The heterogeneity and invasiveness of cancer cells pose serious challenges in cancer diagnosis and treatment.Advancements and innovations in metal-based nanomedicines provide novel avenues for addressing these challen...The heterogeneity and invasiveness of cancer cells pose serious challenges in cancer diagnosis and treatment.Advancements and innovations in metal-based nanomedicines provide novel avenues for addressing these challenges.Metal-based nanomedicines possess unique physicochemical properties that enable their interaction with living organisms,thereby inducing complex biological responses.These nanomaterials have been extensively used to enhance the contrast and sensitivity of cancer imaging and to amplify the distinction between cancerous and healthy tissues.Moreover,these nanomaterials can effectively combat a wide spectrum of cancers through various methods,including drug delivery,radiotherapy,photothermal therapy(PTT),photodynamic therapy(PDT),sonodynamic therapy(SDT),biocatalytic therapy,ion interference therapy(IIT),and immunotherapy.Currently,there is still a need for a comprehensive summary on the metal-based nanomaterials for cancer diagnosis and treatment.Herein,we present a systematic and complete overview of action mechanisms and the applications of metal-based nanomaterials in cancer theranostics.A summary of common strategies for synthesizing and modifying metal-based nanomedicines is presented,and their biosafety is analyzed.Then,the latest developments in their applications for cancer imaging and anticancer treatment are provided.Finally,the key technical challenges and reasonable perspectives of metal-based nanomedicines for cancer theranostics in clinical applications are discussed.展开更多
目的:分析磁共振成像(magnetic resonance imaging,MRI)在后踝关节撞击综合征(posterior impingement syndrome of the anklejoint,PAIS)诊断中的应用效果。方法:选取新疆医科大学第六附属医院2019年11月—2020年10月收治的70例PAIS患...目的:分析磁共振成像(magnetic resonance imaging,MRI)在后踝关节撞击综合征(posterior impingement syndrome of the anklejoint,PAIS)诊断中的应用效果。方法:选取新疆医科大学第六附属医院2019年11月—2020年10月收治的70例PAIS患者进行研究,以随机抽签法分组,各35例。对照组采用X线检查,观察组采用MRI检查,对比不同影像学检查方法对后踝关节撞击综合征的影响。结果:观察组成像质量评分高于对照组,差异有统计学意义(P<0.05)。观察组对骨质结构损伤的检出率高于对照组,差异有统计学意义(P<0.05)。观察组对软组织损伤的检出率高于对照组,差异有统计学意义(P<0.05)。结论:与采用X线检查相比,MRI在PAIS检查中具有成像质量高的优势,可对患者后踝关节骨质结构损伤及软组织损伤的检出率高,可有效辅助临床诊疗。展开更多
目的探究活血定眩胶囊对椎动脉型颈椎病(cervical spondylosis of vertebral artery type,CSA)模型大鼠椎动脉血流量以及血浆中组织型纤溶酶原激活物(tissue type plasminogen activator,t-PA)和纤溶酶原激活物抑制物(plasminogen activ...目的探究活血定眩胶囊对椎动脉型颈椎病(cervical spondylosis of vertebral artery type,CSA)模型大鼠椎动脉血流量以及血浆中组织型纤溶酶原激活物(tissue type plasminogen activator,t-PA)和纤溶酶原激活物抑制物(plasminogen activator inhibitor,PAI)的影响。方法将90只健康雄性Wistar大鼠随机分为对照组、模型组及治疗组3组,每组30只。对照组不做处理,模型组及治疗组采用复合造模法制造CSA模型大鼠。治疗组在造模4周后按照人鼠折算系数开始给予活血定眩胶囊药物干预6周。每组分别在造模前、干预前及干预后3个不同时间点检测椎动脉血流量及血浆PAI、t-PA含量。结果干预前,模型组与治疗组的椎动脉血流量均低于对照组(P<0.05);干预后,治疗组高于对照组(P<0.05)。与本组造模前分别比较,模型组及治疗组干预前血清PAI、tPA含量均升高(P<0.01)。与对照组同期比较,模型组及治疗组干预前PAI、t-PA含量升高(P<0.01)。与本组干预前进行比较,模型组造模后血清PAI、t-PA含量升高(P<0.01),治疗组干预后血清PAI、t-PA含量降低(P<0.01)。与模型组同期比较,治疗组干预后血清PAI、t-PA含量降低(P<0.01)。结论活血定眩胶囊可提高椎动脉血流量,降低血清PAI、t-PA含量。展开更多
基金supported by the National Natural Science Foundation of China(82071981)the Program of Youth Science and Technology Innovation and Entrepreneurship Outstanding Talents(Team)of Jilin Province,China(20230508063RC)+3 种基金the Excellent Youth Training Foundation of Jilin University,China(419080520665)the Innovation and Entrepreneurship Talent Funding Program of Jilin Province,Chinathe Health Special Project of the Finance Department of Jilin Province,Chinathe Graduate Innovation Fund of Jilin University,China(2025CX297)。
文摘The heterogeneity and invasiveness of cancer cells pose serious challenges in cancer diagnosis and treatment.Advancements and innovations in metal-based nanomedicines provide novel avenues for addressing these challenges.Metal-based nanomedicines possess unique physicochemical properties that enable their interaction with living organisms,thereby inducing complex biological responses.These nanomaterials have been extensively used to enhance the contrast and sensitivity of cancer imaging and to amplify the distinction between cancerous and healthy tissues.Moreover,these nanomaterials can effectively combat a wide spectrum of cancers through various methods,including drug delivery,radiotherapy,photothermal therapy(PTT),photodynamic therapy(PDT),sonodynamic therapy(SDT),biocatalytic therapy,ion interference therapy(IIT),and immunotherapy.Currently,there is still a need for a comprehensive summary on the metal-based nanomaterials for cancer diagnosis and treatment.Herein,we present a systematic and complete overview of action mechanisms and the applications of metal-based nanomaterials in cancer theranostics.A summary of common strategies for synthesizing and modifying metal-based nanomedicines is presented,and their biosafety is analyzed.Then,the latest developments in their applications for cancer imaging and anticancer treatment are provided.Finally,the key technical challenges and reasonable perspectives of metal-based nanomedicines for cancer theranostics in clinical applications are discussed.
文摘目的:分析磁共振成像(magnetic resonance imaging,MRI)在后踝关节撞击综合征(posterior impingement syndrome of the anklejoint,PAIS)诊断中的应用效果。方法:选取新疆医科大学第六附属医院2019年11月—2020年10月收治的70例PAIS患者进行研究,以随机抽签法分组,各35例。对照组采用X线检查,观察组采用MRI检查,对比不同影像学检查方法对后踝关节撞击综合征的影响。结果:观察组成像质量评分高于对照组,差异有统计学意义(P<0.05)。观察组对骨质结构损伤的检出率高于对照组,差异有统计学意义(P<0.05)。观察组对软组织损伤的检出率高于对照组,差异有统计学意义(P<0.05)。结论:与采用X线检查相比,MRI在PAIS检查中具有成像质量高的优势,可对患者后踝关节骨质结构损伤及软组织损伤的检出率高,可有效辅助临床诊疗。
