OBJECTIVE:To investigate whether Mianyi granules(免疫Ⅱ颗粒)are effective and safe in reversing immune nonresponse following antiretroviral therapy(ART)in individuals with human immunodeficiency virus(HIV)infection.ME...OBJECTIVE:To investigate whether Mianyi granules(免疫Ⅱ颗粒)are effective and safe in reversing immune nonresponse following antiretroviral therapy(ART)in individuals with human immunodeficiency virus(HIV)infection.METHODS:Randomized,double-blind,multi-center,placebo-controlled trial(factorial design)of daily oral Mianyi granules versus placebo for 72 weeks.A total of 361 HIV-positive individuals receiving ART at five ClassⅢGradeⅠhospitals in China between September 2013 and January 2016 completed the study.The primary endpoints were frequencies of CD3+,CD4+,CD8+,and CD45 RA+cells at seven timepoints over the 72 weeks.Secondary endpoints included viral loads,clinical symptoms,and quality of life at 72 weeks.RESULTS:A total of 400 participants were enrolled in the study and randomized,of whom 361 completed the study:189 individuals(140 men and 49 women)in the Mianyi granule group and 172 individuals(135 men and 37 women)in the placebo group.In the intent-to-treat population,CD4+T cell counts increased from(193±71)cells/mm^(3)at baseline to(288±131)cells/mm^(3)posttreatment in the Mianyi granule group and from(200±75)cells/mm^(3)at baseline to(264±124)cells/mm^(3)posttreatment in the placebo group.Patients treated with Mianyi granule had higher increases in CD4+T cell counts than those treated with placebo(P=0.045).Reversal of immune nonresponse was defined as a CD4+T cell increase of more than 100 cells/mm^(3).After treatment for 72 weeks,Mianyi granule was effective in reversing immune nonresponse in a higher proportion of individuals(20.2%)compared with placebo(9.7%).CD45 RA+cell counts increased from(34±32)cell/mm^(3)at baseline to(51±61)cells/mm^(3)post-treatment in the Mianyi granule group and from(37±33)cells/mm^(3)at baseline to(48±37)cells/mm^(3)post-treatment in the placebo group.Mianyi granules were more effective than placebo in increasing CD45 RA+cell counts.CONCLUSIONS:In ART-treated HIV-positive adults with immune nonresponse,treatment with Mianyi granules for 72 weeks was safe and significantly increased CD4+and CD45 RA+cell counts,thereby promoting immune reconstitution.展开更多
Seventy-two patients of chronic obstructive pulmonary disease (COPD) of Qi deficiency syn-drome with abnormal immune indices were treated with Yiqi Mianyi Granule (YQMYG) and the efficacy wascompared with that of 30 c...Seventy-two patients of chronic obstructive pulmonary disease (COPD) of Qi deficiency syn-drome with abnormal immune indices were treated with Yiqi Mianyi Granule (YQMYG) and the efficacy wascompared with that of 30 cases treated with Zhenqi fuzheng Granule (ZQFZG) for control. Results showedthat the markedly effective rate of symptomatic improvement ot Qi deficiency in YQMYG group was 65. 3%,the total effective rate 93. 1 % . 88. 6% of the immune indices lower than normal were corrected and 43. 7%ot them were normalized, while for indices that were higher than normal the rate were 78. 2 % and 52 . 9% re-spectively. These results suggested that YQMYG could improve symptom of Qi Deficiency markedly,strengthen cellutar immunity and regulate immune dysfunction. its therapeutic efficacy was obvfously superiorto ZQFZG ( P < 0 . 05 ).展开更多
INTRODUCTION： Latent autoimmune diabetes in adults （LADA） is regarded as one of the Insulin-de- pendent diabetes mellitus that progress slowly. It gradually became understood since 1970s. The on- set usually appear...INTRODUCTION： Latent autoimmune diabetes in adults （LADA） is regarded as one of the Insulin-de- pendent diabetes mellitus that progress slowly. It gradually became understood since 1970s. The on- set usually appears in adulthood, the islet autoanti- bodies are positive and the function of 13 cell is de- clined rapidly. The treatment is insulin injection. CASE PRESENTATION： The case reported followed is a 37-year-old male patient who was newly diag- nosed with type 2 diabetes. He abandoned oral hy- poglycemic agents since they caused stomach in- disposed. Before visiting, his islet autoantibodies were detected positive and he had never injected insulin before. We treated him with traditional Chi- nese herbals under the guidance of Traditional Chi- nese Medicine and differentiation, and achieved fine efficacy. CONCLUSION： Because the initial presentation of LADA is similar to Type 2 Diabetes Mellitus and ex- amination is not in common use, misdiagnosis isnot rare. Once LADA is diagnosed, the therapy must be adjusted. This case report indicated that Traditional Chinese Medicine might be an alterna- tive treatment for LADA.展开更多
基金Supported by the State Major Science&Technology Specific Projects,Prevention and Treatment of Serious Infectious Diseases such as Acquired Immune Deficiency Syndrome and Viral Hepatitis(2017ZX10205501,2013ZX10005-001)National Nature Science Foundation of China,Mechanism of PD-1 Receptor Mediated Immunosuppression based on the Improvement of Digestive Tract Mucosal Function in HIV/AIDS Patients by Removing Dampness and Detoxification(82174221)
文摘OBJECTIVE:To investigate whether Mianyi granules(免疫Ⅱ颗粒)are effective and safe in reversing immune nonresponse following antiretroviral therapy(ART)in individuals with human immunodeficiency virus(HIV)infection.METHODS:Randomized,double-blind,multi-center,placebo-controlled trial(factorial design)of daily oral Mianyi granules versus placebo for 72 weeks.A total of 361 HIV-positive individuals receiving ART at five ClassⅢGradeⅠhospitals in China between September 2013 and January 2016 completed the study.The primary endpoints were frequencies of CD3+,CD4+,CD8+,and CD45 RA+cells at seven timepoints over the 72 weeks.Secondary endpoints included viral loads,clinical symptoms,and quality of life at 72 weeks.RESULTS:A total of 400 participants were enrolled in the study and randomized,of whom 361 completed the study:189 individuals(140 men and 49 women)in the Mianyi granule group and 172 individuals(135 men and 37 women)in the placebo group.In the intent-to-treat population,CD4+T cell counts increased from(193±71)cells/mm^(3)at baseline to(288±131)cells/mm^(3)posttreatment in the Mianyi granule group and from(200±75)cells/mm^(3)at baseline to(264±124)cells/mm^(3)posttreatment in the placebo group.Patients treated with Mianyi granule had higher increases in CD4+T cell counts than those treated with placebo(P=0.045).Reversal of immune nonresponse was defined as a CD4+T cell increase of more than 100 cells/mm^(3).After treatment for 72 weeks,Mianyi granule was effective in reversing immune nonresponse in a higher proportion of individuals(20.2%)compared with placebo(9.7%).CD45 RA+cell counts increased from(34±32)cell/mm^(3)at baseline to(51±61)cells/mm^(3)post-treatment in the Mianyi granule group and from(37±33)cells/mm^(3)at baseline to(48±37)cells/mm^(3)post-treatment in the placebo group.Mianyi granules were more effective than placebo in increasing CD45 RA+cell counts.CONCLUSIONS:In ART-treated HIV-positive adults with immune nonresponse,treatment with Mianyi granules for 72 weeks was safe and significantly increased CD4+and CD45 RA+cell counts,thereby promoting immune reconstitution.
文摘Seventy-two patients of chronic obstructive pulmonary disease (COPD) of Qi deficiency syn-drome with abnormal immune indices were treated with Yiqi Mianyi Granule (YQMYG) and the efficacy wascompared with that of 30 cases treated with Zhenqi fuzheng Granule (ZQFZG) for control. Results showedthat the markedly effective rate of symptomatic improvement ot Qi deficiency in YQMYG group was 65. 3%,the total effective rate 93. 1 % . 88. 6% of the immune indices lower than normal were corrected and 43. 7%ot them were normalized, while for indices that were higher than normal the rate were 78. 2 % and 52 . 9% re-spectively. These results suggested that YQMYG could improve symptom of Qi Deficiency markedly,strengthen cellutar immunity and regulate immune dysfunction. its therapeutic efficacy was obvfously superiorto ZQFZG ( P < 0 . 05 ).
基金Supported by the National Basic Research Program of China(973 Program,No.2010CB530600)
文摘INTRODUCTION： Latent autoimmune diabetes in adults （LADA） is regarded as one of the Insulin-de- pendent diabetes mellitus that progress slowly. It gradually became understood since 1970s. The on- set usually appears in adulthood, the islet autoanti- bodies are positive and the function of 13 cell is de- clined rapidly. The treatment is insulin injection. CASE PRESENTATION： The case reported followed is a 37-year-old male patient who was newly diag- nosed with type 2 diabetes. He abandoned oral hy- poglycemic agents since they caused stomach in- disposed. Before visiting, his islet autoantibodies were detected positive and he had never injected insulin before. We treated him with traditional Chi- nese herbals under the guidance of Traditional Chi- nese Medicine and differentiation, and achieved fine efficacy. CONCLUSION： Because the initial presentation of LADA is similar to Type 2 Diabetes Mellitus and ex- amination is not in common use, misdiagnosis isnot rare. Once LADA is diagnosed, the therapy must be adjusted. This case report indicated that Traditional Chinese Medicine might be an alterna- tive treatment for LADA.
