摘要
目的分析大连市伤寒、副伤寒的流行特征和分子分型,为制定有效的伤寒、副伤寒防控措施提供科学依据。方法采用描述流行病学方法对大连市2019—2023年报告的伤寒、副伤寒数据进行分析,并采用脉冲场凝胶电泳(PFGE)的方法对菌株同源性进行聚类分析。结果2019—2023年大连市共报告伤寒、副伤寒病例32例,各年份之间发病率差异无统计学意义(χ^(2)=4.41,P>0.05);时间分布上呈现两个波峰;发病年龄集中在30~69岁,男女性别比例差异有统计学意义(χ^(2)=4.00,P<0.05);伤寒、副伤寒发病例数居前两位的为离退人员、家务及待业,各职业间发病率差异无统计学意义(χ^(2)=4.59,P>0.05)。PFGE实验结果显示32株伤寒、副伤寒菌株可分为25个型别。结论2019—2023年大连地区伤寒疫情稳定在相对较低的流行水平,PFGE带型较为分散,但是其中存在着优势分型,有可能是当地的流行菌株。
Objective To analyze the epidemiological characteristics and molecular subtypes of typhoid and paratyphoid fever in Dalian,and to provide scientific basis for the development of effective prevention and control measures for typhoid and paratyphoid fever.Methods Descriptive epidemiological methods were used to analyze the data of typhoid and paratyphoid reported in Dalian from 2019 to 2023.Pulsed field gel electrophoresis(PFGE)was used for bacterial molecular typing and cluster analysis of the homology of strains.Results A total of 32 cases of typhoid and paratyphoid fever were reported in Dalian from 2019 to 2023.There was no statistically significant difference in the incidence rate between years(χ^(2)=4.41,P>0.05).There were two peaks in the time distribution.The age of onset was between 30 and 69 years old,and the difference in sex ratio between men and women was statistically significant(χ^(2)=4.00,P<0.05).The top two occupations with the highest number of cases of typhoid and paratyphoid fever were retired people,housework and unemployed,and the difference in the incidence rate among occupations was not statistically significant(χ^(2)=4.59,P>0.05).PFGE experiment results showed that 32 typhoid and paratyphoid strains isolated from patients can be divided into 25 types.Conclusion The typhoid fever epidemic in Dalian remains stable at a relatively low level from 2019 to 2023.The PFGE banding patterns are relatively scattered,but there are dominant subtypes among them,which may be local epidemic strains.
作者
肖冰
矫继龙
范雪松
栾明春
XIAO Bing;JIAO Jilong;FAN Xuesong;LUAN Mingchun(Microbial Laboratory Department of Dalian Center for Disease Control and Prevention(Dalian City Health Supervision Institute),Dalian,Liaoning 116000,China)
出处
《公共卫生与预防医学》
2026年第2期153-156,共4页
Journal of Public Health and Preventive Medicine
基金
大连市科技创新课题(2022JJ13SN082)。
关键词
伤寒
副伤寒
流行病学特征
脉冲场凝胶电泳
分子分型
Typhoid fever
Paratyphoid fever
Epidemiological characteristics
Pulsed field gel electrophoresis
Molecular typing
