Chiral metal-organic clusters(MOCs)integrating lanthanide ions(Ln^(3+))and organic luminophores present a promising platform for modulating circularly polarized luminescence(CPL).However,achieving dual-wavelength CPL ...Chiral metal-organic clusters(MOCs)integrating lanthanide ions(Ln^(3+))and organic luminophores present a promising platform for modulating circularly polarized luminescence(CPL).However,achieving dual-wavelength CPL in discrete cluster systems constitutes a considerable challenge.Herein,two enantiomeric pairs of heterometallic EuSn oxo clusters,designated as Sn_(2)EuL_(2)-R/S and Sn_(2)EuL_(4)-R/S,were strategically synthesized using axially chiral binaphthol-phosphonate ligands.These hybrid clusters exhibit dual emission,characterized by a broad ligand-derived fluorescence band superimposed with sharp,characteristic Eu^(3+)f-f transitions,which enables excitation-dependent luminescence color tuning.Their emission profiles and quantum yields are found to be exquisitely adjusted by the distinct coordination environments of Sn^(4+)centers.Notably,Sn_(2)EuL_(2)-R/S demonstrates CPL activity in both near-UV(|g_(lum)|=1.7×10^(-3))and visible(|g_(lum)|=3.1×10^(-2))regions.This work not only reports the first instance of dual-wavelength CPL in a lanthanide/tin oxo complex but also establishes a robust design strategy for fabricating color-tunable chiral photonic materials.展开更多
目的探讨尿液中核酸氧化代谢产物8-oxo-Gsn和8-oxo-d Gsn对HBV感染引起肝损伤程度的评估价值。方法收集笔者医院94例慢性乙型肝炎(以下简称慢乙肝)患者行超声引导下肝穿刺活检前的尿液,95例健康者以及25例乙肝表面携带者的随机尿液,采...目的探讨尿液中核酸氧化代谢产物8-oxo-Gsn和8-oxo-d Gsn对HBV感染引起肝损伤程度的评估价值。方法收集笔者医院94例慢性乙型肝炎(以下简称慢乙肝)患者行超声引导下肝穿刺活检前的尿液,95例健康者以及25例乙肝表面携带者的随机尿液,采用同位素稀释高效液相-串联质谱法(ID-LC-MS/MS)分析尿液中DNA氧化标志物8-oxod Gsn和RNA氧化标志物8-oxo-Gsn,并结合病理结果和生化指标(ALT和AST),分析各指标之间的相关性,通过ROC曲线评估二者对肝损伤程度的预测价值,并分析8-oxo-Gsn和8-oxo-d Gsn在不同炎症活动度和不同纤维化程度患者中的水平差异。结果实验组中,88.5%(46/52)的男性8-oxo-Gsn高于正常对照组,85.7%(36/42)的女性8-oxo-Gsn高于正常对照组;肝脏炎症程度高的患者(G_3~G_4)尿液中RNA氧化标志物8-oxo-Gsn显著高于炎症程度低的患者(G_0~G_2)(4.28 vs 3.26,χ~2=11.117,P=0.009),纤维化程度高的患者8-oxo-Gsn水平也高于纤维化程度低的患者(3.66 vs 3.29),但未达到显著性水平(χ~2=3.626,P=0.323)。尿液中RNA氧化标志物8-oxo-Gsn对肝脏炎症程度有较好的预测价值(敏感度为82.4%,特异性为75%,AUC=0.813),对纤维化程度有较好的预测价值(敏感度为83.3%,特异性为77.1%,AUC=0.824)。结论尿液中RNA氧化标志物8-oxo-Gsn可能是HBV感染引起的肝损伤严重程度的评估指标。展开更多
The reaction mechanism of OXO(X=Cl, Br) with H(2\%S\%) was studied theoretically by using the B3LYP/6-311+G(3df, 3pd) and the high-level electron-correlation QCISD(T)/6-311+G ** at single-point. The results show that ...The reaction mechanism of OXO(X=Cl, Br) with H(2\%S\%) was studied theoretically by using the B3LYP/6-311+G(3df, 3pd) and the high-level electron-correlation QCISD(T)/6-311+G ** at single-point. The results show that the mechanism for the title reaction involves three channels, from which OH+XO, HO 2+X and HX+O 2 products could be obtained, respectively. Therefore, the channel to yield the products OH+XO is the dominant one in agreement with the experiments.展开更多
Halobenzoquinones（HBQs） are an emerging class of halogenated disinfection byproducts（DBPs） in drinking water, which raised public concerns due to potential carcinogenic effects to human bladder. Our previous work ...Halobenzoquinones（HBQs） are an emerging class of halogenated disinfection byproducts（DBPs） in drinking water, which raised public concerns due to potential carcinogenic effects to human bladder. Our previous work demonstrated that HBQs and hydrogen peroxide（H_2O_2）together generated oxidative DNA damage via a metal-independent and intercalationenhanced oxidation mechanism in vitro. This study further investigated the efficiency of various HBQs to induce oxidative DNA damage in T24 bladder cancer cells. Compared with T24 cells without treatment（3.1 lesions per 10~6 d G）, the level of 8-oxo-7,8-dihydro-2′-deoxyguanosine（8-oxod G） significantly increased by 1.4, 3.2, 8.8, and 9.2 times after treatment with tetrabromo-1,4-benzoquinone（TBBQ）, terachloro-1,4-benzoquinone（TCBQ）,2,6-dichloro-1,4-benzoquinone（2,6-DCBQ） and 2,5-dichloro-1,4-benzoquinone（2,5-DCBQ） for24 hr, respectively. Interestingly, we found that the oxidative potency of HBQs in T24 cells（2,5-DCBQ ≈ 2,6-DCBQ 〉 TCBQ 〉 TBBQ） is inconsistent with that of in vitro ds DNA oxidation（TCBQ 〉 TBBQ 〉 2,5-DCBQ 〉 2,6-DCBQ）, suggesting HBQs induce oxidative lesions in cellular genomic DNA probably involved with a complex mechanism.展开更多
A variety of gold（Ⅲ） adducts having a-ligated oxygen-donor ligands have been prepared from [Au（ppy）Cl2]（ppy.phenylpyridine）（1） either by partial or total replacement of the chloride ions. The new species comp...A variety of gold（Ⅲ） adducts having a-ligated oxygen-donor ligands have been prepared from [Au（ppy）Cl2]（ppy.phenylpyridine）（1） either by partial or total replacement of the chloride ions. The new species comprise hydroxo-[Au（ppy）（OH）Cl]（2）, and [Au（ppy）（OH）2]（3）, oxo-[Au2（ppy）2（μ-O）2]（4）, acetate-[Au（ppy）（O2CMe2）] （5）, and alkoxo complexes-[Au（ppy）（OR）Cl]（6, 7） and [Au（ppy）（OR）2]（8--10）（R=Me, 6 and 8; Et, 7 and 9; Pr, 10）. The dihydroxo and the oxo complexes can be interconverted by refluxing the former in anhydrous THF and the latter in water. The hydroxides 2 and 3 and the acetato complex 5 undergo σ-ligand metathesis in ROH solution（R=Me, Et or Pr） to give the corresponding alkoxides.展开更多
A new metal-oxo-clusters-based inorganic framework[NaCo_(2)Mo_(2)O_(7)(OH)_(3)]_(n)(NaCoMo),named as 3D platelike ternary-oxo-cluster,has been hydrothermally synthesized and characterized by single-crystal X-ray diffr...A new metal-oxo-clusters-based inorganic framework[NaCo_(2)Mo_(2)O_(7)(OH)_(3)]_(n)(NaCoMo),named as 3D platelike ternary-oxo-cluster,has been hydrothermally synthesized and characterized by single-crystal X-ray diffraction structure analysis,FT-IR spectroscopy,powder X-ray diffraction(PXRD),scanning electron microscope(SEM),energy-dispersive X-ray spectroscopy(EDS)analyses,X-ray photoelectron spectroscopy(XPS)and thermogravimetric analysis(TGA).Structure analysis reveals that there are no classical building units in NaCoMo,and the asymmetric units of NaCoMo are directly extended into a new platelike 3D structure.Density functional theory calculations(DFT)indicates that the crystal formation process is exothermic and the structure is extremely stable.In addition,the compound presents excellent catalytic activity in the condensation and cyclization reaction of sulfonyl hydrazides and 1,3-diketones to synthesize pyrazoles,and the yield of the desired product is up to 99%.The successful synthesis of NaCoMo represents the discovery of a new kind of non-classical polyoxometalates.展开更多
o-Carboxybenzaldehyde (1)and acetone gave the Claisen-Schmidt condensation product, which readily cyclizes on acidification to give 1-oxo-3-acetonyl-dihydrobenzo [c]furan(4)in 68% yield. Other methyl ketones behaved s...o-Carboxybenzaldehyde (1)and acetone gave the Claisen-Schmidt condensation product, which readily cyclizes on acidification to give 1-oxo-3-acetonyl-dihydrobenzo [c]furan(4)in 68% yield. Other methyl ketones behaved similarly.展开更多
N-acyl-homoserines quenching, enzymatic quenching of bacterial quorum sensing, has recently applied to mitigate biofilm in membrane bioreactor. However, the effect of AHLs on the behavior of biofilm formation is still...N-acyl-homoserines quenching, enzymatic quenching of bacterial quorum sensing, has recently applied to mitigate biofilm in membrane bioreactor. However, the effect of AHLs on the behavior of biofilm formation is still sparse. In this study, Pseudomonas aeruginosa biofilm was formed on ultra-filtration membrane under a series of N-（3-0xooxtanoyl）-L-homoserine lactone （C8-0xo-HSL） concentrations. Diffusing Cs-oxo-HSL increased the growth rate of cells on biofilm where the concentration of Cs-oxo-HSL was over 10-7 g/L. The C8-0xo-HSL gradient had no observable influence on cell density and extracellular polymeric substances of biofilm with over 10-7 g/L Cs-oxo-HSL. Surprisingly, 10-11-10-8 g/L of Cs-Oxo-HSL had no effect on cell growth in liquid culture. The cell analysis demonstrated that the quorum sensing system might enhance the growth of neighboring cells in contact with surfaces into biofilm and may influence the structure and organization of biofilm.展开更多
A series of some new 2-imino-5-[（Z）-1-（4-methylphenyl）methylidene]-3-[5-（2-oxo-2H-3-chromenyl）-1,3-oxazol-2-yl]-1,3- thiazolan-4-ones 5a-j has been synthesized and assayed for their antibacterial activity agains...A series of some new 2-imino-5-[（Z）-1-（4-methylphenyl）methylidene]-3-[5-（2-oxo-2H-3-chromenyl）-1,3-oxazol-2-yl]-1,3- thiazolan-4-ones 5a-j has been synthesized and assayed for their antibacterial activity against Gram-positive bacteria viz.Bacillus subtilis（ATCC 6633）,Staphylococcus aureus（ATCC 6538p） and Micrococcus luteus（IFC 12708）,and Gram-negative bacteria viz. Proteus vulgaris（ATCC 3851）.Salmonella typhimurium（ATCC 14028） and Escherichia coli（ATCC 25922）.Among the screened compounds,5d,5e,5f,5g,and 5j exhibited potent inhibitory activity compared to standard drug,and emerged as potential molecules for further development.展开更多
The synthesis and structure of [Fe(Phen)3][(μ-oxo)Fe2Cl6]稤MF are reported. The crystal data for the compound: monoclinic, P2l /c,a =15.491(1),b = 13.217(1),c = 20.748(2)牛?= 93.83(3),V = 4239(2)?,Z = 4,Dc = 1.562g/c...The synthesis and structure of [Fe(Phen)3][(μ-oxo)Fe2Cl6]稤MF are reported. The crystal data for the compound: monoclinic, P2l /c,a =15.491(1),b = 13.217(1),c = 20.748(2)牛?= 93.83(3),V = 4239(2)?,Z = 4,Dc = 1.562g/cm3,μ(MoK)=1.44 mm-1,F(000)= 2040.0, (C39H31Cl6Fe3N7O2) and Mr = 1009.96. X-ray crystallographic studies reveal that the title compound contains complexes of [Fe(Phen)3]2+ and [Fe2(μ-oxo)Cl6]2- which consists of two [FeCl3] fragments connected by an oxo bridge,with the bond distances of Fe(3)O(1) 1.744(4) and Fe(2)O(1) 1.754(4)牛琣nd a bond angle Fe(2)O(1)Fe(3) of 162.9(3). In the [Fe2(μ-oxo)Cl6]2- complex, the two iron (Ⅲ) centres exhibit tetrahedral coordination, with the distorted tetrahedra formed by three Cl atoms and an oxo bridge. The bond lengths to the donor atoms lie in the range 2.211(1)～2.226(1)?for FeCl, and the non-bonded Fe…Fe distance is 3.459?展开更多
Promoted and mediated by an ionic liquid-[bmim][BF4], fused pyrans or arylbis（4-hydroxy-6-methyl-2-oxo-2H-pyran-3- yl）methanes were efficiently and selectively prepared from the reaction of aldehyde and 4-hydroxy-6-...Promoted and mediated by an ionic liquid-[bmim][BF4], fused pyrans or arylbis（4-hydroxy-6-methyl-2-oxo-2H-pyran-3- yl）methanes were efficiently and selectively prepared from the reaction of aldehyde and 4-hydroxy-6-methyl-2-oxo-pyran with or without acetic anhydride. By using these novel procedures, pyrimidine nucleoside-fused pyran and arylbis（pyranon-3-yl）methane hybrids with potential biological activities were constructed.展开更多
基金financially supported by the National Natural Science Foundation of China(22471268)the National Key Research and Development Project(2022YFA1503900)+2 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB1170000)the Natural Science Foundation of Fujian Province(2022J05090,2024T3003)the Self-deployment Project Research Program of Haixi Institutes,Chinese Academy of Sciences(CXZX-2022-GH03,CXZX-2024-JQ08).
文摘Chiral metal-organic clusters(MOCs)integrating lanthanide ions(Ln^(3+))and organic luminophores present a promising platform for modulating circularly polarized luminescence(CPL).However,achieving dual-wavelength CPL in discrete cluster systems constitutes a considerable challenge.Herein,two enantiomeric pairs of heterometallic EuSn oxo clusters,designated as Sn_(2)EuL_(2)-R/S and Sn_(2)EuL_(4)-R/S,were strategically synthesized using axially chiral binaphthol-phosphonate ligands.These hybrid clusters exhibit dual emission,characterized by a broad ligand-derived fluorescence band superimposed with sharp,characteristic Eu^(3+)f-f transitions,which enables excitation-dependent luminescence color tuning.Their emission profiles and quantum yields are found to be exquisitely adjusted by the distinct coordination environments of Sn^(4+)centers.Notably,Sn_(2)EuL_(2)-R/S demonstrates CPL activity in both near-UV(|g_(lum)|=1.7×10^(-3))and visible(|g_(lum)|=3.1×10^(-2))regions.This work not only reports the first instance of dual-wavelength CPL in a lanthanide/tin oxo complex but also establishes a robust design strategy for fabricating color-tunable chiral photonic materials.
文摘目的探讨尿液中核酸氧化代谢产物8-oxo-Gsn和8-oxo-d Gsn对HBV感染引起肝损伤程度的评估价值。方法收集笔者医院94例慢性乙型肝炎(以下简称慢乙肝)患者行超声引导下肝穿刺活检前的尿液,95例健康者以及25例乙肝表面携带者的随机尿液,采用同位素稀释高效液相-串联质谱法(ID-LC-MS/MS)分析尿液中DNA氧化标志物8-oxod Gsn和RNA氧化标志物8-oxo-Gsn,并结合病理结果和生化指标(ALT和AST),分析各指标之间的相关性,通过ROC曲线评估二者对肝损伤程度的预测价值,并分析8-oxo-Gsn和8-oxo-d Gsn在不同炎症活动度和不同纤维化程度患者中的水平差异。结果实验组中,88.5%(46/52)的男性8-oxo-Gsn高于正常对照组,85.7%(36/42)的女性8-oxo-Gsn高于正常对照组;肝脏炎症程度高的患者(G_3~G_4)尿液中RNA氧化标志物8-oxo-Gsn显著高于炎症程度低的患者(G_0~G_2)(4.28 vs 3.26,χ~2=11.117,P=0.009),纤维化程度高的患者8-oxo-Gsn水平也高于纤维化程度低的患者(3.66 vs 3.29),但未达到显著性水平(χ~2=3.626,P=0.323)。尿液中RNA氧化标志物8-oxo-Gsn对肝脏炎症程度有较好的预测价值(敏感度为82.4%,特异性为75%,AUC=0.813),对纤维化程度有较好的预测价值(敏感度为83.3%,特异性为77.1%,AUC=0.824)。结论尿液中RNA氧化标志物8-oxo-Gsn可能是HBV感染引起的肝损伤严重程度的评估指标。
文摘The reaction mechanism of OXO(X=Cl, Br) with H(2\%S\%) was studied theoretically by using the B3LYP/6-311+G(3df, 3pd) and the high-level electron-correlation QCISD(T)/6-311+G ** at single-point. The results show that the mechanism for the title reaction involves three channels, from which OH+XO, HO 2+X and HX+O 2 products could be obtained, respectively. Therefore, the channel to yield the products OH+XO is the dominant one in agreement with the experiments.
基金supported by the Ministry of Science and Technology of China(Nos.2016YFA0203102,2016YFC0900301 and 2014CB932003)the National Natural Science Foundation of China(Nos.21375142,21321004,and 21435008)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB14030000)
文摘Halobenzoquinones（HBQs） are an emerging class of halogenated disinfection byproducts（DBPs） in drinking water, which raised public concerns due to potential carcinogenic effects to human bladder. Our previous work demonstrated that HBQs and hydrogen peroxide（H_2O_2）together generated oxidative DNA damage via a metal-independent and intercalationenhanced oxidation mechanism in vitro. This study further investigated the efficiency of various HBQs to induce oxidative DNA damage in T24 bladder cancer cells. Compared with T24 cells without treatment（3.1 lesions per 10~6 d G）, the level of 8-oxo-7,8-dihydro-2′-deoxyguanosine（8-oxod G） significantly increased by 1.4, 3.2, 8.8, and 9.2 times after treatment with tetrabromo-1,4-benzoquinone（TBBQ）, terachloro-1,4-benzoquinone（TCBQ）,2,6-dichloro-1,4-benzoquinone（2,6-DCBQ） and 2,5-dichloro-1,4-benzoquinone（2,5-DCBQ） for24 hr, respectively. Interestingly, we found that the oxidative potency of HBQs in T24 cells（2,5-DCBQ ≈ 2,6-DCBQ 〉 TCBQ 〉 TBBQ） is inconsistent with that of in vitro ds DNA oxidation（TCBQ 〉 TBBQ 〉 2,5-DCBQ 〉 2,6-DCBQ）, suggesting HBQs induce oxidative lesions in cellular genomic DNA probably involved with a complex mechanism.
基金Supported by the Ministerio De Ciencia Y Technologia(NoSB2004-oobo)
文摘A variety of gold（Ⅲ） adducts having a-ligated oxygen-donor ligands have been prepared from [Au（ppy）Cl2]（ppy.phenylpyridine）（1） either by partial or total replacement of the chloride ions. The new species comprise hydroxo-[Au（ppy）（OH）Cl]（2）, and [Au（ppy）（OH）2]（3）, oxo-[Au2（ppy）2（μ-O）2]（4）, acetate-[Au（ppy）（O2CMe2）] （5）, and alkoxo complexes-[Au（ppy）（OR）Cl]（6, 7） and [Au（ppy）（OR）2]（8--10）（R=Me, 6 and 8; Et, 7 and 9; Pr, 10）. The dihydroxo and the oxo complexes can be interconverted by refluxing the former in anhydrous THF and the latter in water. The hydroxides 2 and 3 and the acetato complex 5 undergo σ-ligand metathesis in ROH solution（R=Me, Et or Pr） to give the corresponding alkoxides.
基金financially supported by the National Natural Science Foundation of China(Nos.22001034,21871026,21804019)the Open Fund of the Jiangxi Province Key Laboratory of Synthetic Chemistry(No.JXSC202008)the Research Found of East China University of Technology(Nos.DHBK2019264,DHBK2019265,DHBK2019267)。
文摘A new metal-oxo-clusters-based inorganic framework[NaCo_(2)Mo_(2)O_(7)(OH)_(3)]_(n)(NaCoMo),named as 3D platelike ternary-oxo-cluster,has been hydrothermally synthesized and characterized by single-crystal X-ray diffraction structure analysis,FT-IR spectroscopy,powder X-ray diffraction(PXRD),scanning electron microscope(SEM),energy-dispersive X-ray spectroscopy(EDS)analyses,X-ray photoelectron spectroscopy(XPS)and thermogravimetric analysis(TGA).Structure analysis reveals that there are no classical building units in NaCoMo,and the asymmetric units of NaCoMo are directly extended into a new platelike 3D structure.Density functional theory calculations(DFT)indicates that the crystal formation process is exothermic and the structure is extremely stable.In addition,the compound presents excellent catalytic activity in the condensation and cyclization reaction of sulfonyl hydrazides and 1,3-diketones to synthesize pyrazoles,and the yield of the desired product is up to 99%.The successful synthesis of NaCoMo represents the discovery of a new kind of non-classical polyoxometalates.
文摘o-Carboxybenzaldehyde (1)and acetone gave the Claisen-Schmidt condensation product, which readily cyclizes on acidification to give 1-oxo-3-acetonyl-dihydrobenzo [c]furan(4)in 68% yield. Other methyl ketones behaved similarly.
基金supported by the National High Technology Research and Development Program(863)of China(No.2009AA062902)
文摘N-acyl-homoserines quenching, enzymatic quenching of bacterial quorum sensing, has recently applied to mitigate biofilm in membrane bioreactor. However, the effect of AHLs on the behavior of biofilm formation is still sparse. In this study, Pseudomonas aeruginosa biofilm was formed on ultra-filtration membrane under a series of N-（3-0xooxtanoyl）-L-homoserine lactone （C8-0xo-HSL） concentrations. Diffusing Cs-oxo-HSL increased the growth rate of cells on biofilm where the concentration of Cs-oxo-HSL was over 10-7 g/L. The C8-0xo-HSL gradient had no observable influence on cell density and extracellular polymeric substances of biofilm with over 10-7 g/L Cs-oxo-HSL. Surprisingly, 10-11-10-8 g/L of Cs-Oxo-HSL had no effect on cell growth in liquid culture. The cell analysis demonstrated that the quorum sensing system might enhance the growth of neighboring cells in contact with surfaces into biofilm and may influence the structure and organization of biofilm.
文摘A series of some new 2-imino-5-[（Z）-1-（4-methylphenyl）methylidene]-3-[5-（2-oxo-2H-3-chromenyl）-1,3-oxazol-2-yl]-1,3- thiazolan-4-ones 5a-j has been synthesized and assayed for their antibacterial activity against Gram-positive bacteria viz.Bacillus subtilis（ATCC 6633）,Staphylococcus aureus（ATCC 6538p） and Micrococcus luteus（IFC 12708）,and Gram-negative bacteria viz. Proteus vulgaris（ATCC 3851）.Salmonella typhimurium（ATCC 14028） and Escherichia coli（ATCC 25922）.Among the screened compounds,5d,5e,5f,5g,and 5j exhibited potent inhibitory activity compared to standard drug,and emerged as potential molecules for further development.
基金Supported by the foundation of Education Committee of Fujian Province (JB01045)
文摘The synthesis and structure of [Fe(Phen)3][(μ-oxo)Fe2Cl6]稤MF are reported. The crystal data for the compound: monoclinic, P2l /c,a =15.491(1),b = 13.217(1),c = 20.748(2)牛?= 93.83(3),V = 4239(2)?,Z = 4,Dc = 1.562g/cm3,μ(MoK)=1.44 mm-1,F(000)= 2040.0, (C39H31Cl6Fe3N7O2) and Mr = 1009.96. X-ray crystallographic studies reveal that the title compound contains complexes of [Fe(Phen)3]2+ and [Fe2(μ-oxo)Cl6]2- which consists of two [FeCl3] fragments connected by an oxo bridge,with the bond distances of Fe(3)O(1) 1.744(4) and Fe(2)O(1) 1.754(4)牛琣nd a bond angle Fe(2)O(1)Fe(3) of 162.9(3). In the [Fe2(μ-oxo)Cl6]2- complex, the two iron (Ⅲ) centres exhibit tetrahedral coordination, with the distorted tetrahedra formed by three Cl atoms and an oxo bridge. The bond lengths to the donor atoms lie in the range 2.211(1)～2.226(1)?for FeCl, and the non-bonded Fe…Fe distance is 3.459?
基金the National Natural Science Foundation of China(No.20772025)the Program for Science & Technology Innovation Talents in Universities of Henan Province(No.2008HASTIT006)the Natural Science Foundation of Department of Education of Henan Province(No.2008A150013).
文摘Promoted and mediated by an ionic liquid-[bmim][BF4], fused pyrans or arylbis（4-hydroxy-6-methyl-2-oxo-2H-pyran-3- yl）methanes were efficiently and selectively prepared from the reaction of aldehyde and 4-hydroxy-6-methyl-2-oxo-pyran with or without acetic anhydride. By using these novel procedures, pyrimidine nucleoside-fused pyran and arylbis（pyranon-3-yl）methane hybrids with potential biological activities were constructed.
