaceutical industry in Liaoning Province will have a bright future.展开更多
Purpose： First, to review the state-of-the-art in patent citation analysis, particularly characteristics of patent citations to scientific literature （scientific non-patent references, SNPRs）. Second, to present a ...Purpose： First, to review the state-of-the-art in patent citation analysis, particularly characteristics of patent citations to scientific literature （scientific non-patent references, SNPRs）. Second, to present a novel mapping approach to identify technology-relevant research based on the papers cited by and referring to the SNPRs. Design/methodology/approach： In the review part we discuss the context of SNPRs such as the time lags between scientific achievements and inventions. Also patent-to-patent citation is addressed particularly because this type of patent citation analysis is a major element in the assessment of the economic value of patents. We also review the research on the role of universities and researchers in technological development, with important issues such as universities as sources of technological knowledge and inventor-author relations. We conclude the review part of this paper with an overview of recent research on mapping and network analysis of the science and technology interface and of technological progress in interaction with science. In the second part we apply new techniques for the direct visualization of the cited and citing relations of SNPRs, the mapping of the landscape around SNPRs by bibliographic coupling and co-citation analysis, and the mapping of the conceptual environment of SNPRs by keyword co-occurrence analysis. Findings： We discuss several properties of SNPRs. Only a small minority of publications covered by the Web of Science or Scopus are cited by patents, about 3%-4%. However, for publications based on university-industry collaboration the number of SNPRs is considerably higher, around 15%. The proposed mapping methodology based on a ＂second order SNPR approach＂ enables a better assessment of the technological relevance of research. Research limitations： The main limitation is that a more advanced merging of patent and publication data, in particular unification of author and inventor names, in still a necessity. Practical implications： The proposed mapping methodology enables the creation of a database of technology-relevant papers （TRPs）. In a bibliometric assessment the publications of research groups, research programs or institutes can be matched with the TRPs and thus the extent to which the work of groups, programs or institutes are relevant for technological development can be measured. Originality/value： The review part examines a wide range of findings in the research of patent citation analysis. The mapping approach to identify a broad range of technologyrelevant papers is novel and offers new opportunities in research evaluation practices.展开更多
尽管已有中文、外文文献对专利合作进行了探讨,但对其的深入分析和系统性归纳仍有不足。为此,以2014—2023年中国知网(CNKI)《中文核心期刊要目总览》及中文社会科学引文索引(CSSCI)来源期刊、Web of Science核心合集数据库中的中文、...尽管已有中文、外文文献对专利合作进行了探讨,但对其的深入分析和系统性归纳仍有不足。为此,以2014—2023年中国知网(CNKI)《中文核心期刊要目总览》及中文社会科学引文索引(CSSCI)来源期刊、Web of Science核心合集数据库中的中文、外文文献为研究对象,运用CiteSpace软件绘制知识图谱进行可视化分析,并对专利合作的研究演进,包括时空分布、研究热点、研究前沿等进行文献计量分析。研究结果表明,专利合作日益受到研究者的重视,在研究数量上,外文成果明显领先于中文成果;在研究合作方面,无论是作者合作还是机构合作,都处于相对较低水平;研究热点方面,中文、外文的研究热点均包括专利合作对技术创新的推动作用、创新绩效及专利合作的产学研合作等;研究前沿方面,中文对专利合作网络的演化、发展以及专利合作测度等较为关注,外文则对专利合作的多元化、多领域化及其在可持续发展中的影响因素更为重视。最后,从专利合作驱动、过程机制与合作效应等方面提出未来研究展望。展开更多
目的运用证据图对中成药治疗骨质疏松症的临床研究文献进行总结和梳理,得到相关研究的证据分布。方法检索2012年1月1日至2024年7月1日中国知网、维普、万方、中国生物医学文献数据库(CBM)、PubMed、Web of Science核心合集和the Cochran...目的运用证据图对中成药治疗骨质疏松症的临床研究文献进行总结和梳理,得到相关研究的证据分布。方法检索2012年1月1日至2024年7月1日中国知网、维普、万方、中国生物医学文献数据库(CBM)、PubMed、Web of Science核心合集和the Cochrane Library数据库发表的中成药治疗骨质疏松症相关文献,采用证据图描述证据分布特点。结果共纳入378篇文献,其中355篇临床研究文献、23篇系统评价/Meta分析,涉及46种中成药。结果显示,在临床研究中仙灵骨葆胶囊使用频次最高;研究类型以随机对照试验为主,样本量为80~110例;研究对象以原发性骨质疏松、肾阴虚型骨质疏松患者为主;试验组干预措施以中成药或中成药联合西药为主,疗程多为3~12个月;主要结局指标为骨密度、临床有效率、骨形成标志物。系统评价/Meta分析均显示证据潜在有效或有效,但AMSTAR质量评分较低。结论中成药治疗骨质疏松虽然展现其独特的优势,但缺乏高质量的临床研究证据。未来需开展多中心、大样本、双盲的随机对照试验,以获得高质量研究证据。展开更多
In view of the lack of patent big data in research on technology foresight in the industrial robot field, this paper introduces an improved method based on patent mining and knowledge map. Firstly, SAO structure is ex...In view of the lack of patent big data in research on technology foresight in the industrial robot field, this paper introduces an improved method based on patent mining and knowledge map. Firstly, SAO structure is extracted from selected patents, secondly, the similarity between patents is calculated based on extracted SAO structure, thirdly, patent network and patent map are drawn based on calculated patent similarity matrix, technology evolution process and future trends of industrial robot are summarized from patent network, and future potential technology opportunities are predicted based on technological vacancies identified from patent map. Finally, this paper identifies six key technical areas and four potential technical opportunities in the field of the industrial robot.展开更多
目的运用文献计量学方法分析贝母属Fritillaria植物的研究现状与发展趋势,并通过专利分析得到贝母属植物的成果转化情况,为未来的开发应用提供方向参考。方法在中国知网数据库、万方数据库、维普数据库、Web of Science核心合集数据库,...目的运用文献计量学方法分析贝母属Fritillaria植物的研究现状与发展趋势,并通过专利分析得到贝母属植物的成果转化情况,为未来的开发应用提供方向参考。方法在中国知网数据库、万方数据库、维普数据库、Web of Science核心合集数据库,以贝母和Fritillaria为主题检索词收集相关文献,导入NoteExpress文献管理软件中进行查重、筛选和格式转换;使用Excel、CiteSpace、VOSviewer软件对中英文文献的年度发文趋势、合作网络、研究热点等进行可视化分析。通过Incopat专利数据库从专利申请趋势、专利申请地域分布、专利申请人等方面对贝母属植物专利申请情况进行分析。结果共纳入符合标准的中文文献1511篇,英文文献805篇。贝母属发文量大体呈现上升的趋势,共有56个国家参与贝母属的研究,发文国家以中国为主。英文文献涉及学科以植物科学为主。中、英文发文量最多的作者分别是周浓和Li Ping,最多的机构分别是中国中医科学院和Chinese Academy of Sciences(中国科学院),部分发文作者间已形成研究团队,发文机构间的合作关系较分散。基于Incopat专利数据库检索得到专利数据10292件,国内专利有9980件,占比96.97%,占据绝对的主导地位。结论贝母属植物的研究处于不断拓展与上升阶段,其研究核心物种为浙贝母和川贝母,热点方向为生物碱等活性成分、药理作用与分子机制、生长栽培与资源保护等。贝母属植物专利在全球分布差距明显,我国的专利申请量占据绝对主导地位,但当前仍面临申请活跃度不足、有效率较低、技术构成单一以及竞争力不强等问题。展开更多
钻井作为油气勘探开发的核心环节之一,随着大数据、人工智能技术在钻井领域的深入应用,智能钻井技术不断取得突破。以德温特创新索引国际专利数据库(DII)为数据来源,利用Derwent Data Analyzer(DDA)、Derwent Innovation(DI)等专利分析...钻井作为油气勘探开发的核心环节之一,随着大数据、人工智能技术在钻井领域的深入应用,智能钻井技术不断取得突破。以德温特创新索引国际专利数据库(DII)为数据来源,利用Derwent Data Analyzer(DDA)、Derwent Innovation(DI)等专利分析工具和平台,对智能钻井领域的专利申请进行了系统分析。结果表明,智能钻井领域专利申请主要集中在中国、美国和加拿大,但美国核心专利数量占据绝对优势。主要研发机构包括中国石油、中国石化、中海油、西南石油大学、哈里伯顿能源服务公司等。技术布局主要集中在利用旋转钻井、测试操作和设备、海洋钻井结构和设备、其他钻井方法和设备、钻井液、打捞和回收工具、缆索钻井等。展开更多
运用证据图对中成药治疗抑郁症的临床研究进行分析,以发掘该领域的优势及不足,为后续研究提供参考。系统检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science、Cochrane Library...运用证据图对中成药治疗抑郁症的临床研究进行分析,以发掘该领域的优势及不足,为后续研究提供参考。系统检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science、Cochrane Library、EMbase数据库发表的中成药治疗抑郁症的临床研究,检索时间从建库至2024年6月1日,对纳入临床研究的特征及方法学质量进行评价,采用图、表展示结果。最终纳入中成药6种,相关文献223篇,包括随机对照试验(RCTs)181篇、非随机对照试验(non-RCTs)29篇、系统评价/Meta分析12篇、专家共识1篇。涉及的6种中成药中,舒肝解郁胶囊在治疗抑郁症方面使用最为广泛。中成药治疗抑郁症的发文趋势为先升后降,以单中心、小样本、短疗程为主;结局指标纳入抑郁、焦虑、安全性指标、使用危害、总有效率偏多,对生活质量、随访及复发率、中医证候积分等关注较少;RCT总体偏倚风险较高,系统评价/Meta分析的质量普遍不高,non-RCT均未提及样本量估算、随访及随访时间,大多数文献未设计盲法,导致研究结果的可信度不高。将来仍需坚持中医理念,按标准设计临床研究,把中医贯彻到临床研究的每一阶段,规范及推广中医证候积分的应用,重视患者的生活质量,以提高中医药治疗抑郁症的研究质量。展开更多
文摘Objective To analyze the technical information in the field of tumor cell therapy in China,and to provide reference for identifying technical trends and predicting technical opportunities.Methods Based on the patent data in the field of tumor cell therapy in China,the patent map method was used to construct a scientific technical information analysis model.Then,the technical status of new drug research and development in this field was explored to identify technical opportunities.Results and Conclusion Studies have found that China’s tumor immunotherapy is in the growth stage.The technical innovation regions are mainly distributed in the east and innovative entities are enterprises.Technology hotspots are concentrated in areas such as A61P35,C12N5,and the patented technical efficacy is high.Besides,the technical research and development opportunities identified are closely related to the background in this field.To better promote the development of the industry,enterprises and research institutions should strengthen cooperation in technological innovation Meanwhile,they should pay attention to technical efficacy analysis to identify more technical opportunities,thereby effectively guiding innovation strategic decisions.
文摘Objective To study the patent map and the relevant theories of the patent development of biopharmaceutical industry for conducting a comprehensive and in-depth analysis of the problems in patent application in Liaoning biopharmaceutical industry.Methods Literature review,information visualization method,empirical analysis method and comparative analysis method were used to research the problems in the patent application.Results and Conclusion While developing biopharmaceutical industry,Liaoning provincial government should strengthen the protection of pharmaceutical patents,creating a new R&D mode of“university+research institutes+enterprises+individuals”to broaden the scope of technical fields.Then,its biopharmaceutical industry will be developed in an all-round way.Besides,it should closely follow the national development direction so that the biopharmaceutical industry in Liaoning Province will have a bright future.
文摘Purpose： First, to review the state-of-the-art in patent citation analysis, particularly characteristics of patent citations to scientific literature （scientific non-patent references, SNPRs）. Second, to present a novel mapping approach to identify technology-relevant research based on the papers cited by and referring to the SNPRs. Design/methodology/approach： In the review part we discuss the context of SNPRs such as the time lags between scientific achievements and inventions. Also patent-to-patent citation is addressed particularly because this type of patent citation analysis is a major element in the assessment of the economic value of patents. We also review the research on the role of universities and researchers in technological development, with important issues such as universities as sources of technological knowledge and inventor-author relations. We conclude the review part of this paper with an overview of recent research on mapping and network analysis of the science and technology interface and of technological progress in interaction with science. In the second part we apply new techniques for the direct visualization of the cited and citing relations of SNPRs, the mapping of the landscape around SNPRs by bibliographic coupling and co-citation analysis, and the mapping of the conceptual environment of SNPRs by keyword co-occurrence analysis. Findings： We discuss several properties of SNPRs. Only a small minority of publications covered by the Web of Science or Scopus are cited by patents, about 3%-4%. However, for publications based on university-industry collaboration the number of SNPRs is considerably higher, around 15%. The proposed mapping methodology based on a ＂second order SNPR approach＂ enables a better assessment of the technological relevance of research. Research limitations： The main limitation is that a more advanced merging of patent and publication data, in particular unification of author and inventor names, in still a necessity. Practical implications： The proposed mapping methodology enables the creation of a database of technology-relevant papers （TRPs）. In a bibliometric assessment the publications of research groups, research programs or institutes can be matched with the TRPs and thus the extent to which the work of groups, programs or institutes are relevant for technological development can be measured. Originality/value： The review part examines a wide range of findings in the research of patent citation analysis. The mapping approach to identify a broad range of technologyrelevant papers is novel and offers new opportunities in research evaluation practices.
文摘尽管已有中文、外文文献对专利合作进行了探讨,但对其的深入分析和系统性归纳仍有不足。为此,以2014—2023年中国知网(CNKI)《中文核心期刊要目总览》及中文社会科学引文索引(CSSCI)来源期刊、Web of Science核心合集数据库中的中文、外文文献为研究对象,运用CiteSpace软件绘制知识图谱进行可视化分析,并对专利合作的研究演进,包括时空分布、研究热点、研究前沿等进行文献计量分析。研究结果表明,专利合作日益受到研究者的重视,在研究数量上,外文成果明显领先于中文成果;在研究合作方面,无论是作者合作还是机构合作,都处于相对较低水平;研究热点方面,中文、外文的研究热点均包括专利合作对技术创新的推动作用、创新绩效及专利合作的产学研合作等;研究前沿方面,中文对专利合作网络的演化、发展以及专利合作测度等较为关注,外文则对专利合作的多元化、多领域化及其在可持续发展中的影响因素更为重视。最后,从专利合作驱动、过程机制与合作效应等方面提出未来研究展望。
文摘目的运用证据图对中成药治疗骨质疏松症的临床研究文献进行总结和梳理,得到相关研究的证据分布。方法检索2012年1月1日至2024年7月1日中国知网、维普、万方、中国生物医学文献数据库(CBM)、PubMed、Web of Science核心合集和the Cochrane Library数据库发表的中成药治疗骨质疏松症相关文献,采用证据图描述证据分布特点。结果共纳入378篇文献,其中355篇临床研究文献、23篇系统评价/Meta分析,涉及46种中成药。结果显示,在临床研究中仙灵骨葆胶囊使用频次最高;研究类型以随机对照试验为主,样本量为80~110例;研究对象以原发性骨质疏松、肾阴虚型骨质疏松患者为主;试验组干预措施以中成药或中成药联合西药为主,疗程多为3~12个月;主要结局指标为骨密度、临床有效率、骨形成标志物。系统评价/Meta分析均显示证据潜在有效或有效,但AMSTAR质量评分较低。结论中成药治疗骨质疏松虽然展现其独特的优势,但缺乏高质量的临床研究证据。未来需开展多中心、大样本、双盲的随机对照试验,以获得高质量研究证据。
文摘In view of the lack of patent big data in research on technology foresight in the industrial robot field, this paper introduces an improved method based on patent mining and knowledge map. Firstly, SAO structure is extracted from selected patents, secondly, the similarity between patents is calculated based on extracted SAO structure, thirdly, patent network and patent map are drawn based on calculated patent similarity matrix, technology evolution process and future trends of industrial robot are summarized from patent network, and future potential technology opportunities are predicted based on technological vacancies identified from patent map. Finally, this paper identifies six key technical areas and four potential technical opportunities in the field of the industrial robot.
文摘运用证据图系统检索与梳理口服中成药治疗脑出血(intracerebral hemorrhage,ICH)的临床研究证据,了解该领域现有证据分布及质量。通过检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science、EMbase、Cochrane Library数据库,建库至2024年7月5日发表的相关文献,采用图、表结合文字形式展示数据分布特征。共检索到35种中成药,纳入261篇文献,将中成药的基本信息、发文趋势、中医证型、干预措施、结局指标等进行对比和分析,并对文献方法学质量进行评价。结果显示,治疗ICH的中成药临床定位宽泛;未充分体现中医优势与特色;安全性信息尚不完善;结局指标评价方面评价标准不统一,对认知功能、心理学方面关注略显不足;文献方法学质量较低。建议在今后的临床研究中,规范试验设计,突出中医特色;将中医证候评价作为重要结局指标,并统一评价标准,多关注患者认知功能与心理学情况;建议治疗ICH中成药的上市许可持有人按照国家药品监督管理局相关要求,规范临床定位,修订完善说明书中安全性信息;提高医保目录中甲类中成药占比,合理配置有限的医疗资源。
文摘目的运用文献计量学方法分析贝母属Fritillaria植物的研究现状与发展趋势,并通过专利分析得到贝母属植物的成果转化情况,为未来的开发应用提供方向参考。方法在中国知网数据库、万方数据库、维普数据库、Web of Science核心合集数据库,以贝母和Fritillaria为主题检索词收集相关文献,导入NoteExpress文献管理软件中进行查重、筛选和格式转换;使用Excel、CiteSpace、VOSviewer软件对中英文文献的年度发文趋势、合作网络、研究热点等进行可视化分析。通过Incopat专利数据库从专利申请趋势、专利申请地域分布、专利申请人等方面对贝母属植物专利申请情况进行分析。结果共纳入符合标准的中文文献1511篇,英文文献805篇。贝母属发文量大体呈现上升的趋势,共有56个国家参与贝母属的研究,发文国家以中国为主。英文文献涉及学科以植物科学为主。中、英文发文量最多的作者分别是周浓和Li Ping,最多的机构分别是中国中医科学院和Chinese Academy of Sciences(中国科学院),部分发文作者间已形成研究团队,发文机构间的合作关系较分散。基于Incopat专利数据库检索得到专利数据10292件,国内专利有9980件,占比96.97%,占据绝对的主导地位。结论贝母属植物的研究处于不断拓展与上升阶段,其研究核心物种为浙贝母和川贝母,热点方向为生物碱等活性成分、药理作用与分子机制、生长栽培与资源保护等。贝母属植物专利在全球分布差距明显,我国的专利申请量占据绝对主导地位,但当前仍面临申请活跃度不足、有效率较低、技术构成单一以及竞争力不强等问题。
文摘钻井作为油气勘探开发的核心环节之一,随着大数据、人工智能技术在钻井领域的深入应用,智能钻井技术不断取得突破。以德温特创新索引国际专利数据库(DII)为数据来源,利用Derwent Data Analyzer(DDA)、Derwent Innovation(DI)等专利分析工具和平台,对智能钻井领域的专利申请进行了系统分析。结果表明,智能钻井领域专利申请主要集中在中国、美国和加拿大,但美国核心专利数量占据绝对优势。主要研发机构包括中国石油、中国石化、中海油、西南石油大学、哈里伯顿能源服务公司等。技术布局主要集中在利用旋转钻井、测试操作和设备、海洋钻井结构和设备、其他钻井方法和设备、钻井液、打捞和回收工具、缆索钻井等。
文摘运用证据图对中成药治疗抑郁症的临床研究进行分析,以发掘该领域的优势及不足,为后续研究提供参考。系统检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science、Cochrane Library、EMbase数据库发表的中成药治疗抑郁症的临床研究,检索时间从建库至2024年6月1日,对纳入临床研究的特征及方法学质量进行评价,采用图、表展示结果。最终纳入中成药6种,相关文献223篇,包括随机对照试验(RCTs)181篇、非随机对照试验(non-RCTs)29篇、系统评价/Meta分析12篇、专家共识1篇。涉及的6种中成药中,舒肝解郁胶囊在治疗抑郁症方面使用最为广泛。中成药治疗抑郁症的发文趋势为先升后降,以单中心、小样本、短疗程为主;结局指标纳入抑郁、焦虑、安全性指标、使用危害、总有效率偏多,对生活质量、随访及复发率、中医证候积分等关注较少;RCT总体偏倚风险较高,系统评价/Meta分析的质量普遍不高,non-RCT均未提及样本量估算、随访及随访时间,大多数文献未设计盲法,导致研究结果的可信度不高。将来仍需坚持中医理念,按标准设计临床研究,把中医贯彻到临床研究的每一阶段,规范及推广中医证候积分的应用,重视患者的生活质量,以提高中医药治疗抑郁症的研究质量。
