The paper aims to present a comparison of visitor behaviors and visitor spatial and temporal distribution in a mountain national park between the pre-Covid-19 period(2017-2019)and Covid-19 pandemic year(2020).The rese...The paper aims to present a comparison of visitor behaviors and visitor spatial and temporal distribution in a mountain national park between the pre-Covid-19 period(2017-2019)and Covid-19 pandemic year(2020).The research is based on pyroelectric sensor data from 2017-2020 and a survey of visitors designed to assess the spatial and temporal distribution of visitors and their behaviors and changes therein.The research data were used to identify two visitor clusters:Impact of Covid-19(IC)and No-Impact of Covid-19(N-IC).The research was conducted in Stolowe Mountains National Park(SMNP)in Poland using data from Monitoring System of tourist traffic(MSTT).A total of 374 respondents participated in the survey in 2020 period,which demonstrated a significant impact of the ongoing pandemic on many aspects of their behavior.These results were compared with the results obtained from 2,642 surveys carried out in 2017-2019.The findings are compared to findings reported by other authors.Some visitors did claim that the pandemic has not affected their behavior in any way.展开更多
目的探讨急性缺血性脑卒中患者早期铁死亡相关蛋白表达与神经功能恶化和预后的潜在联系。方法选取2020年1月~2022年12月中国人民解放军联勤保障部队第966医院收治的190例发病7天内的急性缺血性卒中患者作为研究对象。入院后24h内采集静...目的探讨急性缺血性脑卒中患者早期铁死亡相关蛋白表达与神经功能恶化和预后的潜在联系。方法选取2020年1月~2022年12月中国人民解放军联勤保障部队第966医院收治的190例发病7天内的急性缺血性卒中患者作为研究对象。入院后24h内采集静脉血样,采用ELISA方法检测血浆中神经丝轻链(NfL)、4-羟基-2-壬烯醛(4-HNE)、8-羟基-2’-脱氧鸟苷(8-oxo-dG)和铁蛋白(Ft)的水平,通过公式计算铁死亡模型评分:-100×NfL+20×4-HNE+17×8-oxo-dG+170×Ft。以卒中发作后3个月的改良Rankin评分(mRS)来评估短期结局,将患者分为预后良好组(mRS≤2,n=136)和预后不良组(mRS≥3,n=54)。比较两组临床特征及铁死亡模型评分的差异,采用Logistic回归分析急性缺血性卒中患者3个月不良结局的影响因素。Spearman相关性分析铁死亡模型评分与美国国立卫生研究院卒中量表(NIHSS)评分的相关性。ROC曲线分析铁死亡模型评分预测急性缺血性卒中患者3个月不良结局的能力。结果与预后良好组相比,预后不良组的4-HNE水平(22.92±4.14ng/ml vs 21.06±2.57ng/ml),8-oxo-dG水平(7.00±1.05ng/ml vs 6.40±0.75ng/ml)和铁死亡模型评分(109.93±11.01 vs 90.44±6.67)均显著升高,NfL水平(91.83±5.20ng/ml vs 93.65±4.74ng/ml)显著降低,差异具有统计学意义(t=2.328~14.906,均P<0.05)。铁死亡模型评分(OR=1.633,95%CI=1.326~2.011)和白蛋白(Alb)(OR=63.266,95%CI=5.581~717.214)是急性缺血性卒中患者3个月不良结局的独立影响因素。相关性分析显示,铁死亡模型评分与入院时NIHSS评分、出院时NIHSS评分呈正相关(r=0.165、0.178,均P<0.05)。当铁死亡模型评分截断值为95.5时,其预测急性缺血性脑卒中患者3个月不良结局的AUC为0.931,敏感度为90.7%,特异度为75.0%。结论铁死亡模型评分与缺血性脑卒中后不良结局相关,并可用于预测患者的短期预后。展开更多
文摘The paper aims to present a comparison of visitor behaviors and visitor spatial and temporal distribution in a mountain national park between the pre-Covid-19 period(2017-2019)and Covid-19 pandemic year(2020).The research is based on pyroelectric sensor data from 2017-2020 and a survey of visitors designed to assess the spatial and temporal distribution of visitors and their behaviors and changes therein.The research data were used to identify two visitor clusters:Impact of Covid-19(IC)and No-Impact of Covid-19(N-IC).The research was conducted in Stolowe Mountains National Park(SMNP)in Poland using data from Monitoring System of tourist traffic(MSTT).A total of 374 respondents participated in the survey in 2020 period,which demonstrated a significant impact of the ongoing pandemic on many aspects of their behavior.These results were compared with the results obtained from 2,642 surveys carried out in 2017-2019.The findings are compared to findings reported by other authors.Some visitors did claim that the pandemic has not affected their behavior in any way.
文摘目的探讨急性缺血性脑卒中患者早期铁死亡相关蛋白表达与神经功能恶化和预后的潜在联系。方法选取2020年1月~2022年12月中国人民解放军联勤保障部队第966医院收治的190例发病7天内的急性缺血性卒中患者作为研究对象。入院后24h内采集静脉血样,采用ELISA方法检测血浆中神经丝轻链(NfL)、4-羟基-2-壬烯醛(4-HNE)、8-羟基-2’-脱氧鸟苷(8-oxo-dG)和铁蛋白(Ft)的水平,通过公式计算铁死亡模型评分:-100×NfL+20×4-HNE+17×8-oxo-dG+170×Ft。以卒中发作后3个月的改良Rankin评分(mRS)来评估短期结局,将患者分为预后良好组(mRS≤2,n=136)和预后不良组(mRS≥3,n=54)。比较两组临床特征及铁死亡模型评分的差异,采用Logistic回归分析急性缺血性卒中患者3个月不良结局的影响因素。Spearman相关性分析铁死亡模型评分与美国国立卫生研究院卒中量表(NIHSS)评分的相关性。ROC曲线分析铁死亡模型评分预测急性缺血性卒中患者3个月不良结局的能力。结果与预后良好组相比,预后不良组的4-HNE水平(22.92±4.14ng/ml vs 21.06±2.57ng/ml),8-oxo-dG水平(7.00±1.05ng/ml vs 6.40±0.75ng/ml)和铁死亡模型评分(109.93±11.01 vs 90.44±6.67)均显著升高,NfL水平(91.83±5.20ng/ml vs 93.65±4.74ng/ml)显著降低,差异具有统计学意义(t=2.328~14.906,均P<0.05)。铁死亡模型评分(OR=1.633,95%CI=1.326~2.011)和白蛋白(Alb)(OR=63.266,95%CI=5.581~717.214)是急性缺血性卒中患者3个月不良结局的独立影响因素。相关性分析显示,铁死亡模型评分与入院时NIHSS评分、出院时NIHSS评分呈正相关(r=0.165、0.178,均P<0.05)。当铁死亡模型评分截断值为95.5时,其预测急性缺血性脑卒中患者3个月不良结局的AUC为0.931,敏感度为90.7%,特异度为75.0%。结论铁死亡模型评分与缺血性脑卒中后不良结局相关,并可用于预测患者的短期预后。
