摘要
本文系统综述了金属暴露与肠道微生物群之间复杂的相互作用及其对宿主健康的影响。金属暴露可通过剂量依赖性方式直接扰动肠道菌群结构,抑制有益菌、促进潜在致病菌增殖,并改变菌群多样性与生态互作网络。同时,肠道微生物通过调节金属吸收、转化、分布与排泄,深度参与金属的生物可利用性及毒性表达,在解毒与增毒过程中均发挥关键作用。这些互作共同构成“金属-微生物-宿主”轴,其动态平衡深刻影响金属暴露的最终健康效应。当前研究聚焦益生菌干预以恢复微生态平衡,未来需借助多组学技术深入解析机制,为金属暴露的微生物防治提供新思路和新策略。
This review systematically summarizes the complex interactions between metal exposure and the gut microbiota and their consequential impacts on host health.Metal exposure alters gut microbial composition in a dose-dependent manner,suppressing beneficial bacteria,promoting potential pathogens,and altering microbial diversity and ecological networks.In turn,the gut microbiota modulates metal absorption,transformation,distribution,and excretion,thereby critically influencing metal bioavailability and toxicity,and playing pivotal roles in both detoxification and toxicity enhancement.These interactions constitute the“metal–microbiota–host”axis,whose dynamic equilibrium profoundly shapes the ultimate health outcomes of metal exposure.Current research focuses on probiotic interventions to restore microbial balance,while future studies should employ multi-omics approaches to elucidate underlying mechanisms,thereby informing novel strategies for microbiotabased interventions and mitigation of metal-related health risks.
作者
魏长黎
刘雨琦
高霞
邓翰林
邹镇
许商成
陈承志
WEI Changli;LIU Yuqi;GAO Xia;DENG Hanlin;ZOU Zhen;XU Shangcheng;CHEN Chengzhi(School of Public Health,Chongqing Medical University,Chongqing 400016,China)
出处
《西南医科大学学报》
2026年第2期127-133,共7页
Journal of Southwest Medical University
基金
国家重点研发计划项目(2025YFC2511700)
重庆市自然科学基金创新联合发展基金(CSTB2023NSCQ-LZX0059)。
