This editorial critically evaluated the recent study by Wang et al,which systematically investigated the efficacy of perioperative disinfection and isolation measures(including preoperative povidone-iodine disinfectio...This editorial critically evaluated the recent study by Wang et al,which systematically investigated the efficacy of perioperative disinfection and isolation measures(including preoperative povidone-iodine disinfection,intraoperative sterile barrier techniques,and postoperative intensive care)in reducing infection rates.The study further incorporated the surgical site infection risk prediction model(constructed via the least absolute shrinkage and selection operator al-gorithm,integrating patients'baseline characteristics,surgical indicators,and regional antibiotic-resistant bacterial data),and proposed a dynamic prevention and control system termed“disinfection protocols-predictive models–real-time monitoring”.The article highlighted that preoperative risk stratification,intraoperative personalized antibiotic selection,and postoperative multidimensional monitoring(encompassing inflammatory biomarkers,imaging,and microbiological testing)enabled the precise identification of high-risk patients and optimized intervention thresholds.Future research is deemed necessary to validate the synergistic effects of disinfection protocols and predictive models through large-scale multicenter studies,combined with advanced intraoperative rapid microbial detection technologies.This approach aims to establish standardized infection control protocols tailored for precision medicine and regional adaptability.Future research should prioritize validating the synergistic effects of disinfection protocols and predictive models via multi-center studies,while incorporating advanced rapid intraoperative microbial detection technologies to develop standardized infection prevention and control procedures.Such efforts will enhance the implementation of precise and regionally adaptive infection control strategies.展开更多
To accurately reconstruct the tomographic gamma scanning(TGS)transmission measurement image,this study optimized the transmission reconstruction equation based on the actual situation of TGS transmission measurement.U...To accurately reconstruct the tomographic gamma scanning(TGS)transmission measurement image,this study optimized the transmission reconstruction equation based on the actual situation of TGS transmission measurement.Using the transmission reconstruction equation and the Monte Carlo program Geant4,an innovative virtual trajectory length model was constructed.This model integrated the solving process for the trajectory length and detection efficiency within the same model.To mitigate the influence of the angular distribution ofγ-rays emitted by the transmitted source at the detector,the transport processes of numerous particles traversing a virtual nuclear waste barrel with a density of zero were simulated.Consequently,a certain amount of information was captured at each step of particle transport.Simultaneously,the model addressed the nonuniform detection efficiency of the detector end face by considering whether the energy deposition of particles in the detector equaled their initial energy.Two models were established to validate the accuracy and reliability of the virtual trajectory length model.Model 1 was a simplified nuclear waste barrel,whereas Model 2 closely resembled the actual structure of a nuclear waste barrel.The results indicated that the proposed virtual trajectory length model significantly enhanced the precision of the trajectory length determination,substantially increasing the quality of the reconstructed images.For example,the reconstructed images of Model 2 using the“point-to-point”and average trajectory models revealed a signalto-noise ratio increase of 375.0%and 112.7%,respectively.Thus,the virtual trajectory length model proposed in this study holds paramount significance for the precise reconstruction of transmission images.Moreover,it can provide support for the accurate detection of radioactive activity in nuclear waste barrels.展开更多
As important infrastructure for airborne communication platforms,unmanned aerial vehicles(UAVs)are expected to become a key part of 6G wireless networks.Thus,modeling low-and medium-altitude propagation channels has a...As important infrastructure for airborne communication platforms,unmanned aerial vehicles(UAVs)are expected to become a key part of 6G wireless networks.Thus,modeling low-and medium-altitude propagation channels has attracted much attention.Air-to-ground(A2G)propagation channel models vary in different scenarios,requiring accurate models for designing and evaluating UAV communication links.Unlike terrestrial models,A2G channel models lack detailed investigation.Therefore,this paper provides an overview of existing A2G channel measurement campaigns,different types of A2G channel models for various environments,and future research directions for UAV airland channel modeling.This study focuses on the potential of millimeter-wave technology for UAV A2G channel modeling and highlights nonsuburban scenarios requiring consideration in future modeling efforts.展开更多
In modern industrial design trends featuring with integration,miniaturization,and versatility,there is a growing demand on the utilization of microstructural array devices.The measurement of such microstructural array...In modern industrial design trends featuring with integration,miniaturization,and versatility,there is a growing demand on the utilization of microstructural array devices.The measurement of such microstructural array components often encounters challenges due to the reduced scale and complex structures,either by contact or noncontact optical approaches.Among these microstructural arrays,there are still no optical measurement methods for micro corner-cube reflector arrays.To solve this problem,this study introduces a method for effectively eliminating coherent noise and achieving surface profile reconstruction in interference measurements of microstructural arrays.The proposed denoising method allows the calibration and inverse solving of system errors in the frequency domain by employing standard components with known surface types.This enables the effective compensation of the complex amplitude of non-sample coherent light within the interferometer optical path.The proposed surface reconstruction method enables the profile calculation within the situation that there is complex multi-reflection during the propagation of rays in microstructural arrays.Based on the measurement results,two novel metrics are defined to estimate diffraction errors at array junctions and comprehensive errors across multiple array elements,offering insights into other types of microstructure devices.This research not only addresses challenges of the coherent noise and multi-reflection,but also makes a breakthrough for quantitively optical interference measurement of microstructural array devices.展开更多
The equivalent source(ES)method in the spherical coordinate system has been widely applied to processing,reduction,field modeling,and geophysical and geological interpretation of satellite magnetic anomaly data.Howeve...The equivalent source(ES)method in the spherical coordinate system has been widely applied to processing,reduction,field modeling,and geophysical and geological interpretation of satellite magnetic anomaly data.However,the inversion for the ES model suffers from nonuniqueness and instability,which remain unresolved.To mitigate these issues,we introduce both the minimum and flattest models into the model objective function as an alternative regularization approach in the spherical ES method.We first present the methods,then analyze the accuracy of forward calculation and test the proposed ES method in this study by using synthetic data.The experimental results from simulation data indicate that our proposed regularization effectively suppresses the Backus effect and mitigates inversion instability in the low-latitude region.Finally,we apply the proposed method to magnetic anomaly data from China Seismo-Electromagnetic Satellite-1(CSES-1)and Macao Science Satellite-1(MSS-1)magnetic measurements over Africa by constructing an ES model of the large-scale lithospheric magnetic field.Compared with existing global lithospheric magnetic field models,our ES model demonstrates good consistency at high altitudes and predicts more stable fields at low altitudes.Furthermore,we derive the reduction to the pole(RTP)magnetic anomaly fields and the apparent susceptibility contrast distribution based on the ES model.The latter correlates well with the regional tectonic framework in Africa and surroundings.展开更多
Ensuring highway safety relies heavily on pavement friction resistance.To enable network-level pavement skid resistance monitoring and management,this study proposes a non-contact three-dimensional laser surface testi...Ensuring highway safety relies heavily on pavement friction resistance.To enable network-level pavement skid resistance monitoring and management,this study proposes a non-contact three-dimensional laser surface testing method to obtain detailed aggregate surface data.The existing contact-based skid resistance measurement methods suffer from poor reproducibility and repeatability,hindering their application for network-level management.In this research,traditional multiple linear regression and four machine learning methods,support vector machine(SVM),random forest(RF),gradient boosting decision tree(GBDT),and convolutional neural network(CNN),are utilized to evaluate and predict pavement frictional performance.To assess the proposed methods,data from 45 pavement sites in Oklahoma,including 6 major preventive maintenance(PM)treatments and 7 typical types of aggregates,are collected.Parallel data acquisition is conducted at highway speeds using a grip tester and a high-speed texture profiler to measure pavement skid resistance and surface macro-texture,respectively.Aggregate properties are captured in 3D using a portable ultra-high-resolution 3D laser imaging scanner,leading to the calculation of four types of 3D aggregate parameters characterizing the micro-texture of aggregate surfaces.The relationship between pavement surface friction and texture is explored using machine learning models.The results reveal that the random forest and gradient boosting decision tree models exhibit the highest accuracy,SVM and CNN perform moderately,while the traditional linear regression method fares the worst.By assessing the importance of the 38 parameter variables,the most critical 21 variables were selected for model development.Test results demonstrate that the GBDT model exhibits the best predictive performance,with an explanatory capability of 87.4%for road friction performance.The findings demonstrate the feasibility of replacing contact-based pavement friction evaluation with non-contact texture measurements,offering promising prospects for a network-level pavement skid resistance monitoring and management system.展开更多
Wind turbines are continuously exposed to harsh environmental and operational conditions throughout their lifetime,leading to the gradual degradation of their components.If left unaddressed,these degraded components c...Wind turbines are continuously exposed to harsh environmental and operational conditions throughout their lifetime,leading to the gradual degradation of their components.If left unaddressed,these degraded components can adversely affect turbine performance and significantly increase the likelihood of failure.As degradation progresses,the risk of failure escalates,making it essential to implement appropriate risk control measures.One effective risk control method involves performing inspection and monitoring activities that provide valuable insights into the condition of the structure,enabling the formulation of appropriate maintenance strategies based on accurate assessments.Supervisory Control and Data Acquisition(SCADA)systems offer low-resolution condition monitoring data that can be used for fault detection,diagnosis,quantification,prognosis,and maintenance planning.One commonly used method involves predicting power generation using SCADA data and comparing it against measured power generation.Significant discrepancies between predicted and measured values can indicate suboptimal operation,natural aging,or unnatural faults.Various predictive models,including parametric and non-parametric(statistical)approaches,have been proposed for estimating power generation.However,the imperfect nature of these models introduces uncertainties in the predicted power output.Additionally,SCADA monitoring data is prone to uncertainties arising from various sources.The presence of uncertainties from these two sources-imperfect predictive models and imperfect SCADA data-introduces uncertainty in the predicted power generation.This uncertainty complicates the process of determining whether discrepancies between measured and predicted values are significant enough to warrant maintenance actions.Depending on the nature of uncertainty-aleatory,arising from inherent randomness,or epistemic,stemming from incomplete knowledge or limited data-different analytical approaches,like Probabilistic and Possibilistic,can be applied for effective management.Both,Probabilistic and Possibilistic,Approaches offer distinct advantages and limitations.The Possibilistic Approach,rooted in fuzzy set theory,is particularly well suited for addressing epistemic uncertainties,especially those caused by imprecision or sparse statistical information.This makes it especially relevant for applications such as wind turbines,where it is often challenging to construct accurate probability distribution functions for environmental parameters due to limited sensor data from hard-to-access locations.This research focuses on developing a methodology for identifying suboptimal operation in wind turbines by comparing Grid Produced Power(Measured Produced Power)with Predicted Produced Power.To achieve this,the paper introduces a Possibilistic Approach for power prediction that accounts for uncertainties stemming from both model imperfections and measurement errors in SCADA data.The methodology combines machine learning models,used to establish predictive relationships between environmental inputs and power output,with a Possibilistic Framework that represents uncertainty through possibility distribution functions based on fuzzy logic and interval analysis.A real-world case study using operational SCADA data demonstrates the approach,with XGBoost selected as the final predictive model due to its strong accuracy and computational efficiency.展开更多
The phase equilibria relationship of the system RbCl-PEG6000-H2O were investigated at temperatures of 288.2,298.2,and 308.2 K,the compositions of solid-liquid equilibria(SLE)and liquid-liquid equilibria(LLE)were deter...The phase equilibria relationship of the system RbCl-PEG6000-H2O were investigated at temperatures of 288.2,298.2,and 308.2 K,the compositions of solid-liquid equilibria(SLE)and liquid-liquid equilibria(LLE)were determined.The complete phase diagrams,binodal curve diagrams,and tie-line diagrams were all plotted.Results show that both solid-liquid equilibria and liquid-liquid equilibria relationships at each studied temperature.The complete phase diagrams at 288.2 K,298.2 K and 308.2 K consist of six phase regions:unsaturated liquid region(L),two saturated solutions with one solid phase of RbCl(L_S),one saturated liquid phase with two solid phases of PEG6000 and RbCl(2S+L),an aqueous two-phase region(2L),and a region with two liquids and one solid phase of RbCl(2L_S).With the increase in temperature,the layering ability of the aqueous two-phase system increases,and both regions(2L)and(2L_S)increase.The binodal curves were fitted using the nonlinear equations proposed by Mistry,Hu,and Jayapal.Additionally,the tie-line data were correlated with the Othmer-Tobias,Bancroft,Hand,and Bachman equations.The liquid-liquid equilibria at 288.2 K,298.2 K and 308.2 K were calculated using the NRTL model.The findings confirm that the experimental and calculated values are in close agreement,demonstrating the model’s effectiveness in representing the system’s behavior.展开更多
Despite broad consensus on the importance of enterprise digital transformation,significant discrepancies persist regarding its actual effects.This divergence stems primarily from two key measurement challenges:(1)a la...Despite broad consensus on the importance of enterprise digital transformation,significant discrepancies persist regarding its actual effects.This divergence stems primarily from two key measurement challenges:(1)a lack of clear and consistent definitions of enterprise digital transformation,and(2)a lack of rigorous and accurate measurement methodologies.These shortcomings lead to research findings that are incomparable,difficult to replicate,and often conflicting.To effectively address the aforementioned challenges,this paper employs machine learning and large language models(LLMs)to construct a novel set of indicators for enterprise digital transformation.The work begins by manually annotating sentences from annual reports of listed companies in China from 2006 to 2020.These labeled sentences are then used to train and fine-tune several machine learning models,including LLMs.The ERNIE model,demonstrating the best classification performance among the models tested,is selected as the sentence classifier to predict sentence labels across the full text of the annual reports,ultimately constructing the enterprise digital transformation metrics.Both theoretical analysis and multiple data cross-validations demonstrate that the metrics developed in this paper are more accurate than existing approaches.Based on these metrics,the paper empirically examines the impact of enterprise digital transformation on financial performance.Our findings reveal three key points:(1)enterprise digital transformation significantly enhances financial performance,with big data,AI,mobile internet,cloud computing,and the Internet of Things(IoT)all playing a significant role;however,blockchain technology does not show a significant effect;(2)the significant positive effect of digital transformation on financial performance is primarily observed in firms with weaker initial financial performance;and(3)enterprise digital transformation improves financial performance mainly through enhancing efficiency and reducing costs.This research has practical implications for promoting enterprise digital transformation and fostering high-quality economic development.展开更多
In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asy...In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asymptotic stability of the trivial solution and the positive periodic solution.Finally,numerical simulations are presented to validate our results.Our results show that age-selective harvesting is more conducive to sustainable population survival than non-age-selective harvesting.展开更多
Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important a...Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important and scarce network resources such as bandwidth and processing power.There have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial losses.This paper draws its motivation from such real network disaster incidents attributed to signaling storms.In this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and countermeasures.We provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding solutions.Another important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a table.This paper presents an update and an extension of our earlier conference publication.To our knowledge,no similar survey study exists on the subject.展开更多
In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and cha...In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and change.Likewise,this period has seen a significant increase in our understanding of the physical processes and mechanisms that drive precipitation and its variability across different regions of Africa.By leveraging a large volume of climate model outputs,numerous studies have investigated the model representation of African precipitation as well as underlying physical processes.These studies have assessed whether the physical processes are well depicted and whether the models are fit for informing mitigation and adaptation strategies.This paper provides a review of the progress in precipitation simulation overAfrica in state-of-the-science climate models and discusses the major issues and challenges that remain.展开更多
Utilizing finite element analysis,the ballistic protection provided by a combination of perforated D-shaped and base armor plates,collectively referred to as radiator armor,is evaluated.ANSYS Explicit Dynamics is empl...Utilizing finite element analysis,the ballistic protection provided by a combination of perforated D-shaped and base armor plates,collectively referred to as radiator armor,is evaluated.ANSYS Explicit Dynamics is employed to simulate the ballistic impact of 7.62 mm armor-piercing projectiles on Aluminum AA5083-H116 and Steel Secure 500 armors,focusing on the evaluation of material deformation and penetration resistance at varying impact points.While the D-shaped armor plate is penetrated by the armor-piercing projectiles,the combination of the perforated D-shaped and base armor plates successfully halts penetration.A numerical model based on the finite element method is developed using software such as SolidWorks and ANSYS to analyze the interaction between radiator armor and bullet.The perforated design of radiator armor is to maintain airflow for radiator function,with hole sizes smaller than the bullet core diameter to protect radiator assemblies.Predictions are made regarding the brittle fracture resulting from the projectile core′s bending due to asymmetric impact,and the resulting fragments failed to penetrate the perforated base armor plate.Craters are formed on the surface of the perforated D-shaped armor plate due to the impact of projectile fragments.The numerical model accurately predicts hole growth and projectile penetration upon impact with the armor,demonstrating effective protection of the radiator assemblies by the radiator armor.展开更多
Single-cell biomechanics and electrophysiology measuring tools have transformed biological research over the last few decades,which enabling a comprehensive and nuanced understanding of cellular behavior and function....Single-cell biomechanics and electrophysiology measuring tools have transformed biological research over the last few decades,which enabling a comprehensive and nuanced understanding of cellular behavior and function.Despite their high-quality information content,these single-cell measuring techniques suffer from laborious manual processing by highly skilled workers and extremely low throughput(tens of cells per day).Recently,numerous researchers have automated the measurement of cell mechanical and electrical signals through robotic localization and control processes.While these efforts have demonstrated promising progress,critical challenges persist,including human dependency,learning complexity,in-situ measurement,and multidimensional signal acquisition.To identify key limitations and highlight emerging opportunities for innovation,in this review,we comprehensively summarize the key steps of robotic technologies in single-cell biomechanics and electrophysiology.We also discussed the prospects and challenges of robotics and automation in biological research.By bridging gaps between engineering,biology,and data science,this work aims to stimulate interdisciplinary research and accelerate the translation of robotic single-cell technologies into practical applications in the life sciences and medical fields.展开更多
PM_(1.0),particulate matter with an aerodynamic diameter smaller than 1.0μm,can adversely affect human health.However,fewer stations are capable of measuring PM_(1.0) concentrations than PM2.5 and PM10 concentrations...PM_(1.0),particulate matter with an aerodynamic diameter smaller than 1.0μm,can adversely affect human health.However,fewer stations are capable of measuring PM_(1.0) concentrations than PM2.5 and PM10 concentrations in real time(i.e.,only 9 locations for PM_(1.0) vs.623 locations for PM2.5 or PM10)in South Korea,making it impossible to conduct a nationwide health risk analysis of PM_(1.0).Thus,this study aimed to develop a PM_(1.0) prediction model using a random forest algorithm based on PM_(1.0) data from the nine measurement stations and various environmental input factors.Cross validation,in which the model was trained in eight stations and tested in the remaining station,achieved an average R^(2) of 0.913.The high R^(2) value achieved undermutually exclusive training and test locations in the cross validation can be ascribed to the fact that all the locations had similar relationships between PM_(1.0) and the input factors,which were captured by our model.Moreover,results of feature importance analysis showed that PM2.5 and PM10 concentrations were the two most important input features in predicting PM_(1.0) concentration.Finally,the model was used to estimate the PM_(1.0) concentrations in 623 locations,where input factors such as PM2.5 and PM10 can be obtained.Based on the augmented profile,we identified Seoul and Ansan to be PM_(1.0) concentration hotspots.These regions are large cities or the center of anthropogenic and industrial activities.The proposed model and the augmented PM_(1.0) profiles can be used for large epidemiological studies to understand the health impacts of PM_(1.0).展开更多
Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(...Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].展开更多
To investigate the influence of coarse aggregate parent rock properties on the elastic modulus of concrete,the mineralogical properties and stress-strain curves of granite and dolomite parent rocks,as well as the stre...To investigate the influence of coarse aggregate parent rock properties on the elastic modulus of concrete,the mineralogical properties and stress-strain curves of granite and dolomite parent rocks,as well as the strength and elastic modulus of mortar and concrete prepared with mechanism aggregates of the corresponding lithology,and the stress-strain curves of concrete were investigated.In this paper,a coarse aggregate and mortar matrix bonding assumption is proposed,and a prediction model for the elastic modulus of mortar is established by considering the lithology of the mechanism sand and the slurry components.An equivalent coarse aggregate elastic modulus model was established by considering factors such as coarse aggregate particle size,volume fraction,and mortar thickness between coarse aggregates.Based on the elastic modulus of the equivalent coarse aggregate and the remaining mortar,a prediction model for the elastic modulus of the two and three components of concrete in series and then in parallel was established,and the predicted values differed from the measured values within 10%.It is proposed that the coarse aggregate elastic modulus in highstrength concrete is the most critical factor affecting the elastic modulus of concrete,and as the coarse aggregate elastic modulus increases by 27.7%,the concrete elastic modulus increases by 19.5%.展开更多
Current shipping,tourism,and resource development requirements call for more accurate predictions of the Arctic sea-ice concentration(SIC).However,due to the complex physical processes involved,predicting the spatiote...Current shipping,tourism,and resource development requirements call for more accurate predictions of the Arctic sea-ice concentration(SIC).However,due to the complex physical processes involved,predicting the spatiotemporal distribution of Arctic SIC is more challenging than predicting its total extent.In this study,spatiotemporal prediction models for monthly Arctic SIC at 1-to 3-month leads are developed based on U-Net-an effective convolutional deep-learning approach.Based on explicit Arctic sea-ice-atmosphere interactions,11 variables associated with Arctic sea-ice variations are selected as predictors,including observed Arctic SIC,atmospheric,oceanic,and heat flux variables at 1-to 3-month leads.The prediction skills for the monthly Arctic SIC of the test set(from January 2018 to December 2022)are evaluated by examining the mean absolute error(MAE)and binary accuracy(BA).Results showed that the U-Net model had lower MAE and higher BA for Arctic SIC compared to two dynamic climate prediction systems(CFSv2 and NorCPM).By analyzing the relative importance of each predictor,the prediction accuracy relies more on the SIC at the 1-month lead,but on the surface net solar radiation flux at 2-to 3-month leads.However,dynamic models show limited prediction skills for surface net solar radiation flux and other physical processes,especially in autumn.Therefore,the U-Net model can be used to capture the connections among these key physical processes associated with Arctic sea ice and thus offers a significant advantage in predicting Arctic SIC.展开更多
BACKGROUND Non-erosive reflux disease(NERD),the main gastroesophageal reflux subtype,features reflux symptoms without mucosal damage.Anxiety links to visceral hypersensitivity in NERD,yet mechanisms and animal models ...BACKGROUND Non-erosive reflux disease(NERD),the main gastroesophageal reflux subtype,features reflux symptoms without mucosal damage.Anxiety links to visceral hypersensitivity in NERD,yet mechanisms and animal models are unclear.AIM To establish a translational NERD rat model with anxiety comorbidity via tail clamping and study corticotropin-releasing hormone(CRH)-mediated neuroimmune pathways in visceral hypersensitivity and esophageal injury.METHODS Sprague-Dawley(SD)and Wistar rats were grouped into sham,model,and modified groups(n=10 each).The treatments for the modified groups were as follows:SD rats received ovalbumin/aluminum hydroxide suspension+acid perfusion±tail clamping(40 minutes/day for 7 days),while Wistar rats received fructose water+tail clamping.Esophageal pathology,visceral sensitivity,and behavior were assessed.Serum CRH,calcitonin gene-related peptide(CGRP),5-hydroxytryptamine(5-HT),and mast cell tryptase(MCT)and central amygdala(CeA)CRH mRNA were measured via ELISA and qRT-PCR.RESULTS Tail clamping induced anxiety,worsening visceral hypersensitivity(lower abdominal withdrawal reflex thresholds,P<0.05)and esophageal injury(dilated intercellular spaces and mitochondrial edema).Both models showed raised serum CRH,CGRP,5-HT,and MCT(P<0.01)and CeA CRH mRNA expression(P<0.01).Behavioral tests confirmed anxiety-like phenotypes.NERD-anxiety rats showed clinical-like symptom severity without erosion.CONCLUSION Tail clamping induces anxiety in NERD models,worsening visceral hypersensitivity via CRH neuroimmune dysregulation,offering a translational model and highlighting CRH as a treatment target.展开更多
Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening pa...Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening particles also deteriorates the processability and it is of great importance to establish accurate processing maps to guide the thermomechanical processes to enhance the formability.In this study,we performed particle swarm optimization-based back propagation artificial neural network model to predict the high temperature flow behavior of 0.25wt%Al2O3 particle-reinforced Cu alloys,and compared the accuracy with that of derived by Arrhenius-type constitutive model and back propagation artificial neural network model.To train these models,we obtained the raw data by fabricating ODS Cu alloys using the internal oxidation and reduction method,and conducting systematic hot compression tests between 400 and800℃with strain rates of 10^(-2)-10 S^(-1).At last,processing maps for ODS Cu alloys were proposed by combining processing parameters,mechanical behavior,microstructure characterization,and the modeling results achieved a coefficient of determination higher than>99%.展开更多
文摘This editorial critically evaluated the recent study by Wang et al,which systematically investigated the efficacy of perioperative disinfection and isolation measures(including preoperative povidone-iodine disinfection,intraoperative sterile barrier techniques,and postoperative intensive care)in reducing infection rates.The study further incorporated the surgical site infection risk prediction model(constructed via the least absolute shrinkage and selection operator al-gorithm,integrating patients'baseline characteristics,surgical indicators,and regional antibiotic-resistant bacterial data),and proposed a dynamic prevention and control system termed“disinfection protocols-predictive models–real-time monitoring”.The article highlighted that preoperative risk stratification,intraoperative personalized antibiotic selection,and postoperative multidimensional monitoring(encompassing inflammatory biomarkers,imaging,and microbiological testing)enabled the precise identification of high-risk patients and optimized intervention thresholds.Future research is deemed necessary to validate the synergistic effects of disinfection protocols and predictive models through large-scale multicenter studies,combined with advanced intraoperative rapid microbial detection technologies.This approach aims to establish standardized infection control protocols tailored for precision medicine and regional adaptability.Future research should prioritize validating the synergistic effects of disinfection protocols and predictive models via multi-center studies,while incorporating advanced rapid intraoperative microbial detection technologies to develop standardized infection prevention and control procedures.Such efforts will enhance the implementation of precise and regionally adaptive infection control strategies.
基金supported by The Youth Science Foundation of Sichuan Province(Nos.2022NSFSC1230,2022NSFSC1231,and 23NSFSC5321)the Science and Technology Innovation Seedling Project of Sichuan Province(No.MZGC20230080)+2 种基金the General project of national Natural Science Foundation of China(No.12075039)the Youth Science Foundation of China(No.12105030)the Key project of the National Natural Science Foundation of China(No.U19A2086)。
文摘To accurately reconstruct the tomographic gamma scanning(TGS)transmission measurement image,this study optimized the transmission reconstruction equation based on the actual situation of TGS transmission measurement.Using the transmission reconstruction equation and the Monte Carlo program Geant4,an innovative virtual trajectory length model was constructed.This model integrated the solving process for the trajectory length and detection efficiency within the same model.To mitigate the influence of the angular distribution ofγ-rays emitted by the transmitted source at the detector,the transport processes of numerous particles traversing a virtual nuclear waste barrel with a density of zero were simulated.Consequently,a certain amount of information was captured at each step of particle transport.Simultaneously,the model addressed the nonuniform detection efficiency of the detector end face by considering whether the energy deposition of particles in the detector equaled their initial energy.Two models were established to validate the accuracy and reliability of the virtual trajectory length model.Model 1 was a simplified nuclear waste barrel,whereas Model 2 closely resembled the actual structure of a nuclear waste barrel.The results indicated that the proposed virtual trajectory length model significantly enhanced the precision of the trajectory length determination,substantially increasing the quality of the reconstructed images.For example,the reconstructed images of Model 2 using the“point-to-point”and average trajectory models revealed a signalto-noise ratio increase of 375.0%and 112.7%,respectively.Thus,the virtual trajectory length model proposed in this study holds paramount significance for the precise reconstruction of transmission images.Moreover,it can provide support for the accurate detection of radioactive activity in nuclear waste barrels.
基金supported by the National Natural Science Foundation of China under Grant No.42176190Fundamental Research Funds for the Central Universities,CHD under Grant Nos.300102243401 and 300102244203Research Funds for the Interdisciplinary Projects,CHU under Grant Nos.300104240912 and 300104240922。
文摘As important infrastructure for airborne communication platforms,unmanned aerial vehicles(UAVs)are expected to become a key part of 6G wireless networks.Thus,modeling low-and medium-altitude propagation channels has attracted much attention.Air-to-ground(A2G)propagation channel models vary in different scenarios,requiring accurate models for designing and evaluating UAV communication links.Unlike terrestrial models,A2G channel models lack detailed investigation.Therefore,this paper provides an overview of existing A2G channel measurement campaigns,different types of A2G channel models for various environments,and future research directions for UAV airland channel modeling.This study focuses on the potential of millimeter-wave technology for UAV A2G channel modeling and highlights nonsuburban scenarios requiring consideration in future modeling efforts.
基金Supported by National Natural Science Foundation of China(Grant Nos.52375414,52075100)Shanghai Science and Technology Committee Innovation Grant of China(Grant No.23ZR1404200).
文摘In modern industrial design trends featuring with integration,miniaturization,and versatility,there is a growing demand on the utilization of microstructural array devices.The measurement of such microstructural array components often encounters challenges due to the reduced scale and complex structures,either by contact or noncontact optical approaches.Among these microstructural arrays,there are still no optical measurement methods for micro corner-cube reflector arrays.To solve this problem,this study introduces a method for effectively eliminating coherent noise and achieving surface profile reconstruction in interference measurements of microstructural arrays.The proposed denoising method allows the calibration and inverse solving of system errors in the frequency domain by employing standard components with known surface types.This enables the effective compensation of the complex amplitude of non-sample coherent light within the interferometer optical path.The proposed surface reconstruction method enables the profile calculation within the situation that there is complex multi-reflection during the propagation of rays in microstructural arrays.Based on the measurement results,two novel metrics are defined to estimate diffraction errors at array junctions and comprehensive errors across multiple array elements,offering insights into other types of microstructure devices.This research not only addresses challenges of the coherent noise and multi-reflection,but also makes a breakthrough for quantitively optical interference measurement of microstructural array devices.
基金supported by the National Natural Science Foundation of China(Grant Nos.42250103 and 42174090)the Opening Fund of Key Laboratory of Geological Survey and Evaluation of Ministry of Education(Grant No.GLAB2023ZR02)the MOST Special Fund from the State Key Laboratory of Geological Processes and Mineral Resources(Grant No.MSFGPMR2022-4).
文摘The equivalent source(ES)method in the spherical coordinate system has been widely applied to processing,reduction,field modeling,and geophysical and geological interpretation of satellite magnetic anomaly data.However,the inversion for the ES model suffers from nonuniqueness and instability,which remain unresolved.To mitigate these issues,we introduce both the minimum and flattest models into the model objective function as an alternative regularization approach in the spherical ES method.We first present the methods,then analyze the accuracy of forward calculation and test the proposed ES method in this study by using synthetic data.The experimental results from simulation data indicate that our proposed regularization effectively suppresses the Backus effect and mitigates inversion instability in the low-latitude region.Finally,we apply the proposed method to magnetic anomaly data from China Seismo-Electromagnetic Satellite-1(CSES-1)and Macao Science Satellite-1(MSS-1)magnetic measurements over Africa by constructing an ES model of the large-scale lithospheric magnetic field.Compared with existing global lithospheric magnetic field models,our ES model demonstrates good consistency at high altitudes and predicts more stable fields at low altitudes.Furthermore,we derive the reduction to the pole(RTP)magnetic anomaly fields and the apparent susceptibility contrast distribution based on the ES model.The latter correlates well with the regional tectonic framework in Africa and surroundings.
基金study is under the research project“development of aggregate characteristics-based preventive maintenance treatments using 3D laser imaging and aggregate imaging technology for optimized skid resistance of pavements”sponsored by the Oklahoma Department of Transportation(ODOT SPR 2275).
文摘Ensuring highway safety relies heavily on pavement friction resistance.To enable network-level pavement skid resistance monitoring and management,this study proposes a non-contact three-dimensional laser surface testing method to obtain detailed aggregate surface data.The existing contact-based skid resistance measurement methods suffer from poor reproducibility and repeatability,hindering their application for network-level management.In this research,traditional multiple linear regression and four machine learning methods,support vector machine(SVM),random forest(RF),gradient boosting decision tree(GBDT),and convolutional neural network(CNN),are utilized to evaluate and predict pavement frictional performance.To assess the proposed methods,data from 45 pavement sites in Oklahoma,including 6 major preventive maintenance(PM)treatments and 7 typical types of aggregates,are collected.Parallel data acquisition is conducted at highway speeds using a grip tester and a high-speed texture profiler to measure pavement skid resistance and surface macro-texture,respectively.Aggregate properties are captured in 3D using a portable ultra-high-resolution 3D laser imaging scanner,leading to the calculation of four types of 3D aggregate parameters characterizing the micro-texture of aggregate surfaces.The relationship between pavement surface friction and texture is explored using machine learning models.The results reveal that the random forest and gradient boosting decision tree models exhibit the highest accuracy,SVM and CNN perform moderately,while the traditional linear regression method fares the worst.By assessing the importance of the 38 parameter variables,the most critical 21 variables were selected for model development.Test results demonstrate that the GBDT model exhibits the best predictive performance,with an explanatory capability of 87.4%for road friction performance.The findings demonstrate the feasibility of replacing contact-based pavement friction evaluation with non-contact texture measurements,offering promising prospects for a network-level pavement skid resistance monitoring and management system.
文摘Wind turbines are continuously exposed to harsh environmental and operational conditions throughout their lifetime,leading to the gradual degradation of their components.If left unaddressed,these degraded components can adversely affect turbine performance and significantly increase the likelihood of failure.As degradation progresses,the risk of failure escalates,making it essential to implement appropriate risk control measures.One effective risk control method involves performing inspection and monitoring activities that provide valuable insights into the condition of the structure,enabling the formulation of appropriate maintenance strategies based on accurate assessments.Supervisory Control and Data Acquisition(SCADA)systems offer low-resolution condition monitoring data that can be used for fault detection,diagnosis,quantification,prognosis,and maintenance planning.One commonly used method involves predicting power generation using SCADA data and comparing it against measured power generation.Significant discrepancies between predicted and measured values can indicate suboptimal operation,natural aging,or unnatural faults.Various predictive models,including parametric and non-parametric(statistical)approaches,have been proposed for estimating power generation.However,the imperfect nature of these models introduces uncertainties in the predicted power output.Additionally,SCADA monitoring data is prone to uncertainties arising from various sources.The presence of uncertainties from these two sources-imperfect predictive models and imperfect SCADA data-introduces uncertainty in the predicted power generation.This uncertainty complicates the process of determining whether discrepancies between measured and predicted values are significant enough to warrant maintenance actions.Depending on the nature of uncertainty-aleatory,arising from inherent randomness,or epistemic,stemming from incomplete knowledge or limited data-different analytical approaches,like Probabilistic and Possibilistic,can be applied for effective management.Both,Probabilistic and Possibilistic,Approaches offer distinct advantages and limitations.The Possibilistic Approach,rooted in fuzzy set theory,is particularly well suited for addressing epistemic uncertainties,especially those caused by imprecision or sparse statistical information.This makes it especially relevant for applications such as wind turbines,where it is often challenging to construct accurate probability distribution functions for environmental parameters due to limited sensor data from hard-to-access locations.This research focuses on developing a methodology for identifying suboptimal operation in wind turbines by comparing Grid Produced Power(Measured Produced Power)with Predicted Produced Power.To achieve this,the paper introduces a Possibilistic Approach for power prediction that accounts for uncertainties stemming from both model imperfections and measurement errors in SCADA data.The methodology combines machine learning models,used to establish predictive relationships between environmental inputs and power output,with a Possibilistic Framework that represents uncertainty through possibility distribution functions based on fuzzy logic and interval analysis.A real-world case study using operational SCADA data demonstrates the approach,with XGBoost selected as the final predictive model due to its strong accuracy and computational efficiency.
基金supported by the National Natural Science Foundation of China(U1507111).
文摘The phase equilibria relationship of the system RbCl-PEG6000-H2O were investigated at temperatures of 288.2,298.2,and 308.2 K,the compositions of solid-liquid equilibria(SLE)and liquid-liquid equilibria(LLE)were determined.The complete phase diagrams,binodal curve diagrams,and tie-line diagrams were all plotted.Results show that both solid-liquid equilibria and liquid-liquid equilibria relationships at each studied temperature.The complete phase diagrams at 288.2 K,298.2 K and 308.2 K consist of six phase regions:unsaturated liquid region(L),two saturated solutions with one solid phase of RbCl(L_S),one saturated liquid phase with two solid phases of PEG6000 and RbCl(2S+L),an aqueous two-phase region(2L),and a region with two liquids and one solid phase of RbCl(2L_S).With the increase in temperature,the layering ability of the aqueous two-phase system increases,and both regions(2L)and(2L_S)increase.The binodal curves were fitted using the nonlinear equations proposed by Mistry,Hu,and Jayapal.Additionally,the tie-line data were correlated with the Othmer-Tobias,Bancroft,Hand,and Bachman equations.The liquid-liquid equilibria at 288.2 K,298.2 K and 308.2 K were calculated using the NRTL model.The findings confirm that the experimental and calculated values are in close agreement,demonstrating the model’s effectiveness in representing the system’s behavior.
基金supported by the Fundamental Research Funds for the Central Universitiesfollowing projects:the Major Project of the National Social Science Fund of China(NSSFC)“Research on the Synergistic Mechanisms of Innovation and Governance for High-Quality Development of the Digital Economy”(Grant No.22&ZD070)+1 种基金the Youth Project of the National Natural Science Foundation of China(NSFC)“Research on Risk-Taking of Zombie Enterprises from a Government-Enterprise Interaction Perspective:Tendency,Behavioral Patterns,and Economic Consequences”(Grant No.72002213)the General Program of the National Natural Science Foundation of China(NSFC)“Reshaping Enterprise Nature,Boundaries,and Internal Organization in the Digital Economy”(Grant No.72273144).
文摘Despite broad consensus on the importance of enterprise digital transformation,significant discrepancies persist regarding its actual effects.This divergence stems primarily from two key measurement challenges:(1)a lack of clear and consistent definitions of enterprise digital transformation,and(2)a lack of rigorous and accurate measurement methodologies.These shortcomings lead to research findings that are incomparable,difficult to replicate,and often conflicting.To effectively address the aforementioned challenges,this paper employs machine learning and large language models(LLMs)to construct a novel set of indicators for enterprise digital transformation.The work begins by manually annotating sentences from annual reports of listed companies in China from 2006 to 2020.These labeled sentences are then used to train and fine-tune several machine learning models,including LLMs.The ERNIE model,demonstrating the best classification performance among the models tested,is selected as the sentence classifier to predict sentence labels across the full text of the annual reports,ultimately constructing the enterprise digital transformation metrics.Both theoretical analysis and multiple data cross-validations demonstrate that the metrics developed in this paper are more accurate than existing approaches.Based on these metrics,the paper empirically examines the impact of enterprise digital transformation on financial performance.Our findings reveal three key points:(1)enterprise digital transformation significantly enhances financial performance,with big data,AI,mobile internet,cloud computing,and the Internet of Things(IoT)all playing a significant role;however,blockchain technology does not show a significant effect;(2)the significant positive effect of digital transformation on financial performance is primarily observed in firms with weaker initial financial performance;and(3)enterprise digital transformation improves financial performance mainly through enhancing efficiency and reducing costs.This research has practical implications for promoting enterprise digital transformation and fostering high-quality economic development.
基金Supported by the National Natural Science Foundation of China(12261018)Universities Key Laboratory of Mathematical Modeling and Data Mining in Guizhou Province(2023013)。
文摘In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asymptotic stability of the trivial solution and the positive periodic solution.Finally,numerical simulations are presented to validate our results.Our results show that age-selective harvesting is more conducive to sustainable population survival than non-age-selective harvesting.
基金the Deanship of Graduate Studies and Scientific Research at Qassim University for financial support(QU-APC-2024-9/1).
文摘Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband networks.However,they consume important and scarce network resources such as bandwidth and processing power.There have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial losses.This paper draws its motivation from such real network disaster incidents attributed to signaling storms.In this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and countermeasures.We provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding solutions.Another important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a table.This paper presents an update and an extension of our earlier conference publication.To our knowledge,no similar survey study exists on the subject.
基金the World Climate Research Programme(WCRP),Climate Variability and Predictability(CLIVAR),and Global Energy and Water Exchanges(GEWEX)for facilitating the coordination of African monsoon researchsupport from the Center for Earth System Modeling,Analysis,and Data at the Pennsylvania State Universitythe support of the Office of Science of the U.S.Department of Energy Biological and Environmental Research as part of the Regional&Global Model Analysis(RGMA)program area。
文摘In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and change.Likewise,this period has seen a significant increase in our understanding of the physical processes and mechanisms that drive precipitation and its variability across different regions of Africa.By leveraging a large volume of climate model outputs,numerous studies have investigated the model representation of African precipitation as well as underlying physical processes.These studies have assessed whether the physical processes are well depicted and whether the models are fit for informing mitigation and adaptation strategies.This paper provides a review of the progress in precipitation simulation overAfrica in state-of-the-science climate models and discusses the major issues and challenges that remain.
文摘Utilizing finite element analysis,the ballistic protection provided by a combination of perforated D-shaped and base armor plates,collectively referred to as radiator armor,is evaluated.ANSYS Explicit Dynamics is employed to simulate the ballistic impact of 7.62 mm armor-piercing projectiles on Aluminum AA5083-H116 and Steel Secure 500 armors,focusing on the evaluation of material deformation and penetration resistance at varying impact points.While the D-shaped armor plate is penetrated by the armor-piercing projectiles,the combination of the perforated D-shaped and base armor plates successfully halts penetration.A numerical model based on the finite element method is developed using software such as SolidWorks and ANSYS to analyze the interaction between radiator armor and bullet.The perforated design of radiator armor is to maintain airflow for radiator function,with hole sizes smaller than the bullet core diameter to protect radiator assemblies.Predictions are made regarding the brittle fracture resulting from the projectile core′s bending due to asymmetric impact,and the resulting fragments failed to penetrate the perforated base armor plate.Craters are formed on the surface of the perforated D-shaped armor plate due to the impact of projectile fragments.The numerical model accurately predicts hole growth and projectile penetration upon impact with the armor,demonstrating effective protection of the radiator assemblies by the radiator armor.
基金the National Natural Science Foundation of China[62525301,62127811,62433019]the New Cornerstone Science Foundation through the XPLORER PRIZEthe financial support by the China Postdoctoral Science Foundation[GZB20240797].
文摘Single-cell biomechanics and electrophysiology measuring tools have transformed biological research over the last few decades,which enabling a comprehensive and nuanced understanding of cellular behavior and function.Despite their high-quality information content,these single-cell measuring techniques suffer from laborious manual processing by highly skilled workers and extremely low throughput(tens of cells per day).Recently,numerous researchers have automated the measurement of cell mechanical and electrical signals through robotic localization and control processes.While these efforts have demonstrated promising progress,critical challenges persist,including human dependency,learning complexity,in-situ measurement,and multidimensional signal acquisition.To identify key limitations and highlight emerging opportunities for innovation,in this review,we comprehensively summarize the key steps of robotic technologies in single-cell biomechanics and electrophysiology.We also discussed the prospects and challenges of robotics and automation in biological research.By bridging gaps between engineering,biology,and data science,this work aims to stimulate interdisciplinary research and accelerate the translation of robotic single-cell technologies into practical applications in the life sciences and medical fields.
基金supported by the Fine Particle Research Initiative in East Asia Considering National Differences Project through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(No.NRF-2023M3G1A1090660)supported by a grant from the National Institute of Environmental Research(NIER),funded by the Ministry of Environment of the Republic of Korea(No.NIER-2023-04-02-056).
文摘PM_(1.0),particulate matter with an aerodynamic diameter smaller than 1.0μm,can adversely affect human health.However,fewer stations are capable of measuring PM_(1.0) concentrations than PM2.5 and PM10 concentrations in real time(i.e.,only 9 locations for PM_(1.0) vs.623 locations for PM2.5 or PM10)in South Korea,making it impossible to conduct a nationwide health risk analysis of PM_(1.0).Thus,this study aimed to develop a PM_(1.0) prediction model using a random forest algorithm based on PM_(1.0) data from the nine measurement stations and various environmental input factors.Cross validation,in which the model was trained in eight stations and tested in the remaining station,achieved an average R^(2) of 0.913.The high R^(2) value achieved undermutually exclusive training and test locations in the cross validation can be ascribed to the fact that all the locations had similar relationships between PM_(1.0) and the input factors,which were captured by our model.Moreover,results of feature importance analysis showed that PM2.5 and PM10 concentrations were the two most important input features in predicting PM_(1.0) concentration.Finally,the model was used to estimate the PM_(1.0) concentrations in 623 locations,where input factors such as PM2.5 and PM10 can be obtained.Based on the augmented profile,we identified Seoul and Ansan to be PM_(1.0) concentration hotspots.These regions are large cities or the center of anthropogenic and industrial activities.The proposed model and the augmented PM_(1.0) profiles can be used for large epidemiological studies to understand the health impacts of PM_(1.0).
文摘Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].
基金Funded by State Railway Administration Research Project(No.2023JS007)National Natural Science Foundation of China(No.52438002)+1 种基金Research and Development Programs for Science and Technology of China Railways Corporation(No.J2023G003)New Cornerstone Science Foundation through the XPLORER PRIZE。
文摘To investigate the influence of coarse aggregate parent rock properties on the elastic modulus of concrete,the mineralogical properties and stress-strain curves of granite and dolomite parent rocks,as well as the strength and elastic modulus of mortar and concrete prepared with mechanism aggregates of the corresponding lithology,and the stress-strain curves of concrete were investigated.In this paper,a coarse aggregate and mortar matrix bonding assumption is proposed,and a prediction model for the elastic modulus of mortar is established by considering the lithology of the mechanism sand and the slurry components.An equivalent coarse aggregate elastic modulus model was established by considering factors such as coarse aggregate particle size,volume fraction,and mortar thickness between coarse aggregates.Based on the elastic modulus of the equivalent coarse aggregate and the remaining mortar,a prediction model for the elastic modulus of the two and three components of concrete in series and then in parallel was established,and the predicted values differed from the measured values within 10%.It is proposed that the coarse aggregate elastic modulus in highstrength concrete is the most critical factor affecting the elastic modulus of concrete,and as the coarse aggregate elastic modulus increases by 27.7%,the concrete elastic modulus increases by 19.5%.
基金supported by the National Key Research and Development Program of China[grant number 2022YFE0106800]an Innovation Group Project of the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)[grant number 311024001]+3 种基金a project supported by the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)[grant number SML2023SP209]a Research Council of Norway funded project(MAPARC)[grant number 328943]a Nansen Center´s basic institutional funding[grant number 342624]the high-performance computing support from the School of Atmospheric Science at Sun Yat-sen University。
文摘Current shipping,tourism,and resource development requirements call for more accurate predictions of the Arctic sea-ice concentration(SIC).However,due to the complex physical processes involved,predicting the spatiotemporal distribution of Arctic SIC is more challenging than predicting its total extent.In this study,spatiotemporal prediction models for monthly Arctic SIC at 1-to 3-month leads are developed based on U-Net-an effective convolutional deep-learning approach.Based on explicit Arctic sea-ice-atmosphere interactions,11 variables associated with Arctic sea-ice variations are selected as predictors,including observed Arctic SIC,atmospheric,oceanic,and heat flux variables at 1-to 3-month leads.The prediction skills for the monthly Arctic SIC of the test set(from January 2018 to December 2022)are evaluated by examining the mean absolute error(MAE)and binary accuracy(BA).Results showed that the U-Net model had lower MAE and higher BA for Arctic SIC compared to two dynamic climate prediction systems(CFSv2 and NorCPM).By analyzing the relative importance of each predictor,the prediction accuracy relies more on the SIC at the 1-month lead,but on the surface net solar radiation flux at 2-to 3-month leads.However,dynamic models show limited prediction skills for surface net solar radiation flux and other physical processes,especially in autumn.Therefore,the U-Net model can be used to capture the connections among these key physical processes associated with Arctic sea ice and thus offers a significant advantage in predicting Arctic SIC.
基金Supported by the National Key Specialty of Traditional Chinese Medicine(Spleen and Stomach Diseases),No.0500004National Natural Science Foundation of China,No.82205104 and No.82104850+1 种基金Hospital Capability Enhancement Project of Xiyuan Hospital,CACMS,No.XYZX0303-07the Fundamental Research Funds for the Central Public Welfare Research Institutes,Excellent Young Scientists Training Program of China Academy of Chinese Medical Sciences,No.ZZ16-YQ-002.
文摘BACKGROUND Non-erosive reflux disease(NERD),the main gastroesophageal reflux subtype,features reflux symptoms without mucosal damage.Anxiety links to visceral hypersensitivity in NERD,yet mechanisms and animal models are unclear.AIM To establish a translational NERD rat model with anxiety comorbidity via tail clamping and study corticotropin-releasing hormone(CRH)-mediated neuroimmune pathways in visceral hypersensitivity and esophageal injury.METHODS Sprague-Dawley(SD)and Wistar rats were grouped into sham,model,and modified groups(n=10 each).The treatments for the modified groups were as follows:SD rats received ovalbumin/aluminum hydroxide suspension+acid perfusion±tail clamping(40 minutes/day for 7 days),while Wistar rats received fructose water+tail clamping.Esophageal pathology,visceral sensitivity,and behavior were assessed.Serum CRH,calcitonin gene-related peptide(CGRP),5-hydroxytryptamine(5-HT),and mast cell tryptase(MCT)and central amygdala(CeA)CRH mRNA were measured via ELISA and qRT-PCR.RESULTS Tail clamping induced anxiety,worsening visceral hypersensitivity(lower abdominal withdrawal reflex thresholds,P<0.05)and esophageal injury(dilated intercellular spaces and mitochondrial edema).Both models showed raised serum CRH,CGRP,5-HT,and MCT(P<0.01)and CeA CRH mRNA expression(P<0.01).Behavioral tests confirmed anxiety-like phenotypes.NERD-anxiety rats showed clinical-like symptom severity without erosion.CONCLUSION Tail clamping induces anxiety in NERD models,worsening visceral hypersensitivity via CRH neuroimmune dysregulation,offering a translational model and highlighting CRH as a treatment target.
基金financial support of the National Natural Science Foundation of China(No.52371103)the Fundamental Research Funds for the Central Universities,China(No.2242023K40028)+1 种基金the Open Research Fund of Jiangsu Key Laboratory for Advanced Metallic Materials,China(No.AMM2023B01).financial support of the Research Fund of Shihezi Key Laboratory of AluminumBased Advanced Materials,China(No.2023PT02)financial support of Guangdong Province Science and Technology Major Project,China(No.2021B0301030005)。
文摘Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening particles also deteriorates the processability and it is of great importance to establish accurate processing maps to guide the thermomechanical processes to enhance the formability.In this study,we performed particle swarm optimization-based back propagation artificial neural network model to predict the high temperature flow behavior of 0.25wt%Al2O3 particle-reinforced Cu alloys,and compared the accuracy with that of derived by Arrhenius-type constitutive model and back propagation artificial neural network model.To train these models,we obtained the raw data by fabricating ODS Cu alloys using the internal oxidation and reduction method,and conducting systematic hot compression tests between 400 and800℃with strain rates of 10^(-2)-10 S^(-1).At last,processing maps for ODS Cu alloys were proposed by combining processing parameters,mechanical behavior,microstructure characterization,and the modeling results achieved a coefficient of determination higher than>99%.
