BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM ...BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM To explore the correlations among life satisfaction,pleasure levels,and negative emotions in patients with CRF.METHODS One hundred patients with CRF who received therapy at the First Affiliated Hospital of Jinzhou Medical University between December 2022 and February 2025 were included.The Depression,Anxiety,and Stress Scale(DASS-21),Satisfaction with Life Scale(SWLS),and Temporal Experience of Pleasure Scale(TEPS)were used to evaluate negative emotions,life satisfaction,and pleasure level,respectively.Pearson’s correlation coefficient analyzed the correlation between life satisfaction,pleasure level,and negative emotions.Linear regression analysis identified the factors affecting negative emotions.RESULTS The average DASS-21 score among patients with CRF was 51.90±2.30,with subscale scores of 17.90±1.50 for depression,18.53±1.18 for anxiety,and 15.47±2.36 for stress,all significantly higher than the domestic norm(P<0.05).The average SWLS score was 22.17±4.90.Correlation analysis revealed a negative correlation between the SWLS and total DASS-21 scores(P<0.05),but not with the individual depression,anxiety,or stress dimensions.The average TEPS score was 67.80±8.34.TEPS scores were negatively correlated with the DASS-21 score and the stress dimension(P<0.05),but not with depression or anxiety.Linear regression analysis showed that TEPS scores significantly influenced DASS-21 scores(P<0.05).CONCLUSION Patients with CRF experience high levels of negative emotions,which are negatively correlated with life satisfaction and pleasure.Furthermore,pleasure level had an impact on negative emotions.展开更多
Materials with a negative Poisson’s ratio effect perform significantly better than traditional materials for rock mass impact resistance,shear resistance,and energy absorption.Based on these advantages,a negative Poi...Materials with a negative Poisson’s ratio effect perform significantly better than traditional materials for rock mass impact resistance,shear resistance,and energy absorption.Based on these advantages,a negative Poisson’s ratio anchor cable(NPR anchor cable)with high elongation and constant resistance was developed and successfully applied in the field of mine disaster control.However,theoretical and experimental research on the negative Poisson’s ratio effect and peripheral strain characteristics of NPR anchor cables is currently incomplete.This study used several theories and methods,such as static tensile,peripheral strain measurement,and static negative Poisson’s ratio measurement,to investigate the radial deformation law of an NPR anchor cable and the negative Poisson’s ratio characteristics.Experimental results elucidated constant resistance changes in an NPR anchor cable during operation,the motion of the constant resistance body in the constant resistance sleeve,and the deformation law of the constant resistance sleeve.Negative Poisson’s ratio characteristics of the NPR anchor cable and its superior energy absorption characteristics were verified and it provided a theoretical and experimental basis for energy absorption mechanisms of an NPR anchor cable.展开更多
Beishan Rock Carvings in Chongqing,a renowned cultural heritage site in China,flourished during the Tang and Song dynasties and are often referred to as the“Stone Carving Art Museum of the Tang and Song Dynasties.”C...Beishan Rock Carvings in Chongqing,a renowned cultural heritage site in China,flourished during the Tang and Song dynasties and are often referred to as the“Stone Carving Art Museum of the Tang and Song Dynasties.”Cave 168 is a key component of the Beishan Rock Carvings.At present,several through-going cracks have developed in the roof of Cave 168,severely compromising the structural stability of the grotto.The early internal steel plate supports have suffered severe corrosion and can no longer provide effective reinforcement.In addition,the presence of steel columns obstructs visitor access and negatively affects the viewing experience.A new reinforcement method is urgently needed.Therefore,studying the deformation patterns of the structure is of critical importance.This study analyzes the stratigraphic parameters and fracture distribution of Cave 168,considering key influencing factors such as rainfall,self-weight,and the overlying Quaternary soil.On-site monitoring and physical model experiments were conducted to evaluate the changes in roof crack width and displacement before and after reinforcement with negative Poisson's ratio(NPR)anchor cables.The results reveal that the roof of Cave 168 contains several through-going cracks and numerous microcracks,which serve as infiltration channels for surface water.These accelerate the softening of the mudstone and pose a significant threat to the cave's structural safety.During the experiment,the main change in the crack exhibited a“semi-archshaped”propagation pattern.In the first ten minutes,as the rock transitioned from dry to moist conditions,a slight crack closure was observed.As rainfall continued,crack propagation accelerated.After rainfall ceased,crack width remained stable over a short period.Under NPR anchor support,the influence of rainfall on roof settlement was effectively mitigated,ensuring the safety and stability of the roof.The NPR anchors successfully limited the roof settlement to within 0.3 mm and provided effective control over both total and differential settlement.These findings offer valuable insights into the application of NPR anchor cables in the conservation of grotto heritage structures.展开更多
Minimizing the thermal expansion coefficient(TEC)mismatch between the cathode and electrolyte in solid oxide fuel cells is crucial for achieving stable,durable operation and high performance.Recently,materials with ne...Minimizing the thermal expansion coefficient(TEC)mismatch between the cathode and electrolyte in solid oxide fuel cells is crucial for achieving stable,durable operation and high performance.Recently,materials with negative thermal expansion(NTE)have at-tracted significant attention as effective additives for tailoring the thermomechanical properties of electrodes and enhancing cell durability.In this work,for the first time,single-phase NTE perovskite Sm_(0.85)Zn_(0.15)MnO_(3−δ)(SZM15)was successfully synthesized via the sol-gel method,eliminating the unwanted ZnO phase typically observed in materials obtained through the conventional solid-state reaction route.The sol-gel approach proved highly advantageous,offering low cost,robustness,excellent chemical homogeneity,precise compositional control,and high phase purity.After optimization of synthesis parameters,a negative TEC of approximately−6.5×10^(−6)K^(−1)was achieved in the 400-850℃range.SZM15 was then incorporated as an additive(10wt%-50wt%)into a SmBa0.5Sr0.5CoCuO_(5+δ)(SBSCCO)cathode to tune the thermomechanical properties with a La_(0.8)Sr_(0.2)Ga_(0.8)Mg_(0.2)O_(3−δ)(LSGM)electrolyte,achieving a minimal TEC mismatch of only 1%.Notably,the SBSCCO+10wt%SZM15 composite cathode exhibited the lowest polarization resistance of 0.019Ω·cm^(2)at 900℃,showing approximately 70%lower than that of the pristine cathode.Excellent long-term stability after 100 h of operation was achieved.In addition,a high peak power density of 680 mW·cm^(−2)was achieved in a Ni-YSZ(yttria-stabilized zirconia)|YSZ|Ce_(0.9)Gd_(0.1)O_(2−δ)(GDC10)|SBSCCO+10wt%SZM15 anode-supported fuel cell at 850℃,highlighting the effectiveness of incorporating NTE materials as a promising strategy for regulating the thermomechanical properties and improving the long-term stability of intermediate temperature solid oxide fuel cells(IT-SOFCs).展开更多
Negative Poisson ratio(NPR)steel is a new material with high strength and toughness.This study conducted tensile tests at elevated temperatures to investigate the mechanical properties of NPR steel at high temperature...Negative Poisson ratio(NPR)steel is a new material with high strength and toughness.This study conducted tensile tests at elevated temperatures to investigate the mechanical properties of NPR steel at high temperatures.The stress−strain curve,ultimate strength,yield strength,modulus of elasticity,elongation after fracture,and percentage reduction of area of NPR steel bars were measured at 9 different temperatures ranging from 20 to 800℃.The experimental results indicate that high-temperature environments significantly affect the mechanical properties of NPR steel.However,compared to other types of steel,NPR steel exhibits better resistance to deformation.When the test temperature is below 700℃,NPR steel exhibits a ductile fracture characteristic,while at 800℃,it exhibits a brittle fracture characteristic.Finally,based on the experimental findings,a constitutive model suitable for NPR steel at high temperatures is proposed.展开更多
The impacts of natural boulders carried by debris flows pose serious risks to the safety and reliability of structures and buildings.Natural boulders can be highly random and unpredictable.Consequently,boulder control...The impacts of natural boulders carried by debris flows pose serious risks to the safety and reliability of structures and buildings.Natural boulders can be highly random and unpredictable.Consequently,boulder control during debris flows is crucial but difficult.Herein,an eco-friendly control system featuring anchoring natural boulders(NBs)with(negative Poisson's ratio)NPR anchor cables is proposed to form an NB-NPR baffle.A series of flume experiments are conducted to verify the effect of NB-NPR baffles on controlling debris flow impact.The deployment of NB-NPR baffles substantially influences the kinematic behavior of a debris flow,primarily in the form of changes in the depositional properties and impact intensities.The results show that the NB-NPR baffle matrix successfully controls boulder mobility and exhibits positive feedback on solid particle deposition.The NB-NPR baffle group exhibits a reduction in peak impact force ranging from 29%to 79%compared to that of the control group in the basic experiment.The NPR anchor cables play a significant role in the NB-NPR baffle by demonstrating particular characteristics,including consistent resistance,large deformation,and substantial energy absorption.The NB-NPR baffle innovatively utilizes the natural boulders in a debris flow gully by converting destructive boulders into constructive boulders.Overall,this research serves as a basis for future field experiments and applications.展开更多
The Scholl cyclization for creating seven-membered rings is of great importance in synthesizing negatively curved polycyclic aromatic compounds.In this study,we systematically report a methodical approach for converti...The Scholl cyclization for creating seven-membered rings is of great importance in synthesizing negatively curved polycyclic aromatic compounds.In this study,we systematically report a methodical approach for converting[6]helicenes into negatively curved hexa[7]circulene using Scholl cyclization.The reaction revealed that the electron-donating substituents on the helicene terminal rings of helicenes facilitate the cyclization process while electron-withdrawing substituents would impede the cyclization.This was supported by theoretical calculations on the reaction process focusing on the arenium cation pathways.Through the application of this Scholl cyclization,a series of negatively curved hexa[7]circulene derivatives were synthesized,showing highly curved and twisted geometries.Notably,2,15-substituted derivatives exhibited high conformational stability against racemization,thereby performing circularly polarized luminescence with|glum|up to 4×10^(-3).展开更多
BACKGROUND Patients with schizophrenia may lack awareness of the importance of posttracheotomy care due to the impact of their condition,often showing resistance or misunderstanding of care measures.When coupled with ...BACKGROUND Patients with schizophrenia may lack awareness of the importance of posttracheotomy care due to the impact of their condition,often showing resistance or misunderstanding of care measures.When coupled with the impact of negative symptoms and the risk of complications after tracheotomy,patients may experience emotional fluctuations,restlessness,anxiety,and hostile behaviors,which pose significant challenges to nursing work.CASE SUMMARY We have reported the case of an 87-year-old male patient who was admitted to the hospital because of negative symptoms of schizophrenia and who underwent tracheotomy for severe pneumonia.In this study,we have summarized the nursing experience of a patient with negative symptoms of schizophrenia who underwent tracheotomy.The key nursing strategies included proper tracheotomy care,the management of psychiatric symptoms,a thorough assessment and implementation of enteral and parenteral nutrition,effective skincare,infection prevention,and comprehensive mental care.Individualized nursing skills helped stabilize the patient’s condition,followed by isolation and observation in a psychiatric hospital.CONCLUSION Effective postoperative tracheostomy care in patients with schizophrenia necessitates a tailored,multidisciplinary approach that addresses their psychiatric,physical,and emotional needs to achieve optimal clinical outcomes.展开更多
In geotechnical engineering applications,including mining and tunnel construction,the stability of fractured rock masses is paramount to ensuring structural safety.The spatial distribution and temporal evolution of in...In geotechnical engineering applications,including mining and tunnel construction,the stability of fractured rock masses is paramount to ensuring structural safety.The spatial distribution and temporal evolution of internal fractures fundamentally govern the mechanical behavior and failure mechanisms of rock masses.Nevertheless,the inherent complexity and structural concealment of rock mass systems pose significant challenges for the direct measurement of critical internal mechanical parameters.This study explores the use of deep learning to invert mechanical responses of NPR(Negative Poisson's Ratio)anchored fractured rock masses.Discrete Element Method(DEM)simulations were conducted to generate datasets including stress-strain curves and crack numbers under various initial fracture distributions.Three models—GRU,CNN+GRU,and CNN+GRU+ATT—were developed to predict rock mechanical parameters from NPR cable force data.Results show that the CNN+GRU+ATT model achieves superior accuracy,with R^(2)>0.90 and RMSE<5 on stress prediction tasks.It also accurately estimates initial crack quantity(np),with mean prediction error under 10%for high-fracture scenarios.The proposed model effectively captures stress fluctuations,offering early-warning potential for failure.The approach demonstrates strong generalization and robustness across varying crack configurations,providing a feasible framework for real-time health monitoring and mechanical parameter estimation in fractured rock engineering.展开更多
BACKGROUND Blonanserin,a novel antipsychotic,has demonstrated efficacy in treating both positive and negative symptoms.However,limited research exists on its dose-dependent effectiveness and safety in patients with an...BACKGROUND Blonanserin,a novel antipsychotic,has demonstrated efficacy in treating both positive and negative symptoms.However,limited research exists on its dose-dependent effectiveness and safety in patients with and without prominent nega-tive symptoms(PNS).AIM To evaluate the effectiveness and safety of blonanserin monotherapy for first-episode schizophrenia in real-world clinical settings and to explore the efficacy and safety of different doses of blonanserin for patients with PNS and without PNS.METHODS A 12-week,multicenter,prospective post-marketing surveillance was conducted.In this study,we included patients with first-episode schizophrenia who received blonanserin monotherapy.Patients were divided into those with PNS and without PNS,based on the Brief Psychiatric Rating Scale(BPRS)negative symptoms subscale scores.Additionally,patients were labeled as high-dose and low-dose was evaluated through the incidence of adverse drug reactions(ADRs).RESULTS A total of 653 patients were included in the analysis,with 613 completing the study.The BPRS total score decreased significantly from 47.94±16.31 at baseline to 26.88±9.47 at 12 weeks(P<0.001).A significant interaction of PNS×dose×time was observed for BPRS total scores(F=3.47,P=0.040)and negative symptom subscale scores(F=6.76,P=0.002).In the PNS group,the high-dose group showed greater reductions in BPRS total scores(P=0.001)and negative symptom subscale scores(P=0.003)than the low-dose group in week 12.In the without PNS group,no significant difference was observed between the high-dose and low-dose groups at any visit.Most adverse reactions were mild or moderate,with extrapyramidal symptoms(9.3%)being most common;1.5%of patients gained≥7%body weight at 12 weeks.CONCLUSION Blonanserin effectively alleviated the clinical symptoms of first-episode schizophrenia with an acceptable safety profile.High-dose blonanserin is particularly beneficial for patients with PNS in the acute phase of first-episode schizophrenia.However,due to the limitation of ADR reporting the real world,the ADR incidence observed in this study may be underestimated.展开更多
文摘BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM To explore the correlations among life satisfaction,pleasure levels,and negative emotions in patients with CRF.METHODS One hundred patients with CRF who received therapy at the First Affiliated Hospital of Jinzhou Medical University between December 2022 and February 2025 were included.The Depression,Anxiety,and Stress Scale(DASS-21),Satisfaction with Life Scale(SWLS),and Temporal Experience of Pleasure Scale(TEPS)were used to evaluate negative emotions,life satisfaction,and pleasure level,respectively.Pearson’s correlation coefficient analyzed the correlation between life satisfaction,pleasure level,and negative emotions.Linear regression analysis identified the factors affecting negative emotions.RESULTS The average DASS-21 score among patients with CRF was 51.90±2.30,with subscale scores of 17.90±1.50 for depression,18.53±1.18 for anxiety,and 15.47±2.36 for stress,all significantly higher than the domestic norm(P<0.05).The average SWLS score was 22.17±4.90.Correlation analysis revealed a negative correlation between the SWLS and total DASS-21 scores(P<0.05),but not with the individual depression,anxiety,or stress dimensions.The average TEPS score was 67.80±8.34.TEPS scores were negatively correlated with the DASS-21 score and the stress dimension(P<0.05),but not with depression or anxiety.Linear regression analysis showed that TEPS scores significantly influenced DASS-21 scores(P<0.05).CONCLUSION Patients with CRF experience high levels of negative emotions,which are negatively correlated with life satisfaction and pleasure.Furthermore,pleasure level had an impact on negative emotions.
基金supported by the National Natural Science Foundation of China(NSFC)(41941018)the Second Tibetan Plateau Scientific Expedition and Research Grant 2019QZKK0708。
文摘Materials with a negative Poisson’s ratio effect perform significantly better than traditional materials for rock mass impact resistance,shear resistance,and energy absorption.Based on these advantages,a negative Poisson’s ratio anchor cable(NPR anchor cable)with high elongation and constant resistance was developed and successfully applied in the field of mine disaster control.However,theoretical and experimental research on the negative Poisson’s ratio effect and peripheral strain characteristics of NPR anchor cables is currently incomplete.This study used several theories and methods,such as static tensile,peripheral strain measurement,and static negative Poisson’s ratio measurement,to investigate the radial deformation law of an NPR anchor cable and the negative Poisson’s ratio characteristics.Experimental results elucidated constant resistance changes in an NPR anchor cable during operation,the motion of the constant resistance body in the constant resistance sleeve,and the deformation law of the constant resistance sleeve.Negative Poisson’s ratio characteristics of the NPR anchor cable and its superior energy absorption characteristics were verified and it provided a theoretical and experimental basis for energy absorption mechanisms of an NPR anchor cable.
文摘Beishan Rock Carvings in Chongqing,a renowned cultural heritage site in China,flourished during the Tang and Song dynasties and are often referred to as the“Stone Carving Art Museum of the Tang and Song Dynasties.”Cave 168 is a key component of the Beishan Rock Carvings.At present,several through-going cracks have developed in the roof of Cave 168,severely compromising the structural stability of the grotto.The early internal steel plate supports have suffered severe corrosion and can no longer provide effective reinforcement.In addition,the presence of steel columns obstructs visitor access and negatively affects the viewing experience.A new reinforcement method is urgently needed.Therefore,studying the deformation patterns of the structure is of critical importance.This study analyzes the stratigraphic parameters and fracture distribution of Cave 168,considering key influencing factors such as rainfall,self-weight,and the overlying Quaternary soil.On-site monitoring and physical model experiments were conducted to evaluate the changes in roof crack width and displacement before and after reinforcement with negative Poisson's ratio(NPR)anchor cables.The results reveal that the roof of Cave 168 contains several through-going cracks and numerous microcracks,which serve as infiltration channels for surface water.These accelerate the softening of the mudstone and pose a significant threat to the cave's structural safety.During the experiment,the main change in the crack exhibited a“semi-archshaped”propagation pattern.In the first ten minutes,as the rock transitioned from dry to moist conditions,a slight crack closure was observed.As rainfall continued,crack propagation accelerated.After rainfall ceased,crack width remained stable over a short period.Under NPR anchor support,the influence of rainfall on roof settlement was effectively mitigated,ensuring the safety and stability of the roof.The NPR anchors successfully limited the roof settlement to within 0.3 mm and provided effective control over both total and differential settlement.These findings offer valuable insights into the application of NPR anchor cables in the conservation of grotto heritage structures.
基金supported by the research project within the program“Excellence Initiative-Research University”for the AGH University of Krakow(IDUB AGH,Action 21)Kun Zheng acknowledges financial support from AGH University of Krakow(No.16.16.210.476).
文摘Minimizing the thermal expansion coefficient(TEC)mismatch between the cathode and electrolyte in solid oxide fuel cells is crucial for achieving stable,durable operation and high performance.Recently,materials with negative thermal expansion(NTE)have at-tracted significant attention as effective additives for tailoring the thermomechanical properties of electrodes and enhancing cell durability.In this work,for the first time,single-phase NTE perovskite Sm_(0.85)Zn_(0.15)MnO_(3−δ)(SZM15)was successfully synthesized via the sol-gel method,eliminating the unwanted ZnO phase typically observed in materials obtained through the conventional solid-state reaction route.The sol-gel approach proved highly advantageous,offering low cost,robustness,excellent chemical homogeneity,precise compositional control,and high phase purity.After optimization of synthesis parameters,a negative TEC of approximately−6.5×10^(−6)K^(−1)was achieved in the 400-850℃range.SZM15 was then incorporated as an additive(10wt%-50wt%)into a SmBa0.5Sr0.5CoCuO_(5+δ)(SBSCCO)cathode to tune the thermomechanical properties with a La_(0.8)Sr_(0.2)Ga_(0.8)Mg_(0.2)O_(3−δ)(LSGM)electrolyte,achieving a minimal TEC mismatch of only 1%.Notably,the SBSCCO+10wt%SZM15 composite cathode exhibited the lowest polarization resistance of 0.019Ω·cm^(2)at 900℃,showing approximately 70%lower than that of the pristine cathode.Excellent long-term stability after 100 h of operation was achieved.In addition,a high peak power density of 680 mW·cm^(−2)was achieved in a Ni-YSZ(yttria-stabilized zirconia)|YSZ|Ce_(0.9)Gd_(0.1)O_(2−δ)(GDC10)|SBSCCO+10wt%SZM15 anode-supported fuel cell at 850℃,highlighting the effectiveness of incorporating NTE materials as a promising strategy for regulating the thermomechanical properties and improving the long-term stability of intermediate temperature solid oxide fuel cells(IT-SOFCs).
基金Projects(41702320,52104125)supported by the National Natural Science Foundation of ChinaProject(ZR2021MD005)+2 种基金supported by the Natural Science Foundation of Shandong Province,ChinaProject(TMduracon2022002)supported by the Engineering Research Center of Marine Environmental Concrete Technology,Ministry of Education,China。
文摘Negative Poisson ratio(NPR)steel is a new material with high strength and toughness.This study conducted tensile tests at elevated temperatures to investigate the mechanical properties of NPR steel at high temperatures.The stress−strain curve,ultimate strength,yield strength,modulus of elasticity,elongation after fracture,and percentage reduction of area of NPR steel bars were measured at 9 different temperatures ranging from 20 to 800℃.The experimental results indicate that high-temperature environments significantly affect the mechanical properties of NPR steel.However,compared to other types of steel,NPR steel exhibits better resistance to deformation.When the test temperature is below 700℃,NPR steel exhibits a ductile fracture characteristic,while at 800℃,it exhibits a brittle fracture characteristic.Finally,based on the experimental findings,a constitutive model suitable for NPR steel at high temperatures is proposed.
基金financial support from the National Natural Science Foundation of China(Grant No.41941018).
文摘The impacts of natural boulders carried by debris flows pose serious risks to the safety and reliability of structures and buildings.Natural boulders can be highly random and unpredictable.Consequently,boulder control during debris flows is crucial but difficult.Herein,an eco-friendly control system featuring anchoring natural boulders(NBs)with(negative Poisson's ratio)NPR anchor cables is proposed to form an NB-NPR baffle.A series of flume experiments are conducted to verify the effect of NB-NPR baffles on controlling debris flow impact.The deployment of NB-NPR baffles substantially influences the kinematic behavior of a debris flow,primarily in the form of changes in the depositional properties and impact intensities.The results show that the NB-NPR baffle matrix successfully controls boulder mobility and exhibits positive feedback on solid particle deposition.The NB-NPR baffle group exhibits a reduction in peak impact force ranging from 29%to 79%compared to that of the control group in the basic experiment.The NPR anchor cables play a significant role in the NB-NPR baffle by demonstrating particular characteristics,including consistent resistance,large deformation,and substantial energy absorption.The NB-NPR baffle innovatively utilizes the natural boulders in a debris flow gully by converting destructive boulders into constructive boulders.Overall,this research serves as a basis for future field experiments and applications.
基金financially supported by the Zhejiang Provincial Natural Science Foundation,China(No.LY23B040003)the Science Foundation of Zhejiang Sci-Tech University,China(No.22062026-Y)。
文摘The Scholl cyclization for creating seven-membered rings is of great importance in synthesizing negatively curved polycyclic aromatic compounds.In this study,we systematically report a methodical approach for converting[6]helicenes into negatively curved hexa[7]circulene using Scholl cyclization.The reaction revealed that the electron-donating substituents on the helicene terminal rings of helicenes facilitate the cyclization process while electron-withdrawing substituents would impede the cyclization.This was supported by theoretical calculations on the reaction process focusing on the arenium cation pathways.Through the application of this Scholl cyclization,a series of negatively curved hexa[7]circulene derivatives were synthesized,showing highly curved and twisted geometries.Notably,2,15-substituted derivatives exhibited high conformational stability against racemization,thereby performing circularly polarized luminescence with|glum|up to 4×10^(-3).
基金Supported by Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-033A。
文摘BACKGROUND Patients with schizophrenia may lack awareness of the importance of posttracheotomy care due to the impact of their condition,often showing resistance or misunderstanding of care measures.When coupled with the impact of negative symptoms and the risk of complications after tracheotomy,patients may experience emotional fluctuations,restlessness,anxiety,and hostile behaviors,which pose significant challenges to nursing work.CASE SUMMARY We have reported the case of an 87-year-old male patient who was admitted to the hospital because of negative symptoms of schizophrenia and who underwent tracheotomy for severe pneumonia.In this study,we have summarized the nursing experience of a patient with negative symptoms of schizophrenia who underwent tracheotomy.The key nursing strategies included proper tracheotomy care,the management of psychiatric symptoms,a thorough assessment and implementation of enteral and parenteral nutrition,effective skincare,infection prevention,and comprehensive mental care.Individualized nursing skills helped stabilize the patient’s condition,followed by isolation and observation in a psychiatric hospital.CONCLUSION Effective postoperative tracheostomy care in patients with schizophrenia necessitates a tailored,multidisciplinary approach that addresses their psychiatric,physical,and emotional needs to achieve optimal clinical outcomes.
基金supported by State Key Laboratory for Tunnel Engineering(TESKL202425)the National Natural Science Foundation of China(Grant Nos.U24A2085,52174096,52304110)+1 种基金the Henan Province Key Research and Development Program(Grant Nos.241111322000)the Henan Provincial Science and Technology Research Project(Grant Nos.252102320020)。
文摘In geotechnical engineering applications,including mining and tunnel construction,the stability of fractured rock masses is paramount to ensuring structural safety.The spatial distribution and temporal evolution of internal fractures fundamentally govern the mechanical behavior and failure mechanisms of rock masses.Nevertheless,the inherent complexity and structural concealment of rock mass systems pose significant challenges for the direct measurement of critical internal mechanical parameters.This study explores the use of deep learning to invert mechanical responses of NPR(Negative Poisson's Ratio)anchored fractured rock masses.Discrete Element Method(DEM)simulations were conducted to generate datasets including stress-strain curves and crack numbers under various initial fracture distributions.Three models—GRU,CNN+GRU,and CNN+GRU+ATT—were developed to predict rock mechanical parameters from NPR cable force data.Results show that the CNN+GRU+ATT model achieves superior accuracy,with R^(2)>0.90 and RMSE<5 on stress prediction tasks.It also accurately estimates initial crack quantity(np),with mean prediction error under 10%for high-fracture scenarios.The proposed model effectively captures stress fluctuations,offering early-warning potential for failure.The approach demonstrates strong generalization and robustness across varying crack configurations,providing a feasible framework for real-time health monitoring and mechanical parameter estimation in fractured rock engineering.
文摘BACKGROUND Blonanserin,a novel antipsychotic,has demonstrated efficacy in treating both positive and negative symptoms.However,limited research exists on its dose-dependent effectiveness and safety in patients with and without prominent nega-tive symptoms(PNS).AIM To evaluate the effectiveness and safety of blonanserin monotherapy for first-episode schizophrenia in real-world clinical settings and to explore the efficacy and safety of different doses of blonanserin for patients with PNS and without PNS.METHODS A 12-week,multicenter,prospective post-marketing surveillance was conducted.In this study,we included patients with first-episode schizophrenia who received blonanserin monotherapy.Patients were divided into those with PNS and without PNS,based on the Brief Psychiatric Rating Scale(BPRS)negative symptoms subscale scores.Additionally,patients were labeled as high-dose and low-dose was evaluated through the incidence of adverse drug reactions(ADRs).RESULTS A total of 653 patients were included in the analysis,with 613 completing the study.The BPRS total score decreased significantly from 47.94±16.31 at baseline to 26.88±9.47 at 12 weeks(P<0.001).A significant interaction of PNS×dose×time was observed for BPRS total scores(F=3.47,P=0.040)and negative symptom subscale scores(F=6.76,P=0.002).In the PNS group,the high-dose group showed greater reductions in BPRS total scores(P=0.001)and negative symptom subscale scores(P=0.003)than the low-dose group in week 12.In the without PNS group,no significant difference was observed between the high-dose and low-dose groups at any visit.Most adverse reactions were mild or moderate,with extrapyramidal symptoms(9.3%)being most common;1.5%of patients gained≥7%body weight at 12 weeks.CONCLUSION Blonanserin effectively alleviated the clinical symptoms of first-episode schizophrenia with an acceptable safety profile.High-dose blonanserin is particularly beneficial for patients with PNS in the acute phase of first-episode schizophrenia.However,due to the limitation of ADR reporting the real world,the ADR incidence observed in this study may be underestimated.
