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From Sméagol to Gollum: Mechanical Stress and Bone Remodelling
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作者 Nicole Pace 《Open Journal of Orthopedics》 2018年第4期148-167,共20页
This imaginary transformation from Sméagol to Gollum is a dramatization of the illusive repercussions of mechanical stress affecting bone. This paper presents the main ideas of mechanical stress and bone remodell... This imaginary transformation from Sméagol to Gollum is a dramatization of the illusive repercussions of mechanical stress affecting bone. This paper presents the main ideas of mechanical stress and bone remodelling from a novel’s perspective. The object of this study is to provide evidence for new ways to explore bone’s functional adaptation to mechanical stress made through the copious interpretation and integration of new and existing literature. It tackles the underlying biology of bone cells and how they detect and react to strain stimuli. The different types of mechanical demands in daily activities are sifted through and any misconceptions found fallible in literature are refined. A personal experience of a stress fracture is reviewed to parallel the implications that lead to the incident with the findings on the link between mechanical stress and bone remodelling. Some factors regarding age, gender and ethnicity and the interplay with mechanical stress influencing bone remodelling are considered. Brief overviews of three new medical novelties in bone healing are outlined, hoping that these interventions of proper medical techniques can be a change for the better: one from Gollum to Sméagol rather than vice versa. 展开更多
关键词 Mechanical STRESS BONE REmodelLING CYCLE mechanostat model STRESS FRACTURE
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带有力学调控系统的各向异性骨再造模型 被引量:3
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作者 朱东 马宗民 +2 位作者 麻文焱 董心 朱兴华 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2006年第3期525-529,共5页
目前,骨再造数值模型在生理上和力学上都不能复制骨再造的实际生理过程。本文引入了骨再造的生理机制和骨力学性质的各向异性,在损伤修复理论的基础上,建立了带有力学调控系统的各向异性骨再造模型,使骨再造的数值模拟趋向和生理过程一... 目前,骨再造数值模型在生理上和力学上都不能复制骨再造的实际生理过程。本文引入了骨再造的生理机制和骨力学性质的各向异性,在损伤修复理论的基础上,建立了带有力学调控系统的各向异性骨再造模型,使骨再造的数值模拟趋向和生理过程一致,并以二维方板模型为例进行了计算机模拟,得到了和实际较为一致的结果。本模型可用于在一定力学环境下或力学环境改变后,骨结构的模拟,还可用于植入物植入后骨结构发生结构变化的模拟。 展开更多
关键词 力学调控系统 各向异性 损伤修复理论 骨再造模型
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