This study investigates the viscoelastic behavior of soft bio-fibres in association with their fractal structures. A spring-dashpot fractal network with the self-similar topology, named the -type fractal ladder hyper-...This study investigates the viscoelastic behavior of soft bio-fibres in association with their fractal structures. A spring-dashpot fractal network with the self-similar topology, named the -type fractal ladder hyper-cell (FLHC), is abstracted from the micro/nano-structure of ligaments and tendons (LTs). Its constitutive operator is derived by the Heaviside operational calculus, which is of intrinsic fractional order. In terms of this operator, the long-term viscoelastic relaxation of bio-fibres arising from the fractal ladder topology is expounded. In addition, the fractional-order viscoelastic constitutive equation is obtained based on the FLHC of LTs, and its results are consistent with those of available human knee and spinal LT relaxation experiments. Results on the constitutive equation of FLHCs are formulated into two propositions. The multidisciplinary invariance and implications from the fractal ladder pattern of bio-fibres are also discussed.展开更多
The quantum phase of hard-core bosons in Creutz ladder with zero flux is studied. For a specific regime of the parameters （tx = tp,ty 〈 0）, the exact ground-state is found analytically, which is a dimerized insulat...The quantum phase of hard-core bosons in Creutz ladder with zero flux is studied. For a specific regime of the parameters （tx = tp,ty 〈 0）, the exact ground-state is found analytically, which is a dimerized insulator with one electron bound in each rung of the ladder. For the case tx, ty, tp 〉 0, the system is exactly studied using quantum Monte Carlo （QMC） method without a sign problem. It is found that the system is a Mott insulator for small tp and a quantum phase transition to a superfluid phase is driven by increasing tp. The critical t~ is determined precisely by a scaling analysis. Since it is possible that the Creutz ladder is realized experimentally, the theoretical results are interesting to the cold-atom experiments.展开更多
By combining the cumulant expansion method with the double-chain approximation, we study thermodynamic properties of ladder-like He isenberg system. We find the interaction between interchains has different effect in ...By combining the cumulant expansion method with the double-chain approximation, we study thermodynamic properties of ladder-like He isenberg system. We find the interaction between interchains has different effect in high and low temperature.展开更多
目的探讨椎管内硬膜外腔导管介入镇痛与非椎管内途径多药物联合镇痛治疗胰腺癌所致腹部顽固性癌痛的效果及不良反应。方法收集胰腺癌相关腹部顽固性癌痛患者48例,随机分为两组,非全植入式硬膜外腔导管介入镇痛组(试验组):采用硬膜外腔...目的探讨椎管内硬膜外腔导管介入镇痛与非椎管内途径多药物联合镇痛治疗胰腺癌所致腹部顽固性癌痛的效果及不良反应。方法收集胰腺癌相关腹部顽固性癌痛患者48例,随机分为两组,非全植入式硬膜外腔导管介入镇痛组(试验组):采用硬膜外腔导管介入自控镇痛技术,经侧腹壁做皮下隧道,外接自控镇痛泵。药物联合镇痛组(对照组):采用《癌症疼痛诊疗规范(卫生部2011年版)》建议的非介入性治疗,主要为三阶梯镇痛药物的联合,包括口服、静脉、肌注、黏膜、自控镇痛(patient control analgesia,PCA)等用药方式的联合。随访3个月,以视觉模拟评分法(visual analogue scale,VAS)评估镇痛效果,记录VAS降低>20%和降低>50%的病例数,应用美国国立癌症研究院通用毒性标准(National Cancer Institute Common Toxicity Criteria,NCI-CTC)标准(纳入15项观察指标)计算药物毒性评分,记录通用毒性标准(common toxicity criteria,CTC)降低>20%的病例数,计算等效口服吗啡节俭效应,记录两组患者3个月后存活率。结果镇痛治疗4周时试验组与对照组VAS和CTC评分同时降低>20%的病例数分别为79.2%和39.1%,VAS降低>50%和CTC降低>20%的病例数分别为87.5%和34.8%;对照组VAS评分均值由7.8下降到4.8,CTC评分均值由6.8下降到5.8;试验组VAS评分均值由7.9下降到3.2,CTC评分由6.9下降到2.9;试验组和对照组等效口服吗啡节俭率分别94.5%和31.2%(P<0.01);试验组与对照组患者3个月存活率分别为79.2%和33.3%(P<0.01)。结论与非椎管内途径多药物联合镇痛比较,经椎管内硬膜外腔导管介入镇痛治疗胰腺癌所致腹部顽固性癌痛的镇痛效果更好,镇痛药相关药物不良反应降低,患者生活质量显著改善,存活时间明显延长。展开更多
基金Project supported by the National Natural Science Foundation of China(No.11672150)the Beijing Nova Program Interdisciplinary Cooperation Project(No.xxjc201705)+1 种基金the Capital Clinical Special Promotion Project(No.Z161100000516233)the Key Issue of the 12th Five-Year Plan of People’s Liberation Army of China(No.BKJ13J004)
文摘This study investigates the viscoelastic behavior of soft bio-fibres in association with their fractal structures. A spring-dashpot fractal network with the self-similar topology, named the -type fractal ladder hyper-cell (FLHC), is abstracted from the micro/nano-structure of ligaments and tendons (LTs). Its constitutive operator is derived by the Heaviside operational calculus, which is of intrinsic fractional order. In terms of this operator, the long-term viscoelastic relaxation of bio-fibres arising from the fractal ladder topology is expounded. In addition, the fractional-order viscoelastic constitutive equation is obtained based on the FLHC of LTs, and its results are consistent with those of available human knee and spinal LT relaxation experiments. Results on the constitutive equation of FLHCs are formulated into two propositions. The multidisciplinary invariance and implications from the fractal ladder pattern of bio-fibres are also discussed.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11274032,11774019,51472016,and 51672018)
文摘The quantum phase of hard-core bosons in Creutz ladder with zero flux is studied. For a specific regime of the parameters （tx = tp,ty 〈 0）, the exact ground-state is found analytically, which is a dimerized insulator with one electron bound in each rung of the ladder. For the case tx, ty, tp 〉 0, the system is exactly studied using quantum Monte Carlo （QMC） method without a sign problem. It is found that the system is a Mott insulator for small tp and a quantum phase transition to a superfluid phase is driven by increasing tp. The critical t~ is determined precisely by a scaling analysis. Since it is possible that the Creutz ladder is realized experimentally, the theoretical results are interesting to the cold-atom experiments.
文摘By combining the cumulant expansion method with the double-chain approximation, we study thermodynamic properties of ladder-like He isenberg system. We find the interaction between interchains has different effect in high and low temperature.
文摘目的探讨椎管内硬膜外腔导管介入镇痛与非椎管内途径多药物联合镇痛治疗胰腺癌所致腹部顽固性癌痛的效果及不良反应。方法收集胰腺癌相关腹部顽固性癌痛患者48例,随机分为两组,非全植入式硬膜外腔导管介入镇痛组(试验组):采用硬膜外腔导管介入自控镇痛技术,经侧腹壁做皮下隧道,外接自控镇痛泵。药物联合镇痛组(对照组):采用《癌症疼痛诊疗规范(卫生部2011年版)》建议的非介入性治疗,主要为三阶梯镇痛药物的联合,包括口服、静脉、肌注、黏膜、自控镇痛(patient control analgesia,PCA)等用药方式的联合。随访3个月,以视觉模拟评分法(visual analogue scale,VAS)评估镇痛效果,记录VAS降低>20%和降低>50%的病例数,应用美国国立癌症研究院通用毒性标准(National Cancer Institute Common Toxicity Criteria,NCI-CTC)标准(纳入15项观察指标)计算药物毒性评分,记录通用毒性标准(common toxicity criteria,CTC)降低>20%的病例数,计算等效口服吗啡节俭效应,记录两组患者3个月后存活率。结果镇痛治疗4周时试验组与对照组VAS和CTC评分同时降低>20%的病例数分别为79.2%和39.1%,VAS降低>50%和CTC降低>20%的病例数分别为87.5%和34.8%;对照组VAS评分均值由7.8下降到4.8,CTC评分均值由6.8下降到5.8;试验组VAS评分均值由7.9下降到3.2,CTC评分由6.9下降到2.9;试验组和对照组等效口服吗啡节俭率分别94.5%和31.2%(P<0.01);试验组与对照组患者3个月存活率分别为79.2%和33.3%(P<0.01)。结论与非椎管内途径多药物联合镇痛比较,经椎管内硬膜外腔导管介入镇痛治疗胰腺癌所致腹部顽固性癌痛的镇痛效果更好,镇痛药相关药物不良反应降低,患者生活质量显著改善,存活时间明显延长。
