Due to their persistence,bioaccumulation,and resistance to degradation,perfluorinated substances(PFASs)have significant impacts on the environment and human health.This study comprehensively analyzed and assessed the ...Due to their persistence,bioaccumulation,and resistance to degradation,perfluorinated substances(PFASs)have significant impacts on the environment and human health.This study comprehensively analyzed and assessed the occurrence characteristics,sources,and potential ecological risks of 13 PFASs in the Yangtze River.The results indicated that the concentrations ofΣPFASs range from 5.1 to 57.7 ng/L,with more severe pollution downstream and perfluorobutane sulfonate(PFBuS)being the main pollutant.ΣPFASs showed a positive correlation with total organic carbon and absorbance under the condition of UV wavelength 254 nm(UV_(254)),and a negative correlation with total dissolved solids.Positive matrix factorization model analysis revealed that the primary sources of PFASs in the study area are food packaging,the electroplating industry,and the manufacturing and processing of fluoropolymer-containing products.The total ecological risk value of PFASs indicated that the ecological risks to algae,invertebrates,and fish are negligible.The annual load of ΣPFASs in the Yangtze River was 39.00 t,with the highest concentrations of pollutants being PFBuS(26.41 t/year),perfluorobutanoic acid(6.47 t/year),and perfluorooctanoic acid(PFOA,3.19t/year).While PFASs have not yet posed a risk to aquatic organisms,the increase in the use of short-chain PFASs substitutes(C4-C7)due to the regulation of PFOA and perfluorooctane sulfonate highlights the need for continued monitoring of short-chain PFASs pollution.展开更多
全氟和多氟化合物(per and polyfluoroalkyl substances,PFASs)是一类高持久性环境污染物,其通过胎盘介导的子代神经发育毒性已成为近年研究热点。系统阐述了PFASs通过干扰甲状腺激素平衡、神经营养因子表达、神经细胞功能及表观遗传调...全氟和多氟化合物(per and polyfluoroalkyl substances,PFASs)是一类高持久性环境污染物,其通过胎盘介导的子代神经发育毒性已成为近年研究热点。系统阐述了PFASs通过干扰甲状腺激素平衡、神经营养因子表达、神经细胞功能及表观遗传调控等多途径影响子代神经发育的分子机制,评估了现有干预策略的局限性,以期为揭示PFASs跨代毒性机制提供理论框架,并对制定母婴暴露防控政策提供参考。展开更多
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750000)the National Natural Science Foundation of China(Nos.52270012 and 52470018)the Ministry of Science and Technology of China(Nos.2022YFC3203705 and2021YFC3200904)。
文摘Due to their persistence,bioaccumulation,and resistance to degradation,perfluorinated substances(PFASs)have significant impacts on the environment and human health.This study comprehensively analyzed and assessed the occurrence characteristics,sources,and potential ecological risks of 13 PFASs in the Yangtze River.The results indicated that the concentrations ofΣPFASs range from 5.1 to 57.7 ng/L,with more severe pollution downstream and perfluorobutane sulfonate(PFBuS)being the main pollutant.ΣPFASs showed a positive correlation with total organic carbon and absorbance under the condition of UV wavelength 254 nm(UV_(254)),and a negative correlation with total dissolved solids.Positive matrix factorization model analysis revealed that the primary sources of PFASs in the study area are food packaging,the electroplating industry,and the manufacturing and processing of fluoropolymer-containing products.The total ecological risk value of PFASs indicated that the ecological risks to algae,invertebrates,and fish are negligible.The annual load of ΣPFASs in the Yangtze River was 39.00 t,with the highest concentrations of pollutants being PFBuS(26.41 t/year),perfluorobutanoic acid(6.47 t/year),and perfluorooctanoic acid(PFOA,3.19t/year).While PFASs have not yet posed a risk to aquatic organisms,the increase in the use of short-chain PFASs substitutes(C4-C7)due to the regulation of PFOA and perfluorooctane sulfonate highlights the need for continued monitoring of short-chain PFASs pollution.
文摘全氟和多氟化合物(per and polyfluoroalkyl substances,PFASs)是一类高持久性环境污染物,其通过胎盘介导的子代神经发育毒性已成为近年研究热点。系统阐述了PFASs通过干扰甲状腺激素平衡、神经营养因子表达、神经细胞功能及表观遗传调控等多途径影响子代神经发育的分子机制,评估了现有干预策略的局限性,以期为揭示PFASs跨代毒性机制提供理论框架,并对制定母婴暴露防控政策提供参考。
