The review examines the intricate relationship between the microbiota and its host,highlighting how these microbial communities influence various physiological functions beyond simple coexistence.The microbiota plays ...The review examines the intricate relationship between the microbiota and its host,highlighting how these microbial communities influence various physiological functions beyond simple coexistence.The microbiota plays a crucial role in regulating the immune system,metabolism,and overall health.We explore the diverse microbial populations inhabiting different body regions and their essential contributions to maintaining balance within the host.Recent research has uncovered molecular mechanisms that govern microbiota-host interactions,offering new insights into how these microbes support health and,conversely,how imbalances known as dysbiosis can increase susceptibility to diseases.While much attention has been given to the gut microbiota,this review also explores the influence of microbes in other parts of the body,including their effects on various organs and tissues.Additionally,we discuss emerging evidence on the gut-brain axis,illustrating how the microbiota can impact brain function and behavior.Understanding this connection could open new possibilities for treating neurological and psychological disorders.Finally,we evaluate microbiota-based therapies such as probiotics and fecal microbiota transplantation,emphasizing the importance of personalized approaches.By integrating findings from multiple disciplines,this review provides a comprehensive perspective on the microbiota’s vital role in human health and its potential as a therapeutic target.展开更多
基金Supported by the Indian Council of Medical Research Government of India,No.2021-10264/GTGE-BMS for the Senior Research Fellowship award to Kamthan Mhe Department of Health Research,Government of India,No.R.12014/61/2022-HR for the Young Scientist award to Ali A.
文摘The review examines the intricate relationship between the microbiota and its host,highlighting how these microbial communities influence various physiological functions beyond simple coexistence.The microbiota plays a crucial role in regulating the immune system,metabolism,and overall health.We explore the diverse microbial populations inhabiting different body regions and their essential contributions to maintaining balance within the host.Recent research has uncovered molecular mechanisms that govern microbiota-host interactions,offering new insights into how these microbes support health and,conversely,how imbalances known as dysbiosis can increase susceptibility to diseases.While much attention has been given to the gut microbiota,this review also explores the influence of microbes in other parts of the body,including their effects on various organs and tissues.Additionally,we discuss emerging evidence on the gut-brain axis,illustrating how the microbiota can impact brain function and behavior.Understanding this connection could open new possibilities for treating neurological and psychological disorders.Finally,we evaluate microbiota-based therapies such as probiotics and fecal microbiota transplantation,emphasizing the importance of personalized approaches.By integrating findings from multiple disciplines,this review provides a comprehensive perspective on the microbiota’s vital role in human health and its potential as a therapeutic target.
