Using n [TC 16 PyP(4)]/ n (anthraquinone)(1∶1) mixture as film forming material, the film forming property of TC 16 PyP(4)/AnQ mixture on the air/water interface was studied. The structure of mixed TC 16 PyP(4)/AnQ L...Using n [TC 16 PyP(4)]/ n (anthraquinone)(1∶1) mixture as film forming material, the film forming property of TC 16 PyP(4)/AnQ mixture on the air/water interface was studied. The structure of mixed TC 16 PyP(4)/AnQ LB films was characterized by π A isotherms, UV Vis absorption spectra and low angle X ray diffraction(LAXD). The experimental results indicate that the TC 16 PyP(4)/AnQ mixture can form a stable monolayer on the air/water interface. Most AnQ molecules are incorporated into the cavities between the long alkyl chains of TC 16 PyP(4) molecules in the mixed monolayer and LB films. Mixed TC 16 PyP(4)/AnQ monolayer can be transferred to the substrates. TC 16 PyP(4)/AnQ LB films have a good stability and periodicity. [WT5HZ]展开更多
Our aim was to investigate the effects of MnTE-2-PyP on some markers of inflammation and lipid peroxidation in mouse asthma model. 24 female mice were divided into four groups: group 1, controls;group 2, injected with...Our aim was to investigate the effects of MnTE-2-PyP on some markers of inflammation and lipid peroxidation in mouse asthma model. 24 female mice were divided into four groups: group 1, controls;group 2, injected with ovalbumin (OVA);group 3, treated with MnTE-2-PyP;and group 4, treated with ovalbumin and MnTE-2-PyP. The mice from groups 2 and 4 were injected with 10 μg OVA and 1 mg Imject Alum? in 100 μL phosphate buffered saline (PBS) on days 0 and 14. The animals from groups 1 and 3 were injected with 100 μL PBS + Imject Alum? (1:1). The animals from groups 2 and 4 were subjected to a 30 min aerosol challenge of 1% ovalbumin on days 24, 25 and 26 and those from groups 1 and 3 were subjected to aerosol challenge of PBS at the same time and duration. One hour before inhalation, and 12 hours later the animals from groups 3 and 4 were injected with 100 μL MnTE-2-PyP solution in PBS containing 5 mg/kg. The total cell number, total protein content and 8-isoprostane, IL-4 and IL-5 levels in the bronchialveolar lavage fluid increased in group 2 as compared to the control group. Malone dialdehyde content in the lung homogenate and IgE levels in the serum also increased in this group. The total cell number, total protein content, and levels of 8-isoprostane, IL-4, IL-5 and IgE decreased significantly in group 4 as compared to the OVA group. The parameters set out above in group 3 did not differ significantly from those of the control group. MnTE-2-PyP administered intraperitoneally, 48 hours after the last nebulization, reduced the inflammation and lipid peroxidation in mouse asthma model.展开更多
文摘Using n [TC 16 PyP(4)]/ n (anthraquinone)(1∶1) mixture as film forming material, the film forming property of TC 16 PyP(4)/AnQ mixture on the air/water interface was studied. The structure of mixed TC 16 PyP(4)/AnQ LB films was characterized by π A isotherms, UV Vis absorption spectra and low angle X ray diffraction(LAXD). The experimental results indicate that the TC 16 PyP(4)/AnQ mixture can form a stable monolayer on the air/water interface. Most AnQ molecules are incorporated into the cavities between the long alkyl chains of TC 16 PyP(4) molecules in the mixed monolayer and LB films. Mixed TC 16 PyP(4)/AnQ monolayer can be transferred to the substrates. TC 16 PyP(4)/AnQ LB films have a good stability and periodicity. [WT5HZ]
文摘Our aim was to investigate the effects of MnTE-2-PyP on some markers of inflammation and lipid peroxidation in mouse asthma model. 24 female mice were divided into four groups: group 1, controls;group 2, injected with ovalbumin (OVA);group 3, treated with MnTE-2-PyP;and group 4, treated with ovalbumin and MnTE-2-PyP. The mice from groups 2 and 4 were injected with 10 μg OVA and 1 mg Imject Alum? in 100 μL phosphate buffered saline (PBS) on days 0 and 14. The animals from groups 1 and 3 were injected with 100 μL PBS + Imject Alum? (1:1). The animals from groups 2 and 4 were subjected to a 30 min aerosol challenge of 1% ovalbumin on days 24, 25 and 26 and those from groups 1 and 3 were subjected to aerosol challenge of PBS at the same time and duration. One hour before inhalation, and 12 hours later the animals from groups 3 and 4 were injected with 100 μL MnTE-2-PyP solution in PBS containing 5 mg/kg. The total cell number, total protein content and 8-isoprostane, IL-4 and IL-5 levels in the bronchialveolar lavage fluid increased in group 2 as compared to the control group. Malone dialdehyde content in the lung homogenate and IgE levels in the serum also increased in this group. The total cell number, total protein content, and levels of 8-isoprostane, IL-4, IL-5 and IgE decreased significantly in group 4 as compared to the OVA group. The parameters set out above in group 3 did not differ significantly from those of the control group. MnTE-2-PyP administered intraperitoneally, 48 hours after the last nebulization, reduced the inflammation and lipid peroxidation in mouse asthma model.
