The growing interest in Honeypots has resulted in increased research, and consequently, a large number of research surveys and/or reviews. Most Honeypot surveys and/or reviews focus on specific and narrow Honeypot res...The growing interest in Honeypots has resulted in increased research, and consequently, a large number of research surveys and/or reviews. Most Honeypot surveys and/or reviews focus on specific and narrow Honeypot research areas. This study aims at exploring and presenting advances and trends in Honeypot’s research and development areas. To this end, a systematic methodology and meta-review analysis were applied to the selection, evaluation, and qualitative examination of the most influential Honeypot surveys and/or reviews available in scientific bibliographic databases. A total of 188 papers have been evaluated and 22 research papers are found by this study to have a higher impact. The findings of the study suggest that the Honeypot survey and/or review papers of considerable relevance to the research community were mostly published in 2018, by IEEE, in conferences organized in India, and included in the IEEE Xplore database. Also, there have been few qualities Honeypot surveys and/or reviews published after 2018. Furthermore, the study identified 10 classes of vital and emerging themes and/or key topics in Honeypot research. This work contributes to research efforts employing established systematic review and reporting methods in Honeypot research. We have included our meta-review methodology, in order to allow further work in this area aiming at a better understanding of the progression of Honeypot research and advances.展开更多
Sustainable aviation fuel(SAF)offers various pathways to mitigate the aviation industry’s significant carbon footprint.Over the past years,the SAF research landscape has seen a proliferation of overview/survey papers...Sustainable aviation fuel(SAF)offers various pathways to mitigate the aviation industry’s significant carbon footprint.Over the past years,the SAF research landscape has seen a proliferation of overview/survey papers across diverse domains,driven by an increasing number of primary studies.The fragmentation of these papers across disciplinary boundaries,however,has a strong potential to prevent a comprehensive understanding of SAF state of the art and advancements.In this meta-review,we synthesize insights from the extant SAF survey literature.By systematically analyzing over 60 survey/overview papers on feedstock production,fuel synthesis technologies,lifecycle assessments,policy frameworks,economic viability,and intersections thereof,our review identifies recurring themes and emerging technologies regarding SAF research.Our meta-review also underscores the need of orchestrated future research efforts,by consolidating the top-10 fragmented SAF challenges across all surveys.We highlight feedstock availability problems,opportunities for scaling up production while maintaining sustainability criteria,fostering cooperation,and harmonizing SAF certification standards,among others.Our meta-review seeks to serve as a navigational tool for researchers,policymakers,and industry stakeholders alike,laying the foundation for a more effective and impactful orchestration of future work towards decarbonizing global aviation.展开更多
目的分析伏诺拉生(VPZ)治疗消化性溃疡(PU)和内镜黏膜下剥离术(ESD)术后溃疡的安全性与有效性,为临床实践、医疗决策提供循证药学证据。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Embase、Web of Science、...目的分析伏诺拉生(VPZ)治疗消化性溃疡(PU)和内镜黏膜下剥离术(ESD)术后溃疡的安全性与有效性,为临床实践、医疗决策提供循证药学证据。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Embase、Web of Science、the Cochrane Library等数据库,获取VPZ治疗PU和ESD术后溃疡相关的Meta分析/系统评价。由2名研究者独立进行文献筛选、数据提取、文献质量评估、文献重叠程度评估,采用伞形评价分析方法;当纳入的文献高度重叠时,对所有相关原始研究数据重新进行Meta分析。结果共纳入17项Meta分析,质量从高质量到极低质量不等;所有涉及的结局指标,在纳入的相关Meta分析中均存在非常高的重叠水平(校正覆盖面积为22.22%~100%)。治疗ESD术后溃疡时,与质子泵抑制剂(PPI)比较,VPZ可显著提高ESD术后4周的溃疡愈合率[RR=1.27,95%CI(1.03,1.56),Z=2.21,P=0.027]和溃疡收缩率[MD=0.08,95%CI(0.00,0.16),Z=2.09,P=0.037],显著降低具有PU病史患者的溃疡复发率[RR=0.49,95%CI(0.32,0.73),Z=3.49,P=0.001];VPZ组延迟出血率较兰索拉唑亚组显著降低[RR=0.47,95%CI(0.25,0.90),Z=2.28,P=0.02]。治疗PU时,十二指肠溃疡亚组中,VPZ的不良事件发生率明显高于PPI[RR=1.13,95%CI(1.02,1.26),Z=2.38,P=0.017]。结论对于ESD术后溃疡,VPZ的治疗效果优于PPI,且可以降低具有PU病史患者的溃疡复发率,但在治疗十二指肠溃疡的安全性方面并不具有优势。展开更多
目的评价局部应用环孢素治疗口腔扁平苔藓(OLP)的有效性和安全性,为临床合理用药提供参考。方法计算机检索PubMed、Embase、The Cochrane Library、Web of Science、中国知网、万方和维普等数据库,并在线检索欧洲灰色文献信息系统(SIGLE...目的评价局部应用环孢素治疗口腔扁平苔藓(OLP)的有效性和安全性,为临床合理用药提供参考。方法计算机检索PubMed、Embase、The Cochrane Library、Web of Science、中国知网、万方和维普等数据库,并在线检索欧洲灰色文献信息系统(SIGLE)和ClinicalTrials网站,搜集所有关于环孢素治疗OLP的随机对照试验(RCT),检索时限均从建库至2023年3月25日。由2名评价者独立评价研究质量和提取数据,采用RevMan 5.4和STATA14.0软件进行Meta分析。结果共纳入7项环孢素治疗OLP的RCT研究,包括317名患者。其中6项为比较环孢素和糖皮质激素,1项为比较环孢素和安慰剂。Meta分析结果显示,环孢素组和激素组临床有效率差异无统计学意义[风险比(RR)=0.87,95%置信区间(CI):0.67~1.14,P=0.32]。治疗4周后,环孢素组和激素组疼痛评分改善差异无统计学意义(标准化均数差=-0.23,95%CI:-0.54~0.07,P=0.13)。环孢素组和激素组的不良反应发生率相比,差异无统计学意义(RR=0.71,95%CI:0.18~2.79,P=0.62)。结论当前证据显示,与糖皮质激素相比,环孢素在临床有效率、疼痛评分改善和安全性方面无优势。受纳入研究数量和质量的限制,上述结论还需更多高质量研究予以验证。展开更多
目的系统评价海昆肾喜胶囊治疗慢性肾功能衰竭(CRF)的有效性,为临床提供循证参考。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、Web of Science、Cochrane Library建库至2025年1月17日收...目的系统评价海昆肾喜胶囊治疗慢性肾功能衰竭(CRF)的有效性,为临床提供循证参考。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、Web of Science、Cochrane Library建库至2025年1月17日收录的海昆肾喜胶囊治疗CRF的随机对照试验(RCT)文献,使用RevMan5.4软件进行Meta分析。结果共纳入26篇RCTs,总样本量2322例。Meta分析结果显示,治疗组总有效率明显高于对照组[OR=3.88,95%CI(3.02,4.97),P<0.00001],血肌酐[MD=-43.90,95%CI(-54.45,-33.36),P<0.00001]及血尿素氮[MD=-3.74,95%CI(-4.68,-2.80),P<0.00001]水平均明显低于对照组,两组差异均有统计学意义。结论海昆肾喜胶囊治疗CRF疗效较好,在改善患者血肌酐、血尿素氮上,治疗组优于对照组,但仍需更多大样本、高质量的临床试验加以验证。展开更多
目的系统评价围手术期应用糖皮质激素对肝切除患者术后应激反应及并发症的影响。方法计算机检索PubMed、Cochrane Library、Web of Science、Embase、SinoMed、WanFang Data、CNKI和VIP数据库,搜集关于肝切除患者围手术期应用糖皮质激...目的系统评价围手术期应用糖皮质激素对肝切除患者术后应激反应及并发症的影响。方法计算机检索PubMed、Cochrane Library、Web of Science、Embase、SinoMed、WanFang Data、CNKI和VIP数据库,搜集关于肝切除患者围手术期应用糖皮质激素的随机对照试验(RCT),检索时限均为建库至2025年4月30日。由2名研究者独立筛选文献、提取数据并评价纳入研究的偏倚风险后,采用RevMan 5.4软件进行Meta分析。结果共纳入15个RCT,包括1332例患者。Meta分析结果显示,与对照组相比,糖皮质激素组患者术后总并发症发生率[RR=0.73,95%CI(0.62,0.87),P<0.001]、术后感染发生率[RR=0.59,95%CI(0.38,0.91),P=0.02]、肝衰竭发生率[RR=0.66,95%CI(0.45,0.98),P=0.04]均较低,C反应蛋白[SMD=-0.83,95%CI(-1.02,-0.65),P<0.001]、白细胞介素-6[SMD=-0.99,95%CI(-1.17,-0.80),P<0.001]等炎症因子水平均较低,术后总胆红素[SMD=-0.59,95%CI(-0.88,-0.29),P<0.001]、天冬氨酸转氨酶[SMD=-0.96,95%CI(-1.59,-0.33),P=0.003]、丙氨酸转氨酶[SMD=-1.20,95%CI(-2.16,-0.24),P=0.01]水平等肝功能指标均较低;糖皮质激素组患者住院时间较短[MD=-1.24,95%CI(-2.43,-0.05),P=0.04]。结论当前证据显示,围手术期应用糖皮质激素可显著降低肝切除患者术后总并发症及感染、肝衰竭发生率,减少炎症因子释放,促进术后肝功能恢复,缩短住院时间,促进患者术后恢复。展开更多
目的评价移动健康干预预防脑卒中复发的有效性。方法检索Pub Med、Web of Science核心合集、Cochrane Library、Scopus、EBSCO、中国知网、万方数据知识服务平台和维普网数据库,检索时限2013年1月至2025年6月。纳入移动健康干预和常规...目的评价移动健康干预预防脑卒中复发的有效性。方法检索Pub Med、Web of Science核心合集、Cochrane Library、Scopus、EBSCO、中国知网、万方数据知识服务平台和维普网数据库,检索时限2013年1月至2025年6月。纳入移动健康干预和常规护理干预下脑卒中复发情况的随机对照试验。2名研究者独立筛选、提取资料并评价质量,采用Rev Man 5.4软件进行meta分析。结果 共纳入17项随机对照试验(n=2 326)。移动健康干预显著降低脑卒中复发风险(RR=0.31,95%CI:0.24~0.40)。即时通讯软件干预(RR=0.30)、应用程序或网站干预(RR=0.40)均有效;3、6、9、12个月观察期RR分别为0.32、0.31、0.14、0.29。缺血性脑卒中亚组(11篇,n=1 428)的干预有效(RR=0.33)。敏感性分析表明结果稳健。结论 移动健康干预有助于降低脑卒中复发风险。未来需要更多高质量、长期随访研究予以验证。展开更多
目的对中医药治疗冠状动脉临界病变的随机对照研究进行系统评价与Meta分析,评价中医药疗效与安全性,并评估现有研究的证据等级。方法计算机检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、中国生物医学文献数据库、...目的对中医药治疗冠状动脉临界病变的随机对照研究进行系统评价与Meta分析,评价中医药疗效与安全性,并评估现有研究的证据等级。方法计算机检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、中国生物医学文献数据库、维普和万方数据库中医药治疗冠状动脉临界病变的随机对照研究,采用Cochrane 5.1.0偏倚风险评估工具进行方法学质量评价,运用RevMan 5.3软件进行Meta分析,运用GRADE(grading of recommendations,assessment,development and evaluation)系统对有统计学意义结局指标的证据质量进行评价。结果最终纳入文献18篇,涉及样本量1799例。结果显示,相较于单纯西医治疗,中西医结合治疗可显著改善中医证候有效率、心绞痛有效率、心电图有效率、西雅图心绞痛量表的各项评分,降低超敏C反应蛋白、白细胞介素-6等炎症因子水平,降低总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平,提升高密度脂蛋白胆固醇水平,降低冠状动脉直径平均狭窄程度,减少平板运动阳性人数,提高左室射血分数,降低主要不良心脏事件发生率。GRADE证据等级评价提示,中医药改善冠状动脉临界病变患者心绞痛症状总有效率、中医证候总有效率、主要不良心脏事件、低密度脂蛋白胆固醇、西雅图心绞痛量表-躯体活动、左室射血分数为高质量证据,其余指标为极低质量、低质量或中等质量证据。结论中医药治疗冠状动脉临界病变具有一定优势,但在证据产出方面还存在较多局限,未来应尽快构建适合中医药临床试验的冠状动脉临界病变核心指标集,开展大样本随机对照研究,为该领域提供更多高质量循证医学证据。展开更多
文摘The growing interest in Honeypots has resulted in increased research, and consequently, a large number of research surveys and/or reviews. Most Honeypot surveys and/or reviews focus on specific and narrow Honeypot research areas. This study aims at exploring and presenting advances and trends in Honeypot’s research and development areas. To this end, a systematic methodology and meta-review analysis were applied to the selection, evaluation, and qualitative examination of the most influential Honeypot surveys and/or reviews available in scientific bibliographic databases. A total of 188 papers have been evaluated and 22 research papers are found by this study to have a higher impact. The findings of the study suggest that the Honeypot survey and/or review papers of considerable relevance to the research community were mostly published in 2018, by IEEE, in conferences organized in India, and included in the IEEE Xplore database. Also, there have been few qualities Honeypot surveys and/or reviews published after 2018. Furthermore, the study identified 10 classes of vital and emerging themes and/or key topics in Honeypot research. This work contributes to research efforts employing established systematic review and reporting methods in Honeypot research. We have included our meta-review methodology, in order to allow further work in this area aiming at a better understanding of the progression of Honeypot research and advances.
基金supported by the National Natural Science Foundation of China(Grant No.U2233214,No.62250710166)the Beijing Science Foundation(IS24035).
文摘Sustainable aviation fuel(SAF)offers various pathways to mitigate the aviation industry’s significant carbon footprint.Over the past years,the SAF research landscape has seen a proliferation of overview/survey papers across diverse domains,driven by an increasing number of primary studies.The fragmentation of these papers across disciplinary boundaries,however,has a strong potential to prevent a comprehensive understanding of SAF state of the art and advancements.In this meta-review,we synthesize insights from the extant SAF survey literature.By systematically analyzing over 60 survey/overview papers on feedstock production,fuel synthesis technologies,lifecycle assessments,policy frameworks,economic viability,and intersections thereof,our review identifies recurring themes and emerging technologies regarding SAF research.Our meta-review also underscores the need of orchestrated future research efforts,by consolidating the top-10 fragmented SAF challenges across all surveys.We highlight feedstock availability problems,opportunities for scaling up production while maintaining sustainability criteria,fostering cooperation,and harmonizing SAF certification standards,among others.Our meta-review seeks to serve as a navigational tool for researchers,policymakers,and industry stakeholders alike,laying the foundation for a more effective and impactful orchestration of future work towards decarbonizing global aviation.
文摘目的分析伏诺拉生(VPZ)治疗消化性溃疡(PU)和内镜黏膜下剥离术(ESD)术后溃疡的安全性与有效性,为临床实践、医疗决策提供循证药学证据。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Embase、Web of Science、the Cochrane Library等数据库,获取VPZ治疗PU和ESD术后溃疡相关的Meta分析/系统评价。由2名研究者独立进行文献筛选、数据提取、文献质量评估、文献重叠程度评估,采用伞形评价分析方法;当纳入的文献高度重叠时,对所有相关原始研究数据重新进行Meta分析。结果共纳入17项Meta分析,质量从高质量到极低质量不等;所有涉及的结局指标,在纳入的相关Meta分析中均存在非常高的重叠水平(校正覆盖面积为22.22%~100%)。治疗ESD术后溃疡时,与质子泵抑制剂(PPI)比较,VPZ可显著提高ESD术后4周的溃疡愈合率[RR=1.27,95%CI(1.03,1.56),Z=2.21,P=0.027]和溃疡收缩率[MD=0.08,95%CI(0.00,0.16),Z=2.09,P=0.037],显著降低具有PU病史患者的溃疡复发率[RR=0.49,95%CI(0.32,0.73),Z=3.49,P=0.001];VPZ组延迟出血率较兰索拉唑亚组显著降低[RR=0.47,95%CI(0.25,0.90),Z=2.28,P=0.02]。治疗PU时,十二指肠溃疡亚组中,VPZ的不良事件发生率明显高于PPI[RR=1.13,95%CI(1.02,1.26),Z=2.38,P=0.017]。结论对于ESD术后溃疡,VPZ的治疗效果优于PPI,且可以降低具有PU病史患者的溃疡复发率,但在治疗十二指肠溃疡的安全性方面并不具有优势。
文摘目的系统评价海昆肾喜胶囊治疗慢性肾功能衰竭(CRF)的有效性,为临床提供循证参考。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、Web of Science、Cochrane Library建库至2025年1月17日收录的海昆肾喜胶囊治疗CRF的随机对照试验(RCT)文献,使用RevMan5.4软件进行Meta分析。结果共纳入26篇RCTs,总样本量2322例。Meta分析结果显示,治疗组总有效率明显高于对照组[OR=3.88,95%CI(3.02,4.97),P<0.00001],血肌酐[MD=-43.90,95%CI(-54.45,-33.36),P<0.00001]及血尿素氮[MD=-3.74,95%CI(-4.68,-2.80),P<0.00001]水平均明显低于对照组,两组差异均有统计学意义。结论海昆肾喜胶囊治疗CRF疗效较好,在改善患者血肌酐、血尿素氮上,治疗组优于对照组,但仍需更多大样本、高质量的临床试验加以验证。
文摘目的对中医药治疗冠状动脉临界病变的随机对照研究进行系统评价与Meta分析,评价中医药疗效与安全性,并评估现有研究的证据等级。方法计算机检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、中国生物医学文献数据库、维普和万方数据库中医药治疗冠状动脉临界病变的随机对照研究,采用Cochrane 5.1.0偏倚风险评估工具进行方法学质量评价,运用RevMan 5.3软件进行Meta分析,运用GRADE(grading of recommendations,assessment,development and evaluation)系统对有统计学意义结局指标的证据质量进行评价。结果最终纳入文献18篇,涉及样本量1799例。结果显示,相较于单纯西医治疗,中西医结合治疗可显著改善中医证候有效率、心绞痛有效率、心电图有效率、西雅图心绞痛量表的各项评分,降低超敏C反应蛋白、白细胞介素-6等炎症因子水平,降低总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平,提升高密度脂蛋白胆固醇水平,降低冠状动脉直径平均狭窄程度,减少平板运动阳性人数,提高左室射血分数,降低主要不良心脏事件发生率。GRADE证据等级评价提示,中医药改善冠状动脉临界病变患者心绞痛症状总有效率、中医证候总有效率、主要不良心脏事件、低密度脂蛋白胆固醇、西雅图心绞痛量表-躯体活动、左室射血分数为高质量证据,其余指标为极低质量、低质量或中等质量证据。结论中医药治疗冠状动脉临界病变具有一定优势,但在证据产出方面还存在较多局限,未来应尽快构建适合中医药临床试验的冠状动脉临界病变核心指标集,开展大样本随机对照研究,为该领域提供更多高质量循证医学证据。
