Background Increased backfat thickness of sows in early gestation is negative to reproductive performance.Endometrial receptivity is an important determinant of reproductive success,but it is unclear whether the effec...Background Increased backfat thickness of sows in early gestation is negative to reproductive performance.Endometrial receptivity is an important determinant of reproductive success,but it is unclear whether the effect of sow backfat thickness on litter size is associated with endometrial receptivity and whether melatonin treatment may have benefits.The present study seeks to answer these questions through in vitro and in vivo investigations.Results Excessive lipid deposition and lower melatonin levels in the uterus are detrimental to endometrial receptivity and embryo implantation in high backfat thickness sows.In cells treated with melatonin,the MT2/PI3K/LIF axis played a role in reducing lipid accumulation in porcine endometrial epithelium cells and improved endometrial receptivity.Furthermore,we found a reduction of lipids in the uterus after eight weeks of intraperitoneal administration of melatonin to HFD mice.Notably,melatonin treatment caused a significant reduction in the deposition of endometrial collagen,an increase in the number of glands,and repair of the pinopode structure,ultimately improving endometrial receptivity,promoting embryo implantation,and increasing the number of litter size of mice.Conclusions Collectively,the finding reveals the harmful effects of high backfat thickness sows on embryo implantation and highlight the role of melatonin and the MT2/PI3K/LIF axis in improving endometrial receptivity by enhancing metabolism and reducing the levels of uterine lipids in obese animals.展开更多
The preservation condition of historical buildings is closely related to their ventilation environment.This study focuses on the rock temples in Wudang Mountain,specifically comparing the ventilation conditions of Yin...The preservation condition of historical buildings is closely related to their ventilation environment.This study focuses on the rock temples in Wudang Mountain,specifically comparing the ventilation conditions of Yinxian Rock and Huayang Rock.The following conclusions are drawn:(1)The main wind direction at Yinxian Rock aligns with its orientation,which is an easterly wind,while Huayang Rock experiences a westerly wind,deviating from its southwestern entrance;(2)Huayang Rock has significantly lower wind speeds compared to Yinxian Rock,with minimal airflow;(3)The surrounding environment of Huayang Rock features steep terrain,dense tree cover,and the presence of railings and other structures that impede wind entry into the cave,whereas Yinxian Rock is surrounded by fewer trees and has a flat terrain;(4)In terms of cave morphology,Yinxian Rock is completely open on the east side,while Huayang Rock's opening accounts for only half of its area and is not directly aligned with the rock temple.In summary,Huayang Rock's ventilation environment is inferior to that of Yinxian Rock,leading to more severe pathologies.It is inferred that Huayang Rock's preservation issues are closely related to its poor ventilation environment.Therefore,improving its ventilation conditions is crucial for preventive conservation.Using environmental simulation,this study compares the ventilation conditions of Huayang Rock under different wind directions and speeds,identifies the two most ideal scenarios,and proposes several feasible solutions.展开更多
From October 25 to October 28,2025 International Travel Agency Cooperation and Exchange Activities,an important part of the 2025 International Wudang Tai Chi Culture Festival,was successfully held in Wudang Mountain.W...From October 25 to October 28,2025 International Travel Agency Cooperation and Exchange Activities,an important part of the 2025 International Wudang Tai Chi Culture Festival,was successfully held in Wudang Mountain.With the theme of"Zhiyin Hubei,Alliance at Wudang",about 280 representatives from world tourist organizations such as World Tourism Cities Federation and the Pacific Asia Travel Association,as well as China Tourism Association,participated in the event,covering 17 countries and regions including the United States,Spain,Russia,Germany,etc.展开更多
基金supported by the China Agriculture Research System(CARS-35-PIG)the National Natural Science Foundation of China(32272847,U22A20516)+1 种基金the National Key Research and Development Program of China(No.2021YFF1000602)the Key Research and Development Program of Shaanxi Province(No.2022ZDLNY01–04)。
文摘Background Increased backfat thickness of sows in early gestation is negative to reproductive performance.Endometrial receptivity is an important determinant of reproductive success,but it is unclear whether the effect of sow backfat thickness on litter size is associated with endometrial receptivity and whether melatonin treatment may have benefits.The present study seeks to answer these questions through in vitro and in vivo investigations.Results Excessive lipid deposition and lower melatonin levels in the uterus are detrimental to endometrial receptivity and embryo implantation in high backfat thickness sows.In cells treated with melatonin,the MT2/PI3K/LIF axis played a role in reducing lipid accumulation in porcine endometrial epithelium cells and improved endometrial receptivity.Furthermore,we found a reduction of lipids in the uterus after eight weeks of intraperitoneal administration of melatonin to HFD mice.Notably,melatonin treatment caused a significant reduction in the deposition of endometrial collagen,an increase in the number of glands,and repair of the pinopode structure,ultimately improving endometrial receptivity,promoting embryo implantation,and increasing the number of litter size of mice.Conclusions Collectively,the finding reveals the harmful effects of high backfat thickness sows on embryo implantation and highlight the role of melatonin and the MT2/PI3K/LIF axis in improving endometrial receptivity by enhancing metabolism and reducing the levels of uterine lipids in obese animals.
基金Supported by the National Natural Science Foundation of China(Grant No.52278042)for the research on"Architectural issue mechanisms and defense of architectural heritage under harsh environments-Taking the rock temples of Wudang Mountain as an example."。
文摘The preservation condition of historical buildings is closely related to their ventilation environment.This study focuses on the rock temples in Wudang Mountain,specifically comparing the ventilation conditions of Yinxian Rock and Huayang Rock.The following conclusions are drawn:(1)The main wind direction at Yinxian Rock aligns with its orientation,which is an easterly wind,while Huayang Rock experiences a westerly wind,deviating from its southwestern entrance;(2)Huayang Rock has significantly lower wind speeds compared to Yinxian Rock,with minimal airflow;(3)The surrounding environment of Huayang Rock features steep terrain,dense tree cover,and the presence of railings and other structures that impede wind entry into the cave,whereas Yinxian Rock is surrounded by fewer trees and has a flat terrain;(4)In terms of cave morphology,Yinxian Rock is completely open on the east side,while Huayang Rock's opening accounts for only half of its area and is not directly aligned with the rock temple.In summary,Huayang Rock's ventilation environment is inferior to that of Yinxian Rock,leading to more severe pathologies.It is inferred that Huayang Rock's preservation issues are closely related to its poor ventilation environment.Therefore,improving its ventilation conditions is crucial for preventive conservation.Using environmental simulation,this study compares the ventilation conditions of Huayang Rock under different wind directions and speeds,identifies the two most ideal scenarios,and proposes several feasible solutions.
文摘From October 25 to October 28,2025 International Travel Agency Cooperation and Exchange Activities,an important part of the 2025 International Wudang Tai Chi Culture Festival,was successfully held in Wudang Mountain.With the theme of"Zhiyin Hubei,Alliance at Wudang",about 280 representatives from world tourist organizations such as World Tourism Cities Federation and the Pacific Asia Travel Association,as well as China Tourism Association,participated in the event,covering 17 countries and regions including the United States,Spain,Russia,Germany,etc.
