The theory of"all winds and dizziness belong to the liver"provides a basis for 1ater plysicians to study the etiologic and pathogenesis of vertigo diseases.This theory of pathogenesis suggests that vertigo d...The theory of"all winds and dizziness belong to the liver"provides a basis for 1ater plysicians to study the etiologic and pathogenesis of vertigo diseases.This theory of pathogenesis suggests that vertigo diseases are most closely related to the liver,so the mechanism can be simply understood as liver and spleen damage.Water dampness is unfavourable for transportation and transformation as dampness gathers phlegm,and liver‘wind’carries phlegm to the ear orifice,causing dizziness,or the ear orifice can be attacked due to the deficiency of yin and hyperactivity of yang in liver and kidney,resulting in sudden dizziness.Based on the pathogenesis theory of liver and spleen damage,the treatment principles should be based on strengthening the spleen and dispelling dampness,eliminating phlegm and extinguishing‘wind’.For‘yang-type'hyperactive liver,nourishing yin and suppressing yang,and the clearing of yang in the ears should always be the standard.展开更多
OBJECTIVE： To analyze the characteristics of liver pacifying medicinal in the treatment of brain disease to provide scientific evidence in clinical usage on stroke.METHODS： MEDLINE/PubMed, Google Scholar, and China ...OBJECTIVE： To analyze the characteristics of liver pacifying medicinal in the treatment of brain disease to provide scientific evidence in clinical usage on stroke.METHODS： MEDLINE/PubMed, Google Scholar, and China National Knowledge Infrastructure Database were used as the literature sources. The Scientific name, Latin pharmaceutical name, Chinese name of 7 kinds of liver pacifying medicinal including Gouteng （Ramulus Uncariae Rhynchophyllae cure Uncis）, Tianma （Rhizoma Gastrodiae）, Juemingzi （Semen Cassiae Obtusifoliae）, Quanxie （Scorpio）, Wugong （Scolopendra）, Jiangcan （Bombyx Batryticatus）, and Dilong （Pheretima Aspergillum） were used as the keywords to search the databases for relevant publications up to July 2016. Their major compounds were also used as the keywords. The papers were selected based on the pharmacological activities and mechanisms of action related to brain diseases and subsequently, were analyzed and reviewed. We first described the origin, efficacy, and clinical indications of selected medicines, then brain disease specific activities focusing on stroke after the description of the general pharmacological activities. RESULTS： On the basis of the literature of scientific studies and clinical use in traditional medicine, we found and discussed the characteristics of liver pacifying medicinal in stroke treatment. First, liver-pacifying medicinal, or their components, might pass through the blood-brain barrier and act directly on neurons or on the neural network to provide protective effects against brain disease. Second, although it could be used throughout the disease duration, treatment of stroke might be more effective from the subacute up to the convalescent phase than the acute phase.CONCLUSION： We can suggest that live pacifying medicinal has beneficial pharmacological activities directly or indirectly on neurons in brain disease and is useful for the treatment of stroke from subacute to convalescent phase.展开更多
目的:观察钩藤止动汤对肝亢风动型小儿多发性抽动症的临床疗效。方法:将72例患儿分为治疗组和对照组,两组均用常规西药硫必利片治疗,治疗组加用钩藤止动汤内服治疗。结果:治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗...目的:观察钩藤止动汤对肝亢风动型小儿多发性抽动症的临床疗效。方法:将72例患儿分为治疗组和对照组,两组均用常规西药硫必利片治疗,治疗组加用钩藤止动汤内服治疗。结果:治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后两组中医症状积分与治疗前相比均降低,差异有统计学意义(P<0.05),且治疗组中医症状积分低于对照组,差异有统计学意义(P<0.05)。治疗后两组运动性抽动评分、发声性抽动评分和耶鲁综合抽动严重程度量表(Yale Global Tic Severity Scale,YGTSS)评分总分低于治疗前,差异有统计学意义(P<0.05),且治疗组上述评分低于对照组,差异有统计学意义(P<0.05)。治疗后两组血清铅离子水平均低于治疗前,且治疗组铅离子水平低于对照组,差异有统计学意义(P<0.05)。治疗后两组血清铁离子及锌离子水平均高于治疗前,且治疗组高于对照组,差异有统计学意义(P<0.05)。结论:钩藤止动汤联合盐酸硫比利片治疗肝亢风动型小儿多发性抽动症的效果较好。展开更多
目的观察泻青丸结合清心平肝法针刺治疗小儿多发性抽动症(肝亢风动证)临床效果。方法研究纳入106例多发性抽动症(肝亢风动证)儿童,以随机数字表法进行分组,分为对照组与观察组,每组53例,对照组采取常规治疗(氟哌啶醇片),观察组在对照组...目的观察泻青丸结合清心平肝法针刺治疗小儿多发性抽动症(肝亢风动证)临床效果。方法研究纳入106例多发性抽动症(肝亢风动证)儿童,以随机数字表法进行分组,分为对照组与观察组,每组53例,对照组采取常规治疗(氟哌啶醇片),观察组在对照组的基础上,结合泻青丸及清心平肝法针刺治疗,两组数据观察:治疗前后耶鲁综合抽动严重程度量表(Yale global tie severityb scale,YGTSS)评分变化、临床疗效、不良反应、中医证候积分变化、血清多巴胺(Dopamine,DA)以及5-羟色胺(5-Hydroxytryptophan,5-HT)、γ-氨基丁酸(γ-Aminobutyric acid,GABA)水平变化、Achenbach儿童行为量表(Child behavior check list,CBCL)及生活质量量表(Short form 36 questionnaire,SF-36)评分变化。结果观察组患儿总有效率(96.23%,51/53)比对照组患儿(84.91%,45/53)更高,差异有统计学意义(P<0.05);两组患儿治疗前YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分比较,差异无统计学意义(P>0.05),治疗后两组患儿YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分等指标均改善,观察组患儿治疗后YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分等指标优于对照组,差异有统计学意义(P<0.05);观察组患儿不良反应率(3.77%,2/53)比对照组患儿(16.98%,9/53)更低,差异有统计学意义(P<0.05)。结论泻青丸结合清心平肝法针刺治疗小儿多发性抽动症(肝亢风动证)临床效果显著,且患儿症状改善,恢复较好,患儿行为改善,生活质量提升,不良反应率降低,较为安全可靠。展开更多
基金Shaanxi Province Famous TCM Doctor Zhang Xiong Studio[Shaan Wei TCM Development(2018)No.95]。
文摘The theory of"all winds and dizziness belong to the liver"provides a basis for 1ater plysicians to study the etiologic and pathogenesis of vertigo diseases.This theory of pathogenesis suggests that vertigo diseases are most closely related to the liver,so the mechanism can be simply understood as liver and spleen damage.Water dampness is unfavourable for transportation and transformation as dampness gathers phlegm,and liver‘wind’carries phlegm to the ear orifice,causing dizziness,or the ear orifice can be attacked due to the deficiency of yin and hyperactivity of yang in liver and kidney,resulting in sudden dizziness.Based on the pathogenesis theory of liver and spleen damage,the treatment principles should be based on strengthening the spleen and dispelling dampness,eliminating phlegm and extinguishing‘wind’.For‘yang-type'hyperactive liver,nourishing yin and suppressing yang,and the clearing of yang in the ears should always be the standard.
基金Supported by a Grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI)funded by the Ministry of Health&Welfare,Republic of Korea(No.HI15C0116)a Grant of Basic Science Research Program through the National Research Foundation of Korea(NRF)Funded by the Ministry of Science,ICT&Future Planning(No.2016R1A2B4012546)
文摘OBJECTIVE： To analyze the characteristics of liver pacifying medicinal in the treatment of brain disease to provide scientific evidence in clinical usage on stroke.METHODS： MEDLINE/PubMed, Google Scholar, and China National Knowledge Infrastructure Database were used as the literature sources. The Scientific name, Latin pharmaceutical name, Chinese name of 7 kinds of liver pacifying medicinal including Gouteng （Ramulus Uncariae Rhynchophyllae cure Uncis）, Tianma （Rhizoma Gastrodiae）, Juemingzi （Semen Cassiae Obtusifoliae）, Quanxie （Scorpio）, Wugong （Scolopendra）, Jiangcan （Bombyx Batryticatus）, and Dilong （Pheretima Aspergillum） were used as the keywords to search the databases for relevant publications up to July 2016. Their major compounds were also used as the keywords. The papers were selected based on the pharmacological activities and mechanisms of action related to brain diseases and subsequently, were analyzed and reviewed. We first described the origin, efficacy, and clinical indications of selected medicines, then brain disease specific activities focusing on stroke after the description of the general pharmacological activities. RESULTS： On the basis of the literature of scientific studies and clinical use in traditional medicine, we found and discussed the characteristics of liver pacifying medicinal in stroke treatment. First, liver-pacifying medicinal, or their components, might pass through the blood-brain barrier and act directly on neurons or on the neural network to provide protective effects against brain disease. Second, although it could be used throughout the disease duration, treatment of stroke might be more effective from the subacute up to the convalescent phase than the acute phase.CONCLUSION： We can suggest that live pacifying medicinal has beneficial pharmacological activities directly or indirectly on neurons in brain disease and is useful for the treatment of stroke from subacute to convalescent phase.
文摘目的:观察钩藤止动汤对肝亢风动型小儿多发性抽动症的临床疗效。方法:将72例患儿分为治疗组和对照组,两组均用常规西药硫必利片治疗,治疗组加用钩藤止动汤内服治疗。结果:治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后两组中医症状积分与治疗前相比均降低,差异有统计学意义(P<0.05),且治疗组中医症状积分低于对照组,差异有统计学意义(P<0.05)。治疗后两组运动性抽动评分、发声性抽动评分和耶鲁综合抽动严重程度量表(Yale Global Tic Severity Scale,YGTSS)评分总分低于治疗前,差异有统计学意义(P<0.05),且治疗组上述评分低于对照组,差异有统计学意义(P<0.05)。治疗后两组血清铅离子水平均低于治疗前,且治疗组铅离子水平低于对照组,差异有统计学意义(P<0.05)。治疗后两组血清铁离子及锌离子水平均高于治疗前,且治疗组高于对照组,差异有统计学意义(P<0.05)。结论:钩藤止动汤联合盐酸硫比利片治疗肝亢风动型小儿多发性抽动症的效果较好。
文摘目的观察泻青丸结合清心平肝法针刺治疗小儿多发性抽动症(肝亢风动证)临床效果。方法研究纳入106例多发性抽动症(肝亢风动证)儿童,以随机数字表法进行分组,分为对照组与观察组,每组53例,对照组采取常规治疗(氟哌啶醇片),观察组在对照组的基础上,结合泻青丸及清心平肝法针刺治疗,两组数据观察:治疗前后耶鲁综合抽动严重程度量表(Yale global tie severityb scale,YGTSS)评分变化、临床疗效、不良反应、中医证候积分变化、血清多巴胺(Dopamine,DA)以及5-羟色胺(5-Hydroxytryptophan,5-HT)、γ-氨基丁酸(γ-Aminobutyric acid,GABA)水平变化、Achenbach儿童行为量表(Child behavior check list,CBCL)及生活质量量表(Short form 36 questionnaire,SF-36)评分变化。结果观察组患儿总有效率(96.23%,51/53)比对照组患儿(84.91%,45/53)更高,差异有统计学意义(P<0.05);两组患儿治疗前YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分比较,差异无统计学意义(P>0.05),治疗后两组患儿YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分等指标均改善,观察组患儿治疗后YGTSS评分、中医证候积分、DA及5-HT、GABA水平、CBCL及SF-36评分等指标优于对照组,差异有统计学意义(P<0.05);观察组患儿不良反应率(3.77%,2/53)比对照组患儿(16.98%,9/53)更低,差异有统计学意义(P<0.05)。结论泻青丸结合清心平肝法针刺治疗小儿多发性抽动症(肝亢风动证)临床效果显著,且患儿症状改善,恢复较好,患儿行为改善,生活质量提升,不良反应率降低,较为安全可靠。
