A novel electromagnetic induction detector with two inductors for CE was described here.The two inductors were used as signal detection and reference,respectively.The parameters affecting the detector performance（inc...A novel electromagnetic induction detector with two inductors for CE was described here.The two inductors were used as signal detection and reference,respectively.The parameters affecting the detector performance（including coil turns,detection distance, excitation frequency,voltage,etc.） were optimized.Under the optimum condition,the feasibility of the detector was examined by analyzing inorganic ions.The fabricated detector showed good linear relationship between the response and the analytes concentrations,with a detection limit of 13μmol/L for Na~＋（S/N = 3）.A variety of advantages,such as simple construction, ease of operation,and considerably universal response,suggested this novel detector a promising application prospect in analytical area.展开更多
As a vital component of innate immunity,the cGAS-STING pathway has attracted widespread attention in cancer therapy,among which Mn^(2+)has emerged as a promising antitumor agent.Combining cGAS-STING agonists with chem...As a vital component of innate immunity,the cGAS-STING pathway has attracted widespread attention in cancer therapy,among which Mn^(2+)has emerged as a promising antitumor agent.Combining cGAS-STING agonists with chemotherapy or cancer vaccines represents an effective strategy to enhance their therapeutic efficacy.In this study,we construct simple manganese chloride nanosheets(MnCl_(2) NSs)that achieve combined effects resembling those of cGAS-STING activation,chemotherapy,and in situ vaccination without requiring additional drugs or energy input.The synthesized MnCl_(2) NSs release high concentrations of Mn^(2+)into tumor cells,causing a storm of Mn^(2+).Through the combined effects of osmotic pressure,chemodynamic therapy(CDT),and cGAS-STING activation,they significantly enhance the cytotoxicity of MnCl_(2) and induce DNA damage,thereby achieving chemotherapy-like combined therapeutic effects.Concurrently,tumor cells undergo PANoptosis,leading to the release of damage-associated molecular patterns(DAMPs)and tumor antigens,which effectively generate an in situ tumor vaccine,ultimately activating both innate(cGAS-STING)and adaptive(PANoptosis)immune responses.Our study proposes a novel strategy to synergistically enhance immunotherapy by inducing tumor cell PANoptosis while concurrently activating the cGAS-STING pathway,offering valuable guidance for the design of immunotherapeutic nanomaterials.展开更多
基金support from the National Natural Science Foundation of China(Nos20727006 and 21075139)
文摘A novel electromagnetic induction detector with two inductors for CE was described here.The two inductors were used as signal detection and reference,respectively.The parameters affecting the detector performance（including coil turns,detection distance, excitation frequency,voltage,etc.） were optimized.Under the optimum condition,the feasibility of the detector was examined by analyzing inorganic ions.The fabricated detector showed good linear relationship between the response and the analytes concentrations,with a detection limit of 13μmol/L for Na~＋（S/N = 3）.A variety of advantages,such as simple construction, ease of operation,and considerably universal response,suggested this novel detector a promising application prospect in analytical area.
基金supported by the Natural Science Founda-tion of Henan Province of China(Key Program,No.242300421205)the Foundation of Henan Educational Committee(25A150015)+1 种基金Science and Technology Innovation Talents in Universities of Henan Province(23HASTIT002)National Natural Science Foundation of China(21877027).
文摘As a vital component of innate immunity,the cGAS-STING pathway has attracted widespread attention in cancer therapy,among which Mn^(2+)has emerged as a promising antitumor agent.Combining cGAS-STING agonists with chemotherapy or cancer vaccines represents an effective strategy to enhance their therapeutic efficacy.In this study,we construct simple manganese chloride nanosheets(MnCl_(2) NSs)that achieve combined effects resembling those of cGAS-STING activation,chemotherapy,and in situ vaccination without requiring additional drugs or energy input.The synthesized MnCl_(2) NSs release high concentrations of Mn^(2+)into tumor cells,causing a storm of Mn^(2+).Through the combined effects of osmotic pressure,chemodynamic therapy(CDT),and cGAS-STING activation,they significantly enhance the cytotoxicity of MnCl_(2) and induce DNA damage,thereby achieving chemotherapy-like combined therapeutic effects.Concurrently,tumor cells undergo PANoptosis,leading to the release of damage-associated molecular patterns(DAMPs)and tumor antigens,which effectively generate an in situ tumor vaccine,ultimately activating both innate(cGAS-STING)and adaptive(PANoptosis)immune responses.Our study proposes a novel strategy to synergistically enhance immunotherapy by inducing tumor cell PANoptosis while concurrently activating the cGAS-STING pathway,offering valuable guidance for the design of immunotherapeutic nanomaterials.
