In view of their excellent mechanical properties, workability and heat treatment characteristics, MDN 138 & MDN 250 have been widely used in missile, rocket and aerospace industries. With light weight and high per...In view of their excellent mechanical properties, workability and heat treatment characteristics, MDN 138 & MDN 250 have been widely used in missile, rocket and aerospace industries. With light weight and high performance characteristics HE 20 aluminium alloy acts as an important material in defence and aerospace applications. The galvanic corrosion behaviour of the metal combinations HE 20 / MDN 138 and HE 20 / MDN 250, with 1:1 area ratio, has been studied in natural seawater using the open well facility of CECRI's Offshore Platform at Tuticorin for a year. The open circuit potentials of MDN 138, MDN 250 and HE 20 of the individual metal, the mixed potential and galvanic current of the couples HE 20 / MDN 138 and HE 20 / MDN 250 were periodically monitored throughout the study period. The calcareous deposits on MDN 138 and MDN 250 were analysed using XRD. The results of the study reveal that that HE 20 has offered required amount of protection to MDN 138 & MDN 250.展开更多
HE15 is a heat treatable high strength alloy with excellent machinability find wide applications in aerospace and defence industries. In view of their excellent mechanical properties, workability, machinability, heat ...HE15 is a heat treatable high strength alloy with excellent machinability find wide applications in aerospace and defence industries. In view of their excellent mechanical properties, workability, machinability, heat treatment characteristics and good resistance to general and stress corrosion cracking, MDN138 & MDN250 have been widely used in petrochemical, nuclear and aerospace industries. The galvanic corrosion behaviour of the metal combinations HE15 / MDN138 and HE15 / MDN250, with 1:1 area ratio, has been studied in natural seawater using the open well facility of CECRI's Offshore Platform at Tuticorin for a year. The open circuit potentials of MDN138, MDN250 and HE15 of the individual metal, the galvanic potential and galvanic current of the couples HE15 / MDN138 and HE15 / MDN250 were periodically monitored throughout the study period. The calcareous deposits on MDN138 and MDN250 in galvanic contact with HE15 were analyzed using XRD. The electrochemical behaviors of MDN138, MDN250 and HE15 in seawater have been studied using an electrochemical work station. The surface characteristics of MDN138 and MDN250 in galvanic contact with HE15 have been examined with scanning electron microscope. The results of the study reveal that HE15 offered required amount of protection to MDN138 & MDN250.展开更多
The galvanic corrosion behavior of the metal combinations 15CDV6/MDN138 and 15CDV6/MDN250,with 1:1 area ratio,has been studied in natural seawater using the open well facility of CECRI’s Offshore Platform at Tuticori...The galvanic corrosion behavior of the metal combinations 15CDV6/MDN138 and 15CDV6/MDN250,with 1:1 area ratio,has been studied in natural seawater using the open well facility of CECRI’s Offshore Platform at Tuticorin for a year.The open circuit potentials of MDN138,MDN250,and 15CDV6 of the individual metal,the galvanic potential and galvanic current of the couples 15CDV6/MDN138 and 15CDV6/MDN250,were periodically monitored throughout the study period.The calcareous deposits on MDN138 and MDN250 in galvanic contact with 15CDV6 were analyzed using XRD.The electrochemical behavior of MDN138,MDN250,and 15CDV6 in seawater was studied using an electrochemical work station.The surface characteristics of MDN138 and MDN250 in galvanic contact with 15CDV6 have been examined with a scanning electron microscope.The results of the study reveal that the galvanic protection offered by 15CDV6 to MDN250 and MDN138 in natural seawater amounts to 93%and 98%,respectively,implying that the galvanic protection offered by 15CDV6 is continuous and effective,which has been further evinced from the adherent nature of the calcareous deposit film comprising compounds such as CaCO3(calcite,aragonite,and vaterite),MgCO3(magnesite),Mg(OH)2(brucite),and MgO(brucite).展开更多
Background The Midasin AAA(ATPase associated with various activities)ATPase 1(MDN1)gene,a member of the AAA protein family,plays a crucial role in ribosome maturation.MDN1 is expressed in the human brain throughout li...Background The Midasin AAA(ATPase associated with various activities)ATPase 1(MDN1)gene,a member of the AAA protein family,plays a crucial role in ribosome maturation.MDN1 is expressed in the human brain throughout life,especially during early development and adulthood.However,MDN1 variants have not been previously reported in patients with epilepsy.This study aims to explore the association between MDN1 variants and epilepsy.Methods Trios-based whole-exome sequencing was performed in a cohort of patients with epilepsy susceptibility from the China Epilepsy Gene 1.0 Project.The excess,damaging efects,and molecular subregional implications of variants,as well as the spatio-temporal expression of MDN1,were analyzed to validate the gene-disease association.Results Compound heterozygous variants in MDN1 were identifed in fve unrelated patients with febrile seizures or secondary epilepsy.Three patients presented with febrile seizures/epilepsy with febrile seizures plus,while two patients developed epilepsy secondary to brain damage(fve or seven years after).These variants were either absent or present at low frequencies in the control group,and exhibited statistically signifcant higher frequencies in the case group compared to controls.All the missense variants were predicted to be damaging by at least one in silico tool.In each pair of compound heterozygous variants,one allele was located in the AAA2-AAA3 domains,while the other allele was located in the linker domain or its vicinity.In contrast,most of the variants from the asymptomatic control group were located outside the AAA domains,suggesting a molecular subregional implication of the MDN1 variants.Conclusions MDN1 is potentially a susceptibility gene for epilepsy.展开更多
基金the Project Director, DRDL, Hyderabad for the financial support (Project No. SSP0709)
文摘In view of their excellent mechanical properties, workability and heat treatment characteristics, MDN 138 & MDN 250 have been widely used in missile, rocket and aerospace industries. With light weight and high performance characteristics HE 20 aluminium alloy acts as an important material in defence and aerospace applications. The galvanic corrosion behaviour of the metal combinations HE 20 / MDN 138 and HE 20 / MDN 250, with 1:1 area ratio, has been studied in natural seawater using the open well facility of CECRI's Offshore Platform at Tuticorin for a year. The open circuit potentials of MDN 138, MDN 250 and HE 20 of the individual metal, the mixed potential and galvanic current of the couples HE 20 / MDN 138 and HE 20 / MDN 250 were periodically monitored throughout the study period. The calcareous deposits on MDN 138 and MDN 250 were analysed using XRD. The results of the study reveal that that HE 20 has offered required amount of protection to MDN 138 & MDN 250.
基金Supported by Project Director,DRDL,Hyderabad,India(Project No.SSP 0709)
文摘HE15 is a heat treatable high strength alloy with excellent machinability find wide applications in aerospace and defence industries. In view of their excellent mechanical properties, workability, machinability, heat treatment characteristics and good resistance to general and stress corrosion cracking, MDN138 & MDN250 have been widely used in petrochemical, nuclear and aerospace industries. The galvanic corrosion behaviour of the metal combinations HE15 / MDN138 and HE15 / MDN250, with 1:1 area ratio, has been studied in natural seawater using the open well facility of CECRI's Offshore Platform at Tuticorin for a year. The open circuit potentials of MDN138, MDN250 and HE15 of the individual metal, the galvanic potential and galvanic current of the couples HE15 / MDN138 and HE15 / MDN250 were periodically monitored throughout the study period. The calcareous deposits on MDN138 and MDN250 in galvanic contact with HE15 were analyzed using XRD. The electrochemical behaviors of MDN138, MDN250 and HE15 in seawater have been studied using an electrochemical work station. The surface characteristics of MDN138 and MDN250 in galvanic contact with HE15 have been examined with scanning electron microscope. The results of the study reveal that HE15 offered required amount of protection to MDN138 & MDN250.
基金financially supported by Project Director,DRDL,Hyderabad,India(Project No.SSP 0709)
文摘The galvanic corrosion behavior of the metal combinations 15CDV6/MDN138 and 15CDV6/MDN250,with 1:1 area ratio,has been studied in natural seawater using the open well facility of CECRI’s Offshore Platform at Tuticorin for a year.The open circuit potentials of MDN138,MDN250,and 15CDV6 of the individual metal,the galvanic potential and galvanic current of the couples 15CDV6/MDN138 and 15CDV6/MDN250,were periodically monitored throughout the study period.The calcareous deposits on MDN138 and MDN250 in galvanic contact with 15CDV6 were analyzed using XRD.The electrochemical behavior of MDN138,MDN250,and 15CDV6 in seawater was studied using an electrochemical work station.The surface characteristics of MDN138 and MDN250 in galvanic contact with 15CDV6 have been examined with a scanning electron microscope.The results of the study reveal that the galvanic protection offered by 15CDV6 to MDN250 and MDN138 in natural seawater amounts to 93%and 98%,respectively,implying that the galvanic protection offered by 15CDV6 is continuous and effective,which has been further evinced from the adherent nature of the calcareous deposit film comprising compounds such as CaCO3(calcite,aragonite,and vaterite),MgCO3(magnesite),Mg(OH)2(brucite),and MgO(brucite).
基金funded by Medical Joint Fund of Jinan University(No.YXJC2022010)Dongguan Science and Technology Bureau 2023(No.20231800905272)+3 种基金The City School(institute)Enterprise Joint Funding Project of Guangzhou Science and Technology Bureau(No.2025A03J4094)Guangdong Basic and Applied Basic Research Foundation(No.2023A1515010218)Science and Technology Projects in Guangzhou(No.2023A03J1026)Fundamental Research Funds for the Central Universities(No.21623405).
文摘Background The Midasin AAA(ATPase associated with various activities)ATPase 1(MDN1)gene,a member of the AAA protein family,plays a crucial role in ribosome maturation.MDN1 is expressed in the human brain throughout life,especially during early development and adulthood.However,MDN1 variants have not been previously reported in patients with epilepsy.This study aims to explore the association between MDN1 variants and epilepsy.Methods Trios-based whole-exome sequencing was performed in a cohort of patients with epilepsy susceptibility from the China Epilepsy Gene 1.0 Project.The excess,damaging efects,and molecular subregional implications of variants,as well as the spatio-temporal expression of MDN1,were analyzed to validate the gene-disease association.Results Compound heterozygous variants in MDN1 were identifed in fve unrelated patients with febrile seizures or secondary epilepsy.Three patients presented with febrile seizures/epilepsy with febrile seizures plus,while two patients developed epilepsy secondary to brain damage(fve or seven years after).These variants were either absent or present at low frequencies in the control group,and exhibited statistically signifcant higher frequencies in the case group compared to controls.All the missense variants were predicted to be damaging by at least one in silico tool.In each pair of compound heterozygous variants,one allele was located in the AAA2-AAA3 domains,while the other allele was located in the linker domain or its vicinity.In contrast,most of the variants from the asymptomatic control group were located outside the AAA domains,suggesting a molecular subregional implication of the MDN1 variants.Conclusions MDN1 is potentially a susceptibility gene for epilepsy.
