摘要
Thrombotic diseases,a class of circulatory system disorders characterized by the abnormal coagulation of blood within arterial and venous vessels,leading to partial or complete vascular occlusion,represent a major global cause of mortality and morbidity.Considering the inefficacy of thrombolytic therapies and high incidence of complications,these diseases pose significant healthcare challenges.Nanotechnology,distinguished by its precise targeting,on-demand drug release,reduced dosage,and lower risk of hemorrhagic complications,offers unique advantages for the diagnosis and treatment of thrombotic disorders.As a cutting-edge technology,micro/nano-robots are novel therapeutic options for managing these conditions.This review elucidates the mechanisms of thrombus formation,discusses the efficacy and limitations of traditional antithrombotic drugs,summarizes research advancements in nanomaterials and micro/nanorobots for thrombotic diseases,and presents their promising clinical translation prospects.
基金
supported by the National Key R&D Program of China(2022YFC2304600)
National Natural Science Foundation of China(No.82170131 and No.82470134)
Young Top-notch Talent Cultivation Program of Hubei Province 202117.
