As a Hong Kong deputy to the NPC,Li has prioritized the policy needs of the TCM industry and the practical challenges faced by enterprises.DURING the“two sessions”in March 2026,the high-quality development and inter...As a Hong Kong deputy to the NPC,Li has prioritized the policy needs of the TCM industry and the practical challenges faced by enterprises.DURING the“two sessions”in March 2026,the high-quality development and international promotion of traditional Chinese medicine(TCM)emerged as a trending topic of discussion.Tommy Li,a Hong Kong deputy to the 14th National People’s Congress(NPC)and president of the Federation of the Hong Kong Chinese Medicine Practitioners and Chinese Medicines Traders Association,has dedicated decades to the development of the TCM industry.展开更多
The number of patients with low back pain has increased due to changes in living and working habits.It has become one of the most common diseases in Chinese and Thai clinics.Treatment with Thai traditional medicine ca...The number of patients with low back pain has increased due to changes in living and working habits.It has become one of the most common diseases in Chinese and Thai clinics.Treatment with Thai traditional medicine can effectively alleviate and manage low back pain.This paper aims to summarize the clinical efficacy and distinctive features of Thai traditional medicine(TTM)in managing low back pain.By reviewing recent literature on TTM treatments,including Thai massage,herbal hot massage,and Thai herbal medicine,the paper aims to lay a foundation for TTM treatment in the world and to promote the convergence and development of traditional Chinese and Thai traditional medicine treatment.Additionally,it advocates for the integration and advancement of both Chinese and Thai traditional medical practices,while also encouraging the dissemination of traditional medicine to other countries globally.展开更多
Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for...Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for TCM modernization has hindered clear guidance for its development.Additionally,cancer remains a significant global public health challenge,largely untreatable with current methods.Therefore,a comprehensive understanding of TCM modernization is crucial for its evolution,revolution,drug discovery,and cancer therapy.This study provides an overview of the history,theory,characteristics,and evolution of TCM,highlighting its potential in cancer prevention and treatment.We propose a definition for TCM modernization,innovative Chinese medicine(ICM),and elucidate strategies to elevate TCM from a supporting role to a leading one.Electronic databases such as PubMed,Web of Science,ScienceDirect,and Clinical Trials were utilized to retrieve relevant literature spanning from 1979 to 2024,with most publications being from the last five years,using keywords like“Traditional Chinese medicine”,“Cancer”,“Mechanism”,and“Clinical trial”.In this study,we introduce the theory of TCM modernization following target identification and initial compound screening:ICM,defined by“3 D”elements:definite active ingredient composition and content,determined functional mechanism,and detection through evidence-based medicine.Overall,the“3 D”definition of ICM will establish a standard for ICM,accelerate TCM modernization,enhance drug discovery targeting cancer and various human diseases,and benefit patients worldwide.展开更多
Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developme...Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.展开更多
Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philologica...Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philological and historical analysis of ST,tracing its evolution from early battlefield applications to contemporary clinical use.By critically examining classical Mongolian medical texts alongside modern case studies,we aim to systematize ST’s therapeutic methods,indications,and limitations,while exploring its mechanisms of action through both traditional theory and modern biomedical perspectives.ST has undergone significant transformation,shifting from whole-body cavity immersion in the 13th century to targeted,organ-specific applications in modern practice.Its four primary methods–Covering,Mounted,Organ Placement,and Suction–demonstrate efficacy in treating cold-natured diseases,musculoskeletal disorders,gynecological conditions,and certain emergencies.ST embodies the core principles of TMM,particularly the balance of the“Three Roots”and the correction of cold-induced pathologies through heat.Despite challenges related to standardization,cultural translation,and regulatory acceptance,ST holds translational potential for integrative medicine.Future research should prioritize mechanistic validation,clinical standardization,and the development of biocompatible thermal technologies to bridge traditional practice with modern healthcare systems.展开更多
Bioelectronic medicine is a discipline that employs various electronic devices and technologies to diagnose,treat,and monitor biological systems and diseases.With continuous technological advancement,numerous bioelect...Bioelectronic medicine is a discipline that employs various electronic devices and technologies to diagnose,treat,and monitor biological systems and diseases.With continuous technological advancement,numerous bioelectronic devices are now utilized as independent therapeutic interventions or as adjunct treatments,and their applications continue to expand.This article briefly outlines the discovery process of several common electrophysiological signals in the human body and focuses on diverse electrical stimulation technologies.Their applications in the nervous system,cancer treatment,tissue regeneration and repair,and cardiovascular therapy are discussed,along with the underlying mechanisms of action.Furthermore,the rapid development of artificial intelligence and technological innovation has significantly broadened the scope and application of bioelectronic medicine.Finally,the current limitations and future prospects of bioelectronic medicine are explored.展开更多
Stroke can be categorized as ischemic and hemorrhagic on the basis of its origin.The pathophysiology following a stroke is complex,and is characterized by ongoing inflammation,neuronal injury,and the accumulation of r...Stroke can be categorized as ischemic and hemorrhagic on the basis of its origin.The pathophysiology following a stroke is complex,and is characterized by ongoing inflammation,neuronal injury,and the accumulation of reactive oxygen species in the brain,all of which reflect a dynamic process of change.This complexity hinders achievement of significant therapeutic outcomes with standard stroke treatment procedures,limiting post-stroke recovery.This review presents an innovative post-stroke therapeutic approach that utilizes nanomedicines to modify the cerebral microenvironment.It highlights the primary roles of chronic inflammation and nerve repair issues in causing prolonged impairment in stroke patients.Traditional therapies show limited effectiveness in achieving neuroprotection,immunoregulation,and neural regeneration during the subacute and chronic phases of stroke.Therefore,effective stroke management requires the use of specific therapeutic strategies tailored to the pathological characteristics of each phase.Various types of nanomedicines possess distinct physicochemical properties and can be selected on the basis of the specific therapeutic needs.Surface-modification technologies have significantly enhanced the ability of nanomedicines to penetrate the blood-brain barrier and improve their targeting capabilities in drug administration.However,the stability,biocompatibility,and long-term safety of nanomedicines require further optimization for clinical application.Nanomedicines represent a novel approach to stroke treatment through targeted delivery and multifaceted regulatory mechanisms.These medicines provide distinct advantages,particularly in addressing chronic inflammation and promoting nerve regeneration.As a result,nanomedicines are expected to significantly improve rehabilitation outcomes and quality of life for stroke patients in the future,emerging as a crucial modality for stroke treatment.展开更多
Professor Zhan Hongsheng(詹红生),as the national representative inheritor of Shanghai Shi’s Orthopedics and Traumatology,has led his team in long-term dedication to the research of Chinese spinal manipulative medicin...Professor Zhan Hongsheng(詹红生),as the national representative inheritor of Shanghai Shi’s Orthopedics and Traumatology,has led his team in long-term dedication to the research of Chinese spinal manipulative medicine.He has achieved outstanding accomplishments in areas such as school inheritance,theoretical construction,technological innovation,standard establishment,scientific research translation,and talent cultivation,thereby advancing the modernization,standardization,and internationalization of Chinese spinal manipulative medicine.展开更多
For more than four hundred years,the modern medical system has primarily inherited the Western cultural tradition and taken shape gradually on the basis of innovating classical Western medicine.In the tradition of anc...For more than four hundred years,the modern medical system has primarily inherited the Western cultural tradition and taken shape gradually on the basis of innovating classical Western medicine.In the tradition of ancient Greek medicine,the Hippocratic school and its successor,the Galenic school,based their medical understanding on the humoral theory and theory of temperaments,holding that there exists an intimate connection between human bodily functions and the mind.展开更多
1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western med...1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western medicine.Such a binary framework,however,oversimplifies the intricate realities of medical encounters in China.展开更多
Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesi...Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.展开更多
Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal ...Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.展开更多
目的:揭示印度藏药材的品种及主治特点,以及与中国同品种的药名和临床应用异同。方法:从印度出版的Materia Medica of Tibetan Medicine和《世界植物速查辞典》《中国民族药辞典》《藏药晶镜本草》《晶珠本草》中提取和发掘印度和中国...目的:揭示印度藏药材的品种及主治特点,以及与中国同品种的药名和临床应用异同。方法:从印度出版的Materia Medica of Tibetan Medicine和《世界植物速查辞典》《中国民族药辞典》《藏药晶镜本草》《晶珠本草》中提取和发掘印度和中国使用的藏药材的信息,包括药材藏文名、梵文名、拉丁学名、药材类型、科属名、性味、药用部位和治疗用途等,建立数据库并进行统计和对比分析。结果:本书共收载568味药材,植物类、动物类、矿物类和其它类药材的占比依次为70.07%、10.92%、6.69%和12.32%,涉及161个科和316个属;中国三本专著中记载的同品种共有158味。记载了药性的药材共有228味,其中同品种药材有50味(药性相似的有25味,不相似的有25味)。记载了药味的药材有296味,其中同品种药材有74味(药味相似的有46味,部分相似的有4味,不相似的有24味)。药材的梵文名与印度撰写的藏语发音相似的有181味药材,不相似的有347味;中国藏语发音和印度撰写的藏语发音相似的有91味,不相似的有66味;三种发音均相似的有13味同品种药材,均不相似的有49味。常用药用部位有动物肉类、果实类、根和根茎类、花类、叶类、树皮类和种子类等,而中国使用同品种的药用部位有一定的差异,主要为果实类、种子类、根类、叶类和树皮类等。多用于治疗消化系统疾病、某些传染病和寄生虫病等,常见主治的症状有便秘、中毒和溃疡等,而中国使用同品种的主治有一定的差异,主要用于消化系统疾病、呼吸系统疾病、皮肤和皮下组织疾病等常见主治的症状有消化不良、腹泻和咳嗽等。结论:印度藏药材的品种较丰富,与中国使用的同品种在药性、药味、药用部位及主治等方面均有差异,有助于扩大藏药材的应用价值,藏药材的发音研究提示其来源和使用交流情况。展开更多
Machado-Joseph disease,or spinocerebellar ataxia type 3(SCA3),represents the most common autosomal dominant cerebellar ataxia worldwide.Despite its progressive and debilitating nature,disease-modifying therapies remai...Machado-Joseph disease,or spinocerebellar ataxia type 3(SCA3),represents the most common autosomal dominant cerebellar ataxia worldwide.Despite its progressive and debilitating nature,disease-modifying therapies remain elusive.Repetitive transcranial magnetic stimulation(rTMS)has emerged as a promising non-invasive intervention;however,its clinical application has been hindered by inconsistent protocols and a lack of mechanistic understanding.A recent landmark study published in Brain Stimulation by Chen et al.addressed these challenges by combining a high-dose intermittent theta-burst stimulation(iTBS)protocol with concurrent transcranial magnetic stimulation-electroencephalography(TMS-EEG).This commentary provides an in-depth analysis of their findings,highlighting the restoration of cerebello-cortical inhibition(CBI)as a key therapeutic mechanism.Furthermore,we discuss the broader implications of this work,proposing that future translational research should integrate accelerated iTBS(aiTBS)paradigms,cortical response measurements(CRM),and individualized neuro-navigation to establish a new era of precision neuromodulation for ataxia.展开更多
In the dynamic landscape of modern healthcare and precision medicine,the digital revolution is reshaping medical industries at an unprecedented pace,and traditional Chinese medicine(TCM)is no exception[1-4].The paper...In the dynamic landscape of modern healthcare and precision medicine,the digital revolution is reshaping medical industries at an unprecedented pace,and traditional Chinese medicine(TCM)is no exception[1-4].The paper“From digits towards digitization:the past,present,and future of traditional Chinese medicine”by Academician&TCM National Master Qi WANG(王琦).展开更多
Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A p...Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.展开更多
Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、...Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、科学研究、教育、保健方面经验和成果的科学论文。1995年创刊,由中国科学院院士陈可冀担任主编。设有述评、专题笔谈、论著、临床经验、病例报道、综述、药物相互作用、法规指南、学术探讨、思路与方法、跨学科知识、会议纪要、书评、读者来信等栏目。展开更多
Punica granatum L.is a deciduous shrub belonging to the family Punicaceae and the genus Punica,recognized as a plant with both medicinal and edible value.Its peel,seeds,juice,flowers,and leaves have long been used in ...Punica granatum L.is a deciduous shrub belonging to the family Punicaceae and the genus Punica,recognized as a plant with both medicinal and edible value.Its peel,seeds,juice,flowers,and leaves have long been used in traditional Chinese,Mongolian,Tibetan,and Uyghur medicine,illustrating the characteristic phenomenon of“different applications of the same drug”.This article systematically reviews research progress from 2000 to 2025,focusing on chemical composition and pharmacological effects.Clinical practice and accumulated experience have led to distinct preferences across medical traditions:traditional Chinese medicine mainly uses dried peel to relieve diarrhea,stop bleeding,and expel parasites;traditional Mongolian medicine employs processed dried fruits to eliminate“Badgan”,warm the stomach,and aid digestion;Tibetan medicine often applies the seeds to strengthen the stomach and warm the middle energizer;Uyghur medicine uses the flowers to treat diarrhea and trauma.Modern studies show that chemical composition varies significantly among plant parts:the peel is rich in tannins and phenolic acids,seeds contain mostly fatty acids,and flowers are high in flavonoids.These differences lead to varied pharmacological activities,such as antioxidant,anti-inflammatory,and antibacterial effects.Furthermore,studies reveal synergistic effects among active components from different parts,with whole fruit or multi-part combinations showing better efficacy than single components.It should be noted that such synergies were identified through modern pharmacological studies–not derived directly from traditional theories.Together,these findings provide a scientific basis for the traditional“different applications of the same drug”and support further development of pomegranate resources based on multi-component synergy.展开更多
It’s widely believed that we’re experiencing a crisis of trust in institutions.Medicine,alongside government and media,stands accused of losing the public’s confidence.During the pandemic,this narrative intensified...It’s widely believed that we’re experiencing a crisis of trust in institutions.Medicine,alongside government and media,stands accused of losing the public’s confidence.During the pandemic,this narrative intensified.Medical authorities changed their recommendations as new evidence emerged,social media amplified doubts about vaccines and treatments,and the politicization of public health measures seemed to drive wedges between medicine and large segments of the population.展开更多
Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish ...Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish a TCM-informed tool for early depression screening,thereby bridging traditional diagnostic principles with modern computational approaches.Methods The study included patients with depression who visited the Shanghai Pudong New Area Mental Health Center from October 1,2022 to October 1,2023,as well as students and teachers from Shanghai University of Traditional Chinese Medicine during the same period as the healthy control group.Videos of 3–10 s were captured using a Xiaomi Pad 5,and the TCM spirit and expressions were determined by TCM experts(at least 3 out of 5 experts agreed to determine the category of TCM spirit and expressions).Basic information,facial images,and interview information were collected through a portable TCM intelligent analysis and diagnosis device,and facial diagnosis features were extracted using the Open CV computer vision library technology.Statistical analysis methods such as parametric and non-parametric tests were used to analyze the baseline data,TCM spirit and expression features,and facial diagnosis feature parameters of the two groups,to compare the differences in TCM spirit and expression and facial features.Five machine learning algorithms,including extreme gradient boosting(XGBoost),decision tree(DT),Bernoulli naive Bayes(BernoulliNB),support vector machine(SVM),and k-nearest neighbor(KNN)classification,were used to construct a depression recognition model based on the fusion of TCM spirit and expression features.The performance of the model was evaluated using metrics such as accuracy,precision,and the area under the receiver operating characteristic(ROC)curve(AUC).The model results were explained using the Shapley Additive exPlanations(SHAP).Results A total of 93 depression patients and 87 healthy individuals were ultimately included in this study.There was no statistically significant difference in the baseline characteristics between the two groups(P>0.05).The differences in the characteristics of the spirit and expressions in TCM and facial features between the two groups were shown as follows.(i)Quantispirit facial analysis revealed that depression patients exhibited significantly reduced facial spirit and luminance compared with healthy controls(P<0.05),with characteristic features such as sad expressions,facial erythema,and changes in the lip color ranging from erythematous to cyanotic.(ii)Depressed patients exhibited significantly lower values in facial complexion L,lip L,and a values,and gloss index,but higher values in facial complexion a and b,lip b,low gloss index,and matte index(all P<0.05).(iii)The results of multiple models show that the XGBoost-based depression recognition model,integrating the TCM“spirit-expression”diagnostic framework,achieved an accuracy of 98.61%and significantly outperformed four benchmark algorithms—DT,BernoulliNB,SVM,and KNN(P<0.01).(iv)The SHAP visualization results show that in the recognition model constructed by the XGBoost algorithm,the complexion b value,categories of facial spirit,high gloss index,low gloss index,categories of facial expression and texture features have significant contribution to the model.Conclusion This study demonstrates that integrating TCM spirit-expression diagnostic features with machine learning enables the construction of a high-precision depression detection model,offering a novel paradigm for objective depression diagnosis.展开更多
文摘As a Hong Kong deputy to the NPC,Li has prioritized the policy needs of the TCM industry and the practical challenges faced by enterprises.DURING the“two sessions”in March 2026,the high-quality development and international promotion of traditional Chinese medicine(TCM)emerged as a trending topic of discussion.Tommy Li,a Hong Kong deputy to the 14th National People’s Congress(NPC)and president of the Federation of the Hong Kong Chinese Medicine Practitioners and Chinese Medicines Traders Association,has dedicated decades to the development of the TCM industry.
基金the grants from the National Administration of Traditional Chinese Medicine Project for Enhancing Innovation Capabilities in Chinese Medicine(No.BJTH 2024-02F-0009)Shanghai Municipal Health Commission Seed Program for Research and Transformation of Medical New Technologies(No.2024ZZ1006)Shanghai Three-year Action Plan to Further Accelerate the Inheritance and Innovative Development of Traditional Chinese Medicine(No.2025-2027)(3-1-1).
文摘The number of patients with low back pain has increased due to changes in living and working habits.It has become one of the most common diseases in Chinese and Thai clinics.Treatment with Thai traditional medicine can effectively alleviate and manage low back pain.This paper aims to summarize the clinical efficacy and distinctive features of Thai traditional medicine(TTM)in managing low back pain.By reviewing recent literature on TTM treatments,including Thai massage,herbal hot massage,and Thai herbal medicine,the paper aims to lay a foundation for TTM treatment in the world and to promote the convergence and development of traditional Chinese and Thai traditional medicine treatment.Additionally,it advocates for the integration and advancement of both Chinese and Thai traditional medical practices,while also encouraging the dissemination of traditional medicine to other countries globally.
基金supported by the National Natural Science Foundation of China(No.82203343)the National Postdoctoral Program for Innovative Talents of China(No.BX20220273)+3 种基金China Postdoctoral Science Foundation(No.2022M712874)Henan Province Key Research and Development Promotion Special Project(Science and Technology)in 2023(No.232102311007)Henan Province Key Scientific Research Project of Colleges and Universities in 2023(No.23A310007)the Outstanding Youth Project of Henan Provincial Natural Science Foundation(No.252300421123)。
文摘Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for TCM modernization has hindered clear guidance for its development.Additionally,cancer remains a significant global public health challenge,largely untreatable with current methods.Therefore,a comprehensive understanding of TCM modernization is crucial for its evolution,revolution,drug discovery,and cancer therapy.This study provides an overview of the history,theory,characteristics,and evolution of TCM,highlighting its potential in cancer prevention and treatment.We propose a definition for TCM modernization,innovative Chinese medicine(ICM),and elucidate strategies to elevate TCM from a supporting role to a leading one.Electronic databases such as PubMed,Web of Science,ScienceDirect,and Clinical Trials were utilized to retrieve relevant literature spanning from 1979 to 2024,with most publications being from the last five years,using keywords like“Traditional Chinese medicine”,“Cancer”,“Mechanism”,and“Clinical trial”.In this study,we introduce the theory of TCM modernization following target identification and initial compound screening:ICM,defined by“3 D”elements:definite active ingredient composition and content,determined functional mechanism,and detection through evidence-based medicine.Overall,the“3 D”definition of ICM will establish a standard for ICM,accelerate TCM modernization,enhance drug discovery targeting cancer and various human diseases,and benefit patients worldwide.
文摘Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.
基金supported by The China Ethnic Medicine Association Research Grant(No.2023MY055-81)Science and Technology Program of the Joint Fund of Scientific Research for the Public Hospitals of Inner Mongolia Academy of Medical Sciences(2023GLLHD177,2023GLLH0174)Inner Mongolia Autonomous Region Regional Medical Center for Specialized Care(2025).
文摘Serbisütherapy(ST)is a distinctive external treatment modality within traditional Mongolian medicine(TMM),historically developed within a nomadic cultural framework.This study presents a comprehensive philological and historical analysis of ST,tracing its evolution from early battlefield applications to contemporary clinical use.By critically examining classical Mongolian medical texts alongside modern case studies,we aim to systematize ST’s therapeutic methods,indications,and limitations,while exploring its mechanisms of action through both traditional theory and modern biomedical perspectives.ST has undergone significant transformation,shifting from whole-body cavity immersion in the 13th century to targeted,organ-specific applications in modern practice.Its four primary methods–Covering,Mounted,Organ Placement,and Suction–demonstrate efficacy in treating cold-natured diseases,musculoskeletal disorders,gynecological conditions,and certain emergencies.ST embodies the core principles of TMM,particularly the balance of the“Three Roots”and the correction of cold-induced pathologies through heat.Despite challenges related to standardization,cultural translation,and regulatory acceptance,ST holds translational potential for integrative medicine.Future research should prioritize mechanistic validation,clinical standardization,and the development of biocompatible thermal technologies to bridge traditional practice with modern healthcare systems.
基金supported by the National Natural Science Foundation of China[grant numbers 82350003 and 92049201].
文摘Bioelectronic medicine is a discipline that employs various electronic devices and technologies to diagnose,treat,and monitor biological systems and diseases.With continuous technological advancement,numerous bioelectronic devices are now utilized as independent therapeutic interventions or as adjunct treatments,and their applications continue to expand.This article briefly outlines the discovery process of several common electrophysiological signals in the human body and focuses on diverse electrical stimulation technologies.Their applications in the nervous system,cancer treatment,tissue regeneration and repair,and cardiovascular therapy are discussed,along with the underlying mechanisms of action.Furthermore,the rapid development of artificial intelligence and technological innovation has significantly broadened the scope and application of bioelectronic medicine.Finally,the current limitations and future prospects of bioelectronic medicine are explored.
基金supported by the National Natural Science Foundation of China,Nos.82272616(to ZL),82271325(to WS)the Natural Science Foundation of Beijing,No.7252076(to YR).
文摘Stroke can be categorized as ischemic and hemorrhagic on the basis of its origin.The pathophysiology following a stroke is complex,and is characterized by ongoing inflammation,neuronal injury,and the accumulation of reactive oxygen species in the brain,all of which reflect a dynamic process of change.This complexity hinders achievement of significant therapeutic outcomes with standard stroke treatment procedures,limiting post-stroke recovery.This review presents an innovative post-stroke therapeutic approach that utilizes nanomedicines to modify the cerebral microenvironment.It highlights the primary roles of chronic inflammation and nerve repair issues in causing prolonged impairment in stroke patients.Traditional therapies show limited effectiveness in achieving neuroprotection,immunoregulation,and neural regeneration during the subacute and chronic phases of stroke.Therefore,effective stroke management requires the use of specific therapeutic strategies tailored to the pathological characteristics of each phase.Various types of nanomedicines possess distinct physicochemical properties and can be selected on the basis of the specific therapeutic needs.Surface-modification technologies have significantly enhanced the ability of nanomedicines to penetrate the blood-brain barrier and improve their targeting capabilities in drug administration.However,the stability,biocompatibility,and long-term safety of nanomedicines require further optimization for clinical application.Nanomedicines represent a novel approach to stroke treatment through targeted delivery and multifaceted regulatory mechanisms.These medicines provide distinct advantages,particularly in addressing chronic inflammation and promoting nerve regeneration.As a result,nanomedicines are expected to significantly improve rehabilitation outcomes and quality of life for stroke patients in the future,emerging as a crucial modality for stroke treatment.
文摘Professor Zhan Hongsheng(詹红生),as the national representative inheritor of Shanghai Shi’s Orthopedics and Traumatology,has led his team in long-term dedication to the research of Chinese spinal manipulative medicine.He has achieved outstanding accomplishments in areas such as school inheritance,theoretical construction,technological innovation,standard establishment,scientific research translation,and talent cultivation,thereby advancing the modernization,standardization,and internationalization of Chinese spinal manipulative medicine.
基金funded by National Social Science Fund of China,grant number 23XZX006.
文摘For more than four hundred years,the modern medical system has primarily inherited the Western cultural tradition and taken shape gradually on the basis of innovating classical Western medicine.In the tradition of ancient Greek medicine,the Hippocratic school and its successor,the Galenic school,based their medical understanding on the humoral theory and theory of temperaments,holding that there exists an intimate connection between human bodily functions and the mind.
文摘1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western medicine.Such a binary framework,however,oversimplifies the intricate realities of medical encounters in China.
基金supported by the National Natural Science Foundation of China(No.82360238,82071245)。
文摘Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.
基金Supported by the Project of National Social Science Fund of China(22CMZ015).
文摘Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.
文摘目的:揭示印度藏药材的品种及主治特点,以及与中国同品种的药名和临床应用异同。方法:从印度出版的Materia Medica of Tibetan Medicine和《世界植物速查辞典》《中国民族药辞典》《藏药晶镜本草》《晶珠本草》中提取和发掘印度和中国使用的藏药材的信息,包括药材藏文名、梵文名、拉丁学名、药材类型、科属名、性味、药用部位和治疗用途等,建立数据库并进行统计和对比分析。结果:本书共收载568味药材,植物类、动物类、矿物类和其它类药材的占比依次为70.07%、10.92%、6.69%和12.32%,涉及161个科和316个属;中国三本专著中记载的同品种共有158味。记载了药性的药材共有228味,其中同品种药材有50味(药性相似的有25味,不相似的有25味)。记载了药味的药材有296味,其中同品种药材有74味(药味相似的有46味,部分相似的有4味,不相似的有24味)。药材的梵文名与印度撰写的藏语发音相似的有181味药材,不相似的有347味;中国藏语发音和印度撰写的藏语发音相似的有91味,不相似的有66味;三种发音均相似的有13味同品种药材,均不相似的有49味。常用药用部位有动物肉类、果实类、根和根茎类、花类、叶类、树皮类和种子类等,而中国使用同品种的药用部位有一定的差异,主要为果实类、种子类、根类、叶类和树皮类等。多用于治疗消化系统疾病、某些传染病和寄生虫病等,常见主治的症状有便秘、中毒和溃疡等,而中国使用同品种的主治有一定的差异,主要用于消化系统疾病、呼吸系统疾病、皮肤和皮下组织疾病等常见主治的症状有消化不良、腹泻和咳嗽等。结论:印度藏药材的品种较丰富,与中国使用的同品种在药性、药味、药用部位及主治等方面均有差异,有助于扩大藏药材的应用价值,藏药材的发音研究提示其来源和使用交流情况。
基金supported by grants from the Open Research Fund of the Zhejiang Key Laboratory of Precision Psychiatry(2025A2)the Natural Science Foundation of Zhejiang Province(LY23C090002)。
文摘Machado-Joseph disease,or spinocerebellar ataxia type 3(SCA3),represents the most common autosomal dominant cerebellar ataxia worldwide.Despite its progressive and debilitating nature,disease-modifying therapies remain elusive.Repetitive transcranial magnetic stimulation(rTMS)has emerged as a promising non-invasive intervention;however,its clinical application has been hindered by inconsistent protocols and a lack of mechanistic understanding.A recent landmark study published in Brain Stimulation by Chen et al.addressed these challenges by combining a high-dose intermittent theta-burst stimulation(iTBS)protocol with concurrent transcranial magnetic stimulation-electroencephalography(TMS-EEG).This commentary provides an in-depth analysis of their findings,highlighting the restoration of cerebello-cortical inhibition(CBI)as a key therapeutic mechanism.Furthermore,we discuss the broader implications of this work,proposing that future translational research should integrate accelerated iTBS(aiTBS)paradigms,cortical response measurements(CRM),and individualized neuro-navigation to establish a new era of precision neuromodulation for ataxia.
文摘In the dynamic landscape of modern healthcare and precision medicine,the digital revolution is reshaping medical industries at an unprecedented pace,and traditional Chinese medicine(TCM)is no exception[1-4].The paper“From digits towards digitization:the past,present,and future of traditional Chinese medicine”by Academician&TCM National Master Qi WANG(王琦).
基金National Multidisciplinary Innovation Team of Traditional Chinese Medicine (ZYYCXTD-D-202204)Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine (22HHZYSS00013)。
文摘Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.
文摘Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、科学研究、教育、保健方面经验和成果的科学论文。1995年创刊,由中国科学院院士陈可冀担任主编。设有述评、专题笔谈、论著、临床经验、病例报道、综述、药物相互作用、法规指南、学术探讨、思路与方法、跨学科知识、会议纪要、书评、读者来信等栏目。
基金funded by the Key Project of the First-class Discipline Scientific Research Special Plan of Inner Mongolia Autonomous Region(Grant No.YLXKZX-NYD-001)the University-Industry Collaborative Innovation Fund of the Ministry of Education of China(Grant No.2024MZ002).
文摘Punica granatum L.is a deciduous shrub belonging to the family Punicaceae and the genus Punica,recognized as a plant with both medicinal and edible value.Its peel,seeds,juice,flowers,and leaves have long been used in traditional Chinese,Mongolian,Tibetan,and Uyghur medicine,illustrating the characteristic phenomenon of“different applications of the same drug”.This article systematically reviews research progress from 2000 to 2025,focusing on chemical composition and pharmacological effects.Clinical practice and accumulated experience have led to distinct preferences across medical traditions:traditional Chinese medicine mainly uses dried peel to relieve diarrhea,stop bleeding,and expel parasites;traditional Mongolian medicine employs processed dried fruits to eliminate“Badgan”,warm the stomach,and aid digestion;Tibetan medicine often applies the seeds to strengthen the stomach and warm the middle energizer;Uyghur medicine uses the flowers to treat diarrhea and trauma.Modern studies show that chemical composition varies significantly among plant parts:the peel is rich in tannins and phenolic acids,seeds contain mostly fatty acids,and flowers are high in flavonoids.These differences lead to varied pharmacological activities,such as antioxidant,anti-inflammatory,and antibacterial effects.Furthermore,studies reveal synergistic effects among active components from different parts,with whole fruit or multi-part combinations showing better efficacy than single components.It should be noted that such synergies were identified through modern pharmacological studies–not derived directly from traditional theories.Together,these findings provide a scientific basis for the traditional“different applications of the same drug”and support further development of pomegranate resources based on multi-component synergy.
文摘It’s widely believed that we’re experiencing a crisis of trust in institutions.Medicine,alongside government and media,stands accused of losing the public’s confidence.During the pandemic,this narrative intensified.Medical authorities changed their recommendations as new evidence emerged,social media amplified doubts about vaccines and treatments,and the politicization of public health measures seemed to drive wedges between medicine and large segments of the population.
基金General Program of National Natural Science Foundation of China(82474390)Construction Project of Pudong New Area Famous TCM Studios(National Pilot Zone for TCM Development,Shanghai)(PDZY-2025-0716)Shanghai Municipal Science and Technology Program Project Shanghai Key Laboratory of Health Identification and Assessment(21DZ2271000).
文摘Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish a TCM-informed tool for early depression screening,thereby bridging traditional diagnostic principles with modern computational approaches.Methods The study included patients with depression who visited the Shanghai Pudong New Area Mental Health Center from October 1,2022 to October 1,2023,as well as students and teachers from Shanghai University of Traditional Chinese Medicine during the same period as the healthy control group.Videos of 3–10 s were captured using a Xiaomi Pad 5,and the TCM spirit and expressions were determined by TCM experts(at least 3 out of 5 experts agreed to determine the category of TCM spirit and expressions).Basic information,facial images,and interview information were collected through a portable TCM intelligent analysis and diagnosis device,and facial diagnosis features were extracted using the Open CV computer vision library technology.Statistical analysis methods such as parametric and non-parametric tests were used to analyze the baseline data,TCM spirit and expression features,and facial diagnosis feature parameters of the two groups,to compare the differences in TCM spirit and expression and facial features.Five machine learning algorithms,including extreme gradient boosting(XGBoost),decision tree(DT),Bernoulli naive Bayes(BernoulliNB),support vector machine(SVM),and k-nearest neighbor(KNN)classification,were used to construct a depression recognition model based on the fusion of TCM spirit and expression features.The performance of the model was evaluated using metrics such as accuracy,precision,and the area under the receiver operating characteristic(ROC)curve(AUC).The model results were explained using the Shapley Additive exPlanations(SHAP).Results A total of 93 depression patients and 87 healthy individuals were ultimately included in this study.There was no statistically significant difference in the baseline characteristics between the two groups(P>0.05).The differences in the characteristics of the spirit and expressions in TCM and facial features between the two groups were shown as follows.(i)Quantispirit facial analysis revealed that depression patients exhibited significantly reduced facial spirit and luminance compared with healthy controls(P<0.05),with characteristic features such as sad expressions,facial erythema,and changes in the lip color ranging from erythematous to cyanotic.(ii)Depressed patients exhibited significantly lower values in facial complexion L,lip L,and a values,and gloss index,but higher values in facial complexion a and b,lip b,low gloss index,and matte index(all P<0.05).(iii)The results of multiple models show that the XGBoost-based depression recognition model,integrating the TCM“spirit-expression”diagnostic framework,achieved an accuracy of 98.61%and significantly outperformed four benchmark algorithms—DT,BernoulliNB,SVM,and KNN(P<0.01).(iv)The SHAP visualization results show that in the recognition model constructed by the XGBoost algorithm,the complexion b value,categories of facial spirit,high gloss index,low gloss index,categories of facial expression and texture features have significant contribution to the model.Conclusion This study demonstrates that integrating TCM spirit-expression diagnostic features with machine learning enables the construction of a high-precision depression detection model,offering a novel paradigm for objective depression diagnosis.
