Concepts for a virtual 3D space and a hyper-sphere are proposed and the formulae for determining the computable nodes of the mesh are derived.Then a new optimization design method('Virtual Mesh Method'or V.M.M...Concepts for a virtual 3D space and a hyper-sphere are proposed and the formulae for determining the computable nodes of the mesh are derived.Then a new optimization design method('Virtual Mesh Method'or V.M.M)is developed.Three examples are given,showing that the method proposed is especially suitable for the optimized design of complex structures,and that the global approximate optimal solution can be searched with remarkably reduced computational work.展开更多
The dynamic analysis and optimal design of reactive extraction are challenging due to high nonlinearity of model equations and tough decision of judging criteria. In this work, a dynamic rate-based method is developed...The dynamic analysis and optimal design of reactive extraction are challenging due to high nonlinearity of model equations and tough decision of judging criteria. In this work, a dynamic rate-based method is developed on g PROMS platform to get easy access to the solutions of reactive extraction with phase splitting. Based on rigorous criteria, dynamic analysis from initial state to final equilibrium(e.g., evolution of phase composition, mass transfer rate and reaction rate) and optimal design of operating conditions(e.g., extractant dosage and feed molar ratio) are achieved. To illustrate the method, the esterification of n-hexyl acetate is taken as an example. The approach proves to be reliable in the analysis and optimization of the exemplified system, which provides instructive reference for further process design and simulation of reactive extraction.展开更多
An impeller is the most important component affecting the performance of centrifugal fans. The flow in the impeller is very complicated, and the 3\|D viscous flow is difficult to simulate numerically. This paper prese...An impeller is the most important component affecting the performance of centrifugal fans. The flow in the impeller is very complicated, and the 3\|D viscous flow is difficult to simulate numerically. This paper presents a numerical method for simulating the flow in practical commercial impellers. The predictions are compared with experimentally measured fan performance results. The predicted total pressure and efficiency for two fan models, whose optimum designs were determined by this method, agree well with the measured data for the design flow rate. The results show that the aerodynamic and noise levels for these two models are excellent. The paper also presents several new ideas about the shape of the front plate and the blade flow pattern to improve the flow in an impeller channel. The practical simulation methodology and results developed here will be very useful to the fan industry in the future.展开更多
A t-(v,k,λ)design(X,B)is a set X of points,of cardinality v,and a collection B of k-subsets of X called blocks,with the property that every t-subset of X is contained in precisely λ blocks.A t-design is a t-(v,k,λ)...A t-(v,k,λ)design(X,B)is a set X of points,of cardinality v,and a collection B of k-subsets of X called blocks,with the property that every t-subset of X is contained in precisely λ blocks.A t-design is a t-(v,k,λ) design for some v,k,γ.In this paper,we give a generalization of t-design called balanced n-ary t-design,and obtain some properties of the new combinatorial structure.展开更多
Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new anti-TB agents.Many of them show excellent in vitro activit...Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new anti-TB agents.Many of them show excellent in vitro activity against both drug-sensitive MTB strain H37Rv and two MDR-MTB clinical isolates(MIC:<0.002-0.030 μg/mL).Compounds 2f,5e and 5g display acceptable safety and pharmacokinetic profiles,opening a new direction for further development.展开更多
Presents the new concept of ″Desired to be small″ based on the basic function of vehicle flight control system for an optimal design of flying vehicle control system, and the definition of S/N ratio and calculation ...Presents the new concept of ″Desired to be small″ based on the basic function of vehicle flight control system for an optimal design of flying vehicle control system, and the definition of S/N ratio and calculation formula for ″Desired to be small″ dynamic characteristics, and the S/N ratio method established for design of velicle flight control systems, by which, an orthogrnal table is used to arrange test schemes, and error facters are used to simulate various interferences, and the use of S/N ratio as a design criterion to synthesise the design of dynamic and static characteristics for definition of an optimal scheme, the application of S/N ratio method to the design of a type of vehicle control system and the single run success abtained in design of control system, technical evaluation test and design finalization flight test.展开更多
基金Project supported by the Natural Science Foundation of Henan Province,China(No.0311010400).
文摘Concepts for a virtual 3D space and a hyper-sphere are proposed and the formulae for determining the computable nodes of the mesh are derived.Then a new optimization design method('Virtual Mesh Method'or V.M.M)is developed.Three examples are given,showing that the method proposed is especially suitable for the optimized design of complex structures,and that the global approximate optimal solution can be searched with remarkably reduced computational work.
基金Supported by the National Natural Science Foundation of China(21776074,21576081,2181101120).
文摘The dynamic analysis and optimal design of reactive extraction are challenging due to high nonlinearity of model equations and tough decision of judging criteria. In this work, a dynamic rate-based method is developed on g PROMS platform to get easy access to the solutions of reactive extraction with phase splitting. Based on rigorous criteria, dynamic analysis from initial state to final equilibrium(e.g., evolution of phase composition, mass transfer rate and reaction rate) and optimal design of operating conditions(e.g., extractant dosage and feed molar ratio) are achieved. To illustrate the method, the esterification of n-hexyl acetate is taken as an example. The approach proves to be reliable in the analysis and optimization of the exemplified system, which provides instructive reference for further process design and simulation of reactive extraction.
文摘An impeller is the most important component affecting the performance of centrifugal fans. The flow in the impeller is very complicated, and the 3\|D viscous flow is difficult to simulate numerically. This paper presents a numerical method for simulating the flow in practical commercial impellers. The predictions are compared with experimentally measured fan performance results. The predicted total pressure and efficiency for two fan models, whose optimum designs were determined by this method, agree well with the measured data for the design flow rate. The results show that the aerodynamic and noise levels for these two models are excellent. The paper also presents several new ideas about the shape of the front plate and the blade flow pattern to improve the flow in an impeller channel. The practical simulation methodology and results developed here will be very useful to the fan industry in the future.
文摘A t-(v,k,λ)design(X,B)is a set X of points,of cardinality v,and a collection B of k-subsets of X called blocks,with the property that every t-subset of X is contained in precisely λ blocks.A t-design is a t-(v,k,λ) design for some v,k,γ.In this paper,we give a generalization of t-design called balanced n-ary t-design,and obtain some properties of the new combinatorial structure.
基金supported by the CAMS Innovation Fund for Medical Science(No.CAMS-2017-I2M-1-011)National Mega-project for Innovative Drugs(Nos.2015ZX09102007-008,2018ZX09721001004-007,2018ZX09711001-007-002)the National Natural Science Foundation of China(No.81872753)。
文摘Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new anti-TB agents.Many of them show excellent in vitro activity against both drug-sensitive MTB strain H37Rv and two MDR-MTB clinical isolates(MIC:<0.002-0.030 μg/mL).Compounds 2f,5e and 5g display acceptable safety and pharmacokinetic profiles,opening a new direction for further development.
文摘Presents the new concept of ″Desired to be small″ based on the basic function of vehicle flight control system for an optimal design of flying vehicle control system, and the definition of S/N ratio and calculation formula for ″Desired to be small″ dynamic characteristics, and the S/N ratio method established for design of velicle flight control systems, by which, an orthogrnal table is used to arrange test schemes, and error facters are used to simulate various interferences, and the use of S/N ratio as a design criterion to synthesise the design of dynamic and static characteristics for definition of an optimal scheme, the application of S/N ratio method to the design of a type of vehicle control system and the single run success abtained in design of control system, technical evaluation test and design finalization flight test.
