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Correction:Jetting-based bioprinting:process,dispense physics,and applications
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作者 Wei Long Ng Viktor Shkolnikov 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第5期823-823,共1页
The article Jetting-based bioprinting:process,dispense physics,and applications,written by Wei Long Ng and Viktor Shkolnikov,was originally published electronically on the publisher’s internet portal on 12 July 2024 ... The article Jetting-based bioprinting:process,dispense physics,and applications,written by Wei Long Ng and Viktor Shkolnikov,was originally published electronically on the publisher’s internet portal on 12 July 2024 without open access. 展开更多
关键词 PRINTING pens internet
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Study of the Compensatory Growth Following Starvation of Juvenile Golden Pompano Trachinotus ovatus
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作者 Liu Longlong Luo Ming +3 位作者 Chen Fuxiao Tan Wei Zhang Junbin Li Xiangmin 《Animal Husbandry and Feed Science》 CAS 2015年第3期178-181,190,共5页
A starvation trial was conducted to determine compensatory growth of the juvenile golden pompano Trachinotus ovatus which were deprived of food for 1, 2, 5 and 7 days respectively. The results of tests in outdoor ceme... A starvation trial was conducted to determine compensatory growth of the juvenile golden pompano Trachinotus ovatus which were deprived of food for 1, 2, 5 and 7 days respectively. The results of tests in outdoor cement pools and net pens showed that, in the first 15 days and 30 days, the growth of 1 day and 2 days-deprived groups was probably the same with that of control group, which accorded with fully compensatory description. However, the weight of 5 days and 7 days-deprived fingerlings were lower than that of the control group, which accorded with the description of the partial compensatory growth. As the starvation prolonged, feed conversion efficiency of the starved groups increased and was higher than the control group. Meanwhile, feeding rate also increased, but the fish of 1 day and 2 days-deprived groups was lower than that of the control group, and feeding quantity reduced and was lower than that of the control group. It suggested that the mechanism of compensatory growth was mainly due to improving feed conversion efficiency. Fish biochemical composition was analyzed: the water content and ash of fish sample increased due to starvation, while the lipid and protein decreased. The loss of lipid was greater than that of the protein, and the biochemical composition of fish in each group was restored to the control level by the end of the experiment. It suggested that Trachinotus ovatus may mainly consume lipid during the period of starvation. 展开更多
关键词 Trachinotus ovatus JUVENILE Net pens STARVATION Compensatory growth Feed conversion efficiency Fish biochemical composition
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Synthesis of Water-Soluble Chitosan From Squid Pens Waste for Capsule Shell Materials
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作者 Malinda Syifa Yusharani Stenley +3 位作者 Harmami Ita Ulfin Suprapto Suprapto Yatim Lailun Ni’mah 《Journal of Renewable Materials》 SCIE 2019年第7期643-653,共11页
Water-Soluble Chitosan(WSC)has been sucessfuly synthesized from squid pens waste.The synthesis of chitosan from chitin was carried out by optimization of deacetylation temperature and time.Chitin was obtained from squ... Water-Soluble Chitosan(WSC)has been sucessfuly synthesized from squid pens waste.The synthesis of chitosan from chitin was carried out by optimization of deacetylation temperature and time.Chitin was obtained from squid pens waste by demineralization and deproteinization process.HCl 7%was used for demineralization and NaOH 10%at 60℃ was applied for deproteinization process.Deacetylation reaction was carried out at varied temperatures i.e.,60℃,70℃,80℃,90℃ and 100℃ in NaOH 50%solution for 10 hours.Deacetylation reaction time were varied for 2 hours,4 hours,6 hours,8 hours,and 10 hours.The crude chitosan obtained then reacted with H2O230%to depolymerize.The synthesis product obtained then characterized by FTIR.The result of squid chitin yield was 33.9%.The optimum temperature and time of chitosan deacetylation process were 90℃ for 8 hours as indicated by the value of deacetylation degree(DD)that equal to 83.94%at optimum temperature and 82.22%at optimum reaction time.The percentage of WSC yield at optimum temperature(90℃)and optimum time(8 hours)were 27.59%and 23.16%,respectively.WSC solubility test was done in water and HCl 0,1N.The solubility of 2.8325 mg/mL and 0.8125 mg/mL were obtained in acid medium and water medium,respectively. 展开更多
关键词 CHITOSAN DEACETYLATION squid pens TEMPERATURE TIME water-soluble chitosan
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Inappropriate antibiotic dispensing and use:A public health threat in the Philippines
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作者 Eric David B.Ornos Elgin Paul B.Quebral +1 位作者 Jeremy A.Ceriales Ourlad Alzeus G.Tantengco 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2022年第8期341-342,共2页
A high rate of improper antibiotic dispensing was reported to patients with presumed viral infections even without a prescription from a physician in Vietnam[1]. Imprudent antibiotic dispensing and use were also obser... A high rate of improper antibiotic dispensing was reported to patients with presumed viral infections even without a prescription from a physician in Vietnam[1]. Imprudent antibiotic dispensing and use were also observed in other countries, including the Philippines. A large number of patients experienced respiratory symptoms, such as cough and rhinorrhea during the COVID-19 pandemic, which exacerbated this problem with antibiotic use. 展开更多
关键词 DIS pens VIETNAM
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The Quality of Chinese Pens Upgraded
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《China's Foreign Trade》 1997年第3期9-,12,共2页
During the Eighth Five-Year Plan period, (1991-95), China’s pen industry maintained sustained, rapid, stable and sound development with the further promotion of product quality and grade in production, and its techno... During the Eighth Five-Year Plan period, (1991-95), China’s pen industry maintained sustained, rapid, stable and sound development with the further promotion of product quality and grade in production, and its technological advancement. At the same time, new varieties of products and more patterns and specifications were developed. The industry also further developed its business ties with clients abroad and ex- 展开更多
关键词 The Quality of Chinese pens Upgraded
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Establishment of Alloptilella splendida gen.et sp.nov.and resurrection of Scytalium veneris(Thomson&Henderson,1906),two sea pens(Cnidaria:Pennatulacea)from seamounts in the tropical Western Pacific 被引量:1
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作者 Yang LI Zifeng ZHAN Kuidong XU 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2021年第5期1790-1804,共15页
Sea pens are a highly specialized and morphologically distinct group of octocorallians,but many taxa were poorly described and their phylogenetic relationships are still poorly known.We describe two species of sea pen... Sea pens are a highly specialized and morphologically distinct group of octocorallians,but many taxa were poorly described and their phylogenetic relationships are still poorly known.We describe two species of sea pens collected from the tropical Western Pacific:Alloptilella splendida gen.et sp.nov.and Scytalium veneris(Thomson&Henderson,1906).Alloptilella splendida gen.et sp.nov.accords with the definition of the recently resurrected genus Ptilella Gray,1870 in most characters,but differs from the latter in the arrangement of autozooids and the location of mesozooids.The new species mostly resembles Pennatula naresi K(o|")lliker(1880),but differs by the location of me sozooids and the reddish color of sclerite s surrounding siphonozooids.The generic separation is also well supported by their genetic distances and the molecular phylogenetic trees constructed by the concatenated mtMutS-COI-28 S,where Alloptilella clustered with Scytalium Herklots,1858 and formed a clade with the cluster of Ptilella and Distichoptilum.Scytalium veneris,usually considered as a junior synonym of Scytalium sarsii Herklots,1858,is resurrected by recognizing their distinctive differences.This is the first record of Scytalium veneris outside its type locality,and the phylogenetic analysis indicates that Scytalium is a monophyletic group.Both the families Pennatulidae and Virgulariidae are polyphyletic,and more morphological and molecular data are needed to clarify the phylogenetic positions of pennatulacean families and genera. 展开更多
关键词 sea pen Pennatulidae Alloptilella new species Scytalium SEAMOUNT
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La pensée de la nouvelle ère
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《中国与非洲(法文版)》 2024年第1期6-6,共1页
La 28e session de la Conférence des Parties de la Convention-cadre des Nattions unies sur les changements climatiques s'est tenue à Dubaï.Emirats arabes unis,tu 30 novembre au 12 décembre 2023.... La 28e session de la Conférence des Parties de la Convention-cadre des Nattions unies sur les changements climatiques s'est tenue à Dubaï.Emirats arabes unis,tu 30 novembre au 12 décembre 2023.l'aceàl'urgence du changement climatique.un enjeu mondial. 展开更多
关键词 NAT pens SESSION
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WHICH IS BETTER
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《空中英语教室(初级版.大家说英语)》 2025年第9期20-20,56,共2页
Conversation B Susie:I know.Pencils are also better for drawing.You can make lines lighter or darker.Sam:But you have to sharpen pencils or add lead to them.Susie:You do.But pencils last longer than pens.Pen ink can d... Conversation B Susie:I know.Pencils are also better for drawing.You can make lines lighter or darker.Sam:But you have to sharpen pencils or add lead to them.Susie:You do.But pencils last longer than pens.Pen ink can dry out,but pencil lead doesn’t.Sam:But words look neater when you write in pen.Susie:They do.So,which pen do you want?Sam:One with blue ink,thanks. 展开更多
关键词 DRAWING PENCILS INK lead pens WRITING
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基于PEN柔性基底XBAR谐振器的声学特性研究
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作者 王地懋 谢鹏飞 +2 位作者 曾龙 缪加耀 王艳 《压电与声光》 北大核心 2025年第3期459-464,共6页
采用有限元方法(FEM)分析了基于PEN (Polyethylene Naphthalate)柔性基底横向激发体声波谐振器(XBAR)的声学特性,包括谐振频率fr、机电耦合系数K2eff、品质因数Qr及频率温度系数(TCF)等。结果表明,PEN柔性基底的引入改善了XBAR性能,如当... 采用有限元方法(FEM)分析了基于PEN (Polyethylene Naphthalate)柔性基底横向激发体声波谐振器(XBAR)的声学特性,包括谐振频率fr、机电耦合系数K2eff、品质因数Qr及频率温度系数(TCF)等。结果表明,PEN柔性基底的引入改善了XBAR性能,如当hPEN=40 nm时,K2eff=35.68%,较同参数的IDT/LiNbO3结构提升了约35%,fr=4.4 GHz,Qr=112;当hPEN=105 nm时,PEN与IDT/LiNbO3结构发生耦合共振,致使XBAR谐振频率发生偏移以及品质因数增加,其频率偏移达到1.32 GHz,Qr增加75。同时XBAR的温度稳定性得到提升,当hPEN=120 nm时,XBAR的TCF为-72.9×10^(-6)/℃,而同参数IDT/LiNbO3结构TCF为-107×10^(-6)/℃。综上可知,IDT/LiNbO3/PEN结构XBAR具有更优异的声学特性,通过合理选择PEN厚度可优化XBAR的不同性能参数。该结果为高频、高机电耦合系数和高温度稳定性XBAR的设计和研制提供了理论依据。 展开更多
关键词 横向激发体声波谐振器(XBAR) 兰姆波 柔性基底PEN 频率温度系数
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The Potential Distribution Prediction of Oncomelania hupensis Based on Newly Emerging and Reemergent Habitats-China,2015−2019 被引量:5
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作者 Yanfeng Gong Yinlong Li +3 位作者 Lijuan Zhang Shan Lv Jing Xu Shizhu Li 《China CDC weekly》 2021年第5期90-93,I0001,I0002,共6页
What is already known about this topic?Oncomelania hupensis(O.hupensis)is the only intermediate host of Schistosoma japonica.The distribution of O.hupensis is affected by a series of climate,geographical,sand ocioecon... What is already known about this topic?Oncomelania hupensis(O.hupensis)is the only intermediate host of Schistosoma japonica.The distribution of O.hupensis is affected by a series of climate,geographical,sand ocioeconomic factors,which reflect the risk areas of schistosomiasis.What is added by this report?There were certain geographical aggregations in the potential high distribution areas of O.hupensis,which were mainly distributed in Poyang Lake area,Dongting Lake area,and the middle and the lower reaches of the Yangtze River.What are the implications for public health practice?Monitoring and forecasting the distribution of O.hupensis is conducive to improving the early warning capabilities of the potential risk of schistosomiasis transmission and progressively promoting the elimination of schistosomiasis nationwide. 展开更多
关键词 SCHISTOSOMA SCHISTOSOMIASIS pens
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英语练习专题(三)
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《初中生辅导》 2025年第9期29-32,共4页
一、阅读理解[核心素养·文化意识](2024·贵州铜仁一模) The brush pen, one of the “Four Treasures of the Study”, was invented thou-sands of years ago. However, the oldest pen was just a stick or a piece of bamb... 一、阅读理解[核心素养·文化意识](2024·贵州铜仁一模) The brush pen, one of the “Four Treasures of the Study”, was invented thou-sands of years ago. However, the oldest pen was just a stick or a piece of bamboo. It was difficult for people to write well on thin silk. 展开更多
关键词 thin silk STICK piece bamboo four treasures study brush pen SILK
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真空紫外光谱仪的研制及性能测试
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作者 耿继宝 李长松 +2 位作者 张志杰 马丽敏 李朝阳 《仪器仪表标准化与计量》 2025年第4期20-22,共3页
本文研制了一台高光谱分辨、高系统接收角,同时具有一定空间分辨的真空紫外波段光谱仪。该光谱仪采用典型的Czerny-Turner结构,系统准直镜和聚焦镜均采用离轴抛物面镜,入射臂272.24mm,采用平面闪耀光栅,线密度300L/mm,闪耀波长230nm,光... 本文研制了一台高光谱分辨、高系统接收角,同时具有一定空间分辨的真空紫外波段光谱仪。该光谱仪采用典型的Czerny-Turner结构,系统准直镜和聚焦镜均采用离轴抛物面镜,入射臂272.24mm,采用平面闪耀光栅,线密度300L/mm,闪耀波长230nm,光栅入射角30°,利用一台可深度制冷、背照式面阵CCD作为光谱探测器进行信号探测。谱仪研制完成后,利用Penning灯放电光源测试谱仪性能,并利用光源的标准谱线进行了波长标定,结果显示该谱仪波长覆盖范围112.5~406nm,全波段光谱分辨率优于0.5nm,波长精度优于0.05nm,达到设计指标。 展开更多
关键词 真空紫外 光谱仪 离轴抛物面镜 光谱分辨率 Penning放电光源
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LA PENSÉE DE LA NOUVELLE ÉRE REMARQUES SÉLECTIONNÉES DU PRÉSIDENT CHINOIS XI JINPING
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《中国与非洲(法文版)》 2023年第12期6-6,共1页
Lsixieme Exposition internationale des importations de Chine(CIIE)s'est ouverte a Shanghai le 5 novembre,sur le theme<Nouvelle ere,avenir partage>.Le Preésident chinois Xi Jinping a envoye une lettre de... Lsixieme Exposition internationale des importations de Chine(CIIE)s'est ouverte a Shanghai le 5 novembre,sur le theme<Nouvelle ere,avenir partage>.Le Preésident chinois Xi Jinping a envoye une lettre de felicitations a I'exposition,declarant que la CIE avait apporte une contribution positive a la creation d'un nouveau modele de développement et a la promotion du développement economique mondial. 展开更多
关键词 pensÉE NOUVELLE PRÉSIDENT
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Effects of inductive methods on dunging behavior of weaning pigs in slatted floor pens
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作者 Wang Yu Li Dapeng +1 位作者 Shen Xiong Shi Zhengxiang 《International Journal of Agricultural and Biological Engineering》 SCIE EI CAS 2016年第4期192-198,共7页
The excreta of pig is generally utilized to induce pigs to excrete in particular area,which reduces the subsequent work required to clean pens.This paper discussed a new induction device design based on the biological... The excreta of pig is generally utilized to induce pigs to excrete in particular area,which reduces the subsequent work required to clean pens.This paper discussed a new induction device design based on the biological characteristics of pigs.Using different induction materials in the devices,the frequency and location of the excretory behavior of pigs through five treatments and a control group were compared.According to the results,different induction methods had significant(p<0.05)effects on frequency and duration of excretory behavior.Compared to the conventional induction method,the induction devices were significantly(p<0.05)more effective in training pigs to excrete in the assigned area,the most effective material used in the induction devices was feces.If the inductive feces had been preserved in the air for a longer time,the effect of inducing excretory behavior would have been more obvious.Empty devices did not work to induce pigs to excrete in the induction area. 展开更多
关键词 animal behavior weaning pigs slatted floor pen pig training excretory behavior inductive material
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My Lucky Money
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作者 王思琪 陈传光(指导) 《中学生英语》 2024年第45期7-7,共1页
Every Spring Festival,my father gives me some lucky money.It makes me very happy.I usually spend most of my lucky money on pens and books.I like reading books and I think pens are useful in schoolwork.Sometimes I spen... Every Spring Festival,my father gives me some lucky money.It makes me very happy.I usually spend most of my lucky money on pens and books.I like reading books and I think pens are useful in schoolwork.Sometimes I spend the money buying lots of delicious food and share them with my friends. 展开更多
关键词 reading SCHOOLWORK lucky money SHARING food pens BOOKS
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高阻隔性复合PEN/PET饮料包装瓶的制备及阻隔性能研究 被引量:4
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作者 李梓绮 李雪 +1 位作者 尹昊 任迪峰 《饮料工业》 2024年第2期1-8,共8页
PET瓶是当前市场上广泛应用的饮料包装瓶之一,但随着消费者对饮料品质要求的提升,对饮料包装瓶的气体阻隔性有了更高的要求。为了改进纯聚对苯二甲酸乙二醇酯(PET)瓶的阻隔性,本实验利用熔融共混的方法制备PEN/PET复合材料,在确定共混... PET瓶是当前市场上广泛应用的饮料包装瓶之一,但随着消费者对饮料品质要求的提升,对饮料包装瓶的气体阻隔性有了更高的要求。为了改进纯聚对苯二甲酸乙二醇酯(PET)瓶的阻隔性,本实验利用熔融共混的方法制备PEN/PET复合材料,在确定共混材料的最佳配比后,加工制得复合聚萘二甲酸乙二醇酯/聚对苯二甲酸乙二醇酯(PEN/PET)饮料包装瓶,并通过测定氧气、二氧化碳和水蒸气的透过量,以及紫外阻隔性能、光学性能、机械性能和耐热性能,对其进行阻隔性能分析。通过综合分析比较,确定PEN30%wt、PET70%wt为最佳配比。制得的复合PEN/PET饮料包装瓶与普通PET瓶相比,氧气阻隔性增加3.48倍,二氧化碳阻隔性增加7.36倍,水蒸气阻隔性增加2.25倍,除此之外,其紫外线阻隔性等性能也有显著提高。在常温下贮藏70d后,复合PEN/PET瓶对饮料的保存效果明显优于纯PET瓶。复合PEN/PET饮料包装瓶改进了纯PET瓶的阻隔性较弱的问题。 展开更多
关键词 PET PEN 高阻隔性 熔融共混
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伴随中子管Penning源诊断及仿真研究
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作者 叶龙建 董攀 +3 位作者 李杰 张东东 陈宇航 胡志杰 《强激光与粒子束》 CAS CSCD 北大核心 2024年第9期66-73,共8页
Penning离子源因为结构简单、体积小、功耗低等优点,被广泛应用在伴随中子管中。基于实验室所用的潘宁(Penning)离子源,分析其电离时的伏-安特性;通过CCD相机拍摄观察离子源内部等离子体分布情况;采用光谱法诊断氢等离子体中电子的密度... Penning离子源因为结构简单、体积小、功耗低等优点,被广泛应用在伴随中子管中。基于实验室所用的潘宁(Penning)离子源,分析其电离时的伏-安特性;通过CCD相机拍摄观察离子源内部等离子体分布情况;采用光谱法诊断氢等离子体中电子的密度和温度。基于实验测试用的Penning离子源结构,建立H2分子碰撞电离的全局模型,分析离子源的工作参数与等离子体中电子温度和电子密度之间的关系。仿真结果表明:电子温度和电子密度与离子源的运行压强、磁场和功率密切相关;电子密度随功率增加逐渐增加、随磁场强度和压强都是先增加后减小,因此需将磁场强度控制在0.03~0.05 T,压强控制在(0.2~2)×10^(-2)Pa之间;电子温度随功率增加逐渐增加、随压强增加逐渐减小。通过模型可知,在Penning离子源的工作区间内,电子平均温度小于10 eV,电子密度数量级为10^(10) cm^(-3)。 展开更多
关键词 Penning离子源 离子诊断 氢等离子体 数值分析 全局模型
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特征图谱、一测多评与模式识别相结合的茵陈【茵陈蒿(绵茵陈)】配方颗粒质量评价分析 被引量:2
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作者 曹桂云 庄雪松 +8 位作者 宁波 刘羽康 王全军 刘兴村 林永强 崔伟亮 张风超 刘子夜 孟兆青 《药物分析杂志》 CAS CSCD 北大核心 2024年第4期689-704,共16页
目的:建立特征图谱、一测多评和化学模式识别分析相结合的茵陈【茵陈蒿(绵茵陈)】配方颗粒质量评价方法。方法:利用制备的15批茵陈【茵陈蒿(绵茵陈)】标准汤剂和3批配方颗粒建立了HPLC特征图谱,并对其中6个主要成分建立一测多评法进行... 目的:建立特征图谱、一测多评和化学模式识别分析相结合的茵陈【茵陈蒿(绵茵陈)】配方颗粒质量评价方法。方法:利用制备的15批茵陈【茵陈蒿(绵茵陈)】标准汤剂和3批配方颗粒建立了HPLC特征图谱,并对其中6个主要成分建立一测多评法进行含量测定。采用AcclaimTMRSLC 120 C18(100 mm×2.1 mm,2.2μm)色谱柱,以乙腈-0.05%磷酸水溶液为流动相,梯度洗脱,流速0.4 mL·min^(-1),检测波长327 nm。进行相似度评价、聚类分析(HCA)及主成分分析(PCA)。计算指标成分从饮片到标准汤剂及配方颗粒的转移率。结果:15批茵陈【茵陈蒿(绵茵陈)】标准汤剂和3批配方颗粒特征图谱相似度>0.85,共确定了8个共有峰。HCA、PCA的分析结果显示茵陈【茵陈蒿(绵茵陈)】配方颗粒与标准汤剂成分一致性较好。15批茵陈【茵陈蒿(绵茵陈)】标准汤剂中新绿原酸、绿原酸、隐绿原酸、异绿原酸B、异绿原酸A、异绿原酸C含量分别为1.87~5.23、7.44~15.26、2.85~8.18、3.05~6.14、0.99~3.93、3.23~10.38 mg·g^(-1),饮片到标准汤剂的转移率分别为23.85%~37.28%、19.57%~31.93%、28.15%~45.88%、22.34%~36.59%、16.64%~28.36%、21.81%~39.19%。茵陈【茵陈蒿(绵茵陈)】配方颗粒指标成分含量、转移率与标准汤剂接近。结论:所建立所建指纹图谱及一测多评分析方法可用于茵陈【茵陈蒿(绵茵陈)】配方颗粒的质量评价及工艺研究。 展开更多
关键词 茵陈【茵陈蒿(绵茵陈)】 标准汤剂 配方颗粒 特征图谱 一测多评(QAMS) 聚类分析(HCA) 主成分分析(PCA)
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门诊“互联网+”智慧药学服务在门诊药学服务管理中的运用探讨 被引量:1
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作者 秦国亮 李国妍 陈超 《中国卫生产业》 2024年第14期152-155,共4页
目的对门诊“互联网+”智慧药学服务应用在门诊药学服务中的效果进行探讨。方法选取2022年1月—2023年12月菏泽市中医医院的12名工作人员为研究对象,2022年1—12月实施常规药学服务,并选取1000份门诊处方作为对照组。2023年1—12月开展... 目的对门诊“互联网+”智慧药学服务应用在门诊药学服务中的效果进行探讨。方法选取2022年1月—2023年12月菏泽市中医医院的12名工作人员为研究对象,2022年1—12月实施常规药学服务,并选取1000份门诊处方作为对照组。2023年1—12月开展门诊“互联网+”智慧药学服务,并选取1000份门诊处方作为观察组。对比两组工作人员工作效率、护患纠纷发生情况、处方调剂差错发生情况、满意度。结果观察组人均日调剂处方数量高于对照组,单张处方调剂时间短于对照组,差异有统计学意义(P均<0.05)。对照组发生10起护患纠纷,观察组发生1起护患纠纷。观察组处方调剂差错发生率低于对照组低,差异有统计学意义(P<0.05)。观察组工作人员满意度为100.00%(12/12),高于对照组的58.33%(7/12),差异有统计学意义(χ^(2)=4.042,P<0.05)。结论门诊“互联网+”智慧药学服务能够有效提升药房人员工作效率,降低护患纠纷以及不合理处方发生概率,提升工作人员满意度。 展开更多
关键词 互联网+ 智慧药学服务 门诊 工作效率 处方调剂 满意度
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Phenolic-enabled nanotechnology:a new strategy for central nervous system disease therapy
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作者 Yuyi ZHENG Xiaojie CHEN +2 位作者 Yi WANG Zhong CHEN Di WU 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2024年第10期890-913,共24页
Polyphenolic compounds have received tremendous attention in biomedicine because of their good biocompatibility and unique physicochemical properties.In recent years,phenolic-enabled nanotechnology(PEN)has become a ho... Polyphenolic compounds have received tremendous attention in biomedicine because of their good biocompatibility and unique physicochemical properties.In recent years,phenolic-enabled nanotechnology(PEN)has become a hotspot of research in the medical field,and many promising studies have been reported,especially in the application of central nervous system(CNS)diseases.Polyphenolic compounds have superior anti-inflammatory and antioxidant properties,and can easily cross the blood‒brain barrier,as well as protect the nervous system from metabolic damage and promote learning and cognitive functions.However,although great advances have been made in this field,a comprehensive review regarding PEN-based nanomaterials for CNS therapy is lacking.A systematic summary of the basic mechanisms and synthetic strategies of PEN-based nanomaterials is beneficial for meeting the demand for the further development of novel treatments for CNS diseases.This review systematically introduces the fundamental physicochemical properties of PEN-based nanomaterials and their applications in the treatment of CNS diseases.We first describe the different ways in which polyphenols interact with other substances to form high-quality products with controlled sizes,shapes,compositions,and surface chemistry and functions.The application of PEN-based nanomaterials in the treatment of CNS diseases is then described,which provides a reference for subsequent research on the treatment of CNS diseases. 展开更多
关键词 Phenolic-enabled nanotechnology(PEN) Metal-phenolic network POLYDOPAMINE Central nervous system(CNS) Drug delivery system
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