摘要
目的探究外周血白细胞计数(WBC)、中性粒细胞与血小板计数比值(NPR)、血小板与淋巴细胞比值(PLR)在成人肺炎中的变化特征及其对病情评估和预后预测的价值。方法将2022年1月至2025年1月南京医科大学康达学院附属涟水人民医院收治的104例成人社区获得性肺炎患者纳入研究。根据患者的肺炎严重指数(PSI)分为低危组(66例,PSI≤90分)和高危组(38例,PSI>90分),再根据患者预后效果分为预后良好组(78例)和预后不良组(26例),比较不同病情严重程度及不同预后患者的外周血WBC、NPR、PLR水平,分析外周血指标与病情及预后的关系,使用ROC分析外周血指标对预后的预测价值,使用Logistic回归分析影响患者预后的危险因素。结果高危组外周血WBC、NPR、PLR均高于低危组,差异有统计学意义(P<0.05);经Spearman分析,外周血WBC、NPR、PLR与病情严重程度呈正相关性(P<0.05);预后不良组患者的外周血WBC、NPR、PLR水平均高于预后良好组,差异有统计学意义(P<0.05);经ROC分析,外周血WBC、NPR、PLR及联合检测对患者预后预测的曲线下面积分别为0.805、0.802、0.831、0.908(P<0.05),Logistic回归分析显示,外周血WBC≥13.08×10^(9)/L、NPR≥3.2、PLR≥175.60是影响成人社区获得性肺炎患者预后的危险因素(P<0.05)。结论外周血WBC、NPR、PLR水平会随成人肺炎患者病情加重而升高,可作为临床评估预后的辅助检测指标。
Objective To explore characteristics of peripheral blood white blood cell count(WBC),neutrophil-to-platelet ratio(NPR)and platelet-to-lymphocyte ratio(PLR),and their value in evalua-tion of disease severity and prognosis prediction in adult patients with pneumonia.Methods A total of 104 adult patients with community-acquired pneumonia were enrolled at the Affiliated Hospital of Kangda College,Nanjing Medical University,between January 2022 and January 2025.Based on the pneumonia severity index(PSI),patients were divided into a low-risk group(66 cases,PSI≤90 points)and a high-risk group(38 cases,PSI>90 points).Additionally,patients were divided into a good prognosis group(78 cases)and a poor progno-sis group(26 cases).The levels of peripheral blood WBC,NPR,and PLR were compared among patients with different disease severity and prognosis.The relationship between peripheral blood indexes and disease severity and prognosis were analyzed.The predictive value of peripheral blood indexes for prognosis was analyzed using ROC curves,and risk factors for prognosis were analyzed through logistic regression analysis.Results The levels of peripheral blood WBC,NPR,and PLR in the high-risk group were higher than those in the low-risk group(P<0.05).Spearman analysis showed that WBC,NPR,and PLR were positively correlated with disease severity(P<0.05).The levels of peripheral blood WBC,NPR,and PLR in the poor prognosis group were higher than those in the good prognosis group(P<0.05).ROC curves analysis showed that the area under the curve(AUC)values of WBC,NPR,PLR,and combined detection for predicting prognosis were 0.805,0.802,0.831 and 0.908,respectively(P<0.05).Logistic regression analysis showed that peripheral blood WBC≥13.08×10^(9)/L,NPR≥3.2 and PLR≥175.60 were risk factors for prognosis in adult patients with commu-nity-acquired pneumonia(P<0.05).Conclusion The levels of peripheral blood WBC,NPR,and PLR in-crease with disease severity in adult patients with pneumonia.These can all be applied as auxiliary detection indi-cators to clinically evaluate prognosis.
作者
冯珊珊
孙静
左芳
耿新普
盛丽丽
刘荣
赵峰
FENG Shanshan;SUN Jing;ZUO Fang;GENG Xinpu;SHENG Lili;LIU Rong;ZHAO Feng(Department of Respiratory Medicine,Lianshui People's Hospital Affiliated to Kangda College,Nanjing Medical University,Nanjing,Jiangsu,China,223400;Department of Respiratory and Critical Care Medi-cine,Huai'an Hospital,Huai'an,Jiangsu,China,223200)
出处
《分子诊断与治疗杂志》
2025年第12期2322-2324,2328,共4页
Journal of Molecular Diagnostics and Therapy
基金
江苏护理职业学院科教融汇临床科研项目(SHKRD2312)。
