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Comparison study on measurement of rail weld joint between inertial reference method and multi-point chord reference method
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作者 Yifan Shi Yuan Wang +1 位作者 Xiaozhou Liu Ping Wang 《Railway Sciences》 2024年第1期69-83,共15页
Purpose – Straightness measurement of rail weld joint is of essential importance to railway maintenance. Dueto the lack of efficient measurement equipment, there has been limited in-depth research on rail weld joint ... Purpose – Straightness measurement of rail weld joint is of essential importance to railway maintenance. Dueto the lack of efficient measurement equipment, there has been limited in-depth research on rail weld joint with a5-m wavelength range, leaving a significant knowledge gap in this field.Design/methodology/approach – In this study, the authors used the well-established inertial referencemethod (IR-method), and the state-of-the-art multi-point chord reference method (MCR-method). Two methodshave been applied in different types of rail straightness measurement trollies, respectively. These instrumentswere tested in a high-speed rail section within a certain region of China. The test results were ultimatelyvalidated through using traditional straightedge and feeler gauge methods as reference data to evaluate the railweld joint straightness within the 5-m wavelength range.Findings – The research reveals that IR-method and MCR-method produce reasonably similar measurementresults for wavelengths below 1 m. However, MCR-method outperforms IR-method in terms of accuracy forwavelengths exceeding 3 m. Furthermore, it was observed that IR-method, while operating at a slower speed,carries the risk of derailing and is incapable of detecting rail weld joints and low joints within the track.Originality/value – The research compare two methods’ measurement effects in a longer wavelength rangeand demonstrate the superiority of MCR-method. 展开更多
关键词 Rail weld joint Inertial reference method Short-wavelength irregularities multi-point chord reference method 5-m wavelength range
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A centroid measurement method based on 3D scanning 被引量:1
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作者 HE Xin LI Zhen 《Journal of Measurement Science and Instrumentation》 2025年第2期186-194,共9页
The centroid coordinate serves as a critical control parameter in motion systems,including aircraft,missiles,rockets,and drones,directly influencing their motion dynamics and control performance.Traditional methods fo... The centroid coordinate serves as a critical control parameter in motion systems,including aircraft,missiles,rockets,and drones,directly influencing their motion dynamics and control performance.Traditional methods for centroid measurement often necessitate custom equipment and specialized positioning devices,leading to high costs and limited accuracy.Here,we present a centroid measurement method that integrates 3D scanning technology,enabling accurate measurement of centroid across various types of objects without the need for specialized positioning fixtures.A theoretical framework for centroid measurement was established,which combined the principle of the multi-point weighing method with 3D scanning technology.The measurement accuracy was evaluated using a designed standard component.Experimental results demonstrate that the discrepancies between the theoretical and the measured centroid of a standard component with various materials and complex shapes in the X,Y,and Z directions are 0.003 mm,0.009 mm,and 0.105 mm,respectively,yielding a spatial deviation of 0.106 mm.Qualitative verification was conducted through experimental validation of three distinct types.They confirmed the reliability of the proposed method,which allowed for accurate centroid measurements of various products without requiring positioning fixtures.This advancement significantly broadened the applicability and scope of centroid measurement devices,offering new theoretical insights and methodologies for the measurement of complex parts and systems. 展开更多
关键词 centroid measurement mass characteristic parameter 3D scanning 3D point cloud data no specialized positioning fixtures multi-point weighing method
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Measurement device and method for mass and centroid of large aircraft
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作者 ZHANG Xiaolin ZHANG Yuyang +2 位作者 YANG Lifeng ZHAO Hongzhi WANG Meibao 《Journal of Measurement Science and Instrumentation》 2025年第3期341-349,共9页
The precise acquisition of the quality characteristic parameters of large aircraft directly affects its performance characteristics.For large aircrafts such as missiles and rockets with internal fillings,traditional m... The precise acquisition of the quality characteristic parameters of large aircraft directly affects its performance characteristics.For large aircrafts such as missiles and rockets with internal fillings,traditional measurement methods involving large-angle tilting or rotation may pose safety risks.In light of the characteristics of large aircraft and in combination with existing measurement methods,we design a mass and centroid measurement method based on four-point support and small-angle tilting,and develop a set of mass and centroid testing system.This method obtains the intersection point of the gravity action line in the product coordinate system through coordinate transformation in two postures,thereby obtaining the three-dimensional centroid of the aircraft.We first elaborate on the principle of this method in detail,then introduce the composition of the equipment,and analyze the structural stress of key components.Finally,experimental verification and uncertainty analysis are carried out.Experimental verification shows that the maximum deviation of the mass measurement accuracy is less than 0.02%,the centroid measurement accuracy in the X direction is±0.15 mm,in the Y direction it is±0.21 mm,and in the Z direction it is±0.19 mm. 展开更多
关键词 large aircraft centroid measurement coordinate transformation multi-point weighing method gravity line
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A pilot randomized control study to evaluate endoscopic resection using a ligation device for rectal carcinoid tumors 被引量:3
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作者 Hiroyuki Sakata Ryuichi Iwakiri +10 位作者 Akifumi Ootani Seiji Tsunada Shinichi Ogata Hibiki Ootani Ryo Shimoda Kanako Yamaguchi Yasuhisa Sakata Sadahiro Amemori Kotaro Mannen Masanobu Mizuguchi Kazuma Fujimoto 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第25期4026-4028,共3页
AIM: Rectal carcinoid tumors smaller than 10 mm can be resected with local excision using endoscopy. In order to remove rectal carcinoid tumors completely, we evaluated endoscopic mucosal resection with a ligation de... AIM: Rectal carcinoid tumors smaller than 10 mm can be resected with local excision using endoscopy. In order to remove rectal carcinoid tumors completely, we evaluated endoscopic mucosal resection with a ligation device in this pilot control randomized study. METHODS: Fifteen patients were diagnosed with rectal carcinoid tumor (less than 10 mm) in our hospital from 1993 to 2002. There were 9 males and 6 females, with a mean age 61.5 years (range, 34-77 years). The patientshad no complaints of carcinoid syndrome symptoms. Fifteen patients were randomly divided into 2 groups: 7 carcinoid tumors were treated by conventional endoscopic resection, and 8 carcinoid tumors were treated by endoscopic resection using a ligation device. RESULTS: All rectal carcinoid tumors were located at the middle to distal rectum. The size of the tumors varied from 3 mm to 10 mm and background characteristics of the patients were not different in the two groups. The rate of complete removal of carcinoid tumors using a ligation device (100%, 8/8) was significantly higher than that of conventional endoscopic resection (57.1%, 4/7). The three patients had tumor involvement of deep margin, for which additional treatment was performed. No complications occurred during or after endoscopic resection using a ligation device. All patients in the both groups were alive during the 3-year observation period. CONCLUSION: Endoscopic resection using a ligation device is a useful and safe method for resection of small rectal carcinoid tumors. 展开更多
关键词 CARCINOID ligation mucosectomy ENDOSCOPY RECTUM Conventional method
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Multi-point impact behavior and the relationship between CAI strength and DBIP of PMI foam sandwich structures
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作者 Keyu ZHU Xitao ZHENG +2 位作者 Jiaming SUN Guoyue WANG Leilei YAN 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第10期265-274,共10页
Sandwich structures are vulnerable to multi-point impacts,and such impacts can result in a reduction in residual strength even catastrophic accident.Therefore,the multi-point impact behaviors of PMI foam sandwich stru... Sandwich structures are vulnerable to multi-point impacts,and such impacts can result in a reduction in residual strength even catastrophic accident.Therefore,the multi-point impact behaviors of PMI foam sandwich structure are investigated and studied using experimental and numerical coupled methods.Three impact energy levels and five Distances Between Impact Positions(DBIP)are considered in details,and representative impact characteristics are compared to reveal the association between Compression After Impact(CAI)strength and DBIP.Results indicate that the interference between the multi-point impact events has a dominant effect on CAI strength when DBIP is small,and the variation in bending stiffness induced by the boundary effect is the dominant factor affecting CAI strength when DBIP ranges from 20 mm to 60 mm.In addition,matrix damage represents the primary damage mode in multi-point impact,and the calculated ratio of energy absorbed by the top face sheet and honeycomb core,in relation to the total absorbed energy,serves as a clear indicator of the damage severity experienced by both components.This work is enlightening for the structural design of impact-resistant composites. 展开更多
关键词 multi-point impact Damage mechanism Interference effect CAI strength Numerical method
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改良结扎法用于脊髓损伤造模的优势分析 被引量:1
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作者 李道辉 徐晓霜 +5 位作者 李郑涛 田新鹏 毕航川 刘源 戴永文 陈凌强 《中国组织工程研究》 CAS 北大核心 2025年第2期379-384,共6页
背景:目前根据脊髓损伤的损伤方式不同衍生出不同的模型构建方法,传统物理损伤造模方法都有各自的优缺点,尚缺乏较为有效和稳定的脊髓损伤动物模型。目的:建立一种可复制、可调控、创伤小、死亡率低、模型更稳定、适用范围广、术后护理... 背景:目前根据脊髓损伤的损伤方式不同衍生出不同的模型构建方法,传统物理损伤造模方法都有各自的优缺点,尚缺乏较为有效和稳定的脊髓损伤动物模型。目的:建立一种可复制、可调控、创伤小、死亡率低、模型更稳定、适用范围广、术后护理时间短的脊髓损伤大鼠模型。方法:将体质量和鼠龄相似的40只SD大鼠随机分为对照组和改良组,每组20只,对照组采用钳夹造模法构建脊髓损伤模型,改良组选用基于压迫法改良的结扎法,在开窗的基础上使用缝线结扎的方法进行脊髓损伤的造模。比较两组大鼠的排尿行为、血尿、脓尿(感染率)、死亡率、脊柱畸形率及术后1,3,5,7 d的BBB运动功能学评分。结果与结论:基于压迫法改良的结扎法建立的脊髓损伤大鼠模型比常规建模方法排尿行为恢复较快、血尿率低、感染率低、死亡率低、脊柱畸形率低,BBB评分结果更集中稳定(1周内均<2分),由此可证明基于压迫法改良的结扎法更适用于脊髓损伤大鼠模型的建立。 展开更多
关键词 改良 脊髓损伤模型 钳夹造模法 结扎法 排尿反射 排尿行为 脊柱畸形 BBB评分
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多点套扎法在内痔内镜套扎术中的应用效果
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作者 陆游 《中外医药研究》 2025年第19期25-27,共3页
目的:探讨多点套扎法在内痔内镜套扎术中的应用效果。方法:选取2023年1月—2024年6月于上海市青浦区中医医院接受内镜套扎术治疗的Ⅱ~Ⅲ度内痔患者84例,采用随机数字表法分为观察组与对照组,每组42例。对照组术中采用基础套扎法,观察组... 目的:探讨多点套扎法在内痔内镜套扎术中的应用效果。方法:选取2023年1月—2024年6月于上海市青浦区中医医院接受内镜套扎术治疗的Ⅱ~Ⅲ度内痔患者84例,采用随机数字表法分为观察组与对照组,每组42例。对照组术中采用基础套扎法,观察组采用多点套扎法。比较两组临床疗效、不良事件发生情况、肛肠动力学指标。结果:观察组治疗总有效率高于对照组(P=0.004)。观察组肛门疼痛、肛门坠胀感发生率高于对照组(P<0.05);两组控便异常、尿潴留发生率比较,无统计学差异(P>0.05)。术前及术后3个月,两组直肠最大耐受量、肛管最大收缩压、肛管静息压比较,无统计学差异(P>0.05);术后1个月,观察组直肠最大耐受量、肛管最大收缩压、肛管静息压小于对照组(P<0.05)。结论:多点套扎法在内痔内镜套扎术中的应用效果显著,但肛门疼痛、肛门坠胀感发生率高于基础套扎法,且术后短期可影响肛肠动力学。 展开更多
关键词 内痔 内镜套扎术 多点套扎法 基础套扎法
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垂体后叶素联合线圈套扎法子宫肌瘤剔除对高龄妊娠合并子宫肌瘤孕妇剖宫产术结局的影响
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作者 刘亚冰 乔靖斐 许维维 《医药论坛杂志》 2025年第19期2047-2051,共5页
目的 研究高龄妊娠合并子宫肌瘤孕妇剖宫产术采用垂体后叶素联合线圈套扎法子宫肌瘤剔除术的并发症发生率、术中出血量及子宫复旧情况。方法 选取2021年3月—2023年3月郑州大学第一附属医院收治的高龄妊娠合并子宫肌瘤患者200例,随机分... 目的 研究高龄妊娠合并子宫肌瘤孕妇剖宫产术采用垂体后叶素联合线圈套扎法子宫肌瘤剔除术的并发症发生率、术中出血量及子宫复旧情况。方法 选取2021年3月—2023年3月郑州大学第一附属医院收治的高龄妊娠合并子宫肌瘤患者200例,随机分为观察组和对照组各100例,对照组开展子宫肌瘤剔除术,观察组在对照组基础上应用垂体后叶素联合线圈套扎法,对比两组并发症发生率、术中出血量及子宫复旧情况。结果 两组年龄、平均肌瘤直径、体重、肌瘤位置、肌瘤类型等一般资料比较差异均无统计学意义(P>0.05);观察组术中出血量(92.26±14.91)mL低于对照组(214.21±16.11)mL,产后恶露排净时间(26.11±2.31)d短于对照组(31.27±2.91)d,子宫复旧速度(1.69±0.62)cm/d优于对照组的(1.41±0.21)cm/d,差异有统计学意义(P<0.05);观察组产褥感染2例(轻度手术切口感染和子宫内膜炎各1例),残腔出血1例(轻度术后迟发性出血),并发症发生率4.00%,对照组产褥感染6例(轻、中度手术切口感染各1例,轻中度子宫内膜炎各1例,轻度盆腔脓肿2例),残腔出血3例(轻度术中急性出血1例,轻度术后迟发性出血2例),并发症发生率12.00%,差异有统计学意义(P<0.05)。结论 高龄妊娠合并子宫肌瘤孕妇采用垂体后叶素联合线圈套扎法子宫肌瘤剔除,具有显著应用价值,不仅能降低并发症发生率,还能减少术中出血量。 展开更多
关键词 垂体后叶素 线圈套扎法 子宫肌瘤剔除 高龄 妊娠 子宫肌瘤
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自锁托槽矫治器联合微种植体支抗与传统矫治方法在治疗双颌前突错[牙合]畸形中的效果比较
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作者 郭培珠 郭旭东 杨烁 《世界复合医学(中英文)》 2025年第6期89-92,共4页
目的 对比自锁托槽矫治器与微种植体支抗的结合应用及传统直丝弓托槽矫治器配合微种植体支抗在双颌前突错[牙合]畸形的治疗中的效果。方法 选取2021年1月至2023年1月在单县中心医院接受矫治修复的87例双颌前突错[牙合]畸形患者,所有患... 目的 对比自锁托槽矫治器与微种植体支抗的结合应用及传统直丝弓托槽矫治器配合微种植体支抗在双颌前突错[牙合]畸形的治疗中的效果。方法 选取2021年1月至2023年1月在单县中心医院接受矫治修复的87例双颌前突错[牙合]畸形患者,所有患者均使用微种植体支抗,按照使用矫治器不同分为常规组(43例,采用传统直丝弓托槽矫治器)和探究组(44例,采用自锁托槽矫治器)。对比两组面部美学改善程度、软组织头影测量结果、并发症发生率。结果 矫治后,探究组上下颌骨关系评分为(17.44±1.26)分、面部轮廓对称性评分为(17.56±1.41)分、面部比例协调性评分为(17.43±1.28)分、软组织轮廓改善评分为(17.16±1.28)分、整体面部美观度评分为(17.41±1.37)分,均高于常规组的(16.39±1.18)分、(16.32±1.17)分、(16.19±1.37)分、(16.47±1.39)分、(16.49±1.52)分,差异均有统计学意义(t=4.010、4.459、4.363、2.409、2.967,P均<0.05)。矫治后,探究组上唇-E线、下唇-E线、上唇突度及上下唇角测量结果均优于常规组,差异均有统计学意义(P均<0.05)。探究组并发症发生率低于常规组,差异有统计学意义(P<0.05)。结论 自锁托槽矫治器联合微种植体支抗在治疗双颌前突错[牙合]畸形中相较于传统直丝弓托槽矫治器联合微种植体支抗具有更显著的面部美学改善效果及矫治效果,且并发症发生率更低。 展开更多
关键词 自锁托槽矫治器 微种植体支抗 传统矫治方法 双颌前突错[牙合]畸形
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单纯动脉结扎法识别段间平面在NSCLC患者胸腔镜解剖性肺段切除术中的应用效果
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作者 郁喆 杨健 +2 位作者 戴春雷 彭勇 许经伟 《中外医学研究》 2025年第24期61-64,共4页
目的:探究对行胸腔镜解剖性肺段切除术的非小细胞肺癌(NSCLC)患者术中应用单纯动脉结扎法识别段间平面的效果。方法:选取2021年1月—2024年6月南京医科大学附属苏州医院(苏州市立医院)拟行胸腔镜解剖性肺段切除术治疗的112例NSCLC患者... 目的:探究对行胸腔镜解剖性肺段切除术的非小细胞肺癌(NSCLC)患者术中应用单纯动脉结扎法识别段间平面的效果。方法:选取2021年1月—2024年6月南京医科大学附属苏州医院(苏州市立医院)拟行胸腔镜解剖性肺段切除术治疗的112例NSCLC患者的临床资料进行回顾性分析,根据患者术中所使用的不同段间平面识别方式分组为试验组(n=46)与对照组(n=66)。两组均接受胸腔镜解剖性肺段切除术治疗,术中试验组采用单纯动脉结扎法,对照组采用改良膨胀萎陷法。观察两组手术情况,比较两组术前及术后1个月时的生存质量[肺癌治疗功能评价量表(FACT-L)]及自我效能感[一般自我效能感量表(GSES)]差异,记录两组术后1个月内的并发症发生情况。结果:两组段间平面出现时长比较,差异无统计学意义(P>0.05);试验组手术总时长、住院时长及术中出血量均少于对照组,差异有统计学意义(P<0.05)。两组手术前的FACT-L及GSES评分比较,差异无统计学意义(P>0.05);两组手术后1个月的FACT-L及GSES评分较手术前均有升高,且试验组高于对照组,差异有统计学意义(P<0.05)。两组手术后1个月内肺漏气、乳糜胸及肺部感染总发生率相比,差异无统计学意义(P>0.05)。结论:单纯动脉结扎法在行胸腔镜解剖性肺段切除术NSCLC患者的段间平面识别中具有良好效果,并能提高手术效率及安全性,有利于患者术后生存质量及自我效能感的提高。 展开更多
关键词 单纯动脉结扎法 改良膨胀萎陷法 胸腔镜解剖性肺段切除术 非小细胞肺癌 自我效能感
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改良套扎法联合聚多卡醇泡沫硬化注射治疗中青年Ⅱ~Ⅲ期内痔疗效观察
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作者 王馥秋 纪达 解福海 《新乡医学院学报》 2025年第5期391-396,共6页
目的 探讨改良套扎法联合聚多卡醇泡沫硬化注射治疗中青年Ⅱ~Ⅲ期内痔的疗效。方法 选择2020年4月至2023年4月界首市人民医院收治的140例中青年Ⅱ~Ⅲ期内痔患者为研究对象。采用随机数字表法将患者分为对照组和观察组,每组70例。对照组... 目的 探讨改良套扎法联合聚多卡醇泡沫硬化注射治疗中青年Ⅱ~Ⅲ期内痔的疗效。方法 选择2020年4月至2023年4月界首市人民医院收治的140例中青年Ⅱ~Ⅲ期内痔患者为研究对象。采用随机数字表法将患者分为对照组和观察组,每组70例。对照组患者给予聚多卡醇泡沫硬化注射治疗,观察组患者给予改良套扎法联合聚多卡醇泡沫硬化注射治疗。比较2组患者的治疗效果、手术前后血清炎症因子[白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、肛门疼痛、肛门狭窄程度、肛门功能、生活质量、并发症发生率;术后随访6个月,统计比较2组患者复发情况。结果 术后3个月,对照组和观察组患者治愈率分别为72.86%(51/70)、88.57%(62/70),观察组患者治愈率显著高于对照组(χ^(2)=5.552,P<0.05)。术前,2组患者血清IL-1、IL-6、TNF-α水平比较差异无统计学意义(P>0.05);2组患者术后第1、3个月血清IL-1、IL-6、TNF-α水平显著低于术前(P<0.05);术后第3个月,2组患者血清IL-1、IL-6、TNF-α水平显著低于术后第1个月(P<0.05);术后第1、3个月,观察组患者血清IL-1、IL-6、TNF-α水平显著低于对照组(P<0.05)。术前,2组患者疼痛程度评分、狭窄程度比较差异无统计学意义(P>0.05);2组患者术后第3、7天肛门疼痛、狭窄程度评分显著低于术前(P<0.05);术后第3、7天,观察组患者肛门疼痛程度、狭窄程度评分显著低于对照组(P<0.05);术后第7天,2组患者肛门疼痛、狭窄程度评分显著低于术后第3天(P<0.05)。术前,2组患者大便失禁严重程度指数量表(FISI)评分比较差异无统计学意义(P>0.05);2组患者术后第1、3个月FISI评分显著低于术前(P<0.05);术后第1、3个月,观察组患者FISI评分显著低于对照组(P<0.05);术后第3个月,2组患者FISI评分显著低于术后第1个月(P<0.05)。术前,2组患者生活质量评分比较差异无统计学意义(P>0.05);2组患者术后第1、3、6个月生活质量评分显著高于术前(P<0.05);术后1、3、6个月,观察组患者生活质量评分显著高于对照组(P<0.05)。对照组和观察组患者术后并发症发生率分别为5.71%(4/70)、8.57%(6/70),2组患者术后并发症发生率比较差异无统计学意义(χ^(2)=0.431,P>0.05)。对照组和观察组患者术后复发率分别为5.88%(3/51)、1.61%(1/62),2组患者术后复发率比较差异无统计学意义(χ^(2)=0.505,P>0.05)。结论 改良套扎法联合聚多卡醇泡沫硬化注射治疗术能提高中青年Ⅱ~Ⅲ期内痔的临床疗效,减轻炎症反应,降低术后疼痛感,改善肛门功能、生活质量,安全性较好。 展开更多
关键词 改良套扎法 聚多卡醇泡沫硬化剂 内痔 治疗效果 肛门疼痛 炎症因子 狭窄程度
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光固化树脂钢丝固定法在外伤脱位再植前牙中的应用效果
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作者 朱永珍 崔国志 朱崇标 《中国当代医药》 2025年第19期76-81,共6页
目的 探究外伤脱位再植前牙进行光固化树脂钢丝固定法治疗的应用效果。方法 选取2021年11月至2023年11月清远市清新区人民医院收治的41例外伤脱位再植前牙患者作为研究对象,按照随机数字表法分为对照组(20例)与观察组(21例)。对照组采... 目的 探究外伤脱位再植前牙进行光固化树脂钢丝固定法治疗的应用效果。方法 选取2021年11月至2023年11月清远市清新区人民医院收治的41例外伤脱位再植前牙患者作为研究对象,按照随机数字表法分为对照组(20例)与观察组(21例)。对照组采用不锈钢丝结扎固定,观察组采用光固化树脂钢丝固定方法。比较两组治疗总有效率、牙周情况、并发症总发生率、口腔美学满意度。结果 两组治疗总有效率比较,差异无统计学意义(P>0.05)。观察组治疗后菌斑指数、出血指数、探诊深度及附着水平均低于对照组,并发症总发生率低于对照组,差异有统计学意义(P<0.05)。观察组对美观效果、色泽效果、外形效果、面容改善、自信心增强的满意度均高于对照组,差异有统计学意义(P<0.05)。结论 光固化树脂钢丝固定法在外伤脱位再植前牙的治疗中获得满意和安全的疗效,促进美观度和口腔功能改善,不易发生并发症。 展开更多
关键词 光固化树脂钢丝固定法 外伤脱位 再植前牙 不锈钢丝结扎
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新生儿脊髓性肌萎缩症筛查方法的建立与应用
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作者 王双 杨池菊 +5 位作者 蒋桂荣 陈西贵 周成 段宁宁 张雪利 周艳彬 《中国妇幼保健》 2025年第8期1505-1509,共5页
目的 建立新生儿滤纸干血斑基因组DNA自动化提取方法和流程,通过荧光定量PCR法检测运动神经元存活基因1(SMN1)外显子7(E7)和外显子8(E8)缺失情况,进行新生儿脊髓性肌萎缩症(SMA)筛查,探讨筛查方法的有效性和当地新生儿SMA基因携带和患... 目的 建立新生儿滤纸干血斑基因组DNA自动化提取方法和流程,通过荧光定量PCR法检测运动神经元存活基因1(SMN1)外显子7(E7)和外显子8(E8)缺失情况,进行新生儿脊髓性肌萎缩症(SMA)筛查,探讨筛查方法的有效性和当地新生儿SMA基因携带和患病情况。方法 选取2023年3—12月在济宁地区出生的10 942例新生儿进行SMA筛查。随机抽取80份新生儿干血斑样本,用于SMN1基因检测最低起始浓度测试。选择58例不同SMA基因型新生儿干血斑样本,同时应用荧光定量PCR法和多重连接探针扩增技术(MLPA)检测,进行方法学比较,验证筛查方法的有效性。结果 3片直径为3.2 mm的新生儿滤纸干血斑提取的DNA浓度为13.5~20.3 ng/μl,可满足SMN1检测要求。26例正常基因型、30例基因携带者和2例SMA患者的荧光定量PCR和MLPA检测结果一致,符合率均为100.00%。10 942例新生儿接受SMA筛查,检测到SMA携带者213例,携带率为1∶51。其中SMN1 E7杂合缺失伴SMN1 E8杂合缺失146例,占68.54%(146/213),单独SMN1 E7杂合缺失14例,占6.57%(14/213),单独SMN1 E8杂合缺失53例,占24.89%(53/213)。男女SMN1携带率差异无统计学意义(χ^(2)=1.09,P>0.05)。2例门诊SMA患儿未参加济宁市组织的新生儿SMA筛查,因出现相关症状来院就诊,SMA筛查结果提示为SMN1 E7和E8纯合缺失,MLPA检测SMN1拷贝数为0,运动神经元存活基因2(SMN2)拷贝数分别为2和3,均属SMAⅠ型。结论 建立了简便、快捷、准确的筛查方法,依托现有的新生儿筛查体系,开展全市新生儿SMA筛查,能够及早发现SMA基因携带者和患儿,为SMA的三级预防和早期干预提供依据。 展开更多
关键词 新生儿脊髓性肌萎缩症筛查 运动神经元存活基因1 荧光定量PCR法 多重连接探针扩增技术
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保留括约肌内口切除引流术治疗复杂性肛瘘的临床效果
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作者 王晓斌 《智慧健康》 2025年第2期63-66,共4页
目的探讨在复杂性肛瘘患者中采用保留括约肌内口切除引流术所取得的临床疗效。方法选取2023年3月—2024年3月本院收治的82例复杂性肛瘘患者选为研究对象,随机将其分为两组,每组41例。对照组采用肛门括约肌间瘘管结扎术;观察组采用保留... 目的探讨在复杂性肛瘘患者中采用保留括约肌内口切除引流术所取得的临床疗效。方法选取2023年3月—2024年3月本院收治的82例复杂性肛瘘患者选为研究对象,随机将其分为两组,每组41例。对照组采用肛门括约肌间瘘管结扎术;观察组采用保留括约肌内口切除引流术,比较两组的临床效果、肛门功能、住院时长、创面愈合时间、卧床时长和疼痛程度。结果相较于对照组,观察组治疗总有效率更高(P<0.05)。术后1个月,两组Wexner肛门失禁评分均较之术前降低,且观察组低于对照组(P<0.05)。观察组创面愈合时间、住院时间、卧床时间均短于对照组(P<0.05)。术后24 h、3 d和7 d,两组VAS评分均呈下降趋势,且观察组低于对照组(P<0.05)。结论在复杂性肛瘘患者中采用括约肌内口切除引流术,可缩短患者住院时间、卧床时间和疼痛持续时间,同时能加速创面愈合和改善肛门功能,获得显著疗效。 展开更多
关键词 视觉模拟评分法 保留括约肌内口切除引流术 复杂性肛瘘 肛门括约肌间瘘管结扎术 肛门功能
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Multi-point Contact of the High-speed Vehicle-turnout System Dynamics 被引量:5
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作者 REN Zunsong 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2013年第3期518-525,共8页
The wheel-rail contact problems, such as the number, location and the track of contact patches, are very important for optimizing the spatial structure of the rails and lowering the vehicle-turnout system dynamics. Ho... The wheel-rail contact problems, such as the number, location and the track of contact patches, are very important for optimizing the spatial structure of the rails and lowering the vehicle-turnout system dynamics. However, the above problems are not well solved currently because of having the difficulties in how to determine the multi-contact, to preciously present the changeable profiles of the rails and to establish an accurate spatial turnout system dynamics model. Based on a high-speed vehicle-turnout coupled model in which the track is modeled as flexible with rails and sleepers represented by beams, the line tracing extreme point method is introduced to investigate the wheel-rail multiple contact conditions and the key sections of the blade rail, longer nose rail, shorter rail in the switch and nose rail area are discretized to represent the varying profiles of rails in the turnout. The dynamic interaction between the vehicle and turnout is simulated for cases of the vehicle divergently passing the turnout and the multi-point contact is obtained. The tracks of the contact patches on the top of the rails are presented and the wheel-rail impact forces are offered in comparison with the contact patches transference on the rails. The numerical simulation results indicate that the length of two-point contact occurrence of a worn wheel profile and rails is longer than that of the new wheel profile and rails; The two-point contact definitely occurs in the switch and crossing area. Generally, three-point contact doesn’t occur for the new rail profile, which is testified by the wheel-rails interpolation distance and the first order derivative function of the tracing line extreme points. The presented research is not only helpful to optimize the structure of the turnout, but also useful to lower the dynamics of the high speed vehicle-turnout system. 展开更多
关键词 line tracing extreme point method multi-point contact high-speed vehicle-turnout system track of contact point on rails wheel-rail force transference
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An efficient SPH methodology for modelling mechanical characteristics of particulate composites 被引量:1
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作者 Z.J.Zheng S.Kulasegaram +1 位作者 P.Chen Y.Q.Chen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2021年第1期135-146,共12页
Particulate composites are one of the widely used materials in producing numerous state-of-the-art components in biomedical,automobile,aerospace including defence technology.Variety of modelling techniques have been a... Particulate composites are one of the widely used materials in producing numerous state-of-the-art components in biomedical,automobile,aerospace including defence technology.Variety of modelling techniques have been adopted in the past to model mechanical behaviour of particulate composites.Due to their favourable properties,particle-based methods provide a convenient platform to model failure or fracture of these composites.Smooth particle hydrodynamics(SPH)is one of such methods which demonstrate excellent potential for modelling failure or fracture of particulate composites in a Lagrangian setting.One of the major challenges in using SPH method for modelling composite materials depends on accurate and efficient way to treat interface and boundary conditions.In this paper,a masterslave method based multi-freedom constraints is proposed to impose essential boundary conditions and interfacial displacement constraints in modelling mechanical behaviour of composite materials using SPH method.The proposed methodology enforces the above constraints more accurately and requires only smaller condition number for system stiffness matrix than the procedures based on typical penalty function approach.A minimum cut-off value-based error criteria is employed to improve the computational efficiency of the proposed methodology.In addition,the proposed method is further enhanced by adopting a modified numerical interpolation scheme along the boundary to increase the accuracy and computational efficiency.The numerical examples demonstrate that the proposed master-slave approach yields better accuracy in enforcing displacement constraints and requires approximately the same computational time as that of penalty method. 展开更多
关键词 Particulate composites SPH Essential boundary condition multi-point constraints Master-slave method
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A Compact Difference Scheme for Multi-point Boundary Value Problems of Heat Equations
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作者 Xuping Wang Zhizhong Sun 《Communications on Applied Mathematics and Computation》 2019年第4期545-563,共19页
In this paper,a compact difference scheme is established for the heat equations with multi-point boundary value conditions.The truncation error of the difference scheme is O(τ2+h^4),where t and h are the temporal ste... In this paper,a compact difference scheme is established for the heat equations with multi-point boundary value conditions.The truncation error of the difference scheme is O(τ2+h^4),where t and h are the temporal step size and the spatial step size.A prior estimate of the difference solution in a weighted norm is obtained.The unique solvability,stability and convergence of the difference scheme are proved by the energy method.The theoretical statements for the solution of the difference scheme are supported by numerical examples. 展开更多
关键词 Heat EQUATION - multi-point BOUNDARY VALUE CONDITION COMPACT DIFFERENCE scheme Energy method
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腹腔镜胆囊切除术中改良结扎法的临床应用效果及安全性 被引量:1
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作者 李宗倍 吴畏 +1 位作者 安宏超 李华志 《中外医学研究》 2024年第22期1-5,共5页
目的:研究腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)中改良结扎法的临床应用效果及安全性。方法:选取2022年1月—2023年12月北京市垂杨柳医院收治的98例LC患者。根据电脑编号奇偶数字法随机将其分为改良组(n=49)及传统组(n=49... 目的:研究腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)中改良结扎法的临床应用效果及安全性。方法:选取2022年1月—2023年12月北京市垂杨柳医院收治的98例LC患者。根据电脑编号奇偶数字法随机将其分为改良组(n=49)及传统组(n=49)。改良组LC中实施改良结扎法,传统组LC中实施传统结扎法。比较两组围手术期指标,并发症,术前1 d及术后3 d肝功能指标、炎症因子。结果:改良组手术时长短于传统组,差异有统计学意义(P<0.05)。两组腹腔出血、胆漏及切口感染发生率比较,差异无统计学意义(P>0.05)。术后3 d,两组丙氨酸转氨酶(alanine transaminase,ALT)、天冬氨酸转氨酶(aspartate transaminase,AST)及总胆红素(total bilirubin,TBIL)水平均高于术前1 d,改良组ALT、AST、TBIL水平均低于传统组,差异有统计学意义(P<0.05)。术后3 d,两组白细胞介素-6(interleukin-6,IL-6)、降钙素原(procalcitonin,PCT)及C反应蛋白(C-reactive protein,CRP)水平均高于术前1 d,改良组IL-6、PCT、CRP水平均低于传统组,差异有统计学意义(P<0.05)。结论:改良结扎法应用于LC中安全可行,且能减轻对患者肝功能与炎症反应的影响。 展开更多
关键词 腹腔镜胆囊切除术 改良结扎法 应用效果 安全性 炎症因子
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解剖区段挂线术治疗高位马蹄形肛瘘:一项长期随访的临床对照研究 被引量:2
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作者 徐进 毛畅 +5 位作者 张俊 叶倩倩 黄烃 吴闯 赵文俊 汪庆明 《安徽医药》 CAS 2024年第9期1819-1823,共5页
目的比较解剖区段挂线术与传统切开挂线术治疗高位马蹄形肛瘘在长期随访过程中的临床疗效。方法前瞻性对照研究。选择2019年3月至2020年6月于上海中医药大学附属曙光医院肛肠科接受手术治疗的86例高位马蹄形肛瘘病人,依据随机数字表法... 目的比较解剖区段挂线术与传统切开挂线术治疗高位马蹄形肛瘘在长期随访过程中的临床疗效。方法前瞻性对照研究。选择2019年3月至2020年6月于上海中医药大学附属曙光医院肛肠科接受手术治疗的86例高位马蹄形肛瘘病人,依据随机数字表法分为治疗组(解剖区段挂线术组,n=43)与对照组(传统切开挂线术组,n=43)。随访时间31~44个月(中位随访时间36个月),比较两组在术中及术后并发症情况、创面愈合及复发情况以及卫生经济学指标方面的差异。结果两组病人的一般资料情况及肛瘘既往手术史,肛瘘解剖学特征情况(肛瘘分型与内口情况等)比较差异无统计学意义(均P>0.05)。治疗组治愈率86%(37/43)高于对照组治愈率76.7%(33/43),但差异无统计学意义(P>0.05)。治疗组术中出血为15(15,20)mL小于对照组20(20,25)mL(P<0.05);治疗组术后疼痛评分[视觉模拟评分法(VAS)评分]及肛门失禁严重程度(Wexner)评分分别为2(0,3)分、0(0,0)分均优于对照组[4(2,5)分,0(0,2)分](均P<0.05);治疗组手术时间、住院时间及创面愈合时间分别为(27.67±4.85)min、6(4,7)d、(6.78±2.00)周均明显小于对照组[(32.67±7.27)min、7(6,10)d、(8.10±2.12)周](均P<0.05)。结论解剖区段挂线术能有效治愈高位马蹄形肛瘘,相较于传统切开挂线术,解剖区段挂线术治疗高位马蹄形肛瘘具有保护肛门功能、减少术中及术后并发症、缩短创面愈合时间及住院时间等方面的优势,是一种安全有效的肛门括约肌保护术式。 展开更多
关键词 肛瘘 挂线法 解剖区段挂线术 传统切开挂线术 大便失禁 肛门括约肌保护
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两种确定肺段间平面的胸腔镜精准肺段切除术的临床对照研究
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作者 陈大庆 詹必成 +1 位作者 周新涛 陈剑 《局解手术学杂志》 2024年第3期264-267,共4页
目的 比较单纯动脉结扎法与改良膨胀萎陷法在胸腔镜精准肺段切除术中确定肺段间平面的应用效果。方法 前瞻性纳入2021年8月至2023年2月于本院行胸腔镜精准肺段切除术的80例患者,采用随机数字表法将患者分为观察组和对照组,每组40例。观... 目的 比较单纯动脉结扎法与改良膨胀萎陷法在胸腔镜精准肺段切除术中确定肺段间平面的应用效果。方法 前瞻性纳入2021年8月至2023年2月于本院行胸腔镜精准肺段切除术的80例患者,采用随机数字表法将患者分为观察组和对照组,每组40例。观察组患者采用单纯动脉结扎法确定肺段间平面,对照组患者采用改良膨胀萎陷法确定肺段间平面。比较2组患者围术期相关指标、肺功能指标、术后并发症及随访情况。结果 观察组患者手术时间及术中出血量均显著短/少于对照组(P<0.05);而2组患者段间平面显现时间、术后总引流量、引流管留置时间、术后住院时间及肺段切除分布情况比较,差异均无统计学意义(P>0.05)。术后2组患者用力肺活量占预计值百分比(FVC%pred)、第1秒用力呼气容积占预计值百分比(FEV1%pred)较术前均显著降低(P<0.05),且观察组患者术后FVC%pred、FEV1%pred显著高于对照组(P<0.05)。2组患者术后各并发症的发生情况比较,差异均无统计学意义(P>0.05)。随访期间所有患者均未出现死亡、肿瘤局部复发或远处转移情况。结论 在胸腔镜精准肺段切除术中应用单纯动脉结扎法确定段间平面较改良膨胀萎陷法具有操作简便、损伤小、对患者肺功能影响小等显著优势,安全性较高,是一种可行且有效的技术。 展开更多
关键词 段间平面 胸腔镜 肺段切除术 改良膨胀萎陷法 单纯动脉结扎法
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