Increasing evidence,including from our laboratory,has revealed that opening of ATP sensitive potassium channels(K-ATP channels)plays the neuronal protective roles both in vivo and in vitro.Thus K-ATP channel openers(K...Increasing evidence,including from our laboratory,has revealed that opening of ATP sensitive potassium channels(K-ATP channels)plays the neuronal protective roles both in vivo and in vitro.Thus K-ATP channel openers(KCOs)have been proposed as potential neuroprotectants.Our previous studies demonstrated that K-ATP channels could regulate glutamate uptake activity in PC12 cells as well as in synaptosomes of rats.Since glutamate transporters(GluTs)of astrocytes play crucial roles in glutamate uptake and KATP channels are also expressed in astrocytes,the present study showed whether and how KATP channels regulated the function of GluTs in primary cultured astrocytes.The results showed that nonselective KCO pinacidil,selective mitochondrial KCO diazoxide,novel,and blood-brain barrier permeable KCO iptakalim could enhance glutamate uptake,except for the sarcolemmal KCO P1075.Moreover pinacidil,diazoxide,and iptakalim reversed the inhibition of glutamate uptake induced by 1-methyl-4-phenylpyridinium(MPP+).These potentiated effects were completely abolished by mitochondrial K-ATP blocker 5-hydroxydecanoate.Furthermore,either diazoxide or iptakalim could inhibit MPP+-induced elevation of reactive oxygen species(ROS)and phosphorylation of protein kinases C(PKC).These findings are the first to demonstrate that activation of K-ATP channel,especially mitochondrial K-ATP channel,improves the function of GluTs in astrocytes due to reducing ROS production and downregulating PKC phosphorylation.Therefore,the present study not only reveals a novel pharmacological profile of KCOs as regulators of GluTs,but also provides a new strategy for neuroprotection.展开更多
Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim ...Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.展开更多
Journal of Future Foods(ISSN 2772-5669.Owner:Beijing Academy of Food Scicnces.Production and Hosting:Elsevier B.V.on bchalf of KeAi Communications Co.,Ltd)is an international,peer reviewed open access joumal belonging...Journal of Future Foods(ISSN 2772-5669.Owner:Beijing Academy of Food Scicnces.Production and Hosting:Elsevier B.V.on bchalf of KeAi Communications Co.,Ltd)is an international,peer reviewed open access joumal belonging to the discipline of food science and technology.The aim of the joumal is to report latest research results of high-tech in food science.We welcone submissions that drive the ficld of food scicnce towards whole food nutrition,intelligence and high technology.展开更多
Journal of Future Foods(ISSN 2772-5669.Owner:Beijing Academy of Food Sciences.Production and Hosting:Elsevier B.V.on behalf of KeAi Communications Co.,Ltd.)is an international,peer-reviewed open access journal belongi...Journal of Future Foods(ISSN 2772-5669.Owner:Beijing Academy of Food Sciences.Production and Hosting:Elsevier B.V.on behalf of KeAi Communications Co.,Ltd.)is an international,peer-reviewed open access journal belonging to the discipline of food science and technology.The aim of the journal is to report latest research results of high-tech in food science.We welcome submissions that drive the field of food science towards whole food nutrition,intelligence and high technology.展开更多
Journal of Future Foods(ISSN 2772-5669.Owner:Beijing Academy of Food Sciences.Production and Hosting:Elsevier B.V.on behalf of KeAi Communications Co.,Ltd.)is an international,peer-reviewed open access journal belongi...Journal of Future Foods(ISSN 2772-5669.Owner:Beijing Academy of Food Sciences.Production and Hosting:Elsevier B.V.on behalf of KeAi Communications Co.,Ltd.)is an international,peer-reviewed open access journal belonging to the discipline of food science and technology.The aim of the journal is to report latest research results of high-tech in food science.We welcome submissions that drive the field of food science towards whole food nutrition,intelligence and high technology.展开更多
When China announced that it would “seal customs operations” in Hainan,the phrase travelled poorly beyond its borders. To many foreign readers, the term sounds defensive, even restrictive—as if an island were being...When China announced that it would “seal customs operations” in Hainan,the phrase travelled poorly beyond its borders. To many foreign readers, the term sounds defensive, even restrictive—as if an island were being closed off at a time when the global economy urgently needs openness.From Southeast Asia, however, the policy looks less like retreat and more like revelation.It shines light on how China’s understanding of openness has evolved—shaped not by slogans, but by the trade frictions of recent years. What is unfolding in Hainan is not an attempt to close an island, but an effort to define,with unusual precision, where openness begins and how it is sustained.展开更多
China’s commitment to high-standard opening-up during its 15th Five-Year Plan period offers Europe an alternative approach to economic resilience.IN medical practice,a wise doctor does not treat a fever by plunging t...China’s commitment to high-standard opening-up during its 15th Five-Year Plan period offers Europe an alternative approach to economic resilience.IN medical practice,a wise doctor does not treat a fever by plunging the patient into an ice bath.The sudden shock may lower the temperature,but it risks systemic collapse.Instead,the proper treatment should support the body’s own resilience,combat the infection.展开更多
Hainan Province in south China is the country’s second-largest island and the largest free trade port by area.It has entered a historic phase in China’s drive to promote high-level institutional opening up.On 18 Dec...Hainan Province in south China is the country’s second-largest island and the largest free trade port by area.It has entered a historic phase in China’s drive to promote high-level institutional opening up.On 18 December 2025,Hainan officially launched island-wide special customs operations,commonly referred to as“customs closure.”From that date,goods entering or leaving the island,except those traded with the Chinese mainland,are subject to simplified customs procedures and potentially reduced or zero tariffs.展开更多
Metok,located in Nyingchi,the Xizang Autonomous Region,is known as the last county in China to be connected by road.Poor transportation and limited access to petroleum were two obstacles to its development.As soon as ...Metok,located in Nyingchi,the Xizang Autonomous Region,is known as the last county in China to be connected by road.Poor transportation and limited access to petroleum were two obstacles to its development.As soon as the highway connecting Metok and the outside world was completed in 2014,China National Petroleum Corporation’s(CNPC)first gas station in the county was put into operation,providing the momentum for this"secret land of Lotus"and helping it embark on a journey toward openness and prosperity.展开更多
Local residents,artists,and entrepreneurs who converge on Haikou’s historical Qilou Street are contributing to a new chapter in the story of Hainan’s opening-up.MORE than 100 years ago,the area alongQilou(Sotto Port...Local residents,artists,and entrepreneurs who converge on Haikou’s historical Qilou Street are contributing to a new chapter in the story of Hainan’s opening-up.MORE than 100 years ago,the area alongQilou(Sotto Portico)Street in Haikou,capital of Hainan Province,served asthe embarkation point for Hainanesesetting out on their maritime voyages to seek greener pastures.展开更多
Local residents,international artists and entrepreneurs are converging on Haikou’s historical Qilou Street,writing a new chapter of openness in Hainan More than 100 years ago,the area along Qilou(Sotto Portico)Street...Local residents,international artists and entrepreneurs are converging on Haikou’s historical Qilou Street,writing a new chapter of openness in Hainan More than 100 years ago,the area along Qilou(Sotto Portico)Street in Haikou,the capital of Hainan Province,served as the embarkation point for Hainanese setting out on their maritime voyages to seek greener pastures.展开更多
AIM:To evaluate the clinical characteristics and risk factors associated with visual prognosis in patients with open globe injuries(OGIs)treated at Vietnam National Eye Hospital.METHODS:A prospective observational stu...AIM:To evaluate the clinical characteristics and risk factors associated with visual prognosis in patients with open globe injuries(OGIs)treated at Vietnam National Eye Hospital.METHODS:A prospective observational study included patients with OGIs treated between June 2023 and June 2024.Data on demographics,injury features,and clinical findings were extracted from medical records.Poor visual outcome was defined as final best-corrected visual acuity(BCVA)worse than 20/400 or no light perception.Multivariable logistic regression was performed to identify independent risk factors.RESULTS:Among 509 patients(636 eyes),the mean age was 35.13y(range 20–51y),and 67.6%were male.After treatment,the proportion of eyes achieving≥20/40 increased from 12.6%to 42.1%,while no light perception decreased from 29.1%to 9.4%.Independent predictors of poor visual outcomes included delayed admission[>4h,odds ratio(OR)=3.33,95%confidence intervals(CI):1.76–6.33,P<0.001],Zone III injury(OR=5.90,95%CI:2.85–12.24,P<0.001),wound length>10 mm(OR=2.59,95%CI:1.60–4.18,P<0.001),relative afferent pupillary defect(RAPD,OR=1.65,95%CI:1.03–2.64,P=0.039),endophthalmitis(OR=1.75,95%CI:1.01–3.03,P=0.047),retinal detachment(OR=3.32,95%CI:2.02–5.45,P<0.001),and eyelid lacerations(OR=1.94,95%CI:1.13–3.33,P=0.016)associated with OGIs.Vitreous hemorrhage(OR=0.44,95%CI:0.22–0.89,P=0.023)was associated with better outcomes,and female gender appeared protective.CONCLUSION:Poor visual outcomes remain common after OGIs,despite improve visual acuity in many cases.Several clinical and injury-related factors are strongly associated with prognosis.Early recognition of these predictors can support risk stratification and improve trauma care in similar settings.展开更多
Contemporary Social Sciences publishes outstanding research in the field of social sciences in China and also includes high-quality research work by foreign scholars on the development of China’s western regions and ...Contemporary Social Sciences publishes outstanding research in the field of social sciences in China and also includes high-quality research work by foreign scholars on the development of China’s western regions and its reform and opening up.The aim is to help promote China’s academic achievements to the world and give China a stronger voice in the global community of social sciences.The scopes of research fields for consideration include,but not limited to political science,economics,literature,linguistics,journalism and communication,education,sociology,philosophy,history,law,and interdisciplinary research.展开更多
Aims&Scope Grain&Oil Science and Technology(GOST),quarterly,is a peer-reviewed Open Access(OA)journal with distinctive features in the field of grain and oil food research.Upon acceptance all articles are perm...Aims&Scope Grain&Oil Science and Technology(GOST),quarterly,is a peer-reviewed Open Access(OA)journal with distinctive features in the field of grain and oil food research.Upon acceptance all articles are permanently and freely available on ScienceDirect.GOST publishes original research papers and relevant review articles focusing on grain and oil food science and technology.The journal primarily covers new achievements,advanced technologies,and research progress in key areas such as grain and oil food engineering,food science,and food safety.It is dedicated to building an international academic exchange platform for grain and oil food science and technology that spans the entire chain from post-harvest grain handling to food consumption.展开更多
China’s commitment to high-standard opening-upduring its 15th Five-Year Plan period offers Europe analternative approach to economic resilience.AT a time when much of the Westernworld is retreating behind tariff wall...China’s commitment to high-standard opening-upduring its 15th Five-Year Plan period offers Europe analternative approach to economic resilience.AT a time when much of the Westernworld is retreating behind tariff wallsand industrial policy rhetoric framedaround“unfair competition,”China ismoving steadfastly in the opposite direction.展开更多
Vulnerabilities are a known problem in modern Open Source Software(OSS).Most developers often rely on third-party libraries to accelerate feature implementation.However,these libraries may contain vulnerabilities that...Vulnerabilities are a known problem in modern Open Source Software(OSS).Most developers often rely on third-party libraries to accelerate feature implementation.However,these libraries may contain vulnerabilities that attackers can exploit to propagate malicious code,posing security risks to dependent projects.Existing research addresses these challenges through Software Composition Analysis(SCA)for vulnerability detection and remediation.Nevertheless,current solutions may introduce additional issues,such as incompatibilities,dependency conflicts,and additional vulnerabilities.To address this,we propose Vulnerability Scan and Protection(VulnScanPro),a robust solution for detection and remediation vulnerabilities in Java projects.Specifically,VulnScanPro builds a finegrained method graph to identify unreachable methods.The method graph is mapped to the project’s dependency tree,constructing a comprehensive vulnerability propagation graph that identifies unreachable vulnerable APIs and dependencies.Based on this analysis,we propose three solutions for vulnerability remediation:(1)Removing unreachable vulnerable dependencies,thereby resolving security risks and reducing maintenance overhead.(2)Upgrading vulnerable dependencies to the closest non-vulnerable versions,while pinning the versions of transitive dependencies introduced by the vulnerable dependency,in order to mitigate compatibility issues and prevent the introduction of new vulnerabilities.(3)Eliminating unreachable vulnerable APIs,particularly when security patches are either incompatible or absent.Experimental results show that these solutions effectively mitigate vulnerabilities and enhance the overall security of the project.展开更多
The accuracy of genomic annotation is crucial for subsequent functional investigations;however,computational protocols used in high-throughput annotation of open reading frames(ORFs)can introduce inconsistencies.These...The accuracy of genomic annotation is crucial for subsequent functional investigations;however,computational protocols used in high-throughput annotation of open reading frames(ORFs)can introduce inconsistencies.These inconsistencies,which lead to non-uniform extension or truncation of sequence ends,pose challenges for downstream analyses.Existing strategies to rectify these inconsistencies are time-consuming and labor-intensive,lacking specific approaches.To address this gap,we developed to GC,a tool that integrates genomic annotation with RNA-seq datasets to rectify annotation inconsistencies.Using to GC,we achieved an accuracy of nearly 100%accuracy in correcting inconsistencies in published Phytophthora sojae ORFs.We applied this innovative pipeline to the GPCR-bigrams gene family,which was predicted to have 42 members in the P.sojae genome but lacked experimental validation.By employing to GC,we identified 32 GPCR-bigram ORFs with inconsistencies between previous annotations and to GC-corrected sequences.Notably,among these were 5 genes(GPCR-TKL9,GPCR-TKL15,GPCR-PDE3,GPCR-AC3,and GPCR-AC4)showed substantial inconsistencies.Experimental gene annotation confirmed the effectiveness of to GC,as sequences obtained through cloning matched those annotated by to GC.Importantly,we discovered two novel GPCRs(GPCR-AC3 and GPCR-AC4),which were previously mispredicted as a single gene.CRISPR/Cas9-mediated knockout experiments revealed the involvement of GPCR-AC4 but not GPCR-AC3 in oospore production,further confirming their status as two separate genes.In addition to P.sojae,the reliability of the to GC pipeline in Phytophthora capsici and Pythium ultimum further emphasizes the robustness of this pipeline.Our findings highlight the utility of to GC for reliable gene model correction,facilitating investigations into biological functions and offering potential applications in diverse species analyses.展开更多
At present, enhancing the digital literacy of village cadres faces practical constraints such as governance capability gaps induced by the second-level digital divide, the absence of a systematic cultivation system, i...At present, enhancing the digital literacy of village cadres faces practical constraints such as governance capability gaps induced by the second-level digital divide, the absence of a systematic cultivation system, incomplete last-kilometer implementation for translating skills into practice, and inadequate incentive mechanisms. As a novel educational form deeply integrating digital information technology with teaching and learning, distance open education provides multi-directional empowerment for enhancing village cadres digital literacy. This is achieved through open learning methods, the application of modern digital technologies, tailored learning programs, and the establishment of "overpass bridges" for translating learning outcomes into practice. Based on this, it is essential to further streamline the pathways for educating and cultivating village cadres, vigorously promote the digitalization of teaching, practice, and support services, develop systematic and localized digital education resources, and actively explore and establish a complementary credit bank system for their digital literacy cultivation.展开更多
文摘Increasing evidence,including from our laboratory,has revealed that opening of ATP sensitive potassium channels(K-ATP channels)plays the neuronal protective roles both in vivo and in vitro.Thus K-ATP channel openers(KCOs)have been proposed as potential neuroprotectants.Our previous studies demonstrated that K-ATP channels could regulate glutamate uptake activity in PC12 cells as well as in synaptosomes of rats.Since glutamate transporters(GluTs)of astrocytes play crucial roles in glutamate uptake and KATP channels are also expressed in astrocytes,the present study showed whether and how KATP channels regulated the function of GluTs in primary cultured astrocytes.The results showed that nonselective KCO pinacidil,selective mitochondrial KCO diazoxide,novel,and blood-brain barrier permeable KCO iptakalim could enhance glutamate uptake,except for the sarcolemmal KCO P1075.Moreover pinacidil,diazoxide,and iptakalim reversed the inhibition of glutamate uptake induced by 1-methyl-4-phenylpyridinium(MPP+).These potentiated effects were completely abolished by mitochondrial K-ATP blocker 5-hydroxydecanoate.Furthermore,either diazoxide or iptakalim could inhibit MPP+-induced elevation of reactive oxygen species(ROS)and phosphorylation of protein kinases C(PKC).These findings are the first to demonstrate that activation of K-ATP channel,especially mitochondrial K-ATP channel,improves the function of GluTs in astrocytes due to reducing ROS production and downregulating PKC phosphorylation.Therefore,the present study not only reveals a novel pharmacological profile of KCOs as regulators of GluTs,but also provides a new strategy for neuroprotection.
文摘Agricultural Products Processing and Storage(ISSN 3059-4510,Owner:Hunan Academy of Agricultural Sciences,China.Production and hosting:Springer Nature)is an international,peer-reviewed open access journal with the aim to offer a platform for the rapid dissemination of signifi cant,novel,and high-impact research in the fi elds of agricultural product processing science,technology,engineering,and nutrition.Additionally,supplemental issues are curated and published to facilitate in-depth discussions on special topics.
文摘Journal of Future Foods(ISSN 2772-5669.Owner:Beijing Academy of Food Scicnces.Production and Hosting:Elsevier B.V.on bchalf of KeAi Communications Co.,Ltd)is an international,peer reviewed open access joumal belonging to the discipline of food science and technology.The aim of the joumal is to report latest research results of high-tech in food science.We welcone submissions that drive the ficld of food scicnce towards whole food nutrition,intelligence and high technology.
文摘Journal of Future Foods(ISSN 2772-5669.Owner:Beijing Academy of Food Sciences.Production and Hosting:Elsevier B.V.on behalf of KeAi Communications Co.,Ltd.)is an international,peer-reviewed open access journal belonging to the discipline of food science and technology.The aim of the journal is to report latest research results of high-tech in food science.We welcome submissions that drive the field of food science towards whole food nutrition,intelligence and high technology.
文摘Journal of Future Foods(ISSN 2772-5669.Owner:Beijing Academy of Food Sciences.Production and Hosting:Elsevier B.V.on behalf of KeAi Communications Co.,Ltd.)is an international,peer-reviewed open access journal belonging to the discipline of food science and technology.The aim of the journal is to report latest research results of high-tech in food science.We welcome submissions that drive the field of food science towards whole food nutrition,intelligence and high technology.
文摘When China announced that it would “seal customs operations” in Hainan,the phrase travelled poorly beyond its borders. To many foreign readers, the term sounds defensive, even restrictive—as if an island were being closed off at a time when the global economy urgently needs openness.From Southeast Asia, however, the policy looks less like retreat and more like revelation.It shines light on how China’s understanding of openness has evolved—shaped not by slogans, but by the trade frictions of recent years. What is unfolding in Hainan is not an attempt to close an island, but an effort to define,with unusual precision, where openness begins and how it is sustained.
文摘China’s commitment to high-standard opening-up during its 15th Five-Year Plan period offers Europe an alternative approach to economic resilience.IN medical practice,a wise doctor does not treat a fever by plunging the patient into an ice bath.The sudden shock may lower the temperature,but it risks systemic collapse.Instead,the proper treatment should support the body’s own resilience,combat the infection.
文摘Hainan Province in south China is the country’s second-largest island and the largest free trade port by area.It has entered a historic phase in China’s drive to promote high-level institutional opening up.On 18 December 2025,Hainan officially launched island-wide special customs operations,commonly referred to as“customs closure.”From that date,goods entering or leaving the island,except those traded with the Chinese mainland,are subject to simplified customs procedures and potentially reduced or zero tariffs.
文摘Metok,located in Nyingchi,the Xizang Autonomous Region,is known as the last county in China to be connected by road.Poor transportation and limited access to petroleum were two obstacles to its development.As soon as the highway connecting Metok and the outside world was completed in 2014,China National Petroleum Corporation’s(CNPC)first gas station in the county was put into operation,providing the momentum for this"secret land of Lotus"and helping it embark on a journey toward openness and prosperity.
文摘Local residents,artists,and entrepreneurs who converge on Haikou’s historical Qilou Street are contributing to a new chapter in the story of Hainan’s opening-up.MORE than 100 years ago,the area alongQilou(Sotto Portico)Street in Haikou,capital of Hainan Province,served asthe embarkation point for Hainanesesetting out on their maritime voyages to seek greener pastures.
文摘Local residents,international artists and entrepreneurs are converging on Haikou’s historical Qilou Street,writing a new chapter of openness in Hainan More than 100 years ago,the area along Qilou(Sotto Portico)Street in Haikou,the capital of Hainan Province,served as the embarkation point for Hainanese setting out on their maritime voyages to seek greener pastures.
文摘AIM:To evaluate the clinical characteristics and risk factors associated with visual prognosis in patients with open globe injuries(OGIs)treated at Vietnam National Eye Hospital.METHODS:A prospective observational study included patients with OGIs treated between June 2023 and June 2024.Data on demographics,injury features,and clinical findings were extracted from medical records.Poor visual outcome was defined as final best-corrected visual acuity(BCVA)worse than 20/400 or no light perception.Multivariable logistic regression was performed to identify independent risk factors.RESULTS:Among 509 patients(636 eyes),the mean age was 35.13y(range 20–51y),and 67.6%were male.After treatment,the proportion of eyes achieving≥20/40 increased from 12.6%to 42.1%,while no light perception decreased from 29.1%to 9.4%.Independent predictors of poor visual outcomes included delayed admission[>4h,odds ratio(OR)=3.33,95%confidence intervals(CI):1.76–6.33,P<0.001],Zone III injury(OR=5.90,95%CI:2.85–12.24,P<0.001),wound length>10 mm(OR=2.59,95%CI:1.60–4.18,P<0.001),relative afferent pupillary defect(RAPD,OR=1.65,95%CI:1.03–2.64,P=0.039),endophthalmitis(OR=1.75,95%CI:1.01–3.03,P=0.047),retinal detachment(OR=3.32,95%CI:2.02–5.45,P<0.001),and eyelid lacerations(OR=1.94,95%CI:1.13–3.33,P=0.016)associated with OGIs.Vitreous hemorrhage(OR=0.44,95%CI:0.22–0.89,P=0.023)was associated with better outcomes,and female gender appeared protective.CONCLUSION:Poor visual outcomes remain common after OGIs,despite improve visual acuity in many cases.Several clinical and injury-related factors are strongly associated with prognosis.Early recognition of these predictors can support risk stratification and improve trauma care in similar settings.
文摘Contemporary Social Sciences publishes outstanding research in the field of social sciences in China and also includes high-quality research work by foreign scholars on the development of China’s western regions and its reform and opening up.The aim is to help promote China’s academic achievements to the world and give China a stronger voice in the global community of social sciences.The scopes of research fields for consideration include,but not limited to political science,economics,literature,linguistics,journalism and communication,education,sociology,philosophy,history,law,and interdisciplinary research.
文摘Aims&Scope Grain&Oil Science and Technology(GOST),quarterly,is a peer-reviewed Open Access(OA)journal with distinctive features in the field of grain and oil food research.Upon acceptance all articles are permanently and freely available on ScienceDirect.GOST publishes original research papers and relevant review articles focusing on grain and oil food science and technology.The journal primarily covers new achievements,advanced technologies,and research progress in key areas such as grain and oil food engineering,food science,and food safety.It is dedicated to building an international academic exchange platform for grain and oil food science and technology that spans the entire chain from post-harvest grain handling to food consumption.
文摘China’s commitment to high-standard opening-upduring its 15th Five-Year Plan period offers Europe analternative approach to economic resilience.AT a time when much of the Westernworld is retreating behind tariff wallsand industrial policy rhetoric framedaround“unfair competition,”China ismoving steadfastly in the opposite direction.
基金supported by the National Natural Science Foundation of China(Grant No.62141210)the Fundamental Research Funds for the Central Universities(Grant No.N2217005)+1 种基金Open Fund of State Key Lab.for Novel Software Technology,Nanjing University(KFKT2021B01)111 Project(B16009).
文摘Vulnerabilities are a known problem in modern Open Source Software(OSS).Most developers often rely on third-party libraries to accelerate feature implementation.However,these libraries may contain vulnerabilities that attackers can exploit to propagate malicious code,posing security risks to dependent projects.Existing research addresses these challenges through Software Composition Analysis(SCA)for vulnerability detection and remediation.Nevertheless,current solutions may introduce additional issues,such as incompatibilities,dependency conflicts,and additional vulnerabilities.To address this,we propose Vulnerability Scan and Protection(VulnScanPro),a robust solution for detection and remediation vulnerabilities in Java projects.Specifically,VulnScanPro builds a finegrained method graph to identify unreachable methods.The method graph is mapped to the project’s dependency tree,constructing a comprehensive vulnerability propagation graph that identifies unreachable vulnerable APIs and dependencies.Based on this analysis,we propose three solutions for vulnerability remediation:(1)Removing unreachable vulnerable dependencies,thereby resolving security risks and reducing maintenance overhead.(2)Upgrading vulnerable dependencies to the closest non-vulnerable versions,while pinning the versions of transitive dependencies introduced by the vulnerable dependency,in order to mitigate compatibility issues and prevent the introduction of new vulnerabilities.(3)Eliminating unreachable vulnerable APIs,particularly when security patches are either incompatible or absent.Experimental results show that these solutions effectively mitigate vulnerabilities and enhance the overall security of the project.
基金supported by the grants to Min Qiu and Ming Wang from the National Natural Science Foundation of China(32100160 and 32100044)the grants to Ming Wang from the Jiangsu“Innovative and Entrepreneurial Talent”Program,China(JSSCRC2021510)the grants to Yuanchao Wang from the Chinese Modern Agricultural Industry Technology System(CARS-004-PS14)。
文摘The accuracy of genomic annotation is crucial for subsequent functional investigations;however,computational protocols used in high-throughput annotation of open reading frames(ORFs)can introduce inconsistencies.These inconsistencies,which lead to non-uniform extension or truncation of sequence ends,pose challenges for downstream analyses.Existing strategies to rectify these inconsistencies are time-consuming and labor-intensive,lacking specific approaches.To address this gap,we developed to GC,a tool that integrates genomic annotation with RNA-seq datasets to rectify annotation inconsistencies.Using to GC,we achieved an accuracy of nearly 100%accuracy in correcting inconsistencies in published Phytophthora sojae ORFs.We applied this innovative pipeline to the GPCR-bigrams gene family,which was predicted to have 42 members in the P.sojae genome but lacked experimental validation.By employing to GC,we identified 32 GPCR-bigram ORFs with inconsistencies between previous annotations and to GC-corrected sequences.Notably,among these were 5 genes(GPCR-TKL9,GPCR-TKL15,GPCR-PDE3,GPCR-AC3,and GPCR-AC4)showed substantial inconsistencies.Experimental gene annotation confirmed the effectiveness of to GC,as sequences obtained through cloning matched those annotated by to GC.Importantly,we discovered two novel GPCRs(GPCR-AC3 and GPCR-AC4),which were previously mispredicted as a single gene.CRISPR/Cas9-mediated knockout experiments revealed the involvement of GPCR-AC4 but not GPCR-AC3 in oospore production,further confirming their status as two separate genes.In addition to P.sojae,the reliability of the to GC pipeline in Phytophthora capsici and Pythium ultimum further emphasizes the robustness of this pipeline.Our findings highlight the utility of to GC for reliable gene model correction,facilitating investigations into biological functions and offering potential applications in diverse species analyses.
基金Supported by Science Research Fund Project of Yunnan Provincial Department of Education-Research on the Pathways for Distance Open Education to Empower the Enhancement of Digital Literacy and Skills of Rural"Leading Geese"in Ethnic Areas(2023J0792)The Ideological and Political Education Reform Project of Yunnan Province in 2022-Exploration and Practice of Integrating Ideological and Political Education into the Training Mode of"Leading Goose"Talents for Rural Revitalization in the Course of Agricultural and Forestry Economics and Management in Open Education.
文摘At present, enhancing the digital literacy of village cadres faces practical constraints such as governance capability gaps induced by the second-level digital divide, the absence of a systematic cultivation system, incomplete last-kilometer implementation for translating skills into practice, and inadequate incentive mechanisms. As a novel educational form deeply integrating digital information technology with teaching and learning, distance open education provides multi-directional empowerment for enhancing village cadres digital literacy. This is achieved through open learning methods, the application of modern digital technologies, tailored learning programs, and the establishment of "overpass bridges" for translating learning outcomes into practice. Based on this, it is essential to further streamline the pathways for educating and cultivating village cadres, vigorously promote the digitalization of teaching, practice, and support services, develop systematic and localized digital education resources, and actively explore and establish a complementary credit bank system for their digital literacy cultivation.
