On the basis of analyzing both domestic and foreign evaluation systems for the e-government and also taking into account of the current situation of government portals in urban centers,the paper is aimed to construct ...On the basis of analyzing both domestic and foreign evaluation systems for the e-government and also taking into account of the current situation of government portals in urban centers,the paper is aimed to construct an evaluation system primarily for the measurement of the service capability of business-oriented G2B portals of local governments in general and those G2B portals of the new development zones in particular.This system is composed of 6 first tier indicators,18 second tier indicators and 90 third tier indicators.And the weight of each indicator is determined by Delphi Method and Analytic Hierarchy Process(AHP) Method.Subsequently,we used this system to evaluate the government portals of Tianjin Binhai New Area and Shanghai Pudong New Area and proved to have the desired practicability.展开更多
The authors of the existing version of the special theory of relativity had to use the princi-ple of light speed non-exceedance to explain relativistic formulas obtained therein within the space of real numbers. The p...The authors of the existing version of the special theory of relativity had to use the princi-ple of light speed non-exceedance to explain relativistic formulas obtained therein within the space of real numbers. The principle implied existence of only our visible universe and absence of physical content in imaginary numbers. However, since the principle is just a postulate, i.e. an unproven assumption, it has always carried little credibility. The paper refutes the principle by the experimentally proven principle of physical reality of imagi-nary numbers. As follows from the principle of physical reality of imaginary numbers, relativistic formulas of the existing version of the STR are wrong and incorrectly ex-plained, and conclusions drawn from them are misguided. In other words, this version is incorrect1 and, thus, the STR was not actually created in the 20th century. Moreover, it could not be created in the 20th century, as its creation required experimental data ob-tained in the 21st century. The paper provides an alternative version of the STR contain-ing relativistic formulas corrected given experimental data obtained in the 21st century. These formulas imply that instead of the Monoverse, whose existence is supposed in the existing version of the STR, there is a Multiverse, whose universes are mutually invisible (and the invisibility is explainable) and therefore it has been referred to as hidden. The paper explains that existence of invisible universes of the hidden Multiverse gives rise to the phenomenon of dark matter and dark energy that is actually a sort of optical effect (however, not electromagnetic, but gravitational), a shadow, rather than some physical substance2. It also explains that existence of other invisible universes outside the hidden Multiverse gives rise to the phenomenon of dark space. Invisible universes are claimed to really exist, which can be experimentally proved by astronomical observations in portals, where universes not visible outside portals become partially visible. Therefore, constella-tions observed in the starry sky inside the portals are different from those observed in our visible universe. The alternative version of the special theory of relativity can also suc-cessfully solve other issues of astrophysics. In particular, it can explain where antimatter is located and why it does not annihilate with matter, as well as where tachyons are locat-ed and why they don’t violate the principle of causality, etc.展开更多
Network congestion, one of the challenging tasks in communication networks, leads to queuing delays, packet loss, or the blocking of new connections. In this study, a data portal is considered as an application-based ...Network congestion, one of the challenging tasks in communication networks, leads to queuing delays, packet loss, or the blocking of new connections. In this study, a data portal is considered as an application-based network, and a cognitive method is proposed to deal with congestion in this kind of network. Unlike previous methods for congestion control, the proposed method is an effective approach for congestion control when the link capacity and information inquiries are unknown or variable. Using sufficient training samples and the current value of the network parameters, available bandwidth is adjusted to distribute the bandwidth among the active flows. The proposed cognitive method was tested under such situations as unexpected variations in link capacity and oscillatory behavior of the bandwidth. Based on simulation results, the proposed method is capable of adjusting the available bandwidth by tuning the queue length, and provides a stable queue in the network.展开更多
The personalization in knowledge portals and knowledge management systems is mainly performed based on users' explicitly specified categories and keywords. The explicit specification approach requires users' p...The personalization in knowledge portals and knowledge management systems is mainly performed based on users' explicitly specified categories and keywords. The explicit specification approach requires users' participation to start personalization services, and has limitation to adapt changes of users' preference. This paper suggests two implicit personalization approaches: automatic user category assignment method and automatic keyword profile generation method. The performances of the implicit personalization approaches are compared with traditional personalization approach using an Internet news site experiment. The result of the experiment shows that the suggested personalization approaches provide sufficient recommendation effectiveness with lessening users' unwanted involvement in personalization process.展开更多
Muqarnas （stalactite vault） is a distinctive structural and configurational feature of Islamic architecture. It is used to provide a transition from a square plan to a circular perimeter, thus allowing a domicat or ...Muqarnas （stalactite vault） is a distinctive structural and configurational feature of Islamic architecture. It is used to provide a transition from a square plan to a circular perimeter, thus allowing a domicat or semi-domical space to be erected above a square or rectangular layout. It is similar to the Roman pendentive in its structural logic but quite different in form and architectonic detail. The use of muqarnas has become ubiquitous in Islamic architecture and was applied structurally and decoratively above major spaces in mosques and mausoleums, wall niches, facades, arches, friezes, and entrance typological, and stylistic analysis of Bahri Mamluk portals. This paper provides a historical, rnuqarnas portals developed in Cairo, Egypt during the 13th and 14th centuries. Due to the complexity and breadth of this undertaking, the current study focuses on the earliest 10 monuments that exemplify the type and examines the origin, meaning, and development of muqarnas portals in Egypt. Local and foreign influences are analyzed with an eye on identifying similarities and variations in terms of constructability, geometry, and complexity of muqarnas configurations. The paper concludes with a discussion of the primary innovative features of Bahri Mamiuk Muqarnas and their effect on subsequent muqarnas development in Egypt.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)is a major type of liver cancer worldwide.In advanced stages,portal vein tumor thrombosis(PVTT)and jaundice are common,whereas obstructive jaundice(OJ)is relatively rare.Both co...BACKGROUND Hepatocellular carcinoma(HCC)is a major type of liver cancer worldwide.In advanced stages,portal vein tumor thrombosis(PVTT)and jaundice are common,whereas obstructive jaundice(OJ)is relatively rare.Both conditions markedly reduce survival and increase therapeutic complexity.Recently,hepatic artery infusion chemotherapy(HAIC)in combination with targeted immunotherapy has shown promise for advanced HCC.CASE SUMMARY We report a 47-year-old male with advanced HCC complicated by PVTT and OJ,who was admitted with marked jaundice of the skin and sclera.Imaging revealed a large hepatic mass(14.5 cm×11.3 cm)in the right lobe with associated portal vein tumor thrombus.The tertiary bile duct was only mildly dilated,making percutaneous transhepatic cholangiography drainage infeasible.The patient underwent reduced-dose HAIC,which resulted in significant tumor shrinkage and marked reduction in serum bilirubin.This improvement enabled sequential treatment with lenvatinib and camrelizumab.After six cycles,both liver function and alphafetoprotein levels improved.The patient achieved a progression-free survival of 20 months and an overall survival of 29 months.CONCLUSION HAIC can treat high-bilirubin HCC with PVTT and OJ,allowing for subsequent targeted immunotherapy.展开更多
Presentation level integration now becomes an important and fast growing trend in enterprise computing Portal-based composite applications use portlet and interactive web service, which usually offers several portlets...Presentation level integration now becomes an important and fast growing trend in enterprise computing Portal-based composite applications use portlet and interactive web service, which usually offers several portlets, as their basic constituents. Hence, portlet description and discovery are the key issues that have to be considered for the development of portal-based composite applications. This paper proposes a novel concept POI （Presentation Oriented Interface） to describe the presentation features of a portlet, so that interactive web services may be extended to facilitate the selection and interoperation of portlets. Portlet discovery can be effectively achieved based on the calculation of POI similarity that considers both type and structure similarity. Experiments show that the proposed approach can improve the satisfaction of portlet discovery, and also facilitate the portlet interoperation, thereby achieving better application integration at presentation level.展开更多
Purpose:Recurrent dislocation of shoulder(RDS)is a common injury in high demand professionals,like athletes and military personnel.The treatment for the patients with Bankart lesion is the arthroscopic repair.This pre...Purpose:Recurrent dislocation of shoulder(RDS)is a common injury in high demand professionals,like athletes and military personnel.The treatment for the patients with Bankart lesion is the arthroscopic repair.This present study compares the outcomes of two different techniques of arthroscopic Bankart repair i.e.a standard two anterior portals technique and a single anterior portal technique in patients with RDS.Methods:Patients with traumatic RDS met the inclusion criteria were managed with Bankart repair using either two anterior portals(Group A)or a single anterior portal(Group B)technique.Patients were evaluated before the intervention and at the mean follow-up of approximately two years using Rowe score,Oxford shoulder score and Tegner activity scale.Results:The mean age of the patients in Groups A(n=34)and B(n=37)was 29.64 years and 29.05 years respectively(p=0.66).The dominant shoulder was involved in 27 patients in Group A and 22 patients in Group B(p=0.069).The operative time in Group A and B was 68.52 min and 46.35 min,respectively(p<0.001).The complications at follow-up,the mean Rowe score and Oxford score improved significantly in both groups compared with the pre-operative values.However,the final outcome scores were not significantly different between the both groups.The median Tegner's score preoperatively and at follow-up was 7 and 6,respectively in Groups A and B.Conclusions:Single anterior portal technique is an effective treatment modality,yielding a similar outcome as two anterior portals technique in the management of RDS.展开更多
Once he starts talking about his China experiences,Wilson Barroso Diaz from Cuba simply cannot stop.He speaks about his standard Chinese studies but also discusses his opinions on the country's economy and social ...Once he starts talking about his China experiences,Wilson Barroso Diaz from Cuba simply cannot stop.He speaks about his standard Chinese studies but also discusses his opinions on the country's economy and social development.His mastery of the language is impressive-he can articulate his thoughts very well.展开更多
BACKGROUND Esophageal and gastric variceal bleeding is a catastrophic complication of portal hypertension,most commonly caused by cirrhosis of various etiologies.Although a considerable body of research has been condu...BACKGROUND Esophageal and gastric variceal bleeding is a catastrophic complication of portal hypertension,most commonly caused by cirrhosis of various etiologies.Although a considerable body of research has been conducted in this area,the complexity of the disease and the lack of standardized treatment strategies have led to fragmented findings,insufficient information,and a lack of systematic investigation.Bibliometric analysis can help clarify research trends,identify core topics,and reveal potential future directions.Therefore,this study aims to use bibliometric methods to conduct an in-depth exploration of research progress in this field,with the expectation of providing new insights for both clinical practice and scientific research.AIM To evaluate research trends and advancements in esophagogastric variceal bleeding(EGVB)over the past twenty years.METHODS Relevant publications on EGVB were retrieved from the Web of Science Core Collection.VOSviewer,Pajek,CiteSpace,and the bibliometrix package were then employed to perform bibliometric visualizations of publication volume,countries,institutions,journals,authors,keywords,and citation counts.RESULTS The analysis focused on original research articles and review papers.From 2004 to 2023,a total of 2097 records on EGVB were retrieved.The number of relevant publications has increased significantly over the past two decades,especially in China and the United States.The leading contributors in this field,in terms of countries,institutions,authors,and journals,were China,Assistance Publique-Hôpitaux de Paris,Bosch Jaime,and World Journal of Gastroenterology,respectively.Core keywords in this field include portal hypertension,management,liver cirrhosis,risk,prevention,and diagnosis.Future research directions may focus on optimizing diagnostic methods,personalized treatment,and multidisciplinary collaboration.CONCLUSION Using bibliometric methods,this study reveals the developmental trajectory and trends in research on EGVB,underscoring risk assessment and diagnostic optimization as the core areas of current focus.The study provides an innovative and systematic perspective for this field,indicating that future research could center on multidisciplinary collaboration,personalized treatment approaches,and the development of new diagnostic tools.Moreover,this work offers practical research directions for both the academic community and clinical practice,driving continued advancement in this domain.展开更多
Liver regeneration(LR)following partial hepatectomy(PH)is a unique and complex physiological response that restores hepatic mass and function through tightly orchestrated cellular and molecular events.Traditionally vi...Liver regeneration(LR)following partial hepatectomy(PH)is a unique and complex physiological response that restores hepatic mass and function through tightly orchestrated cellular and molecular events.Traditionally viewed as a proliferation-driven process,LR is now understood to involve both hepatocyte hyperplasia and hypertrophy,triggered primarily by hemodynamic alterations such as increased portal pressure and shear stress.These promote LR through endothelial–hepatocyte communication via activation of Piezo1-a mechanosensitive ion channel highly expressed in vascular endothelial cells.This channel is considered one of the potential upstream activators of molecular cascades including the interleukin(IL)-6/signal transducer and activator of transcription 3,tumour necrosis factor-alpha/nuclear factor-kappa B,Wnt/β-catenin,Hippo/YAP,transforming growth factor-beta,and Notch pathways,which contribute variably to the proliferation,differentiation,or suppression of hepatic cells.Novel insights into the IL-22 and IL-33 signaling axes,bile acid and glutamine metabolism,and the role of intestinal microbiota are also presented as promising emerging targets.This review synthesizes current insights into the interplay between mechanical cues,key signaling pathways,and metabolic reprogramming that govern early regenerative responses.We explore the mechanisms dictating the balance between hyperplasia and hypertrophy,noting that hypertrophy predominates after minor resections,while proliferation is dominant in larger resections.Polyploidization emerges as a significant adaptive mechanism,contributing to hepatocyte survival and tissue remodeling.The importance of ductular reactions,microvascular adjustments,and extracellular matrix dynamics in lobular architecture remodeling is also highlighted.The study explores the occurrence of ductular reactions in both minor and major resections,particularly within the granulation tissue near dissection areas.The paper also examines structural remodeling in regenerated liver tissue,demonstrating ongoing transformations in hepatocyte morphology and sinusoidal architecture even months after PH,and emphasizing that the termination of liver mass regrowth does not equate to the cessation of LR.展开更多
The traditional view of the decompensated stage as a point of no return in the natural history of liver cirrhosis(LC)is currently being questioned.This is due to the appearance of data indicating the possibility of re...The traditional view of the decompensated stage as a point of no return in the natural history of liver cirrhosis(LC)is currently being questioned.This is due to the appearance of data indicating the possibility of restoring the structure and function of the liver,reducing the portal pressure with a positive effect on complications associated with portal hypertension and decreasing the risk of developing hepatocellular carcinoma after elimination of the etiological factor.To create a unified understanding the recompensation of decompensated LC,at the Baveno VII consensus workshop were developed criteria confirming it.At the moment,the efficacy of etiological therapy in achieving established criteria for recompensation has been evaluated only in patients with alcohol-related,as well as hepatitis B virus-related and hepatitis C virus-related decompensated LC.The purpose of the review is to provide up–to-date information on the role of etiological therapy in achieving recompensation of decompensated LC according to Baveno VII criteria.So far,only the first steps have been taken in studying this problem.To further understand it,research is needed to identify pathophysiological mechanisms,modifying factors,predictors,and potential noninvasive biomarkers of recompensation of decompensated LC.展开更多
基金supported by the Korea Foundation for Advanced Studies and Asia Research Center of Nankai University(Grant No.AS0719)
文摘On the basis of analyzing both domestic and foreign evaluation systems for the e-government and also taking into account of the current situation of government portals in urban centers,the paper is aimed to construct an evaluation system primarily for the measurement of the service capability of business-oriented G2B portals of local governments in general and those G2B portals of the new development zones in particular.This system is composed of 6 first tier indicators,18 second tier indicators and 90 third tier indicators.And the weight of each indicator is determined by Delphi Method and Analytic Hierarchy Process(AHP) Method.Subsequently,we used this system to evaluate the government portals of Tianjin Binhai New Area and Shanghai Pudong New Area and proved to have the desired practicability.
文摘The authors of the existing version of the special theory of relativity had to use the princi-ple of light speed non-exceedance to explain relativistic formulas obtained therein within the space of real numbers. The principle implied existence of only our visible universe and absence of physical content in imaginary numbers. However, since the principle is just a postulate, i.e. an unproven assumption, it has always carried little credibility. The paper refutes the principle by the experimentally proven principle of physical reality of imagi-nary numbers. As follows from the principle of physical reality of imaginary numbers, relativistic formulas of the existing version of the STR are wrong and incorrectly ex-plained, and conclusions drawn from them are misguided. In other words, this version is incorrect1 and, thus, the STR was not actually created in the 20th century. Moreover, it could not be created in the 20th century, as its creation required experimental data ob-tained in the 21st century. The paper provides an alternative version of the STR contain-ing relativistic formulas corrected given experimental data obtained in the 21st century. These formulas imply that instead of the Monoverse, whose existence is supposed in the existing version of the STR, there is a Multiverse, whose universes are mutually invisible (and the invisibility is explainable) and therefore it has been referred to as hidden. The paper explains that existence of invisible universes of the hidden Multiverse gives rise to the phenomenon of dark matter and dark energy that is actually a sort of optical effect (however, not electromagnetic, but gravitational), a shadow, rather than some physical substance2. It also explains that existence of other invisible universes outside the hidden Multiverse gives rise to the phenomenon of dark space. Invisible universes are claimed to really exist, which can be experimentally proved by astronomical observations in portals, where universes not visible outside portals become partially visible. Therefore, constella-tions observed in the starry sky inside the portals are different from those observed in our visible universe. The alternative version of the special theory of relativity can also suc-cessfully solve other issues of astrophysics. In particular, it can explain where antimatter is located and why it does not annihilate with matter, as well as where tachyons are locat-ed and why they don’t violate the principle of causality, etc.
文摘Network congestion, one of the challenging tasks in communication networks, leads to queuing delays, packet loss, or the blocking of new connections. In this study, a data portal is considered as an application-based network, and a cognitive method is proposed to deal with congestion in this kind of network. Unlike previous methods for congestion control, the proposed method is an effective approach for congestion control when the link capacity and information inquiries are unknown or variable. Using sufficient training samples and the current value of the network parameters, available bandwidth is adjusted to distribute the bandwidth among the active flows. The proposed cognitive method was tested under such situations as unexpected variations in link capacity and oscillatory behavior of the bandwidth. Based on simulation results, the proposed method is capable of adjusting the available bandwidth by tuning the queue length, and provides a stable queue in the network.
文摘The personalization in knowledge portals and knowledge management systems is mainly performed based on users' explicitly specified categories and keywords. The explicit specification approach requires users' participation to start personalization services, and has limitation to adapt changes of users' preference. This paper suggests two implicit personalization approaches: automatic user category assignment method and automatic keyword profile generation method. The performances of the implicit personalization approaches are compared with traditional personalization approach using an Internet news site experiment. The result of the experiment shows that the suggested personalization approaches provide sufficient recommendation effectiveness with lessening users' unwanted involvement in personalization process.
文摘Muqarnas （stalactite vault） is a distinctive structural and configurational feature of Islamic architecture. It is used to provide a transition from a square plan to a circular perimeter, thus allowing a domicat or semi-domical space to be erected above a square or rectangular layout. It is similar to the Roman pendentive in its structural logic but quite different in form and architectonic detail. The use of muqarnas has become ubiquitous in Islamic architecture and was applied structurally and decoratively above major spaces in mosques and mausoleums, wall niches, facades, arches, friezes, and entrance typological, and stylistic analysis of Bahri Mamluk portals. This paper provides a historical, rnuqarnas portals developed in Cairo, Egypt during the 13th and 14th centuries. Due to the complexity and breadth of this undertaking, the current study focuses on the earliest 10 monuments that exemplify the type and examines the origin, meaning, and development of muqarnas portals in Egypt. Local and foreign influences are analyzed with an eye on identifying similarities and variations in terms of constructability, geometry, and complexity of muqarnas configurations. The paper concludes with a discussion of the primary innovative features of Bahri Mamiuk Muqarnas and their effect on subsequent muqarnas development in Egypt.
文摘BACKGROUND Hepatocellular carcinoma(HCC)is a major type of liver cancer worldwide.In advanced stages,portal vein tumor thrombosis(PVTT)and jaundice are common,whereas obstructive jaundice(OJ)is relatively rare.Both conditions markedly reduce survival and increase therapeutic complexity.Recently,hepatic artery infusion chemotherapy(HAIC)in combination with targeted immunotherapy has shown promise for advanced HCC.CASE SUMMARY We report a 47-year-old male with advanced HCC complicated by PVTT and OJ,who was admitted with marked jaundice of the skin and sclera.Imaging revealed a large hepatic mass(14.5 cm×11.3 cm)in the right lobe with associated portal vein tumor thrombus.The tertiary bile duct was only mildly dilated,making percutaneous transhepatic cholangiography drainage infeasible.The patient underwent reduced-dose HAIC,which resulted in significant tumor shrinkage and marked reduction in serum bilirubin.This improvement enabled sequential treatment with lenvatinib and camrelizumab.After six cycles,both liver function and alphafetoprotein levels improved.The patient achieved a progression-free survival of 20 months and an overall survival of 29 months.CONCLUSION HAIC can treat high-bilirubin HCC with PVTT and OJ,allowing for subsequent targeted immunotherapy.
文摘Presentation level integration now becomes an important and fast growing trend in enterprise computing Portal-based composite applications use portlet and interactive web service, which usually offers several portlets, as their basic constituents. Hence, portlet description and discovery are the key issues that have to be considered for the development of portal-based composite applications. This paper proposes a novel concept POI （Presentation Oriented Interface） to describe the presentation features of a portlet, so that interactive web services may be extended to facilitate the selection and interoperation of portlets. Portlet discovery can be effectively achieved based on the calculation of POI similarity that considers both type and structure similarity. Experiments show that the proposed approach can improve the satisfaction of portlet discovery, and also facilitate the portlet interoperation, thereby achieving better application integration at presentation level.
文摘Purpose:Recurrent dislocation of shoulder(RDS)is a common injury in high demand professionals,like athletes and military personnel.The treatment for the patients with Bankart lesion is the arthroscopic repair.This present study compares the outcomes of two different techniques of arthroscopic Bankart repair i.e.a standard two anterior portals technique and a single anterior portal technique in patients with RDS.Methods:Patients with traumatic RDS met the inclusion criteria were managed with Bankart repair using either two anterior portals(Group A)or a single anterior portal(Group B)technique.Patients were evaluated before the intervention and at the mean follow-up of approximately two years using Rowe score,Oxford shoulder score and Tegner activity scale.Results:The mean age of the patients in Groups A(n=34)and B(n=37)was 29.64 years and 29.05 years respectively(p=0.66).The dominant shoulder was involved in 27 patients in Group A and 22 patients in Group B(p=0.069).The operative time in Group A and B was 68.52 min and 46.35 min,respectively(p<0.001).The complications at follow-up,the mean Rowe score and Oxford score improved significantly in both groups compared with the pre-operative values.However,the final outcome scores were not significantly different between the both groups.The median Tegner's score preoperatively and at follow-up was 7 and 6,respectively in Groups A and B.Conclusions:Single anterior portal technique is an effective treatment modality,yielding a similar outcome as two anterior portals technique in the management of RDS.
文摘Once he starts talking about his China experiences,Wilson Barroso Diaz from Cuba simply cannot stop.He speaks about his standard Chinese studies but also discusses his opinions on the country's economy and social development.His mastery of the language is impressive-he can articulate his thoughts very well.
基金Supported by the National Natural Science Foundation of China,No.81874390 and No.81573948Shanghai Natural Science Foundation,No.21ZR1464100+1 种基金Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission,No.22S11901700the Shanghai Key Specialty of Traditional Chinese Clinical Medicine,No.shslczdzk01201.
文摘BACKGROUND Esophageal and gastric variceal bleeding is a catastrophic complication of portal hypertension,most commonly caused by cirrhosis of various etiologies.Although a considerable body of research has been conducted in this area,the complexity of the disease and the lack of standardized treatment strategies have led to fragmented findings,insufficient information,and a lack of systematic investigation.Bibliometric analysis can help clarify research trends,identify core topics,and reveal potential future directions.Therefore,this study aims to use bibliometric methods to conduct an in-depth exploration of research progress in this field,with the expectation of providing new insights for both clinical practice and scientific research.AIM To evaluate research trends and advancements in esophagogastric variceal bleeding(EGVB)over the past twenty years.METHODS Relevant publications on EGVB were retrieved from the Web of Science Core Collection.VOSviewer,Pajek,CiteSpace,and the bibliometrix package were then employed to perform bibliometric visualizations of publication volume,countries,institutions,journals,authors,keywords,and citation counts.RESULTS The analysis focused on original research articles and review papers.From 2004 to 2023,a total of 2097 records on EGVB were retrieved.The number of relevant publications has increased significantly over the past two decades,especially in China and the United States.The leading contributors in this field,in terms of countries,institutions,authors,and journals,were China,Assistance Publique-Hôpitaux de Paris,Bosch Jaime,and World Journal of Gastroenterology,respectively.Core keywords in this field include portal hypertension,management,liver cirrhosis,risk,prevention,and diagnosis.Future research directions may focus on optimizing diagnostic methods,personalized treatment,and multidisciplinary collaboration.CONCLUSION Using bibliometric methods,this study reveals the developmental trajectory and trends in research on EGVB,underscoring risk assessment and diagnostic optimization as the core areas of current focus.The study provides an innovative and systematic perspective for this field,indicating that future research could center on multidisciplinary collaboration,personalized treatment approaches,and the development of new diagnostic tools.Moreover,this work offers practical research directions for both the academic community and clinical practice,driving continued advancement in this domain.
文摘Liver regeneration(LR)following partial hepatectomy(PH)is a unique and complex physiological response that restores hepatic mass and function through tightly orchestrated cellular and molecular events.Traditionally viewed as a proliferation-driven process,LR is now understood to involve both hepatocyte hyperplasia and hypertrophy,triggered primarily by hemodynamic alterations such as increased portal pressure and shear stress.These promote LR through endothelial–hepatocyte communication via activation of Piezo1-a mechanosensitive ion channel highly expressed in vascular endothelial cells.This channel is considered one of the potential upstream activators of molecular cascades including the interleukin(IL)-6/signal transducer and activator of transcription 3,tumour necrosis factor-alpha/nuclear factor-kappa B,Wnt/β-catenin,Hippo/YAP,transforming growth factor-beta,and Notch pathways,which contribute variably to the proliferation,differentiation,or suppression of hepatic cells.Novel insights into the IL-22 and IL-33 signaling axes,bile acid and glutamine metabolism,and the role of intestinal microbiota are also presented as promising emerging targets.This review synthesizes current insights into the interplay between mechanical cues,key signaling pathways,and metabolic reprogramming that govern early regenerative responses.We explore the mechanisms dictating the balance between hyperplasia and hypertrophy,noting that hypertrophy predominates after minor resections,while proliferation is dominant in larger resections.Polyploidization emerges as a significant adaptive mechanism,contributing to hepatocyte survival and tissue remodeling.The importance of ductular reactions,microvascular adjustments,and extracellular matrix dynamics in lobular architecture remodeling is also highlighted.The study explores the occurrence of ductular reactions in both minor and major resections,particularly within the granulation tissue near dissection areas.The paper also examines structural remodeling in regenerated liver tissue,demonstrating ongoing transformations in hepatocyte morphology and sinusoidal architecture even months after PH,and emphasizing that the termination of liver mass regrowth does not equate to the cessation of LR.
文摘The traditional view of the decompensated stage as a point of no return in the natural history of liver cirrhosis(LC)is currently being questioned.This is due to the appearance of data indicating the possibility of restoring the structure and function of the liver,reducing the portal pressure with a positive effect on complications associated with portal hypertension and decreasing the risk of developing hepatocellular carcinoma after elimination of the etiological factor.To create a unified understanding the recompensation of decompensated LC,at the Baveno VII consensus workshop were developed criteria confirming it.At the moment,the efficacy of etiological therapy in achieving established criteria for recompensation has been evaluated only in patients with alcohol-related,as well as hepatitis B virus-related and hepatitis C virus-related decompensated LC.The purpose of the review is to provide up–to-date information on the role of etiological therapy in achieving recompensation of decompensated LC according to Baveno VII criteria.So far,only the first steps have been taken in studying this problem.To further understand it,research is needed to identify pathophysiological mechanisms,modifying factors,predictors,and potential noninvasive biomarkers of recompensation of decompensated LC.
