Type-Ⅱ InAs/GaSb superlattiees made of 13 InAs monolayers （MLs） and 7 GaSb MLs are grown on GaSb substrates by solid source molecular beam epitaxy. To obtain lattice-matched structures, thin InSb layers are inserte...Type-Ⅱ InAs/GaSb superlattiees made of 13 InAs monolayers （MLs） and 7 GaSb MLs are grown on GaSb substrates by solid source molecular beam epitaxy. To obtain lattice-matched structures, thin InSb layers are inserted between InAs and GaSb layers. We complete a series of experiments to investigate the influence of the InSb deposition time, Ⅴ/Ⅲ beam-equivalent pressure ratio and interruption time between each layer, and then characterize the superlattice （SL） structures with high-resolution x-ray diffraction and atomic force microscopy. The optimized growth parameters are applied to grow the 100-period SL structure, resulting in the full-width half-maximum of 29.55 arcsee for the first SL satellite peak and zero lattice-mismatch between the zero-order SL peak and the GaSb substrate peak.展开更多
Background: There are few clinical trials addressing the difference in pleiotropic effects among dipeptidyl peptidase (DPP)-4 inhibitors. We aimed to identify difference in effects on biochemical markers of inflammati...Background: There are few clinical trials addressing the difference in pleiotropic effects among dipeptidyl peptidase (DPP)-4 inhibitors. We aimed to identify difference in effects on biochemical markers of inflammation, oxidative stress, and atherosclerosis between two DPP-4 inhibitors in patients with type 2 diabetes. Methods: We prospectively observed twenty subjects with type 2 diabetes before and after a practical medication change from a treatment with pioglitazone and sitagliptin 50 mg to a combination tablet containing the same dose of pioglitazone and alogliptin 25mg, which was actually identical to switching from sitagliptin to alogliptin. After 3 months, changes from baseline in clinical data and various biochemical markers were evaluated. In particular, body mass index (BMI) and hemoglobin A1c (HbA1c) were additionally followed after 12 months for evaluation of chronic outcomes. Results: Among markers, serum levels of high molecular weight (HMW) adiponectin significantly increased from 6.9 ± 3.6 μg/ml to 8.2 ± 4.0 μg/ml (P = 0.0045). Although no clinical data changed after 3 months, significant improvements in HbA1c and BMI were observed after 12 months. Their rates of changes tended to inversely correlate with the increased percentages of serum HMW adiponectin levels during initial 3 months, but they did not reach statistical significance. Conclusions: In spite of pretreatment with pioglitazone, additional increase in serum HMW adiponectin levels was demonstrated after switching from sitagliptin to alogliptin. Given multiple favorable roles of adiponectin in metabolic and cardiovascular states, alogliptin, at least when combined with pioglitazone, would be beneficial in treatment of type 2 diabetes.展开更多
The new crystalline V-Ti-silicalite with mesoporous MCM-41 type molecular sieve structure is synthesized hydrothermally; The framework IR spectra associated with ESR, Si-29 MAS NMR, DRS and XPS data shows that V and T...The new crystalline V-Ti-silicalite with mesoporous MCM-41 type molecular sieve structure is synthesized hydrothermally; The framework IR spectra associated with ESR, Si-29 MAS NMR, DRS and XPS data shows that V and Ti are simultaneously incorporated into V-TiMCM-41 framework.展开更多
Molecular dynamics simulation was adopted to study the interaction between sulfosalicylic acid and aluminum,lanthanum and yttrium,and adsorption on kaolinite surfaces.A complexation reaction occurs between sulfosalicy...Molecular dynamics simulation was adopted to study the interaction between sulfosalicylic acid and aluminum,lanthanum and yttrium,and adsorption on kaolinite surfaces.A complexation reaction occurs between sulfosalicylic acid and aluminum,with an interaction energy of-10472.05 kJ/mol.O—Al covalent bonds are formed with a peak value of 7.93,while there is only weak adsorption between sulfosalicylic acid and rare earth ions.A hydrogen bonding reaction with 13605.82 kJ/mol energy occurs between sulfosalicylic acid and the surface of kaolinite(100).Thus,sulfosalicylic acid can form a complex with free aluminum ions,and can also be adsorbed on kaolinite by hydrogen bonding with aluminum in kaolinite(100)surfaces.Leaching of ion-adsorbed type rare earth ore was performed with aluminum inhibited,results show that when sulfosalicylic acid dosage increases from 0 to 0.15 wt%,aluminum ion concentration in the leaching solution decreases from 273.23 to 47.19 mg/L.And the effect of leaching pH value on the effect of sulfosalicylic acid on aluminum inhibition was studied,the result shows that,when the leaching pH value is 4.0—5.0,the rare earth leaching rate and the aluminum ion concentration basically remain unchanged.The molecular dynamics simulation results were verified by detection and analysis of XPS and SEM.展开更多
目的了解丰台区食源性疾病监测中副溶血性弧菌流行状况、可疑食品、血清型、毒力基因、耐药及分子分型情况。方法对2016—2024年丰台区3家哨点医院粪便标本中检出的180株副溶血性弧菌进行流行病学分析及病原学相关检测。结果副溶血性弧...目的了解丰台区食源性疾病监测中副溶血性弧菌流行状况、可疑食品、血清型、毒力基因、耐药及分子分型情况。方法对2016—2024年丰台区3家哨点医院粪便标本中检出的180株副溶血性弧菌进行流行病学分析及病原学相关检测。结果副溶血性弧菌感染率由11.67%降至4.66%,男女间有显著差异,血清型由O3:K6型转变为O10:K4型,tdh+trh-毒力基因型占96.11%,食用海产品与副溶血性弧菌感染高度相关;副溶血性弧菌对氨苄西林(ampicillin,AMP)耐药率最高为45.00%,其他抗生素耐药率均低于5.00%,多重耐药率较低,脉冲场凝胶电泳(pulsed-field gel electrophoresis,PFGE)分型得到63种带型,其中19种带型相似度为100.00%。结论丰台区副溶血性弧菌检出率有下降趋势,血清型转变且趋于单一化,毒力基因型变化较小,引起副溶血性弧菌感染的食品为海产品;副溶血性弧菌耐药情况不严重,多重耐药较轻;分子分型聚类相对离散,但聚集疫情发生的风险仍然较高。展开更多
基金Supported by the National Basic Research Program of China under Grant Nos 2015CB351902,2015CB932402 and 2012CB619203the National Natural Science Foundation of China under Grant Nos 61177070,11374295 and U1431231the National Key Research Program of China under Grant No 2011ZX01015-001
文摘Type-Ⅱ InAs/GaSb superlattiees made of 13 InAs monolayers （MLs） and 7 GaSb MLs are grown on GaSb substrates by solid source molecular beam epitaxy. To obtain lattice-matched structures, thin InSb layers are inserted between InAs and GaSb layers. We complete a series of experiments to investigate the influence of the InSb deposition time, Ⅴ/Ⅲ beam-equivalent pressure ratio and interruption time between each layer, and then characterize the superlattice （SL） structures with high-resolution x-ray diffraction and atomic force microscopy. The optimized growth parameters are applied to grow the 100-period SL structure, resulting in the full-width half-maximum of 29.55 arcsee for the first SL satellite peak and zero lattice-mismatch between the zero-order SL peak and the GaSb substrate peak.
文摘Background: There are few clinical trials addressing the difference in pleiotropic effects among dipeptidyl peptidase (DPP)-4 inhibitors. We aimed to identify difference in effects on biochemical markers of inflammation, oxidative stress, and atherosclerosis between two DPP-4 inhibitors in patients with type 2 diabetes. Methods: We prospectively observed twenty subjects with type 2 diabetes before and after a practical medication change from a treatment with pioglitazone and sitagliptin 50 mg to a combination tablet containing the same dose of pioglitazone and alogliptin 25mg, which was actually identical to switching from sitagliptin to alogliptin. After 3 months, changes from baseline in clinical data and various biochemical markers were evaluated. In particular, body mass index (BMI) and hemoglobin A1c (HbA1c) were additionally followed after 12 months for evaluation of chronic outcomes. Results: Among markers, serum levels of high molecular weight (HMW) adiponectin significantly increased from 6.9 ± 3.6 μg/ml to 8.2 ± 4.0 μg/ml (P = 0.0045). Although no clinical data changed after 3 months, significant improvements in HbA1c and BMI were observed after 12 months. Their rates of changes tended to inversely correlate with the increased percentages of serum HMW adiponectin levels during initial 3 months, but they did not reach statistical significance. Conclusions: In spite of pretreatment with pioglitazone, additional increase in serum HMW adiponectin levels was demonstrated after switching from sitagliptin to alogliptin. Given multiple favorable roles of adiponectin in metabolic and cardiovascular states, alogliptin, at least when combined with pioglitazone, would be beneficial in treatment of type 2 diabetes.
文摘The new crystalline V-Ti-silicalite with mesoporous MCM-41 type molecular sieve structure is synthesized hydrothermally; The framework IR spectra associated with ESR, Si-29 MAS NMR, DRS and XPS data shows that V and Ti are simultaneously incorporated into V-TiMCM-41 framework.
基金Project supported by the National Natural Science Foundation of China,(51674125,51604128)Outstanding Doctoral Dissertation Project Fund of JXUST(YB2016001)
文摘Molecular dynamics simulation was adopted to study the interaction between sulfosalicylic acid and aluminum,lanthanum and yttrium,and adsorption on kaolinite surfaces.A complexation reaction occurs between sulfosalicylic acid and aluminum,with an interaction energy of-10472.05 kJ/mol.O—Al covalent bonds are formed with a peak value of 7.93,while there is only weak adsorption between sulfosalicylic acid and rare earth ions.A hydrogen bonding reaction with 13605.82 kJ/mol energy occurs between sulfosalicylic acid and the surface of kaolinite(100).Thus,sulfosalicylic acid can form a complex with free aluminum ions,and can also be adsorbed on kaolinite by hydrogen bonding with aluminum in kaolinite(100)surfaces.Leaching of ion-adsorbed type rare earth ore was performed with aluminum inhibited,results show that when sulfosalicylic acid dosage increases from 0 to 0.15 wt%,aluminum ion concentration in the leaching solution decreases from 273.23 to 47.19 mg/L.And the effect of leaching pH value on the effect of sulfosalicylic acid on aluminum inhibition was studied,the result shows that,when the leaching pH value is 4.0—5.0,the rare earth leaching rate and the aluminum ion concentration basically remain unchanged.The molecular dynamics simulation results were verified by detection and analysis of XPS and SEM.
文摘目的了解丰台区食源性疾病监测中副溶血性弧菌流行状况、可疑食品、血清型、毒力基因、耐药及分子分型情况。方法对2016—2024年丰台区3家哨点医院粪便标本中检出的180株副溶血性弧菌进行流行病学分析及病原学相关检测。结果副溶血性弧菌感染率由11.67%降至4.66%,男女间有显著差异,血清型由O3:K6型转变为O10:K4型,tdh+trh-毒力基因型占96.11%,食用海产品与副溶血性弧菌感染高度相关;副溶血性弧菌对氨苄西林(ampicillin,AMP)耐药率最高为45.00%,其他抗生素耐药率均低于5.00%,多重耐药率较低,脉冲场凝胶电泳(pulsed-field gel electrophoresis,PFGE)分型得到63种带型,其中19种带型相似度为100.00%。结论丰台区副溶血性弧菌检出率有下降趋势,血清型转变且趋于单一化,毒力基因型变化较小,引起副溶血性弧菌感染的食品为海产品;副溶血性弧菌耐药情况不严重,多重耐药较轻;分子分型聚类相对离散,但聚集疫情发生的风险仍然较高。
