L1范数约束是目前稀疏地震反演比较常用的正则化方法,但利用L1范数并不能得到最优的稀疏解。为了进一步的得到更稀疏的结果,引入了一种基于Lp稀疏约束和交替方向乘子算法的波阻抗反演方法。从正则化方法出发,采用了比L1范数更为稀疏的L...L1范数约束是目前稀疏地震反演比较常用的正则化方法,但利用L1范数并不能得到最优的稀疏解。为了进一步的得到更稀疏的结果,引入了一种基于Lp稀疏约束和交替方向乘子算法的波阻抗反演方法。从正则化方法出发,采用了比L1范数更为稀疏的Lp范数对目标函数稀疏约束,在此基础上,加入了初始模型约束,旨在得到具有较高精度以及稳定性的反演结果。为了对Lp拟范数这类非凸优化问题进行求解,选择使用交替方向乘子算法(Alternating Direction Method of Multipliers),将目标函数分解为多个可以求解的子目标函数。为了验证反演方法的稳定性和实用性,分别选择了理论模型和实际数据对反演方法进行了测试,得到了较高精度的缝洞型储层预测结果。展开更多
[Objective]The paper was to study the effects of estradiol(E_(2))and progesterone(P4)on the expression of interleukin-1β(IL-1β)mRNA in lipopolysaccharide(LPS)-induced acute salpingitis in ovariectomized mice,and pre...[Objective]The paper was to study the effects of estradiol(E_(2))and progesterone(P4)on the expression of interleukin-1β(IL-1β)mRNA in lipopolysaccharide(LPS)-induced acute salpingitis in ovariectomized mice,and preliminarily explore the anti-inflammatory mechanism associated with estrogen and progesterone.[Method]Healthy female KM mice were randomly assigned to several groups:the sham operation group(LPS+SHAM),the ovarian removal group(LPS+OVX),the ovarian removal+estradiol group(LPS+OVX+E_(2)),the ovarian removal+progesterone group(LPS+OVX+P4),the LPS group and the control group(control).HE staining was conducted to assess the pathological changes in the fallopian tubes of each group.Additionally,the expression levels of IL-1βmRNA in the fallopian tubes of the mice were quantified using RT-qPCR.[Result]The histopathological changes in the fallopian tubes were examined.Estrogen and progesterone demonstrated a significant capacity to mitigate salpingitis induced by LPS.In comparison to the control group,the expression of IL-1βmRNA in the LPS group,LPS+SHAM group,and LPS+OVX+E_(2)group was significantly down-regulated(P<0.05).Furthermore,the expression of IL-1βmRNA in the LPS+OVX+P4 group exhibited an extremely significant down-regulation(P<0.01).When compared to the LPS+OVX group,the expression of IL-1βmRNA in the LPS+OVX+E_(2)group was significantly down-regulated(P<0.05),while the expression in the LPS+OVX+P4 group was extremely significantly down-regulated(P<0.01).[Conclusion]Estrogen and progesterone have the capacity to inhibit the expression of IL-1βmRNA in the inflammatory tissue of the fallopian tubes in mice,consequently diminishing the inflammatory response induced by LPS.展开更多
文摘L1范数约束是目前稀疏地震反演比较常用的正则化方法,但利用L1范数并不能得到最优的稀疏解。为了进一步的得到更稀疏的结果,引入了一种基于Lp稀疏约束和交替方向乘子算法的波阻抗反演方法。从正则化方法出发,采用了比L1范数更为稀疏的Lp范数对目标函数稀疏约束,在此基础上,加入了初始模型约束,旨在得到具有较高精度以及稳定性的反演结果。为了对Lp拟范数这类非凸优化问题进行求解,选择使用交替方向乘子算法(Alternating Direction Method of Multipliers),将目标函数分解为多个可以求解的子目标函数。为了验证反演方法的稳定性和实用性,分别选择了理论模型和实际数据对反演方法进行了测试,得到了较高精度的缝洞型储层预测结果。
基金Supported by Health Science and Technology Programme Project of Inner Mongolia Autonomous Region Health and Health Commission(202201194)General Program of Inner Mongolia Medical University(YKD2023MS032)+2 种基金Innovation and Entrepreneurship Training Program for College Students of Inner Mongolia Medical University(202210132059)Natural Science Foundation of Inner Mongolia Autonomous Region(2022LHMS03001)Talent Introduction Project of Inner Mongolia Autonomous Region in 2020.
文摘[Objective]The paper was to study the effects of estradiol(E_(2))and progesterone(P4)on the expression of interleukin-1β(IL-1β)mRNA in lipopolysaccharide(LPS)-induced acute salpingitis in ovariectomized mice,and preliminarily explore the anti-inflammatory mechanism associated with estrogen and progesterone.[Method]Healthy female KM mice were randomly assigned to several groups:the sham operation group(LPS+SHAM),the ovarian removal group(LPS+OVX),the ovarian removal+estradiol group(LPS+OVX+E_(2)),the ovarian removal+progesterone group(LPS+OVX+P4),the LPS group and the control group(control).HE staining was conducted to assess the pathological changes in the fallopian tubes of each group.Additionally,the expression levels of IL-1βmRNA in the fallopian tubes of the mice were quantified using RT-qPCR.[Result]The histopathological changes in the fallopian tubes were examined.Estrogen and progesterone demonstrated a significant capacity to mitigate salpingitis induced by LPS.In comparison to the control group,the expression of IL-1βmRNA in the LPS group,LPS+SHAM group,and LPS+OVX+E_(2)group was significantly down-regulated(P<0.05).Furthermore,the expression of IL-1βmRNA in the LPS+OVX+P4 group exhibited an extremely significant down-regulation(P<0.01).When compared to the LPS+OVX group,the expression of IL-1βmRNA in the LPS+OVX+E_(2)group was significantly down-regulated(P<0.05),while the expression in the LPS+OVX+P4 group was extremely significantly down-regulated(P<0.01).[Conclusion]Estrogen and progesterone have the capacity to inhibit the expression of IL-1βmRNA in the inflammatory tissue of the fallopian tubes in mice,consequently diminishing the inflammatory response induced by LPS.
