Micro/nanorobots represent a groundbreaking advancement in nanotechnology,with applications spanning medicine,envi-ronmental remediation,and industrial processes.A major challenge in their development is achieving eff...Micro/nanorobots represent a groundbreaking advancement in nanotechnology,with applications spanning medicine,envi-ronmental remediation,and industrial processes.A major challenge in their development is achieving efficient and bio-compatible propulsion.Enzyme-driven propulsion,particularly using catalase,offers a promising solution due to its ability to decompose hydrogen peroxide(H2O2)into water and oxygen,generating thrust for autonomous movement.Compared to metal-based catalysts,catalase-powered systems exhibit superior biocompatibility and lower toxicity,making them ideal for biomedical applications.This review explores the role of catalase in micro/nanorobot propulsion,highlighting self-propulsion mechanisms,different nanorobot types,and their applications in drug delivery,infection treatment,cancer therapy,and biosensing.Additionally,recent advancements in biodegradable enzyme-powered nanorobots and their poten-tial in overcoming biological barriers are discussed.With further research,catalase-driven nanorobots could revolutionize targeted therapy and diagnostic techniques,paving the way for innovative solutions in nanomedicine.展开更多
Micro/nanorobots(MNRs)capable of performing tasks at the micro-and nanoscale hold great promise for applications in cutting-edge fields such as biomedical engineering,environmental engineering,and microfabrication.To ...Micro/nanorobots(MNRs)capable of performing tasks at the micro-and nanoscale hold great promise for applications in cutting-edge fields such as biomedical engineering,environmental engineering,and microfabrication.To cope with the intricate and dynamic environments encountered in practical applications,the development of high performance MNRs is crucial.They have evolved from single-material,single-function,and simple structure to multi-material,multi-function,and complex structure.However,the design and manufacturing of high performance MNRs with complex multi-material three-dimensional structures at the micro-and nanoscale pose significant challenges that cannot be addressed by conventional serial design strategies and single-process manufacturing methods.The material-interface-structure-function/performance coupled design methods and the additive/formative/subtractive composite manufacturing methods offer the opportunity to design and manufacture MNRs with multimaterials and complex structures under multi-factor coupling,thus paving the way for the development of high performance MNRs.In this paper,we take the three core capabilities of MNRs—mobility,controllability,and load capability—as the focal point,emphasizing the coupled design methods oriented towards their function/performance and the composite manufacturing methods for their functional structures.The limitations of current investigation are also discussed,and our envisioned future directions for design and manufacture of MNRs are shared.We hope that this review will provide a framework template for the design and manufacture of high performance MNRs,serving as a roadmap for researchers interested in this area.展开更多
Untethered micro/nanorobots that can wirelessly control their motion and deformation state have gained enormous interest in remote sensing applications due to their unique motion characteristics in various media and d...Untethered micro/nanorobots that can wirelessly control their motion and deformation state have gained enormous interest in remote sensing applications due to their unique motion characteristics in various media and diverse functionalities.Researchers are developing micro/nanorobots as innovative tools to improve sensing performance and miniaturize sensing systems,enabling in situ detection of substances that traditional sensing methods struggle to achieve.Over the past decade of development,significant research progress has been made in designing sensing strategies based on micro/nanorobots,employing various coordinated control and sensing approaches.This review summarizes the latest developments on micro/nanorobots for remote sensing applications by utilizing the self-generated signals of the robots,robot behavior,microrobotic manipulation,and robot-environment interactions.Providing recent studies and relevant applications in remote sensing,we also discuss the challenges and future perspectives facing micro/nanorobots-based intelligent sensing platforms to achieve sensing in complex environments,translating lab research achievements into widespread real applications.展开更多
Inflammatory bowel disease(IBD)is a significant global public health issue in which many therapies are applied in clinical practice.However,efficient drug delivery within the harsh environment of the gastrointestinal(...Inflammatory bowel disease(IBD)is a significant global public health issue in which many therapies are applied in clinical practice.However,efficient drug delivery within the harsh environment of the gastrointestinal(GI)tract containing gastric acid,mucus,and the epithelial cell barrier is still an obstacle.In addition to the undesired delivery efficiency,most clinical drugs for IBD treatment lack the targeting capability to achieve favorable therapeutic efficacy.Therefore,more efficient drug delivery strategies are urgently required to maintain the current upward trend in the treatment of IBD and further improve the therapeutic outcomes of IBD patients.With advances in the development of drug carriers,recent studies have developed traditional drug delivery strategies that use platforms such as hydrogels,living organisms,and nanoparticles.However,these strategies fail to achieve satisfactory delivery efficiency in the GI tract or the required self-propulsion,resulting in reduced drug delivery efficiency.Micro/nanorobots have been identified as ideal carriers to protect drugs from harsh environments within organisms and to realize targeted drug delivery toward inflamed sites.Therefore,the integration of micro/nanorobots into the treatment strategies for IBD is prudent.In this review,the current status of the use of micro/nanorobots in IBD therapy is described,and the challenges associated with their application in IBD-related clinical practice are discussed.This review will hopefully provide valuable insights for further studies on the use of micro/nanorobots in IBD therapy.展开更多
Magnetic helical micro- and nanorobots can perform 3D navigation in various liquids with a sub- micrometer precision under low-strength rotating magnetic fields （〈 10 rer）. Since magnetic fields with low strengths ...Magnetic helical micro- and nanorobots can perform 3D navigation in various liquids with a sub- micrometer precision under low-strength rotating magnetic fields （〈 10 rer）. Since magnetic fields with low strengths are harmless to cells and tissues, magnetic helical micro/ nanorobots are promising tools for biomedical applications, such as minimally invasive surgery, cell manipulation and analysis, and targeted therapy. This review provides general information on magnetic helical micro/nanorobots, including their fabrication, motion control, and further functionalization for biomedical applications.展开更多
Thrombotic diseases,a class of circulatory system disorders characterized by the abnormal coagulation of blood within arterial and venous vessels,leading to partial or complete vascular occlusion,represent a major glo...Thrombotic diseases,a class of circulatory system disorders characterized by the abnormal coagulation of blood within arterial and venous vessels,leading to partial or complete vascular occlusion,represent a major global cause of mortality and morbidity.Considering the inefficacy of thrombolytic therapies and high incidence of complications,these diseases pose significant healthcare challenges.Nanotechnology,distinguished by its precise targeting,on-demand drug release,reduced dosage,and lower risk of hemorrhagic complications,offers unique advantages for the diagnosis and treatment of thrombotic disorders.As a cutting-edge technology,micro/nano-robots are novel therapeutic options for managing these conditions.This review elucidates the mechanisms of thrombus formation,discusses the efficacy and limitations of traditional antithrombotic drugs,summarizes research advancements in nanomaterials and micro/nanorobots for thrombotic diseases,and presents their promising clinical translation prospects.展开更多
Micro/nanorobots can propel and navigate in many hard-to-reach biological environments,and thus may bring revolutionary changes to biomedical research and applications.However,current MNRs lack the capability to colle...Micro/nanorobots can propel and navigate in many hard-to-reach biological environments,and thus may bring revolutionary changes to biomedical research and applications.However,current MNRs lack the capability to collectively perceive and report physicochemical changes in unknown microenvironments.Here we propose to develop swarming responsive photonic nanorobots that can map local physicochemical conditions on the fly and further guide localized photothermal treatment.The RPNRs consist of a photonic nanochain of periodically-assembled magnetic Fe_(3)O_(4)nanoparticles encapsulated in a responsive hydrogel shell,and show multiple integrated functions,including energetic magnetically-driven swarming motions,bright stimuli-responsive structural colors,and photothermal conversion.Thus,they can actively navigate in complex environments utilizing their controllable swarming motions,then visualize unknown targets(e.g.,tumor lesion)by collectively mapping out local abnormal physicochemical conditions(e.g.,pH,temperature,or glucose concentra-tion)via their responsive structural colors,and further guide external light irradiation to initiate localized photothermal treatment.This work facilitates the development of intelligent motile nanosensors and versatile multifunctional nanotheranostics for cancer and inflam-matory diseases.展开更多
A major bottleneck underlying nanomaterial-based tumor therapy lies in complex biological environment and physiological barriers.Micro/nanorobots with the features of self-propulsion and controllable navigation have g...A major bottleneck underlying nanomaterial-based tumor therapy lies in complex biological environment and physiological barriers.Micro/nanorobots with the features of self-propulsion and controllable navigation have gradually become a research hotspot in the tumor therapeutic community,exhibiting their advantages in efficient cargo loading,controllable cargo delivery,stimulitriggered cargo release,deeper tumor tissue penetration,and enhanced cargo accumulation in tumor tissue.In this review,the self-propulsion and controllable navigation are introduced as two major properties of micro/nanorobots,in which micro/nanorobots are propelled by chemical reactions,physical fields,and biological systems and could be navigated by chemotaxis,remote magnetic guidance,and light.Then,the recent advances of micro/nanorobots for chemotherapy,immunotherapy,photothermal therapy,photodynamic therapy,chemodynamic therapy,and multimodal tumor therapy would be discussed.Finally,the perspective and challenges are also mentioned.It is expected that this review gives an insight into intelligent micro/nanorobots for improved tumor therapy,aiming for more extensive and in-depth investigations,and final applications in the clinic.展开更多
Micro/nanorobots have exhibited excellent application potential in the biomedical field,such as drug delivery,minimally invasive surgery,and bio-sensing.Furthermore,in order to achieve practical application,it is esse...Micro/nanorobots have exhibited excellent application potential in the biomedical field,such as drug delivery,minimally invasive surgery,and bio-sensing.Furthermore,in order to achieve practical application,it is essential for swimming micro/nanorobots to navigate towards specific targets or adjust their speed and morphology in complete environments.The navigation of swimming micro/nanorobots with temporal and spatial precision is critical for fulfilling the demand of applications.Here,we introduced a fully integrated wearable control system for micro/nanorobots navigation and manipulation,which is composed of a multifunctional sensor array,an artificial intelligence(AI)planner,and a magnetic field generator.The sensor array could perceive real-time changes in gestures,wrist rotation,and acoustic signals.AI planner based on machine learning offers adaptive path planning in response to dynamically changing signals to generate magnetic fields for the on-demand manipulation of micro/nanorobots.Such a novel,feasible control strategy was validated in the biological experiment in which cancer cells were targeted and killed by photothermal therapy using micro/nanorobots and integrated control platform.This wearable control system could play a crucial role in future intelligent medical applications and could be easily reconfigured toward other medical robots’control.展开更多
Recently,the collective behavior of micro/nanorobots has shown unprecedented potential in biomedicine and environmental remediation.Collective behavior can work more efficiently,adaptively,and robustly than individual...Recently,the collective behavior of micro/nanorobots has shown unprecedented potential in biomedicine and environmental remediation.Collective behavior can work more efficiently,adaptively,and robustly than individual micro/nanorobots.The paradigm of collective behavior needs to be understood in different dimensions,including from individual to cluster,from planar to spatial,and from mono-functional to multifunctional.In this review,the focus will be on summarizing the achievements of collective control of micro/nanorobot swarms in recent years from different dimensions,in an attempt to better understand how the structure and materials of individuals should be designed,how collective behavior should be implemented,and how robots are functionalized to cope with practical applications under the introduction of collective control.The opportunities and challenges that collective control faces at this stage are illustrated to provide perspectives for its future development.展开更多
Micro/nanoplastics(M/NPs)have become pervasive environmental pollutants,posing significant risks to human health through various exposure routes,including ingestion,inhalation,and direct contact.This review systematic...Micro/nanoplastics(M/NPs)have become pervasive environmental pollutants,posing significant risks to human health through various exposure routes,including ingestion,inhalation,and direct contact.This review systematically examined the potential impacts of M/NPs on ocular health,focusing on exposure pathways,toxicological mechanisms,and resultant damage to the eye.Ocular exposure to M/NPs can occur via direct contact and oral ingestion,with the latter potentially leading to the penetration of particles through ocular biological barriers into ocular tissues.The review highlighted that M/NPs can induce adverse effects on the ocular surface,elevate intraocular pressure,and cause abnormalities in the vitreous and retina.Mechanistically,oxidative stress and inflammation are central to M/NP-induced ocular damage,with smaller particles often exhibiting greater toxicity.Overall,this review underscored the potential risks of M/NPs to ocular health and emphasized the need for further research to elucidate exposure mechanisms,toxicological pathways,and mitigation strategies.展开更多
Micro silicon(mSi)is a promising anode candidate for all-solid-state batteries due to its high specific capacity,low side reactions,and high tap density.However,silicon suffers from its poor electronic and ionic condu...Micro silicon(mSi)is a promising anode candidate for all-solid-state batteries due to its high specific capacity,low side reactions,and high tap density.However,silicon suffers from its poor electronic and ionic conductivity,which is particularly severe on a micro scale and in solid-state systems,leading to increased polarization and inferior electrochemical performance.Doping can broaden the transmission pathways and reduce the diffusion energy barrier for electrons and lithium ions.However,achieving effective,uniform doping in mSi is challenging due to its longer diffusion paths and higher energy barriers.Therefore,current doping research is primarily limited to nanosilicon.In this study,we successfully used a Joule-heating activated staged thermal treatment to achieve full-depth doping of germanium(Ge)in the mSi substrate.The Joule-heating process activated the mSi substrate,resulting in abundant vacancy defects that reduced the diffusion barrier of Ge into the silicon lattice and facilitated full-depth Ge doping.Surprisingly,the resulting Si-Ge anode exhibited significantly enhanced electrical conductivity(70 times).Meanwhile,the improved Li-ion conductivity in mSi and the reduced Young’s modulus enhance the electrode reaction kinetics and integrity after cycling.Ge-doped silicon anodes demonstrate excellent electrochemical performance when applied in sulfide solid-state half-cells and full-cells.This work provides substantial insights into the rational structural design of mSi alloyed anode materials,paving the way for the development of high-performance solid-state Li-ion batteries.展开更多
Extreme cold weather seriously harms human thermoregulatory system,necessitating high-performance insulating garments to maintain body temperature.However,as the core insulating layer,advanced fibrous materials always...Extreme cold weather seriously harms human thermoregulatory system,necessitating high-performance insulating garments to maintain body temperature.However,as the core insulating layer,advanced fibrous materials always struggle to balance mechanical properties and thermal insulation,resulting in their inability to meet the demands for both washing resistance and personal protection.Herein,inspired by the natural spring-like structures of cucumber tendrils,a superelastic and washable micro/nanofibrous sponge(MNFS)based on biomimetic helical fibers is directly prepared utilizing multiple-jet electrospinning technology for high-performance thermal insulation.By regulating the conductivity of polyvinylidene fluoride solution,multiple-jet ejection and multiple-stage whipping of jets are achieved,and further control of phase separation rates enables the rapid solidification of jets to form spring-like helical fibers,which are directly entangled to assemble MNFS.The resulting MNFS exhibits superelasticity that can withstand large tensile strain(200%),1000 cyclic tensile or compression deformations,and retain good resilience even in liquid nitrogen(-196℃).Furthermore,the MNFS shows efficient thermal insulation with low thermal conductivity(24.85 mW m^(-1)K^(-1)),close to the value of dry air,and remains structural stability even after cyclic washing.This work offers new possibilities for advanced fibrous sponges in transportation,environmental,and energy applications.展开更多
基金The Large Research Group Project under grant number RGP.02/516/45.
文摘Micro/nanorobots represent a groundbreaking advancement in nanotechnology,with applications spanning medicine,envi-ronmental remediation,and industrial processes.A major challenge in their development is achieving efficient and bio-compatible propulsion.Enzyme-driven propulsion,particularly using catalase,offers a promising solution due to its ability to decompose hydrogen peroxide(H2O2)into water and oxygen,generating thrust for autonomous movement.Compared to metal-based catalysts,catalase-powered systems exhibit superior biocompatibility and lower toxicity,making them ideal for biomedical applications.This review explores the role of catalase in micro/nanorobot propulsion,highlighting self-propulsion mechanisms,different nanorobot types,and their applications in drug delivery,infection treatment,cancer therapy,and biosensing.Additionally,recent advancements in biodegradable enzyme-powered nanorobots and their poten-tial in overcoming biological barriers are discussed.With further research,catalase-driven nanorobots could revolutionize targeted therapy and diagnostic techniques,paving the way for innovative solutions in nanomedicine.
基金National Natural Science Foundation of China(Nos.52125505,U23A20637)。
文摘Micro/nanorobots(MNRs)capable of performing tasks at the micro-and nanoscale hold great promise for applications in cutting-edge fields such as biomedical engineering,environmental engineering,and microfabrication.To cope with the intricate and dynamic environments encountered in practical applications,the development of high performance MNRs is crucial.They have evolved from single-material,single-function,and simple structure to multi-material,multi-function,and complex structure.However,the design and manufacturing of high performance MNRs with complex multi-material three-dimensional structures at the micro-and nanoscale pose significant challenges that cannot be addressed by conventional serial design strategies and single-process manufacturing methods.The material-interface-structure-function/performance coupled design methods and the additive/formative/subtractive composite manufacturing methods offer the opportunity to design and manufacture MNRs with multimaterials and complex structures under multi-factor coupling,thus paving the way for the development of high performance MNRs.In this paper,we take the three core capabilities of MNRs—mobility,controllability,and load capability—as the focal point,emphasizing the coupled design methods oriented towards their function/performance and the composite manufacturing methods for their functional structures.The limitations of current investigation are also discussed,and our envisioned future directions for design and manufacture of MNRs are shared.We hope that this review will provide a framework template for the design and manufacture of high performance MNRs,serving as a roadmap for researchers interested in this area.
基金supported by the National Natural Science Foundation under Project No. 52205590the Natural Science Foundation of Jiangsu Province under Project No. BK20220834+4 种基金the Start-up Research Fund of Southeast University under Project No. RF1028623098the Xiaomi Foundation/ Xiaomi Young Talents Programsupported by the Research Impact Fund (project no. R4015-21)Research Fellow Scheme (project no. RFS2122-4S03)the EU-Hong Kong Research and Innovation Cooperation Co-funding Mechanism (project no. E-CUHK401/20) from the Research Grants Council (RGC) of Hong Kong, the SIAT-CUHK Joint Laboratory of Robotics and Intelligent Systems, and the Multi-Scale Medical Robotics Center (MRC), InnoHK, at the Hong Kong Science Park
文摘Untethered micro/nanorobots that can wirelessly control their motion and deformation state have gained enormous interest in remote sensing applications due to their unique motion characteristics in various media and diverse functionalities.Researchers are developing micro/nanorobots as innovative tools to improve sensing performance and miniaturize sensing systems,enabling in situ detection of substances that traditional sensing methods struggle to achieve.Over the past decade of development,significant research progress has been made in designing sensing strategies based on micro/nanorobots,employing various coordinated control and sensing approaches.This review summarizes the latest developments on micro/nanorobots for remote sensing applications by utilizing the self-generated signals of the robots,robot behavior,microrobotic manipulation,and robot-environment interactions.Providing recent studies and relevant applications in remote sensing,we also discuss the challenges and future perspectives facing micro/nanorobots-based intelligent sensing platforms to achieve sensing in complex environments,translating lab research achievements into widespread real applications.
基金supported by grants from the Open Research Fund of Southeast University and Jiangsu Province Hospital(2024-M01)the National Natural Science Foundation of China(82372127)the Fundamental Research Funds for Central Universities(2242023K5007).
文摘Inflammatory bowel disease(IBD)is a significant global public health issue in which many therapies are applied in clinical practice.However,efficient drug delivery within the harsh environment of the gastrointestinal(GI)tract containing gastric acid,mucus,and the epithelial cell barrier is still an obstacle.In addition to the undesired delivery efficiency,most clinical drugs for IBD treatment lack the targeting capability to achieve favorable therapeutic efficacy.Therefore,more efficient drug delivery strategies are urgently required to maintain the current upward trend in the treatment of IBD and further improve the therapeutic outcomes of IBD patients.With advances in the development of drug carriers,recent studies have developed traditional drug delivery strategies that use platforms such as hydrogels,living organisms,and nanoparticles.However,these strategies fail to achieve satisfactory delivery efficiency in the GI tract or the required self-propulsion,resulting in reduced drug delivery efficiency.Micro/nanorobots have been identified as ideal carriers to protect drugs from harsh environments within organisms and to realize targeted drug delivery toward inflamed sites.Therefore,the integration of micro/nanorobots into the treatment strategies for IBD is prudent.In this review,the current status of the use of micro/nanorobots in IBD therapy is described,and the challenges associated with their application in IBD-related clinical practice are discussed.This review will hopefully provide valuable insights for further studies on the use of micro/nanorobots in IBD therapy.
文摘Magnetic helical micro- and nanorobots can perform 3D navigation in various liquids with a sub- micrometer precision under low-strength rotating magnetic fields （〈 10 rer）. Since magnetic fields with low strengths are harmless to cells and tissues, magnetic helical micro/ nanorobots are promising tools for biomedical applications, such as minimally invasive surgery, cell manipulation and analysis, and targeted therapy. This review provides general information on magnetic helical micro/nanorobots, including their fabrication, motion control, and further functionalization for biomedical applications.
基金supported by the National Key R&D Program of China(2022YFC2304600)National Natural Science Foundation of China(No.82170131 and No.82470134)Young Top-notch Talent Cultivation Program of Hubei Province 202117.
文摘Thrombotic diseases,a class of circulatory system disorders characterized by the abnormal coagulation of blood within arterial and venous vessels,leading to partial or complete vascular occlusion,represent a major global cause of mortality and morbidity.Considering the inefficacy of thrombolytic therapies and high incidence of complications,these diseases pose significant healthcare challenges.Nanotechnology,distinguished by its precise targeting,on-demand drug release,reduced dosage,and lower risk of hemorrhagic complications,offers unique advantages for the diagnosis and treatment of thrombotic disorders.As a cutting-edge technology,micro/nano-robots are novel therapeutic options for managing these conditions.This review elucidates the mechanisms of thrombus formation,discusses the efficacy and limitations of traditional antithrombotic drugs,summarizes research advancements in nanomaterials and micro/nanorobots for thrombotic diseases,and presents their promising clinical translation prospects.
基金supported by the National Key Research and Development Project(No.2021YFA1201400)National Natural Science Foundation of China(Nos.52073222,51573144 and 21474078)the Fundamental Research Funds for the Central Universities(WUT:2021IVA118 and 2022IVA201).
文摘Micro/nanorobots can propel and navigate in many hard-to-reach biological environments,and thus may bring revolutionary changes to biomedical research and applications.However,current MNRs lack the capability to collectively perceive and report physicochemical changes in unknown microenvironments.Here we propose to develop swarming responsive photonic nanorobots that can map local physicochemical conditions on the fly and further guide localized photothermal treatment.The RPNRs consist of a photonic nanochain of periodically-assembled magnetic Fe_(3)O_(4)nanoparticles encapsulated in a responsive hydrogel shell,and show multiple integrated functions,including energetic magnetically-driven swarming motions,bright stimuli-responsive structural colors,and photothermal conversion.Thus,they can actively navigate in complex environments utilizing their controllable swarming motions,then visualize unknown targets(e.g.,tumor lesion)by collectively mapping out local abnormal physicochemical conditions(e.g.,pH,temperature,or glucose concentra-tion)via their responsive structural colors,and further guide external light irradiation to initiate localized photothermal treatment.This work facilitates the development of intelligent motile nanosensors and versatile multifunctional nanotheranostics for cancer and inflam-matory diseases.
基金National Key R&D Program of China,Grant/Award Number:2017YFA0206301National Natural Science Foundation of China,Grant/Award Numbers:52027801,51631001+1 种基金Natural Science Foundation of Beijing Municipality,Grant/Award Number:2191001China-Germany Collaboration Project,Grant/Award Number:M-0199。
文摘A major bottleneck underlying nanomaterial-based tumor therapy lies in complex biological environment and physiological barriers.Micro/nanorobots with the features of self-propulsion and controllable navigation have gradually become a research hotspot in the tumor therapeutic community,exhibiting their advantages in efficient cargo loading,controllable cargo delivery,stimulitriggered cargo release,deeper tumor tissue penetration,and enhanced cargo accumulation in tumor tissue.In this review,the self-propulsion and controllable navigation are introduced as two major properties of micro/nanorobots,in which micro/nanorobots are propelled by chemical reactions,physical fields,and biological systems and could be navigated by chemotaxis,remote magnetic guidance,and light.Then,the recent advances of micro/nanorobots for chemotherapy,immunotherapy,photothermal therapy,photodynamic therapy,chemodynamic therapy,and multimodal tumor therapy would be discussed.Finally,the perspective and challenges are also mentioned.It is expected that this review gives an insight into intelligent micro/nanorobots for improved tumor therapy,aiming for more extensive and in-depth investigations,and final applications in the clinic.
基金supported by the National Key Research and Development Program(2022YFB4701700)National Excellent Youth Science Fund Project of the National Natural Science Foundation of China(52322502)+6 种基金the National Outstanding Youth Science Fund Project of National Natural Science Foundation of China(52025054)National Natural Science Foundation of China(52175009),Postdoctoral Fellowship Program of CPSF(GZC20232498)Postdoctoral Innovative Talents in Shandong Province(SDBX2023011)China Postdoctoral Science Foundation Grant(2023M733341)Key R&D Program of Shandong Province,China(2021ZLGX04)National Heilongjiang Providence Nature Science Foundation of China(YQ2022E022)Fundamental Research Funds for the Central Universities。
文摘Micro/nanorobots have exhibited excellent application potential in the biomedical field,such as drug delivery,minimally invasive surgery,and bio-sensing.Furthermore,in order to achieve practical application,it is essential for swimming micro/nanorobots to navigate towards specific targets or adjust their speed and morphology in complete environments.The navigation of swimming micro/nanorobots with temporal and spatial precision is critical for fulfilling the demand of applications.Here,we introduced a fully integrated wearable control system for micro/nanorobots navigation and manipulation,which is composed of a multifunctional sensor array,an artificial intelligence(AI)planner,and a magnetic field generator.The sensor array could perceive real-time changes in gestures,wrist rotation,and acoustic signals.AI planner based on machine learning offers adaptive path planning in response to dynamically changing signals to generate magnetic fields for the on-demand manipulation of micro/nanorobots.Such a novel,feasible control strategy was validated in the biological experiment in which cancer cells were targeted and killed by photothermal therapy using micro/nanorobots and integrated control platform.This wearable control system could play a crucial role in future intelligent medical applications and could be easily reconfigured toward other medical robots’control.
基金National Natural Science Foundation of China,Grant/Award Number:22278241Institute Guo Qiang,Tsinghua University,Grant/Award Number:2021GQG1016+1 种基金National Key Research and Development Program of China,Grant/Award Number:2018YFA0901700Department of Chemical Engineering-iBHE Joint Cooperation Fund。
文摘Recently,the collective behavior of micro/nanorobots has shown unprecedented potential in biomedicine and environmental remediation.Collective behavior can work more efficiently,adaptively,and robustly than individual micro/nanorobots.The paradigm of collective behavior needs to be understood in different dimensions,including from individual to cluster,from planar to spatial,and from mono-functional to multifunctional.In this review,the focus will be on summarizing the achievements of collective control of micro/nanorobot swarms in recent years from different dimensions,in an attempt to better understand how the structure and materials of individuals should be designed,how collective behavior should be implemented,and how robots are functionalized to cope with practical applications under the introduction of collective control.The opportunities and challenges that collective control faces at this stage are illustrated to provide perspectives for its future development.
基金Supported by the Guangdong Provincial Natural Science Foundation(No.2114050001527).
文摘Micro/nanoplastics(M/NPs)have become pervasive environmental pollutants,posing significant risks to human health through various exposure routes,including ingestion,inhalation,and direct contact.This review systematically examined the potential impacts of M/NPs on ocular health,focusing on exposure pathways,toxicological mechanisms,and resultant damage to the eye.Ocular exposure to M/NPs can occur via direct contact and oral ingestion,with the latter potentially leading to the penetration of particles through ocular biological barriers into ocular tissues.The review highlighted that M/NPs can induce adverse effects on the ocular surface,elevate intraocular pressure,and cause abnormalities in the vitreous and retina.Mechanistically,oxidative stress and inflammation are central to M/NP-induced ocular damage,with smaller particles often exhibiting greater toxicity.Overall,this review underscored the potential risks of M/NPs to ocular health and emphasized the need for further research to elucidate exposure mechanisms,toxicological pathways,and mitigation strategies.
基金financially supported by the National Key Research and Development Program(2022YFE0127400)the National Natural Science Foundation of China(52172040,52202041,and U23B2077)+1 种基金Taishan Scholar Project of Shandong Province(tsqn202211086,ts202208832,tsqnz20221118)the Fundamental Research Funds for the Central Universities(23CX06055A).
文摘Micro silicon(mSi)is a promising anode candidate for all-solid-state batteries due to its high specific capacity,low side reactions,and high tap density.However,silicon suffers from its poor electronic and ionic conductivity,which is particularly severe on a micro scale and in solid-state systems,leading to increased polarization and inferior electrochemical performance.Doping can broaden the transmission pathways and reduce the diffusion energy barrier for electrons and lithium ions.However,achieving effective,uniform doping in mSi is challenging due to its longer diffusion paths and higher energy barriers.Therefore,current doping research is primarily limited to nanosilicon.In this study,we successfully used a Joule-heating activated staged thermal treatment to achieve full-depth doping of germanium(Ge)in the mSi substrate.The Joule-heating process activated the mSi substrate,resulting in abundant vacancy defects that reduced the diffusion barrier of Ge into the silicon lattice and facilitated full-depth Ge doping.Surprisingly,the resulting Si-Ge anode exhibited significantly enhanced electrical conductivity(70 times).Meanwhile,the improved Li-ion conductivity in mSi and the reduced Young’s modulus enhance the electrode reaction kinetics and integrity after cycling.Ge-doped silicon anodes demonstrate excellent electrochemical performance when applied in sulfide solid-state half-cells and full-cells.This work provides substantial insights into the rational structural design of mSi alloyed anode materials,paving the way for the development of high-performance solid-state Li-ion batteries.
基金supported by Young Elite Scientists Sponsorship Program by China Association for Science and Technology(No.2022QNRC001)the National Natural Science Foundation of China(No.52273053)the Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission(No.21CGA41)。
文摘Extreme cold weather seriously harms human thermoregulatory system,necessitating high-performance insulating garments to maintain body temperature.However,as the core insulating layer,advanced fibrous materials always struggle to balance mechanical properties and thermal insulation,resulting in their inability to meet the demands for both washing resistance and personal protection.Herein,inspired by the natural spring-like structures of cucumber tendrils,a superelastic and washable micro/nanofibrous sponge(MNFS)based on biomimetic helical fibers is directly prepared utilizing multiple-jet electrospinning technology for high-performance thermal insulation.By regulating the conductivity of polyvinylidene fluoride solution,multiple-jet ejection and multiple-stage whipping of jets are achieved,and further control of phase separation rates enables the rapid solidification of jets to form spring-like helical fibers,which are directly entangled to assemble MNFS.The resulting MNFS exhibits superelasticity that can withstand large tensile strain(200%),1000 cyclic tensile or compression deformations,and retain good resilience even in liquid nitrogen(-196℃).Furthermore,the MNFS shows efficient thermal insulation with low thermal conductivity(24.85 mW m^(-1)K^(-1)),close to the value of dry air,and remains structural stability even after cyclic washing.This work offers new possibilities for advanced fibrous sponges in transportation,environmental,and energy applications.
