The automated proficiencies of the Kingdom of Saudi Arabia, in vision 2030, influence a decade of continual expenditure in contemporary automation and unified government platforms. It affords a reliable base for the C...The automated proficiencies of the Kingdom of Saudi Arabia, in vision 2030, influence a decade of continual expenditure in contemporary automation and unified government platforms. It affords a reliable base for the COVID-19 response’s significant facets, encompassing continued connection to many e-government systems. The worldwide COVID-19 epidemic has reinvigorated the role of e-government. The health crisis has altered SADAIA to lunch Tawakkalna m-government application to execute business continuity strategies, offer important services to people, and assure their fulfilment. The study intends to assess the impact of the COVID-19 pandemic on users’ satisfaction with m-government services and Health Care apps in the Al-Madinah region. It analyses the elements that enable people’s use of online government services, and m-government services are a solution to handle the crisis. The finding shows that trust in e-government, trust in the internet, ease of use and usefulness are the important factors in using the application during the pandemic.展开更多
This study aims to explore the Sultan Qaboos University undergraduate students’ perceptions and attitudes towards using m-Health app and its impact on improving their sports and health habits. Triangulation was used ...This study aims to explore the Sultan Qaboos University undergraduate students’ perceptions and attitudes towards using m-Health app and its impact on improving their sports and health habits. Triangulation was used by applying a questionnaire and focus groups interviews to answer the research questions. The survey sample was (20) male and female students from four science and humanities colleges. Both quantitative and qualitative findings unequivocally reveal the students’ positive perceptions and attitudes toward the use of the mobile health app. No statistically significant differences were found between the responses of either males or females, or the science and humanitarian colleges of the sample students. In light of these findings, the study set forth its conclusions and recommendations.展开更多
针对移动端电商APP界面交互效率低的难题,本研究借助Tobii Pro X3-120眼动仪,采集50名多类型用户的电商视觉注意力数据,构建“视觉注意力—操作效率”关联模型,并运用A/B测试验证界面优化效果。实验结果表明,优化后的界面使任务完成时...针对移动端电商APP界面交互效率低的难题,本研究借助Tobii Pro X3-120眼动仪,采集50名多类型用户的电商视觉注意力数据,构建“视觉注意力—操作效率”关联模型,并运用A/B测试验证界面优化效果。实验结果表明,优化后的界面使任务完成时间缩短28%,错误率降低41%,眼动热点区域与操作目标的重合度提升35%,充分验证了基于眼动数据驱动的交互设计优化方法的有效性,为电商APP界面设计提供了科学量化的优化路径。展开更多
目的:在前期发现琐琐葡萄总黄酮(Flavones from Vitis vinifera L,VTF)可改善APP/PS-1双转基因(Alzheimer's disease,AD)小鼠认知功能的基础上,进一步验证“VTF是否通过重塑肠道菌群-肠-脑轴而发挥神经保护作用”,并阐明其潜在机制...目的:在前期发现琐琐葡萄总黄酮(Flavones from Vitis vinifera L,VTF)可改善APP/PS-1双转基因(Alzheimer's disease,AD)小鼠认知功能的基础上,进一步验证“VTF是否通过重塑肠道菌群-肠-脑轴而发挥神经保护作用”,并阐明其潜在机制。方法:本研究将从天然药物琐琐葡萄中提取活性成分总黄酮VTF,作用于APP/PS-1小鼠,VTF灌胃8周,通过Morris水迷宫实验评估小鼠空间学习能力;ELISA检测小鼠脑组织中IL-1β、IL-6、TNF-α因子,血清中5-HT、GABA因子的含量;苏木精-伊红(Hematoxylin and eosin staining,HE)染色法观察结肠组织形态,免疫组化法检测Occludin、Claudin、Zo-1、NLRP3蛋白表达;高通量测序检测小鼠粪便肠道菌群;结果:1)水迷宫实验结果显示:VTF低剂量组平均逃逸潜伏期缩短(P<0.05);VTF低、中剂量组有效区域运动距离,运动时间以及进入次数显著增多(P<0.01);2)结肠组织HE染色结果显示;AD模型小鼠肠粘膜膜层萎缩,隐窝丢失和绒毛断裂,而VTF干预之后小鼠上述情况均有所减轻;3)结肠组织免疫组化结果显示:VTF干预可以上调Occludin、Claudin、Zo-1等紧密连接蛋白阳性表达(P<0.01),减少NLRP3炎症相关蛋白的表达(P<0.01);4)ELISA结果:VTF各剂量组小鼠脑组织中IL-1β、IL-6、TNFα等炎症因子水平降低(P<0.01);VTF各剂量组中5-HT和GABA的含量增多(P<0.01);5)肠道菌群检测结果显示:VTF高剂量干预后的AD小鼠厚壁菌门相对丰度增多(P<0.05),与模型组小鼠相比,VTF中、高剂量组中乳杆菌科(Lactobacillaceae)相对丰度增多,VTF低剂量组中Muribaculaceae相对丰度增多,多奈哌齐组,VTF各剂量组中丹毒科(Erysipelotrichaceae)、瘤胃球菌科(Ruminococcaceae)相对丰度增多;而VTF各剂量组中毛螺菌科(Lachnospiraceae)、螺杆菌科(Helicobacteraceae),脱铁杆菌科(Deferribacteraceae)相对丰度减少。结论:这些结果表明,VTF调节肠道菌群可能具有治疗衰老过程中微生物导致脑轴和认知功能缺陷的潜力,其机制可能与改变肠道菌群组成,修复受损的肠道屏障,炎症反应和神经递质有关。因此,调节肠道微生物群可能是治疗AD相关神经疾病的一种潜在策略。展开更多
文摘The automated proficiencies of the Kingdom of Saudi Arabia, in vision 2030, influence a decade of continual expenditure in contemporary automation and unified government platforms. It affords a reliable base for the COVID-19 response’s significant facets, encompassing continued connection to many e-government systems. The worldwide COVID-19 epidemic has reinvigorated the role of e-government. The health crisis has altered SADAIA to lunch Tawakkalna m-government application to execute business continuity strategies, offer important services to people, and assure their fulfilment. The study intends to assess the impact of the COVID-19 pandemic on users’ satisfaction with m-government services and Health Care apps in the Al-Madinah region. It analyses the elements that enable people’s use of online government services, and m-government services are a solution to handle the crisis. The finding shows that trust in e-government, trust in the internet, ease of use and usefulness are the important factors in using the application during the pandemic.
文摘This study aims to explore the Sultan Qaboos University undergraduate students’ perceptions and attitudes towards using m-Health app and its impact on improving their sports and health habits. Triangulation was used by applying a questionnaire and focus groups interviews to answer the research questions. The survey sample was (20) male and female students from four science and humanities colleges. Both quantitative and qualitative findings unequivocally reveal the students’ positive perceptions and attitudes toward the use of the mobile health app. No statistically significant differences were found between the responses of either males or females, or the science and humanitarian colleges of the sample students. In light of these findings, the study set forth its conclusions and recommendations.
文摘针对移动端电商APP界面交互效率低的难题,本研究借助Tobii Pro X3-120眼动仪,采集50名多类型用户的电商视觉注意力数据,构建“视觉注意力—操作效率”关联模型,并运用A/B测试验证界面优化效果。实验结果表明,优化后的界面使任务完成时间缩短28%,错误率降低41%,眼动热点区域与操作目标的重合度提升35%,充分验证了基于眼动数据驱动的交互设计优化方法的有效性,为电商APP界面设计提供了科学量化的优化路径。
文摘目的:在前期发现琐琐葡萄总黄酮(Flavones from Vitis vinifera L,VTF)可改善APP/PS-1双转基因(Alzheimer's disease,AD)小鼠认知功能的基础上,进一步验证“VTF是否通过重塑肠道菌群-肠-脑轴而发挥神经保护作用”,并阐明其潜在机制。方法:本研究将从天然药物琐琐葡萄中提取活性成分总黄酮VTF,作用于APP/PS-1小鼠,VTF灌胃8周,通过Morris水迷宫实验评估小鼠空间学习能力;ELISA检测小鼠脑组织中IL-1β、IL-6、TNF-α因子,血清中5-HT、GABA因子的含量;苏木精-伊红(Hematoxylin and eosin staining,HE)染色法观察结肠组织形态,免疫组化法检测Occludin、Claudin、Zo-1、NLRP3蛋白表达;高通量测序检测小鼠粪便肠道菌群;结果:1)水迷宫实验结果显示:VTF低剂量组平均逃逸潜伏期缩短(P<0.05);VTF低、中剂量组有效区域运动距离,运动时间以及进入次数显著增多(P<0.01);2)结肠组织HE染色结果显示;AD模型小鼠肠粘膜膜层萎缩,隐窝丢失和绒毛断裂,而VTF干预之后小鼠上述情况均有所减轻;3)结肠组织免疫组化结果显示:VTF干预可以上调Occludin、Claudin、Zo-1等紧密连接蛋白阳性表达(P<0.01),减少NLRP3炎症相关蛋白的表达(P<0.01);4)ELISA结果:VTF各剂量组小鼠脑组织中IL-1β、IL-6、TNFα等炎症因子水平降低(P<0.01);VTF各剂量组中5-HT和GABA的含量增多(P<0.01);5)肠道菌群检测结果显示:VTF高剂量干预后的AD小鼠厚壁菌门相对丰度增多(P<0.05),与模型组小鼠相比,VTF中、高剂量组中乳杆菌科(Lactobacillaceae)相对丰度增多,VTF低剂量组中Muribaculaceae相对丰度增多,多奈哌齐组,VTF各剂量组中丹毒科(Erysipelotrichaceae)、瘤胃球菌科(Ruminococcaceae)相对丰度增多;而VTF各剂量组中毛螺菌科(Lachnospiraceae)、螺杆菌科(Helicobacteraceae),脱铁杆菌科(Deferribacteraceae)相对丰度减少。结论:这些结果表明,VTF调节肠道菌群可能具有治疗衰老过程中微生物导致脑轴和认知功能缺陷的潜力,其机制可能与改变肠道菌群组成,修复受损的肠道屏障,炎症反应和神经递质有关。因此,调节肠道微生物群可能是治疗AD相关神经疾病的一种潜在策略。
