The most important achievement in the Paris Agreement is to set up emission reduction target by commitment submitted by each country/ region with the form INDC. However the emission reduction target inside INDCs could...The most important achievement in the Paris Agreement is to set up emission reduction target by commitment submitted by each country/ region with the form INDC. However the emission reduction target inside INDCs could not match with the emission pathway for the global to keep a global temperature rise this century well below 2 ℃ and to drive efforts to limit the temperature increase even further to 1.5 ℃ above pre- industrial levels. It is important for countries to do more than their commitment in INDCs, especially in near term. This paper looks at the near term trend for possibilities for further emission reduction compared with INDCs, and found there do have the possibility. It concludes there is space for the four countries/regions to do more than their INDCs submitted to UNFCCC, and see the light towards to a global 2 ℃ target.展开更多
Background:NDC80 is pivotal in cell division,particularly in regulating the G2/M transition and mitotic progression.Recent studies have demonstrated that NDC80 is significantly overexpressed in multiple solid tumors.F...Background:NDC80 is pivotal in cell division,particularly in regulating the G2/M transition and mitotic progression.Recent studies have demonstrated that NDC80 is significantly overexpressed in multiple solid tumors.Further analysis has suggested that its high expression is significantly associated with an elevated pathological grade,increased metastatic risk,and shortened overall survival in patients with cancer.However,its precise role in pan-cancer development,progression,and prognosis remains unclear.Methods:We conducted a multi-omics analysis of NDC80 using genomic,transcriptomic,and proteomic data from 33 cancer types in The Cancer Genome Atlas,Clinical Proteomic Tumor Analysis Consortium,Genotype-Tissue Expression,and Human Protein Atlas.Results:The results demonstrated frequent NDC80 mutations across multiple malignancies and significantly elevated expression in tumor tissues compared with that in their normal counterparts,correlating with worse overall and disease-free survival.Moreover,NDC80 expression was strongly associated with oncogenic pathways,key protein regulators,cellular components,myeloid-derived suppressor cell infiltration,ESTIMATE scores,and cancer-related signaling networks.Conclusions:These findings underscore the potential of NDC80 as a prognostic biomarker and therapeutic target for cancer treatment.展开更多
IN his video speech to the United Nations Climate Summit held in New York on September 24,Chinese President Xi Jinping announced China’s new Nationally Determined Contributions(NDC)—the efforts taken by each country...IN his video speech to the United Nations Climate Summit held in New York on September 24,Chinese President Xi Jinping announced China’s new Nationally Determined Contributions(NDC)—the efforts taken by each country to reduce their emissions and adapt to the impacts of climate change.展开更多
目的 探讨肝细胞肝癌(LIHC)中NDC1基因的表达水平及临床价值。方法 利用The Human Protein Atlas、GEPIA、TIMER数据库在线分析NDC1基因在健康人体各器官组织、正常肝组织和肝细胞肝癌组织中的表达情况。利用Kaplan-Meier Ploter和UALCA...目的 探讨肝细胞肝癌(LIHC)中NDC1基因的表达水平及临床价值。方法 利用The Human Protein Atlas、GEPIA、TIMER数据库在线分析NDC1基因在健康人体各器官组织、正常肝组织和肝细胞肝癌组织中的表达情况。利用Kaplan-Meier Ploter和UALCAN数据库的肝癌数据集在线分析患者NDC1表达与生存总周期的关系。通过STRING数据库在线检索NDC1的相关蛋白网络图,并进行功能注释和KEGG通路富集分析。通过TIMER数据库检测NDC1在肝癌中的免疫细胞的浸润水平以分析临床不良预后的相关性。结果 人体不同器官的NDC1 m RNA存在差异表达。与对照组相比,NDC1基因在乳腺癌、膀胱癌、结肠癌、胆管癌、肺鳞癌、肝癌的表达水平显著上升,且差异有显著统计学意义(P<0.001)。肝癌组织NDC1 m RNA的表达水平高于正常肝脏组织,肝癌组织中NDC1 m RNA表达水平明显上调,差异有统计学意义(P<0.05)。NDC1基因在正常肝组织中的表达水平为2.356(1.728~2.878)。根据病理分级,NDC1基因在1级肝癌组织中的表达水平为3.071 (2.475~4.981),在2级肝癌组织中的表达水平为3.69 (2.457~5.305),在3级肝癌组织中的表达水平为4.676 (2.745~6.874),在4级肝癌组织中的表达水平为4.586 (3.159~6.954),各级肝癌中NDC1的表达水平差异有显著统计学意义(P<0.01);根据肿瘤临床分期,NDC1基因在Ⅰ期肝癌组织中表达水平为3.323 (2.371~5.414),在Ⅱ期肝癌组织中表达水平为4.294 (2.704~7.496),在Ⅲ期肝癌组织中表达水平为4.684 (2.979~7.037),在Ⅳ期肝癌组织中表达水平为1.983 (1.801~2.669),肝癌Ⅰ、Ⅱ和Ⅲ期中NDC1基因的表达水平均显著高于正常组织(P<0.001),而肝癌Ⅱ期和Ⅲ期中的表达水平显著高于Ⅰ期,差异具有显著统计学意义(P<0.01);根据身体质量指数分组,在正常体质量的肝癌组织表达水平为3.62 (2.584~5.661),在超常体质量的肝癌组织表达水平为3.841 (2.098~6.056),在肥胖的肝癌组织表达水平为3.627 (2.504~5.182),在极度肥胖的肝癌组织表达水平为3.577 (2.359~4.909)。任何BMI患者的肝癌组织中NDC1的表达水平均显著高于正常肝脏组织,差异具有显著统计学意义(P<0.01)。NDC1与CDK1、CCNB1、CCNB2、SEH1L、NUP155、CDCA8等蛋白相关,NDC1 m RNA在肝癌免疫微环境中与CD8^(+)T细胞、CD4^(+)T细胞、T细胞、B细胞、中性粒细胞、单核细胞、巨噬细胞和骨髓细胞等免疫细胞中的表达呈正相关性(P<0.05)。结论 肝癌组织中NDC1基因呈现高表达水平,其表达水平与肝癌的发生、发展及预后密切相关,可能是肝癌潜在的预后生物学标志物及治疗靶标。展开更多
γ-氨基丁酸(GABA)具有降压、降血糖、抗癌等益生功能。玉米低聚肽(CP)作为一种生物活性肽一方面富含产GABA的发酵底物谷氨酸,另一方面可以通过抑制血管紧张素转移酶(ACE)起到降血压的作用。本研究利用酶解法制备玉米低聚肽,并以其为基...γ-氨基丁酸(GABA)具有降压、降血糖、抗癌等益生功能。玉米低聚肽(CP)作为一种生物活性肽一方面富含产GABA的发酵底物谷氨酸,另一方面可以通过抑制血管紧张素转移酶(ACE)起到降血压的作用。本研究利用酶解法制备玉米低聚肽,并以其为基质经植物乳杆菌NDC75017进行发酵,开发一种富含GABA的乳酸菌饮料。实验利用反向液相色谱法(RP-HPLC)检测发酵液中GABA的含量,利用酶解法制备玉米肽。并对玉米肽的脱苦工艺进行了初探,最后选用β-环糊精包埋苦味肽。得出GABA的产量最高为16 mg/100 m L,且饮料口感状态优良。产品在4℃贮藏21 d后GABA维持在14 mg/100 m L以上,活菌数(对数值)维持在7.0 m L-1以上。展开更多
文摘The most important achievement in the Paris Agreement is to set up emission reduction target by commitment submitted by each country/ region with the form INDC. However the emission reduction target inside INDCs could not match with the emission pathway for the global to keep a global temperature rise this century well below 2 ℃ and to drive efforts to limit the temperature increase even further to 1.5 ℃ above pre- industrial levels. It is important for countries to do more than their commitment in INDCs, especially in near term. This paper looks at the near term trend for possibilities for further emission reduction compared with INDCs, and found there do have the possibility. It concludes there is space for the four countries/regions to do more than their INDCs submitted to UNFCCC, and see the light towards to a global 2 ℃ target.
基金supported by grants from the Weifang Municipal Health Commission Research Programme Project(No.WFWSJK-2023-032)the Weifang Science and Technology Development Project(No.2023YX053)the Weifang Young Medical Talent Support Program Funding。
文摘Background:NDC80 is pivotal in cell division,particularly in regulating the G2/M transition and mitotic progression.Recent studies have demonstrated that NDC80 is significantly overexpressed in multiple solid tumors.Further analysis has suggested that its high expression is significantly associated with an elevated pathological grade,increased metastatic risk,and shortened overall survival in patients with cancer.However,its precise role in pan-cancer development,progression,and prognosis remains unclear.Methods:We conducted a multi-omics analysis of NDC80 using genomic,transcriptomic,and proteomic data from 33 cancer types in The Cancer Genome Atlas,Clinical Proteomic Tumor Analysis Consortium,Genotype-Tissue Expression,and Human Protein Atlas.Results:The results demonstrated frequent NDC80 mutations across multiple malignancies and significantly elevated expression in tumor tissues compared with that in their normal counterparts,correlating with worse overall and disease-free survival.Moreover,NDC80 expression was strongly associated with oncogenic pathways,key protein regulators,cellular components,myeloid-derived suppressor cell infiltration,ESTIMATE scores,and cancer-related signaling networks.Conclusions:These findings underscore the potential of NDC80 as a prognostic biomarker and therapeutic target for cancer treatment.
文摘IN his video speech to the United Nations Climate Summit held in New York on September 24,Chinese President Xi Jinping announced China’s new Nationally Determined Contributions(NDC)—the efforts taken by each country to reduce their emissions and adapt to the impacts of climate change.
文摘目的 探讨肝细胞肝癌(LIHC)中NDC1基因的表达水平及临床价值。方法 利用The Human Protein Atlas、GEPIA、TIMER数据库在线分析NDC1基因在健康人体各器官组织、正常肝组织和肝细胞肝癌组织中的表达情况。利用Kaplan-Meier Ploter和UALCAN数据库的肝癌数据集在线分析患者NDC1表达与生存总周期的关系。通过STRING数据库在线检索NDC1的相关蛋白网络图,并进行功能注释和KEGG通路富集分析。通过TIMER数据库检测NDC1在肝癌中的免疫细胞的浸润水平以分析临床不良预后的相关性。结果 人体不同器官的NDC1 m RNA存在差异表达。与对照组相比,NDC1基因在乳腺癌、膀胱癌、结肠癌、胆管癌、肺鳞癌、肝癌的表达水平显著上升,且差异有显著统计学意义(P<0.001)。肝癌组织NDC1 m RNA的表达水平高于正常肝脏组织,肝癌组织中NDC1 m RNA表达水平明显上调,差异有统计学意义(P<0.05)。NDC1基因在正常肝组织中的表达水平为2.356(1.728~2.878)。根据病理分级,NDC1基因在1级肝癌组织中的表达水平为3.071 (2.475~4.981),在2级肝癌组织中的表达水平为3.69 (2.457~5.305),在3级肝癌组织中的表达水平为4.676 (2.745~6.874),在4级肝癌组织中的表达水平为4.586 (3.159~6.954),各级肝癌中NDC1的表达水平差异有显著统计学意义(P<0.01);根据肿瘤临床分期,NDC1基因在Ⅰ期肝癌组织中表达水平为3.323 (2.371~5.414),在Ⅱ期肝癌组织中表达水平为4.294 (2.704~7.496),在Ⅲ期肝癌组织中表达水平为4.684 (2.979~7.037),在Ⅳ期肝癌组织中表达水平为1.983 (1.801~2.669),肝癌Ⅰ、Ⅱ和Ⅲ期中NDC1基因的表达水平均显著高于正常组织(P<0.001),而肝癌Ⅱ期和Ⅲ期中的表达水平显著高于Ⅰ期,差异具有显著统计学意义(P<0.01);根据身体质量指数分组,在正常体质量的肝癌组织表达水平为3.62 (2.584~5.661),在超常体质量的肝癌组织表达水平为3.841 (2.098~6.056),在肥胖的肝癌组织表达水平为3.627 (2.504~5.182),在极度肥胖的肝癌组织表达水平为3.577 (2.359~4.909)。任何BMI患者的肝癌组织中NDC1的表达水平均显著高于正常肝脏组织,差异具有显著统计学意义(P<0.01)。NDC1与CDK1、CCNB1、CCNB2、SEH1L、NUP155、CDCA8等蛋白相关,NDC1 m RNA在肝癌免疫微环境中与CD8^(+)T细胞、CD4^(+)T细胞、T细胞、B细胞、中性粒细胞、单核细胞、巨噬细胞和骨髓细胞等免疫细胞中的表达呈正相关性(P<0.05)。结论 肝癌组织中NDC1基因呈现高表达水平,其表达水平与肝癌的发生、发展及预后密切相关,可能是肝癌潜在的预后生物学标志物及治疗靶标。
文摘γ-氨基丁酸(GABA)具有降压、降血糖、抗癌等益生功能。玉米低聚肽(CP)作为一种生物活性肽一方面富含产GABA的发酵底物谷氨酸,另一方面可以通过抑制血管紧张素转移酶(ACE)起到降血压的作用。本研究利用酶解法制备玉米低聚肽,并以其为基质经植物乳杆菌NDC75017进行发酵,开发一种富含GABA的乳酸菌饮料。实验利用反向液相色谱法(RP-HPLC)检测发酵液中GABA的含量,利用酶解法制备玉米肽。并对玉米肽的脱苦工艺进行了初探,最后选用β-环糊精包埋苦味肽。得出GABA的产量最高为16 mg/100 m L,且饮料口感状态优良。产品在4℃贮藏21 d后GABA维持在14 mg/100 m L以上,活菌数(对数值)维持在7.0 m L-1以上。
