The aim of this study was to design a cage-like radiotherapy system(CRTS)to further promote the clinical application of noncoplanar radiotherapy.The CRTS comprises two stands,two O-rings,several arc girders,an X-ray h...The aim of this study was to design a cage-like radiotherapy system(CRTS)to further promote the clinical application of noncoplanar radiotherapy.The CRTS comprises two stands,two O-rings,several arc girders,an X-ray head,an imaging subsystem,and a treatment couch.The X-ray head rotates with O-rings around the patient’s body and slides along the arc girder.Compared with the C-arm linear accelerator(C-Linac),the clinically available spatial irradiation angle ranges(SIARs)of the CRTS for the head,chest,and abdomen were 33%,63.6%,and 62.6%larger,respectively.Moreover,according to a preliminary planning comparison based on the dose distribution simulation method,the CRTS achieved much better protection of normal tissue than the C-Linac.Furthermore,the CRTS enabled accurate noncoplanar irradiation without movement of the body being irradiated,allowed automatic control of the movements of different parts without risk of collisions,and provided continuous radiation over an angle that considerably exceeded a full turn.These advantages make CRTS very promising for noncoplanar radiotherapy.展开更多
This work aims to summarize and evaluate the current planning progress based on the linear accelerator in stereotactic radiotherapy(SRT).The specific techniques include 3-dimensional conformal radiotherapy,dynamic con...This work aims to summarize and evaluate the current planning progress based on the linear accelerator in stereotactic radiotherapy(SRT).The specific techniques include 3-dimensional conformal radiotherapy,dynamic conformal arc therapy,intensity-modulated radiotherapy,and volumetric-modulated arc therapy(VMAT).They are all designed to deliver higher doses to the target volume while reducing damage to normal tissues;among them,VMAT shows better prospects for application.This paper reviews and summarizes several issues on the planning of SRT to provide a reference for clinical application.展开更多
目的探讨非共面野联合铅门固定计划在左侧小细胞肺癌调强放疗中的剂量学优劣。方法选取2022年10月至2023年5月福建省立医院收治的20例左侧小细胞肺癌患者作为研究对象,根据放疗方案的不同分为对照组与研究组,每组10例。对照组采取常规...目的探讨非共面野联合铅门固定计划在左侧小细胞肺癌调强放疗中的剂量学优劣。方法选取2022年10月至2023年5月福建省立医院收治的20例左侧小细胞肺癌患者作为研究对象,根据放疗方案的不同分为对照组与研究组,每组10例。对照组采取常规共面野计划,研究组采取非共面野联合铅门固定计划。比较两组计划方案靶区95%体积所受剂量(dose to 95%of the target volume,D95)、适形指数(conformability index,CI)、均匀指数(homogeneity index,HI)、危及器官受量及机器出束跳数(monitor unites,MU)。结果两组D95、HI比较差异无统计学意义;研究组计划肿瘤靶体积、计划临床靶区的CI、MU均高于对照组,差异有统计学意义(P<0.05)。在相同处方剂量下,研究组95%和100%等剂量线能紧密地包裹帖合靶区轮廓,与靶区形状高度一致;而对照组相应等剂量线与靶区边界存在明显偏离,适形度显著欠佳。两组右肺V5、V20、V30、Dmean和脊髓D2受量比较差异无统计学意义;研究组左肺和心脏V5、V20、V30及Dmean受量均低于对照组,差异有统计学意义(P<0.05)。结论在左侧小细胞肺癌调强放疗中,非共面野联合铅门固定计划能够改善靶区的适形度,降低左肺和心脏的受量,具有较好的临床应用潜力。展开更多
基金the National Natural Science Foundation of China(No.11475261)partially supported by the National Key Project of Research and Development of China(No.2016YFC0904600).
文摘The aim of this study was to design a cage-like radiotherapy system(CRTS)to further promote the clinical application of noncoplanar radiotherapy.The CRTS comprises two stands,two O-rings,several arc girders,an X-ray head,an imaging subsystem,and a treatment couch.The X-ray head rotates with O-rings around the patient’s body and slides along the arc girder.Compared with the C-arm linear accelerator(C-Linac),the clinically available spatial irradiation angle ranges(SIARs)of the CRTS for the head,chest,and abdomen were 33%,63.6%,and 62.6%larger,respectively.Moreover,according to a preliminary planning comparison based on the dose distribution simulation method,the CRTS achieved much better protection of normal tissue than the C-Linac.Furthermore,the CRTS enabled accurate noncoplanar irradiation without movement of the body being irradiated,allowed automatic control of the movements of different parts without risk of collisions,and provided continuous radiation over an angle that considerably exceeded a full turn.These advantages make CRTS very promising for noncoplanar radiotherapy.
文摘This work aims to summarize and evaluate the current planning progress based on the linear accelerator in stereotactic radiotherapy(SRT).The specific techniques include 3-dimensional conformal radiotherapy,dynamic conformal arc therapy,intensity-modulated radiotherapy,and volumetric-modulated arc therapy(VMAT).They are all designed to deliver higher doses to the target volume while reducing damage to normal tissues;among them,VMAT shows better prospects for application.This paper reviews and summarizes several issues on the planning of SRT to provide a reference for clinical application.
文摘目的探讨非共面野联合铅门固定计划在左侧小细胞肺癌调强放疗中的剂量学优劣。方法选取2022年10月至2023年5月福建省立医院收治的20例左侧小细胞肺癌患者作为研究对象,根据放疗方案的不同分为对照组与研究组,每组10例。对照组采取常规共面野计划,研究组采取非共面野联合铅门固定计划。比较两组计划方案靶区95%体积所受剂量(dose to 95%of the target volume,D95)、适形指数(conformability index,CI)、均匀指数(homogeneity index,HI)、危及器官受量及机器出束跳数(monitor unites,MU)。结果两组D95、HI比较差异无统计学意义;研究组计划肿瘤靶体积、计划临床靶区的CI、MU均高于对照组,差异有统计学意义(P<0.05)。在相同处方剂量下,研究组95%和100%等剂量线能紧密地包裹帖合靶区轮廓,与靶区形状高度一致;而对照组相应等剂量线与靶区边界存在明显偏离,适形度显著欠佳。两组右肺V5、V20、V30、Dmean和脊髓D2受量比较差异无统计学意义;研究组左肺和心脏V5、V20、V30及Dmean受量均低于对照组,差异有统计学意义(P<0.05)。结论在左侧小细胞肺癌调强放疗中,非共面野联合铅门固定计划能够改善靶区的适形度,降低左肺和心脏的受量,具有较好的临床应用潜力。
