Swing nose crossings(SNXs)have been widely used in heavy haul railways to create a smoother load transfer and hence reduced impact load.However,the current design of SNXs hasn’t been fully examined under heavy haul o...Swing nose crossings(SNXs)have been widely used in heavy haul railways to create a smoother load transfer and hence reduced impact load.However,the current design of SNXs hasn’t been fully examined under heavy haul operating conditions.Additionally,maintenance guidelines for SNX wear-related issues in Australian heavy haul railways are relatively lacking.As such,this study aims to investigate the dynamic response of the wheel-rail contact and analyse the wear performance of an SNX currently used in Australian heavy haul railways.Dynamic implicit-explicit finite element analysis was conducted to simulate the wheel-rail contact along the SNX.The distribution of the wear intensity over the SNX was identified by using a local contact-based wear model.The influence of various scenarios on wear was also explored.The results verify the improved dynamic performance of the SNX,as the increased contact force after load transfer remains below 1.2 times the static load.The findings also indicate that the decrease in relative height and increase in nose rail inclination result in greater wear on the nose rail.Notably,the SNX considered in the current study exhibits better wear performance when used with moderately worn wheels.展开更多
为开发新型高品质的蜂蜜茶酒,利用酿酒酵母和非酿酒酵母混菌发酵制备蜂蜜茶酒,采用电子鼻技术结合顶空固相微萃取-气相色谱-质谱(Headspace Solid-Phase Micro Extraction and Gas Chromatography Mass Spectrometry,HS-SPME-GC-MS),并...为开发新型高品质的蜂蜜茶酒,利用酿酒酵母和非酿酒酵母混菌发酵制备蜂蜜茶酒,采用电子鼻技术结合顶空固相微萃取-气相色谱-质谱(Headspace Solid-Phase Micro Extraction and Gas Chromatography Mass Spectrometry,HS-SPME-GC-MS),并对发酵蜂蜜茶酒的基本理化、有机酸和多酚含量进行检测,以酿酒酵母单菌发酵(SF)和非酿酒酵母单菌发酵(HF)产品作为对比分析,综合评价混菌发酵(MF)对蜂蜜茶酒品质和风味的影响。结果表明:相较于SF和HF,MF提高了蜂蜜茶酒总酚和总黄酮含量。发酵后样品的有机酸含量上升,多酚含量下降。HF电子鼻传感器响应值低,且MF大部分传感器响应值大于SF。HS-SPME-GC-MS共鉴定出75种香气成分,混菌发酵使蜂蜜茶酒中的挥发性化合物种类和含量显著增加(P<0.05)。PLS-DA分析共筛选出10种差异化合物(VIP>1),其中有6种为酯类风味物质。OAV>1的关键香气成分共有12种,相较于HF和SF,对MF香气贡献率较高的为具有花香的苯乙醇、蜂蜜甜香的乙酸苯乙酯、水果香气的甲酸戊酯和醋酸正丙酯等。综上,混菌发酵蜂蜜茶酒相较于单菌发酵更具优势,总体风味更丰富浓郁。本文为非酿酒酵母在酒类中的应用及茶叶副产物深加工利用提供了理论依据。展开更多
Electronic nose(eNose) is a modern bioelectronic sensor for monitoring biological processes that convert CO_(2) into valueadded products, such as products formed during photosynthesis and microbial fermentation. eNose...Electronic nose(eNose) is a modern bioelectronic sensor for monitoring biological processes that convert CO_(2) into valueadded products, such as products formed during photosynthesis and microbial fermentation. eNose technology uses an array of sensors to detect and quantify gases, including CO_(2), in the air. This study briefly introduces the concept of eNose technology and potential applications thereof in monitoring CO_(2) conversion processes. It also provides background information on biological CO_(2) conversion processes. Furthermore, the working principles of eNose technology vis-à-vis gas detection are discussed along with its advantages and limitations versus traditional monitoring methods. This study also provides case studies that have used this technology for monitoring biological CO_(2) conversion processes. eNose-predicted measurements were observed to be completely aligned with biological parameters for R~2 values of 0.864, 0.808, 0.802, and 0.948. We test eNose technology in a variety of biological settings, such as algae farms or bioreactors, to determine its effectiveness in monitoring CO_(2) conversion processes. We also explore the potential benefits of employing this technology vis-à-vis monitoring biological CO_(2) conversion processes, such as increased reaction efficiency and reduced costs versus traditional monitoring methods. Moreover, future directions and challenges of using this technology in CO_(2) capture and conversion have been discussed. Overall, we believe this study would contribute to developing new and innovative methods for monitoring biological CO_(2) conversion processes and mitigating climate change.展开更多
The sensory perception of food is a dynamic process,which is closely related to the release of flavor substances during oral processing.It’s not only affected by the food material,but also subjected to the individual...The sensory perception of food is a dynamic process,which is closely related to the release of flavor substances during oral processing.It’s not only affected by the food material,but also subjected to the individual oral environment.To explore the oral processing characteristics of soft-boiled chicken,the sensory properties,texture,particle size,viscosity,characteristic values of electronic nose and tongue of different chicken samples were investigated.The correlation analysis showed that the physical characteristics especially the cohesiveness,springiness,resilience of the sample determined oral processing behavior.The addition of chicken skin played a role in lubrication during oral processing.The particle size of the bolus was heightened at the early stage,and the fluidity was enhanced in the end,which reduced the chewing time to the swallowing point and raised the aromatic compounds signal of electronic nose.But the effect of chicken skin on chicken thigh with relatively high fat content,was opposite in electronic nose,which had a certain masking effect on the perception of umami and sweet taste.In conclusion,fat played a critical role in chicken oral processing and chicken thigh had obvious advantages in comprehensive evaluation of soft-boiled chicken,which was more popular among people.展开更多
The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytic...The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytical study of the evolution of the nose shape of larger hollow projectiles under hypersonic penetration.In the hypersonic penetration test,eight ogive-nose AerMet100 steel projectiles with a diameter of 40 mm were launched to hit concrete targets with impact velocities that ranged from 1351 to 1877 m/s.Severe erosion of the projectiles was observed during high-speed penetration of heterogeneous targets,and apparent localized mushrooming occurred in the front nose of recovered projectiles.By examining the damage to projectiles,a linear relationship was found between the relative length reduction rate and the initial kinetic energy of projectiles in different penetration tests.Furthermore,microscopic analysis revealed the forming mechanism of the localized mushrooming phenomenon for eroding penetration,i.e.,material spall erosion abrasion mechanism,material flow and redistribution abrasion mechanism and localized radial upsetting deformation mechanism.Finally,a model of highspeed penetration that included erosion was established on the basis of a model of the evolution of the projectile nose that considers radial upsetting;the model was validated by test data from the literature and the present study.Depending upon the impact velocity,v0,the projectile nose may behave as undistorted,radially distorted or hemispherical.Due to the effects of abrasion of the projectile and enhancement of radial upsetting on the duration and amplitude of the secondary rising segment in the pulse shape of projectile deceleration,the predicted DOP had an upper limit.展开更多
The high-speed penetration of concrete targets by kinetic energy projectiles results in apparent mass loss,which blunts the nose of the projectile and decrease its penetration performance.The friction work between the...The high-speed penetration of concrete targets by kinetic energy projectiles results in apparent mass loss,which blunts the nose of the projectile and decrease its penetration performance.The friction work between the projectile and the concrete target,the plastic deformation of the projectile,and the cutting of aggregates to the projectile significantly affect the mass loss of the projectile.To address these effects,a discrete iterative model is developed for the mass loss and nose shape evolution of the projectile by coupling three mechanisms based on the effect of temperature on strength.In the model,both friction work and plastic work increase the temperature of the projectile's surface layer,thereby weakening the strength of this part and rendering it easier for mass loss to occur due to aggregate cutting.The model discretizes the projectile and penetration process with respect to the space and time dimensions,respectively.The mass loss and nose shape evolution of the projectile are obtained by iteratively calculating a point-by-point regression.The predicted depth of penetration(DOP),mass loss,and residual projectile profile are compared with experimental data to validate the model.The comparison shows satisfactory agreement between the calculated results and experimental data.Additionally,the deceleration,velocity,DOP,and mass loss during penetration are analyzed with respect to time.Finally,based on the model,the effects of projectile strength,caliber-radius-head(CRH),and concrete target strength on penetration are discussed.展开更多
In this work,the flow surrounding the train was obtained using a detached eddy simulation(DES)for slipstream analysis.Two different streamlined nose lengths were investigated:a short nose(4 m)and a long nose(9 m).The ...In this work,the flow surrounding the train was obtained using a detached eddy simulation(DES)for slipstream analysis.Two different streamlined nose lengths were investigated:a short nose(4 m)and a long nose(9 m).The time-average slipstream velocity and the time-average slipstream pressure along the car bodies were compared and explained in detail.In addition to the time-averaged values,the _(max)imum velocities and the pressure peak-to-peak values around the two trains were analyzed.The result showed that the nose length affected the slipstream velocity along the entire train length at the lower and upper regions of the side of the train.However,no significant effect was recognized at the middle height of the train along its length,except in the nose region.Moreover,within the train’s side regions(y=2.0-2.5 m and z=2-4 m)and(y=2.5-3.5 m and z=0.2-0.7 m),the ratio of slipstream velocity U_(max) between the short and long nose trains was notably higher.This occurrence also manifested at the train’s upper section,specifically where y=0-2.5 m and z=4.2-5.0 m.Similarly,regarding the ratio of _(max)imum pressure peak-to-peak values Cp-p_(max),significant regions were observed at the train’s side(y=1.8-2.6 m and z=1-4 m)and above the train(y=0-2 m and z=3.9-4.8 m).展开更多
The streamlined nose length(SNL)plays a crucial role in determining the aerodynamic performance of high-speed trains.An appropriate SNL can not only effectively reduce the magnitude of aerodynamic drag and lift forces...The streamlined nose length(SNL)plays a crucial role in determining the aerodynamic performance of high-speed trains.An appropriate SNL can not only effectively reduce the magnitude of aerodynamic drag and lift forces,but also improve the performance of the high-speed train in tunnel passing and crosswind circumstances.In this study,a numerical simulation of the aerodynamic performance of high-speed trains at a speed of 400 km/h,with varying SNLs,is conducted using the k-ωshear stress transport(SST)turbulence model.The different SNLs include 6.0,7.0,8.0,9.0,9.8,12.0,15.0,and 18.0 m.In order to validate the accuracy of the numerical simulation,its results are compared with wind tunnel test data obtained from the literature.Numerical simulation is carried out using compressible and incompressible gases to determine the effect of gas compressibility on results.The impact of SNL on the aerodynamic performance of the trains is analyzed in terms of aerodynamic forces,velocity,and pressure distributions.In comparison to the original train,the train with a 6.0 m SNL experienced a 10.8%increase in overall aerodynamic resistance.Additionally,the lift forces on the head and tail cars increased by 35.7%and 75.5%,respectively.On the other hand,the train with an 18.0 m SNL exhibited a 16.5%decrease in aerodynamic drag.Furthermore,the lift forces on the head and tail cars decreased by 21.9%and 49.7%,respectively.The aerodynamic drag force of the entire train varies linearly with the SNL,while the aerodynamic lift of the tail car follows a quadratic function in relation to the SNL.展开更多
A wide number of natural molecules demonstrated neuroprotective effects on synaptic plasticity defects induced by amyloid-β(Aβ)in ex vivo and in vivo Alzheimer's disease(AD)models,suggesting a possible use in th...A wide number of natural molecules demonstrated neuroprotective effects on synaptic plasticity defects induced by amyloid-β(Aβ)in ex vivo and in vivo Alzheimer's disease(AD)models,suggesting a possible use in the treatment of this neurodegenerative disorder.However,several compounds,administered parenterally and orally,are unable to reach the brain due to the presence of the blood-brain barrier(BBB)which prevents the passage of external substances,such as proteins,peptides,or phytocompounds,representing a limit to the development of treatment for neurodegenerative diseases,such as AD.The combination of nano vesicular systems,as colloidal systems,and nose to brain(NtB)delivery depicts a new nanotechnological strategy to overtake this limit and to develop new treatment approaches for brain diseases,including the use of natural molecules in combination therapy for AD.Herein,we will provide an updated overview,examining the literature of the last 20 years and using specific keywords that provide evidence on natural products with the ability to restore synaptic plasticity alterations in AD models,and the possible application using safe and non-invasive strategies focusing on nano vesicular systems for NtB delivery.展开更多
Shimmy can reduce the service life of the nose landing gear, affect ride comfort, and even cause fuselage damage leading to aircraft crashes. Taking a light aircraft as the research object, the torsional freedom of la...Shimmy can reduce the service life of the nose landing gear, affect ride comfort, and even cause fuselage damage leading to aircraft crashes. Taking a light aircraft as the research object, the torsional freedom of landing gear around strut axis and lateral deformation of tire are considered. Since the landing gear shimmy is a nonlinear system, a nonlinear mechanical model of the front landing gear shimmy is established. Sobol index method is proposed to analyze the influence of structural parameters on the stability region of the nose landing gear, and Routh-Huritz criterion is used to verify the reliability of the analysis results of Sobol index method. We analyse the effect of torsional stiffness of strut, caster length, rated initial tire inflation pressure, rake angle, and vertical force on the stability region of theront landing gear. And the research shows that the optimization of the torsional stiffness of the strut and the caster length of the nose landing gear should be emphasized, and the influence of vertical force on the stability region of the nose landing gear should be paid attention to.展开更多
目的:探讨在(疾病)诊断相关分类(diagnosis related groups,DRGs)形势下,腹腔镜结直肠癌经自然腔道取标本(NOSES)手术方式改进及其可行性。方法:回顾性分析安阳市肿瘤医院2019年2月至2021年2月实施DRGs的42例改进后的腹腔镜结直肠癌NOSE...目的:探讨在(疾病)诊断相关分类(diagnosis related groups,DRGs)形势下,腹腔镜结直肠癌经自然腔道取标本(NOSES)手术方式改进及其可行性。方法:回顾性分析安阳市肿瘤医院2019年2月至2021年2月实施DRGs的42例改进后的腹腔镜结直肠癌NOSES术,并与同期进行常规腹腔镜结直肠癌手术的238例患者在费用、治疗结果、并发症等方面相比较。结果:NOSES改进组42例患者DRGs控费成功率为95.2%(40/42),与常规腹腔镜组在DRGs费用及近期并发症发生率方面无显著性差异(P>0.05)。结论:腹腔镜结直肠癌NOSES改进手术可以达到DRGs费用标准,手术安全可靠,应用双7号丝线代替部分直线切割闭合器是可行的。展开更多
基金supported by Australia Research Council through the Linkage Project(Grant No.LP200100110).
文摘Swing nose crossings(SNXs)have been widely used in heavy haul railways to create a smoother load transfer and hence reduced impact load.However,the current design of SNXs hasn’t been fully examined under heavy haul operating conditions.Additionally,maintenance guidelines for SNX wear-related issues in Australian heavy haul railways are relatively lacking.As such,this study aims to investigate the dynamic response of the wheel-rail contact and analyse the wear performance of an SNX currently used in Australian heavy haul railways.Dynamic implicit-explicit finite element analysis was conducted to simulate the wheel-rail contact along the SNX.The distribution of the wear intensity over the SNX was identified by using a local contact-based wear model.The influence of various scenarios on wear was also explored.The results verify the improved dynamic performance of the SNX,as the increased contact force after load transfer remains below 1.2 times the static load.The findings also indicate that the decrease in relative height and increase in nose rail inclination result in greater wear on the nose rail.Notably,the SNX considered in the current study exhibits better wear performance when used with moderately worn wheels.
文摘为开发新型高品质的蜂蜜茶酒,利用酿酒酵母和非酿酒酵母混菌发酵制备蜂蜜茶酒,采用电子鼻技术结合顶空固相微萃取-气相色谱-质谱(Headspace Solid-Phase Micro Extraction and Gas Chromatography Mass Spectrometry,HS-SPME-GC-MS),并对发酵蜂蜜茶酒的基本理化、有机酸和多酚含量进行检测,以酿酒酵母单菌发酵(SF)和非酿酒酵母单菌发酵(HF)产品作为对比分析,综合评价混菌发酵(MF)对蜂蜜茶酒品质和风味的影响。结果表明:相较于SF和HF,MF提高了蜂蜜茶酒总酚和总黄酮含量。发酵后样品的有机酸含量上升,多酚含量下降。HF电子鼻传感器响应值低,且MF大部分传感器响应值大于SF。HS-SPME-GC-MS共鉴定出75种香气成分,混菌发酵使蜂蜜茶酒中的挥发性化合物种类和含量显著增加(P<0.05)。PLS-DA分析共筛选出10种差异化合物(VIP>1),其中有6种为酯类风味物质。OAV>1的关键香气成分共有12种,相较于HF和SF,对MF香气贡献率较高的为具有花香的苯乙醇、蜂蜜甜香的乙酸苯乙酯、水果香气的甲酸戊酯和醋酸正丙酯等。综上,混菌发酵蜂蜜茶酒相较于单菌发酵更具优势,总体风味更丰富浓郁。本文为非酿酒酵母在酒类中的应用及茶叶副产物深加工利用提供了理论依据。
基金supported by the National Key Technologies R & D Program of China during the 14th Five-Year Plan period (No. 2021YFD1700904)Henan Provincial Important Project (No. 221100320200)+1 种基金State Key Laboratory of Wheat and Maize Crap Science (No. SKL2023ZZ09)the Henan Center for Outstanding Overseas Scientists (No. GZS2021007)。
文摘Electronic nose(eNose) is a modern bioelectronic sensor for monitoring biological processes that convert CO_(2) into valueadded products, such as products formed during photosynthesis and microbial fermentation. eNose technology uses an array of sensors to detect and quantify gases, including CO_(2), in the air. This study briefly introduces the concept of eNose technology and potential applications thereof in monitoring CO_(2) conversion processes. It also provides background information on biological CO_(2) conversion processes. Furthermore, the working principles of eNose technology vis-à-vis gas detection are discussed along with its advantages and limitations versus traditional monitoring methods. This study also provides case studies that have used this technology for monitoring biological CO_(2) conversion processes. eNose-predicted measurements were observed to be completely aligned with biological parameters for R~2 values of 0.864, 0.808, 0.802, and 0.948. We test eNose technology in a variety of biological settings, such as algae farms or bioreactors, to determine its effectiveness in monitoring CO_(2) conversion processes. We also explore the potential benefits of employing this technology vis-à-vis monitoring biological CO_(2) conversion processes, such as increased reaction efficiency and reduced costs versus traditional monitoring methods. Moreover, future directions and challenges of using this technology in CO_(2) capture and conversion have been discussed. Overall, we believe this study would contribute to developing new and innovative methods for monitoring biological CO_(2) conversion processes and mitigating climate change.
基金supported by China Agriculture Research System of MOF and MARA(CARS-41)Wens Fifth Five R&D Major Project(WENS-2020-1-ZDZX-007)。
文摘The sensory perception of food is a dynamic process,which is closely related to the release of flavor substances during oral processing.It’s not only affected by the food material,but also subjected to the individual oral environment.To explore the oral processing characteristics of soft-boiled chicken,the sensory properties,texture,particle size,viscosity,characteristic values of electronic nose and tongue of different chicken samples were investigated.The correlation analysis showed that the physical characteristics especially the cohesiveness,springiness,resilience of the sample determined oral processing behavior.The addition of chicken skin played a role in lubrication during oral processing.The particle size of the bolus was heightened at the early stage,and the fluidity was enhanced in the end,which reduced the chewing time to the swallowing point and raised the aromatic compounds signal of electronic nose.But the effect of chicken skin on chicken thigh with relatively high fat content,was opposite in electronic nose,which had a certain masking effect on the perception of umami and sweet taste.In conclusion,fat played a critical role in chicken oral processing and chicken thigh had obvious advantages in comprehensive evaluation of soft-boiled chicken,which was more popular among people.
基金the National Natural Science Foundation of China(Grant No.12102050)the Open Fund of State Key Laboratory of Explosion Science and Technology(Grant No.SKLEST-ZZ-21-18).
文摘The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytical study of the evolution of the nose shape of larger hollow projectiles under hypersonic penetration.In the hypersonic penetration test,eight ogive-nose AerMet100 steel projectiles with a diameter of 40 mm were launched to hit concrete targets with impact velocities that ranged from 1351 to 1877 m/s.Severe erosion of the projectiles was observed during high-speed penetration of heterogeneous targets,and apparent localized mushrooming occurred in the front nose of recovered projectiles.By examining the damage to projectiles,a linear relationship was found between the relative length reduction rate and the initial kinetic energy of projectiles in different penetration tests.Furthermore,microscopic analysis revealed the forming mechanism of the localized mushrooming phenomenon for eroding penetration,i.e.,material spall erosion abrasion mechanism,material flow and redistribution abrasion mechanism and localized radial upsetting deformation mechanism.Finally,a model of highspeed penetration that included erosion was established on the basis of a model of the evolution of the projectile nose that considers radial upsetting;the model was validated by test data from the literature and the present study.Depending upon the impact velocity,v0,the projectile nose may behave as undistorted,radially distorted or hemispherical.Due to the effects of abrasion of the projectile and enhancement of radial upsetting on the duration and amplitude of the secondary rising segment in the pulse shape of projectile deceleration,the predicted DOP had an upper limit.
基金supported by the Exploratory Research Fund of State Key Laboratory of Explosion Science and Safety Protection.
文摘The high-speed penetration of concrete targets by kinetic energy projectiles results in apparent mass loss,which blunts the nose of the projectile and decrease its penetration performance.The friction work between the projectile and the concrete target,the plastic deformation of the projectile,and the cutting of aggregates to the projectile significantly affect the mass loss of the projectile.To address these effects,a discrete iterative model is developed for the mass loss and nose shape evolution of the projectile by coupling three mechanisms based on the effect of temperature on strength.In the model,both friction work and plastic work increase the temperature of the projectile's surface layer,thereby weakening the strength of this part and rendering it easier for mass loss to occur due to aggregate cutting.The model discretizes the projectile and penetration process with respect to the space and time dimensions,respectively.The mass loss and nose shape evolution of the projectile are obtained by iteratively calculating a point-by-point regression.The predicted depth of penetration(DOP),mass loss,and residual projectile profile are compared with experimental data to validate the model.The comparison shows satisfactory agreement between the calculated results and experimental data.Additionally,the deceleration,velocity,DOP,and mass loss during penetration are analyzed with respect to time.Finally,based on the model,the effects of projectile strength,caliber-radius-head(CRH),and concrete target strength on penetration are discussed.
基金Project(52202426)supported by the National Natural Science Foundation of ChinaProjects(15205723,15226424)supported by the Research Grants Council of the Hong Kong Special Administrative Region(SAR),China+1 种基金Project(K2021J041)supported by the Technology Research and Development Program of China RailwayProject(1-BD23)supported by The Hong Kong Polytechnic University,China。
文摘In this work,the flow surrounding the train was obtained using a detached eddy simulation(DES)for slipstream analysis.Two different streamlined nose lengths were investigated:a short nose(4 m)and a long nose(9 m).The time-average slipstream velocity and the time-average slipstream pressure along the car bodies were compared and explained in detail.In addition to the time-averaged values,the _(max)imum velocities and the pressure peak-to-peak values around the two trains were analyzed.The result showed that the nose length affected the slipstream velocity along the entire train length at the lower and upper regions of the side of the train.However,no significant effect was recognized at the middle height of the train along its length,except in the nose region.Moreover,within the train’s side regions(y=2.0-2.5 m and z=2-4 m)and(y=2.5-3.5 m and z=0.2-0.7 m),the ratio of slipstream velocity U_(max) between the short and long nose trains was notably higher.This occurrence also manifested at the train’s upper section,specifically where y=0-2.5 m and z=4.2-5.0 m.Similarly,regarding the ratio of _(max)imum pressure peak-to-peak values Cp-p_(max),significant regions were observed at the train’s side(y=1.8-2.6 m and z=1-4 m)and above the train(y=0-2 m and z=3.9-4.8 m).
基金supported by the National Natural Science Foundation of China(No.12372049)the Sichuan Science and Technology Program(No.2023JDRC0062)+1 种基金the Independent Project of State Key Laboratory of Rail Transit Vehicle System(No.2023TPL-T06)the Fundamental Research Funds for the Central Universities,China(No.2682023ZTPY036).
文摘The streamlined nose length(SNL)plays a crucial role in determining the aerodynamic performance of high-speed trains.An appropriate SNL can not only effectively reduce the magnitude of aerodynamic drag and lift forces,but also improve the performance of the high-speed train in tunnel passing and crosswind circumstances.In this study,a numerical simulation of the aerodynamic performance of high-speed trains at a speed of 400 km/h,with varying SNLs,is conducted using the k-ωshear stress transport(SST)turbulence model.The different SNLs include 6.0,7.0,8.0,9.0,9.8,12.0,15.0,and 18.0 m.In order to validate the accuracy of the numerical simulation,its results are compared with wind tunnel test data obtained from the literature.Numerical simulation is carried out using compressible and incompressible gases to determine the effect of gas compressibility on results.The impact of SNL on the aerodynamic performance of the trains is analyzed in terms of aerodynamic forces,velocity,and pressure distributions.In comparison to the original train,the train with a 6.0 m SNL experienced a 10.8%increase in overall aerodynamic resistance.Additionally,the lift forces on the head and tail cars increased by 35.7%and 75.5%,respectively.On the other hand,the train with an 18.0 m SNL exhibited a 16.5%decrease in aerodynamic drag.Furthermore,the lift forces on the head and tail cars decreased by 21.9%and 49.7%,respectively.The aerodynamic drag force of the entire train varies linearly with the SNL,while the aerodynamic lift of the tail car follows a quadratic function in relation to the SNL.
文摘A wide number of natural molecules demonstrated neuroprotective effects on synaptic plasticity defects induced by amyloid-β(Aβ)in ex vivo and in vivo Alzheimer's disease(AD)models,suggesting a possible use in the treatment of this neurodegenerative disorder.However,several compounds,administered parenterally and orally,are unable to reach the brain due to the presence of the blood-brain barrier(BBB)which prevents the passage of external substances,such as proteins,peptides,or phytocompounds,representing a limit to the development of treatment for neurodegenerative diseases,such as AD.The combination of nano vesicular systems,as colloidal systems,and nose to brain(NtB)delivery depicts a new nanotechnological strategy to overtake this limit and to develop new treatment approaches for brain diseases,including the use of natural molecules in combination therapy for AD.Herein,we will provide an updated overview,examining the literature of the last 20 years and using specific keywords that provide evidence on natural products with the ability to restore synaptic plasticity alterations in AD models,and the possible application using safe and non-invasive strategies focusing on nano vesicular systems for NtB delivery.
文摘Shimmy can reduce the service life of the nose landing gear, affect ride comfort, and even cause fuselage damage leading to aircraft crashes. Taking a light aircraft as the research object, the torsional freedom of landing gear around strut axis and lateral deformation of tire are considered. Since the landing gear shimmy is a nonlinear system, a nonlinear mechanical model of the front landing gear shimmy is established. Sobol index method is proposed to analyze the influence of structural parameters on the stability region of the nose landing gear, and Routh-Huritz criterion is used to verify the reliability of the analysis results of Sobol index method. We analyse the effect of torsional stiffness of strut, caster length, rated initial tire inflation pressure, rake angle, and vertical force on the stability region of theront landing gear. And the research shows that the optimization of the torsional stiffness of the strut and the caster length of the nose landing gear should be emphasized, and the influence of vertical force on the stability region of the nose landing gear should be paid attention to.
文摘目的:探讨在(疾病)诊断相关分类(diagnosis related groups,DRGs)形势下,腹腔镜结直肠癌经自然腔道取标本(NOSES)手术方式改进及其可行性。方法:回顾性分析安阳市肿瘤医院2019年2月至2021年2月实施DRGs的42例改进后的腹腔镜结直肠癌NOSES术,并与同期进行常规腹腔镜结直肠癌手术的238例患者在费用、治疗结果、并发症等方面相比较。结果:NOSES改进组42例患者DRGs控费成功率为95.2%(40/42),与常规腹腔镜组在DRGs费用及近期并发症发生率方面无显著性差异(P>0.05)。结论:腹腔镜结直肠癌NOSES改进手术可以达到DRGs费用标准,手术安全可靠,应用双7号丝线代替部分直线切割闭合器是可行的。
