摘要
目的:本研究通过中药系统毒理学数据库分析中药致肝毒性的特性及其分布规律。方法:检索中药系统毒理学数据库中收录的252味中药,归纳出114味具有致肝毒性的药材,并综合分析相关文献,通过频数算法归纳总结致肝毒性中药在功效类别、四气五味、归经以及毒性成分等方面的分布规律。结果:祛风湿药和清热药致肝毒性药材占比最高,药味以苦为主,药性以寒性为主,归经多在肝、肺、脾、胃;生物碱类成分是主要的致肝毒性活性成分;肝毒性表现包括肝细胞损伤和炎症反应,可能机制涉及氧化应激和细胞凋亡等;为降低毒性,传统采用酒制、醋制等方法。结论:通过中药系统毒理学数据库了解中药致肝毒性的特性及其分布规律,对保障临床用药安全具有重要意义。
Objective:To analyze the characteristics and distribution patterns of hepatotoxicity induced by Chinese medicine based on Traditional Chinese Medicine System Toxicology Database(TCMSTD).Methods:A total of 252 drugs recorded in the TCMSTD were retrieved,with 114 identified as having hepatotoxic effects.Relevant literature was reviewed,and frequency algorithms were used to summarize the distribution patterns of hepatotoxic drugs in terms of therapeutic categories,properties(such as the four qi and five flavors),meridian tropism,and toxic components.Results:The largest proportion of hepatotoxic drugs belong to categories such as wind and dampness-dispelling and heat-clearing drugs.These drugs are primarily bitter and cold,and they often act on the liver,lung,spleen,and stomach meridians.Alkaloids are the main hepatotoxic active components.Hepatotoxicity manifests as liver cell damage and inflammatory responses,with mechanisms involving oxidative stress and apoptosis.Traditional processing methods,such as alcohol and vinegar processing,are used to reduce toxicity.Conclusion:Understanding the characteristics and distribution patterns of hepatotoxicity induced by Chinese medicine through the TCMSTD is crucial for ensuring the safety of clinical use.
作者
黄依婷
磨宁芳
秦秋云
李妞妞
李卓娴
夏猛
HUANG Yiting;MO Ningfang;QIN Qiuyun;LI Niuniu;LI Zhuoxian;XIA Meng(Guangxi University of Chinese Medicine,Nanning 530200,China;School of Basic Medical Sciences,Guangxi University of Chinese Medicine,Nanning 530200,China;Key Laboratory of Liver and Spleen Viscera of Guangxi Traditional Chinese Medicine,Nanning 530200,China;School of Basic Medical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006,China)
出处
《世界中医药》
北大核心
2025年第5期776-784,共9页
World Chinese Medicine
基金
国家自然科学基金项目(82460921)
广西重点研发计划项目(桂科AB23026137)
广西自然科学基金面上项目(2021GXNSFAA220128)。
关键词
中药系统毒理学数据库
肝毒性
四气五味
归经
生物碱类
药物性肝损伤
祛风湿药
清热药
Traditional Chinese Medicine System Toxicology Database
Hepatotoxicity
Four qi and five flavors
Meridian tropism
Alkaloids
Drug-induced liver injury
Wind and dampness-dispelling drugs
Heat-clearing drugs
