Objective To validate and use the Chinese Version of the M.D.Anderson Symptom Inventory(MDASI-C)to assess the symptom burden of breast cancer patients in China.Methods A total of 342 breast cancer patients in China pa...Objective To validate and use the Chinese Version of the M.D.Anderson Symptom Inventory(MDASI-C)to assess the symptom burden of breast cancer patients in China.Methods A total of 342 breast cancer patients in China participated in this study.Their symptoms were investigated with the MDASI-C from November 2020 to February 2021,and the reliability and validity of this tool were evaluated,respectively.Cluster analysis and correlation analysis were also performed.Results The Cronbach’s alpha coefficient values of the symptom and interference items were 0.827 and 0.880,respectively.Construct validity revealed a four-factor structure.The Kaiser—Meyer—Olkin value was 0.760.The Karnofsky Performance Status,treatment phase,and cancer stage of the patients were grouped,and the differences of scores within the groups were significant.In addition,the employment status,education level,and age of the patients were significantly correlated with the symptoms.The correlation analysis of the education level of the patients showed that most of the symptoms and interference items were reduced as the education level was increased.The top three symptoms were disturbed sleep(3.10±2.52),difficulty remembering(2.54±2.30),and fatigue(2.24±2.13).The clinical and biochemical indicators such as body mass index and neutral granulocyte lymphocyte ratio had effects on many symptoms.As the patients’BMI increased,the patients’pain,disturbed sleep,and difficulty remembering were aggravated,and numbness was alleviated.Conclusion The MDASI-C is a reliable and effective assessment tool to evaluate patients with breast cancer in China.The symptoms are related to many clinical and biochemical indicators.展开更多
To overcome the limitations of traditional single-crystal X-ray diffraction(SCXRD)for microcrystalline materials and the peak-overlapping issue of powder X-ray diffraction(PXRD),this study employed cryogenic continuou...To overcome the limitations of traditional single-crystal X-ray diffraction(SCXRD)for microcrystalline materials and the peak-overlapping issue of powder X-ray diffraction(PXRD),this study employed cryogenic continuous rotation electron diffraction(cryo-cRED)with a low-dose strategy to determine the crystal structure of CL30,a novel silicogermanate framework.It is confirmed that CL30 crystallizes in the C2/m space group and has layered topology composed of discontinuous zigzag chains connected by double four-membered ring(d4r)units,with fluoride anions(F^(-))occluded in the d4r units.In CL30,charge balance involves organic structure-directing agent(OSDA)cations,occluded F^(-),and terminal oxygen sites whose protonation state cannot be established from the present three dimensional(3D)ED data.F^(-)encapsulated in the d4r units contributes to charge compensation as the counter-anion to OSDA cations,rather than only balancing the framework charge.Although the refinement indices(R_(1)=0.29,wR_(2)=0.71)exceeded typical small-molecule crystallography standards,the structural model remained highly reliable,as supported by geometric restraints and validation.In electron diffraction,elevated R_(1) values are commonly attributed to the intrinsic factors of the technique,such as dynamic scattering,detector noise from scintillator-based detectors,and TEM stage instability(large spheres of confusion).This study introduces a new structural prototype to the silicogermanate family and establishes a feasible workflow for determining the structures of radiation-sensitive microcrystalline porous materials.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.81672977).
文摘Objective To validate and use the Chinese Version of the M.D.Anderson Symptom Inventory(MDASI-C)to assess the symptom burden of breast cancer patients in China.Methods A total of 342 breast cancer patients in China participated in this study.Their symptoms were investigated with the MDASI-C from November 2020 to February 2021,and the reliability and validity of this tool were evaluated,respectively.Cluster analysis and correlation analysis were also performed.Results The Cronbach’s alpha coefficient values of the symptom and interference items were 0.827 and 0.880,respectively.Construct validity revealed a four-factor structure.The Kaiser—Meyer—Olkin value was 0.760.The Karnofsky Performance Status,treatment phase,and cancer stage of the patients were grouped,and the differences of scores within the groups were significant.In addition,the employment status,education level,and age of the patients were significantly correlated with the symptoms.The correlation analysis of the education level of the patients showed that most of the symptoms and interference items were reduced as the education level was increased.The top three symptoms were disturbed sleep(3.10±2.52),difficulty remembering(2.54±2.30),and fatigue(2.24±2.13).The clinical and biochemical indicators such as body mass index and neutral granulocyte lymphocyte ratio had effects on many symptoms.As the patients’BMI increased,the patients’pain,disturbed sleep,and difficulty remembering were aggravated,and numbness was alleviated.Conclusion The MDASI-C is a reliable and effective assessment tool to evaluate patients with breast cancer in China.The symptoms are related to many clinical and biochemical indicators.
基金supported by the National Natural Science Foundation of China (Grant No.12374021)Beijing Natural Science Foundation (Grant No.1252031)。
文摘To overcome the limitations of traditional single-crystal X-ray diffraction(SCXRD)for microcrystalline materials and the peak-overlapping issue of powder X-ray diffraction(PXRD),this study employed cryogenic continuous rotation electron diffraction(cryo-cRED)with a low-dose strategy to determine the crystal structure of CL30,a novel silicogermanate framework.It is confirmed that CL30 crystallizes in the C2/m space group and has layered topology composed of discontinuous zigzag chains connected by double four-membered ring(d4r)units,with fluoride anions(F^(-))occluded in the d4r units.In CL30,charge balance involves organic structure-directing agent(OSDA)cations,occluded F^(-),and terminal oxygen sites whose protonation state cannot be established from the present three dimensional(3D)ED data.F^(-)encapsulated in the d4r units contributes to charge compensation as the counter-anion to OSDA cations,rather than only balancing the framework charge.Although the refinement indices(R_(1)=0.29,wR_(2)=0.71)exceeded typical small-molecule crystallography standards,the structural model remained highly reliable,as supported by geometric restraints and validation.In electron diffraction,elevated R_(1) values are commonly attributed to the intrinsic factors of the technique,such as dynamic scattering,detector noise from scintillator-based detectors,and TEM stage instability(large spheres of confusion).This study introduces a new structural prototype to the silicogermanate family and establishes a feasible workflow for determining the structures of radiation-sensitive microcrystalline porous materials.
