Light has been clinically utilized as a stimulation in medical treatment,such as Low-level laser therapy and photodynamic thenapy,which has been more and more widely accepted in public.The penetration depth of the tre...Light has been clinically utilized as a stimulation in medical treatment,such as Low-level laser therapy and photodynamic thenapy,which has been more and more widely accepted in public.The penetration depth of the treatment light is important for precision treatment and safety control.The isue of light penetration has been highlighted in biomedical optics field for decades.However,quantitative research is sparse and even there are conflicts of view on the capability of near-infrared light penet ration into brain tissue.This study attempts to quantitatively revisit this issue by innovative high-realistic 3D Monte Caro modeling of stimulated light penetnation within high precision Visible Chinese human head.The properties of light,such as its wave-length,ilumination profle and size are concern in this study.We made stra ightforward and quantitative comparisons among the ffects by the light properties(i.e.,wavelengths:660,810 and 980 nn;beam types:Gaussi an and flat beamn;bear dianeters:0,2,4 and 6 cm)which are in the range of light treatment.The findings include about 3%of light dosage within brain tisue;the combination of Gaussian beam and 810nm light make the max imum light penetration(>5cm),which allows light to cross through gray matter into white mater.This study offered us,the first time as we know,quantitative guide for light stimulation parameter optimization in medical treatment.展开更多
基金supports of the One University One Zone Growth Fund (No.A03013023001019)the Central University Basic Scientific Research Project Business Expenses (No.ZYGX2016J052)+1 种基金CAMS Innovation Fund for Medical Sciences (No.2016-I2M-3-023)National Natural Science Fund Projects (No.61675039).
文摘Light has been clinically utilized as a stimulation in medical treatment,such as Low-level laser therapy and photodynamic thenapy,which has been more and more widely accepted in public.The penetration depth of the treatment light is important for precision treatment and safety control.The isue of light penetration has been highlighted in biomedical optics field for decades.However,quantitative research is sparse and even there are conflicts of view on the capability of near-infrared light penet ration into brain tissue.This study attempts to quantitatively revisit this issue by innovative high-realistic 3D Monte Caro modeling of stimulated light penetnation within high precision Visible Chinese human head.The properties of light,such as its wave-length,ilumination profle and size are concern in this study.We made stra ightforward and quantitative comparisons among the ffects by the light properties(i.e.,wavelengths:660,810 and 980 nn;beam types:Gaussi an and flat beamn;bear dianeters:0,2,4 and 6 cm)which are in the range of light treatment.The findings include about 3%of light dosage within brain tisue;the combination of Gaussian beam and 810nm light make the max imum light penetration(>5cm),which allows light to cross through gray matter into white mater.This study offered us,the first time as we know,quantitative guide for light stimulation parameter optimization in medical treatment.
