Primary pulmonary nuclear protein of the testis(NUT)midline carcinoma(NMC)is a rare and highly aggressive thoracic malignancy that poses significant diagnostic and therapeutic challenges in clinical practice.This tumo...Primary pulmonary nuclear protein of the testis(NUT)midline carcinoma(NMC)is a rare and highly aggressive thoracic malignancy that poses significant diagnostic and therapeutic challenges in clinical practice.This tumor is characterized by its heterogeneous clinical presentations and poor prognosis,often evading accurate initial diagnosis.In this study,we present two cases of primary pulmonary NMC treated with an integrated therapeutic approach combining anti-angiogenic agents,platinum-based chemotherapy,and radiotherapy.This multimodal strategy achieved survival durations of 32 and 13 months,respectively,surpassing the currently reported median survival of advanced NMC.Through a systematic literature review of reported cases,we have summarized the currently used diagnostic methods and treatment modalities for NMC.Our findings suggest that multimodal therapy incorporating anti-angiogenic treatment may offer superior clinical outcomes compared to conventional monotherapy regimens,particularly for patients who are not eligible for surgery.This comprehensive investigation enhances our understanding of NMC management by elucidating diagnostic pitfalls through histopathological correlation and proposing an effective therapeutic combination that demonstrates improved survival outcomes.By providing valuable insights into the diagnosis and treatment of primary pulmonary NMC,we hope to contribute to the development of more effective strategies for managing this rare and aggressive malignancy.展开更多
In order to screen herbicides with ideal safety characteristics to control malignant weed nut grass in sugarcane field, 20% thifensulfuron methyl WP and 65% MCPA·ametryne·diuron WP were selected for the fiel...In order to screen herbicides with ideal safety characteristics to control malignant weed nut grass in sugarcane field, 20% thifensulfuron methyl WP and 65% MCPA·ametryne·diuron WP were selected for the field efficacy trial. The results showed that 20% thifensulfuron methyl WP and 65% MCPA·ametryne·diuron WP had good control effect on nut grass. The optimum dosage of 20% thifensulfuron methyl WP and 65% MCPA.ametryne-diuron WP was 1 125 g/hm^2 （effective ingredients 225 g） and 3 150 g/hm^2 （effective ingredients 2 047.5 g）, respectively. These two herbicides should be dissolved in 675 kg water per hectare and applied in the vigorous growth period of nut grass （height 10-15 cm） with oriented stem leaf spraying. The control effect after 15 days could be above 87.9%.展开更多
NUT癌(NUT carcinoma)又称为伴睾丸核蛋白(the nuclear protein of the testis,NUT)基因重排的中线癌,它是一种组织起源不明的高度侵袭性的恶性肿瘤,非常罕见。以前人们认为该病仅发生于中线器官,但随着病例的积累,现在认为它不仅发生...NUT癌(NUT carcinoma)又称为伴睾丸核蛋白(the nuclear protein of the testis,NUT)基因重排的中线癌,它是一种组织起源不明的高度侵袭性的恶性肿瘤,非常罕见。以前人们认为该病仅发生于中线器官,但随着病例的积累,现在认为它不仅发生于中线器官,还可以发生于非中线器官,如腮腺、颌下腺等。展开更多
Kola nut is a native stimulant which is commonly chewed in many West African cultures, individually or in a group setting. It is often used ceremonially and to honour vip. Phytochemical analysis and antibacterial sc...Kola nut is a native stimulant which is commonly chewed in many West African cultures, individually or in a group setting. It is often used ceremonially and to honour vip. Phytochemical analysis and antibacterial screening of red and white Cola nitida (kola nut) extracts were evaluated using qualitative and quantitative method. Thin layer chromatography (TLC) was used to evaluate the phenolic content. Antibacterial screening was done using agar well diffusion method against odontopathogens;(Lactobacillus sp., Corynebacterium haemolyticum, Proteus vulgans, Bacillus lentus, Streptococcus anginosus and Pseudomonas aeruginosa) obtained from stock cultures. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponin, tannins, glycoside, steroids, volatile oil and balsams. Higher content of alkaloids, saponin and glycoside was obtained in the aqueous extract than the methanol for both red and white kola nut. The results of TLC analysis revealed the presence of quercetin and coumarin in red kola and keamferol and coumarin in white kola respectively. The result of antibacterial activity of red C. nitida showed a zone of inhibition of 18 mm and 23 mm at 60 mg/ml for aqueous extract on Proteus vulgans and Streptococcus anginosus. Similarly white kola inhibited the growth of S. anginosus at 90 mg/ml with a zone of 18 mm. Methanol extract of red kola inhibited the growth of P. vulgans and S. anginosus at 60 mg/ml with a zone of 16 mm and 20 mm respectively. Acetone and ethyl acetate extracts of both red and white kola nut did not show any activity against the tested organism at all concentrations. The results obtained indicate that C. nitida which posses promising chemotherapeutic and antibacterial potentials respectively that could be useful against odontopathogens. The study may serve as baseline for further studies.展开更多
文摘Primary pulmonary nuclear protein of the testis(NUT)midline carcinoma(NMC)is a rare and highly aggressive thoracic malignancy that poses significant diagnostic and therapeutic challenges in clinical practice.This tumor is characterized by its heterogeneous clinical presentations and poor prognosis,often evading accurate initial diagnosis.In this study,we present two cases of primary pulmonary NMC treated with an integrated therapeutic approach combining anti-angiogenic agents,platinum-based chemotherapy,and radiotherapy.This multimodal strategy achieved survival durations of 32 and 13 months,respectively,surpassing the currently reported median survival of advanced NMC.Through a systematic literature review of reported cases,we have summarized the currently used diagnostic methods and treatment modalities for NMC.Our findings suggest that multimodal therapy incorporating anti-angiogenic treatment may offer superior clinical outcomes compared to conventional monotherapy regimens,particularly for patients who are not eligible for surgery.This comprehensive investigation enhances our understanding of NMC management by elucidating diagnostic pitfalls through histopathological correlation and proposing an effective therapeutic combination that demonstrates improved survival outcomes.By providing valuable insights into the diagnosis and treatment of primary pulmonary NMC,we hope to contribute to the development of more effective strategies for managing this rare and aggressive malignancy.
基金Supported by Earmarked Fund for China Agriculture Research System(CARS-20-2-2)Project for Yunnan Provincial Modern Agricultural Industry Technology System(YNGZTX-4-92)~~
文摘In order to screen herbicides with ideal safety characteristics to control malignant weed nut grass in sugarcane field, 20% thifensulfuron methyl WP and 65% MCPA·ametryne·diuron WP were selected for the field efficacy trial. The results showed that 20% thifensulfuron methyl WP and 65% MCPA·ametryne·diuron WP had good control effect on nut grass. The optimum dosage of 20% thifensulfuron methyl WP and 65% MCPA.ametryne-diuron WP was 1 125 g/hm^2 （effective ingredients 225 g） and 3 150 g/hm^2 （effective ingredients 2 047.5 g）, respectively. These two herbicides should be dissolved in 675 kg water per hectare and applied in the vigorous growth period of nut grass （height 10-15 cm） with oriented stem leaf spraying. The control effect after 15 days could be above 87.9%.
文摘NUT癌(NUT carcinoma)又称为伴睾丸核蛋白(the nuclear protein of the testis,NUT)基因重排的中线癌,它是一种组织起源不明的高度侵袭性的恶性肿瘤,非常罕见。以前人们认为该病仅发生于中线器官,但随着病例的积累,现在认为它不仅发生于中线器官,还可以发生于非中线器官,如腮腺、颌下腺等。
文摘Kola nut is a native stimulant which is commonly chewed in many West African cultures, individually or in a group setting. It is often used ceremonially and to honour vip. Phytochemical analysis and antibacterial screening of red and white Cola nitida (kola nut) extracts were evaluated using qualitative and quantitative method. Thin layer chromatography (TLC) was used to evaluate the phenolic content. Antibacterial screening was done using agar well diffusion method against odontopathogens;(Lactobacillus sp., Corynebacterium haemolyticum, Proteus vulgans, Bacillus lentus, Streptococcus anginosus and Pseudomonas aeruginosa) obtained from stock cultures. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponin, tannins, glycoside, steroids, volatile oil and balsams. Higher content of alkaloids, saponin and glycoside was obtained in the aqueous extract than the methanol for both red and white kola nut. The results of TLC analysis revealed the presence of quercetin and coumarin in red kola and keamferol and coumarin in white kola respectively. The result of antibacterial activity of red C. nitida showed a zone of inhibition of 18 mm and 23 mm at 60 mg/ml for aqueous extract on Proteus vulgans and Streptococcus anginosus. Similarly white kola inhibited the growth of S. anginosus at 90 mg/ml with a zone of 18 mm. Methanol extract of red kola inhibited the growth of P. vulgans and S. anginosus at 60 mg/ml with a zone of 16 mm and 20 mm respectively. Acetone and ethyl acetate extracts of both red and white kola nut did not show any activity against the tested organism at all concentrations. The results obtained indicate that C. nitida which posses promising chemotherapeutic and antibacterial potentials respectively that could be useful against odontopathogens. The study may serve as baseline for further studies.
