摘要
目的:观察和比较针药结合对糖尿病周围神经病变(DPN)患者FBG、PBG、NO和SOD含量和MDNS评分的影响,探讨针药结合的作用机制.方法:将70例患者随机分为两组比较观察,有完整资料者58例,其中针药治疗组33例,药物对照组25例.结果:治疗3周后,治疗组和对照组都能使空腹血糖(FBG)及餐后血糖(PBG)显著下降,治疗组餐后血糖比对照组下降更为明显,P<0.05,而空腹血糖的下降两组间无明显差异;两组的NO含量和药物组SOD的含量无明显影响(P>0.05);而针药组的SOD值升高和MDNS改善明显优于对照组,P<0.05;MDNS评分与FBG、PBG明显正相关,与NO和SOD含量呈负相关.结论:针药结合能对单纯药物治疗控制较差的餐后血糖起明显调节作用;针药结合能有效提高SOD水平,改善糖尿病周围神经病变患者MDNS评分,提高临床疗效;但短期疗效上,针药结合对NO含量无明显影响.
Objective：To observe and compare the influences on FBG,PBG,NO,SOD and MDNS on the patients of diabetic peripheral neuropathies（DPN）by acupuncture combined with medicine.Methods：70 patients were randomly divided into 2 groups.And there were 58 patients with comprehensive datas among which the acupuncture combined with medicine group included 33 cases and the medicine comparison group included 25 cases.Results：After 3 weeks＇ treatment,both groups can obviously decrease FBG and PBG.acupuncture combined with medicine group could obviously decrease PBG,compared with the controlled group,acupuncture combined with medicine group decreased the contest of PBG much better﹙ P0.05﹚.There were no differences between the two groups in FBG.Both groups＇ NO and the medicine comparison group＇s SOD had no obvious differences P0.05.The acupuncture combined with medicine group＇s SOD increased and MDNS changed more obviously than medicine comparison group﹙ P0.05﹚.The contents of NO and SOD are negatively correlated with the MDNS,while FBG and PBG are positively correlated.Conclusion：Acupuncture combined with medicine can control the PBG appropriately better than the controlled group,can improve the contents of SOD and can improve the MDNS better in DPN patients,so improve clinical treatment effect.But there is no obvious influence on the contents of NO in the acupuncture combined with medicine group after the short-term therapy.
出处
《江汉大学学报（自然科学版）》
2011年第3期75-78,共4页
Journal of Jianghan University：Natural Science Edition
