Background:In this study,we aimed to validate and test the reliability of the Yonsei lifestyle profile(YLP)in assessing multifaceted health lifestyle levels in a study population from the United States.Methods:The YLP...Background:In this study,we aimed to validate and test the reliability of the Yonsei lifestyle profile(YLP)in assessing multifaceted health lifestyle levels in a study population from the United States.Methods:The YLP-English version and health-promoting lifestyle profile II were administered to 100 individuals living in the United States.Concurrent validity was analyzed using Pearson's correlation coefficient,and discriminant validity was examined by comparing sex and age differences through t-tests and multiple variance analysis.Internal consistency was assessed using Cronbach'sαfor each sub-factor.Results:The YLP-English Version demonstrated concurrent validity with the Health-Promoting Lifestyle Profile II,showing consistent correlations for the total score(0.3,p<0.01)and frequency sub-factors(0.25-0.69,p<0.01).Among the satisfaction sub-factors,only nutrition showed a weak negative correlation(-0.19,p<0.01);all others were nonsignificant.Discriminant validity revealed no significant sex differences,but physical activity frequency varied across age groups.Internal consistency was high(Cronbach'sα=0.80-0.86).Conclusion:In this study,we validated the YLP-English version as a reliable instrument for assessing health-related lifestyle behaviors.The YLP uniquely captures both lifestyle frequency and satisfaction,offering a comprehensive perspective on health behaviors.Although this tool is currently most applicable in population-level studies,future research should establish clinical thresholds to enhance its utility in individualized health assessments and interventions.展开更多
Hepatocellular carcinoma(HCC)represents a major global health burden,ranking third as the leading cause of cancer-related mortality worldwide.This compre-hensive review examines the substantial body of evidence linkin...Hepatocellular carcinoma(HCC)represents a major global health burden,ranking third as the leading cause of cancer-related mortality worldwide.This compre-hensive review examines the substantial body of evidence linking modifiable lifestyle factors to HCC pathogenesis and clinical outcomes.We systematically evaluate dietary components,alcohol consumption patterns,tobacco use,physical activity levels,and emerging factors including metabolic disorders,psychological stress,and sleep disturbances.These factors collectively influence hepatocarcino-genesis through diverse biological mechanisms,including genotoxic damage,metabolic dysregulation,chronic inflammatory responses,and gut microbiome-mediated pathways.The accumulated data underscore the urgent need to inte-grate lifestyle interventions into multidisciplinary HCC management.展开更多
BACKGROUND Obesity impacts 42%of United States adults and results in an estimated economic burden of nearly 1.4 trillion dollars annually.Endoscopic sleeve gastroplasty(ESG)is a United States Food and Drug Administrat...BACKGROUND Obesity impacts 42%of United States adults and results in an estimated economic burden of nearly 1.4 trillion dollars annually.Endoscopic sleeve gastroplasty(ESG)is a United States Food and Drug Administration authorized procedure with an excellent safety,efficacy,and durability profile.The cost-effectiveness of ESG compared to lifestyle modification(LM)in real-world patients with class I-III obesity represents a critical knowledge gap.AIM To approximate the cost-effectiveness of ESG vs LM using a real-world dataset of 860 United States adults with class I-III obesity undergoing ESG.METHODS A 6-state Markov model was employed,including healthy weight,overweight,class I-III obesity,and death.The LM control group was built using transition states previously described in the literature,supplemented by expert opinion.Cycles lasted six-months in the model’s first year and twelve-months thereafter.Existing literature informed approximations of each health state utility,adverse event disutility,and incidence of obesity-associated comorbidities.One-way sensitivity and probabilistic sensitivity analyses were performed.RESULTS The base-case incremental cost-effectiveness ratio(ICER)for ESG vs LM was 5904 dollars per quality-adjusted life year(QALY).In a one-way sensitivity analysis,the utilities assigned to the three obesity classes most greatly influenced the ICER.Probabilistic sensitivity analysis estimated an increase in upper-bound ICER of 8038 dollars per QALY,well under the generally cited United States willingness to pay ratio of 100000 dollars per QALY.CONCLUSION The results of this model support that ESG is overwhelmingly cost-effective compared to LM across all obesity classes.Payors should consider expanding coverage for their members.展开更多
BACKGROUND Prediabetes mellitus(PDM)is receiving increasing attention as a precursor to type 2 diabetes mellitus.Lifestyle and traditional Chinese medicine(TCM)inter-ventions are effective for PDM prevention and treat...BACKGROUND Prediabetes mellitus(PDM)is receiving increasing attention as a precursor to type 2 diabetes mellitus.Lifestyle and traditional Chinese medicine(TCM)inter-ventions are effective for PDM prevention and treatment.Therefore,we con-ducted a preliminary investigation and an exploratory randomised controlled trial to assess the effects of a combined lifestyle and TCM intervention on PDM indicators.AIM To study the effectiveness of Xiaokeqing granules(XQG)and lifestyle inter-ventions in PDM participants while using metabolomics to identify potential markers.METHODS Forty PDM participants with yin deficiency syndrome with excessive heat were recruited and randomly allocated to the control(Con)group or the XQG group(20 per group).The Con group underwent lifestyle interventions,whereas the XQG group underwent lifestyle and XQG interventions.The follow-up duration was 2 months.Fasting blood glucose,2-hour postprandial glucose(2hPG),gly-cated haemoglobin A1c,fasting insulin,homeostasis model assessment-insulin resistance levels,and serum metabolomics characteristics were compared via liquid chromatography-tandem mass spectrometry analysis.RESULTS There were significant differences in 2hPG between the two groups(P<0.05)in the intention-to-treat analysis and per-protocol analysis.The intervention method used in this study was safe(P>0.05).Groenlandicine,kaempferol,isomangiferin,etc.,are the XQG constituents absorbed in the blood.N-Nervonoyl methionine and 5-hydroxy-L-tryptophan are core potential metabolomic biomarkers for the effectiveness of XQG and lifestyle interventions.HTR1A,HTR2C,SLC6A4,etc.,are the core targets of XQG and lifestyle interventions,as well as the reason for their clinical efficacy.Possible mechanistic pathways include tryptophan metabolism,pantothenate and certificate of analysis biosynthesis,lysine degradation and biosynthesis of cofactors.CONCLUSION This pilot study provides evidence that a combined XQG and lifestyle intervention can improve 2hPG in par-ticipants with PDM.The mechanism of action is related to multiple constituents,targets and pathways.展开更多
A low-carbon lifestyle presents new opportunities for sustainable urban development.While previous studies have verified the impact of the built environment and socioeconomic status(SES)on low-carbon lifestyles,they h...A low-carbon lifestyle presents new opportunities for sustainable urban development.While previous studies have verified the impact of the built environment and socioeconomic status(SES)on low-carbon lifestyles,they have primarily focused on direct effects.At present,there is still a lack of analysis on the interaction effects on low-carbon lifestyles,and limited attention has been given to the peer effect in low-carbon lifestyles,especially in the context of residential differentiation.Therefore,we take Zhengzhou city as the case area and first calculate the low-carbon lifestyle of 1485 families from three dimensions:low-carbon action(A),low-carbon interest(I)and low-carbon opinion(O).We then analyze the direct and interactive impacts of the built environment and SES on low-carbon lifestyles and explore the peer effect.Our findings indicate that families with higher SES have higher levels of low-carbon interest and low-carbon opinion,but relatively low levels of low-carbon action.This suggests an interest-action bias in the low-carbon lifestyles of high-SES families.POI density,road network density and accessibility positively affect low-carbon lifestyles—that is,residents living in areas with well-developed infrastructure and convenient transportation tend to be green in their daily behavior.The peer effect influences low-carbon action,interest,and opinion by 54.6%,34.9%,and 16%,respectively,indicating that the peer effect is most evident in low-carbon action.That is,the peer effect is more obvious in low-carbon action.In addition,the built environment affects the low-carbon lifestyles of different SES groups.Land-use mix positively increases low-carbon action and low-carbon interest among high-SES groups but reduces low-carbon opinion.Road network density positively affects the low-carbon action of high-SES groups and the low-carbon interest and low-carbon opinion of low-SES groups.This study explores low-carbon lifestyles from a situational perspective,providing a practical basis for policies aimed at accelerating a transition to sustainable living.展开更多
Non-communicable diseases (NCDs) are on the rise worldwide and in developing countries like Botswana. Unhealthy eating habits and lack of proper nutrition knowledge cause non-communicable diseases and affect adolescen...Non-communicable diseases (NCDs) are on the rise worldwide and in developing countries like Botswana. Unhealthy eating habits and lack of proper nutrition knowledge cause non-communicable diseases and affect adolescents. It is in adolescence that eating habits are formed that persist till adulthood. Lifestyle interventions are needed to curb NCDs in adolescents. This paper reports the findings of a study that aimed to validate a lifestyle intervention program and its effect on food intake, physical activity, and nutrition knowledge. It was a clustered randomized control trial study conducted in four (4) junior secondary schools. There were 46 participants, 21 in the control and 25 in the intervention arm, who were blindly assigned to each arm by a statistician. Information and skills on nutrition were imparted using the Information, Motivation, and Behavioral Skills model. The program was implemented for eight (8) weeks hourly after school. A questionnaire was used to collect data pre- and post-intervention. Number, proportion, percentage, and independent t-test (mean and SD or median and IQR, p-value) were calculated using numerical and categorical data. The findings showed that the lifestyle intervention was valid, and there was a slight decrease in the intake of sweets among participants in both trial arms (p = 0.066). There was no significant difference in terms of food intake. Only a small number of participants still ate a few fruits, and there was no change in vegetable intake in both trial arms (p = 0.641). There was no change in the intake of fried foods in both trail arms (p = 0.402). Regarding nutrition knowledge, there was a slight significant difference of p = 0.079 between the trial arms. Though the effect of the lifestyle intervention program was not statistically significant, the results are promising, especially if the duration could be increased to a longer period and a larger sample size included.展开更多
BACKGROUNDColorectal cancer(CRC)typically progresses from benign colorectal polyps,whichrepresent a precursor to malignancy.Identifying the factors influencing thisprogression is crucial for early intervention and pre...BACKGROUNDColorectal cancer(CRC)typically progresses from benign colorectal polyps,whichrepresent a precursor to malignancy.Identifying the factors influencing thisprogression is crucial for early intervention and prevention.Although genetic andenvironmental factors have been widely studied,the role of lifestyle factors suchas physical activity,diet,smoking,sleep,and stress remains underexplored,especially in patients with early stage CRC or polyps.Recent evidence suggeststhat lifestyle behaviors may influence cancer progression by modulating inflammatorypathways,metabolic health,and immune function.For instance,highlevels of physical activity are linked to a reduced risk of CRC development,whereas poor dietary habits,smoking,and inadequate sleep have all beenimplicated in increased cancer risk and progression.Moreover,early-stage CRCpatients,who are often asymptomatic or have minimal symptoms,may particularlybenefit from lifestyle modifications to slow disease progression andimprove overall prognosis.The gap in understanding the specific influence ofthese lifestyle factors on colorectal polyps and early stage cancer progressionunderscores the need for comprehensive studies.By assessing several modifiablelifestyle factors and their association with disease progression,clinicians canidentify practical intervention points.These interventions could ultimately reducethe need for more aggressive treatments and improve the long-term outcomes inaffected patients.AIMTo investigate the association between lifestyle factors and disease progression inpatients with colorectal polyps and early stage cancer.METHODSIn this observational study conducted from January 2022 to December 2023,werecruited 120 patients with colorectal polyps or early stage cancer from Jiangshan People's Hospital.Lifestyle factors,including physical activity,dietary patterns,smoking status,sleep quality,andstress levels,were assessed using validated questionnaires.Disease progression was evaluated using standardizedfollow-up colonoscopies and pathological examinations.Cox proportional hazards models were used to analyzethe association between lifestyle factors and disease progression after adjusting for potential confounders.RESULTSDuring the median follow-up of 18.4 months,42(35.0%)patients experienced disease progression.High levels ofphysical activity were associated with reduced progression risk[adjusted hazard ratio(HR)0.55,95%confidenceinterval(CI):0.38-0.80,P=0.002]compared to low activity levels.High adherence to a healthy dietary patternshowed similar protective effects(adjusted HR 0.62,95%CI:0.43-0.89,P=0.009).Current smoking(adjusted HR1.92,95%CI:1.35-2.73,P<0.001)and poor sleep quality(adjusted HR 1.38,95%CI:1.05-1.82,P=0.021)wereassociated with increased progression risk.The impact of lifestyle factors was particularly pronounced in patientsyounger than 60 years and those with multiple polyps at baseline.CONCLUSIONThis study demonstrated significant associations between lifestyle factors and disease progression in colorectalpolyps and early stage cancer.Physical activity,dietary patterns,smoking status,and sleep quality have emergedas key modifiable factors influencing disease progression.These findings support the integration of lifestyleassessments and modifications in the clinical management of patients with colorectal neoplasia.展开更多
Objective:Heterogeneity in the evidence of association between lifestyle factors and breast cancer(BC)incidence hampers initiatives to modify BC risk.This overview aims to synthesise evidence from systematic reviews(S...Objective:Heterogeneity in the evidence of association between lifestyle factors and breast cancer(BC)incidence hampers initiatives to modify BC risk.This overview aims to synthesise evidence from systematic reviews(SRs)to inform lifestyle-related modifications for BC prevention.Methods:We systematically searched(MEDLINE,EMBASE,and CINAHL)from January 2013 to August 2023 for SRs of the association between lifestyle factors[alcohol consumption,physical activity(PA),body mass index(BMI),smoking,breastfeeding,oral contraception(OC),hormone replacement therapy(HRT),and sedentary behavior(SB)]and BC incidence.A narrative data synthesis was performed.Results:Sixty-six SRs met the eligibility criteria.Evidence from 40 SRs indicated consistent associations between the risk of BC and postmenopausal BMI increase(relative risk increase:2%-21%),use of HRT(risk increase:23%-33%),smoking(risk increase:4%-86%),and alcohol consumption(risk increase:4%-61%).Additionally,evidence from 23 SRs suggested protective associations with PA(risk decrease:10%-39%),breastfeeding(risk decrease:9%-53%),and healthy lifestyle scores(protective about 20%-26%).However,inconsistent and/or statistically non-significant associations were found between BC incidence and premenopausal BMI increase[relative risk(RR):0.78-1.08],SB(RR:1.01-1.20),and OC use[odds ratio(OR):1.01-1.35].Conclusions:This overview identifies lifestyle factors associated with BC incidence,highlighting both harmful and protective factors.Our summary findings can support information and interventions related to modifying these factors,including limiting alcohol and smoking,or avoiding postmenopausal BMI increase and HRT.展开更多
Purpose:This study aimed to provide comparative evidence on the effectiveness of various lifestyle interventions on body composition management for preschool and school-aged children.Methods:PubMed(MEDLINE),Embase,CIN...Purpose:This study aimed to provide comparative evidence on the effectiveness of various lifestyle interventions on body composition management for preschool and school-aged children.Methods:PubMed(MEDLINE),Embase,CINAHL,and Web of Science were systematically searched for this network meta-analysis.Randomized controlled studies(RCTs)that included children aged 4-12 years with no physical or mental conditions;performed at least 1 type of lifestyle intervention;reported change in body mass index(BMI),BMI z-score,or body fat percentage(BFP);and were published between January2010 and August 2023 were included.Results:The final analysis included 91 RCTs with aggregate data for 58,649 children.All interventions were categorized into single-arm approaches(physical activity,diet,and behavioral and informational support)and combined arms approaches(bicomponent and multicomponent treatment).Multicomponent treatment showed significant effectiveness on the reduction of BMI(mean deviation(MD)-0.49,95%confidence interval(95%CI):-0.88 to-0.12),BMI z-score(MD=-0.11,95%CI:-0.18 to-0.04),and BFP(MD=-1.69,95%CI:-2.97 to-0.42)compared to the usual care condition.Bicomponent treatment also significantly reduced BMI(MD=-0.28,95%CI:-0.54 to-0.04)and BMI z-score(MD=-0.07,95%CI:-0.12 to-0.02)compared to usual care.Conclusion:Interventions targeting multiple lifestyle components achieved greater reductions in children's BMI and BFP.Among single-component approaches,physical activity engagement emerged as the most effective.These findings should guide practitioners in recommending comprehensive lifestyle modifications for children.Moreover,children with higher initial BMI and body fat levels tend to exhibit more positive responses to lifestyle interventions aimed at managing obesity.展开更多
Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12...Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12-80 years.The qi stagnation constitution was assessed using the Constitution in Chinese Medicine Questionnaire.Health status was evaluated through medical records and the Subhealth Measurement Scale V1.0(SHMS V1.0).Health-promoting lifestyles were measured using the Health-Promoting Lifestyle Profile Ⅱ(HPLP-Ⅱ).Results:Of the 24159 participants,16.1%and 15.2%were classified as“always”and“sometimes”having the qi stagnation constitution,respectively.Those classified as“rarely”having the qi stagnation constitution scored higher on both the HPLP-Ⅱ and SHMS V1.0.The participants classified as“always”having the qi stagnation constitution showed a significant association with SHS or disease compared to other imbalanced constitutions.Those in the“always”category were approximately 21 times more likely to be classified as having SHS(odds ratio[OR]:21.17,95%confidence interval[CI]:15.74-28.45),whereas those in the“sometimes”category were approximately six times more likely(OR:5.89,95%CI:5.04-6.90).Accordingly,the qi stagnation constitution score was significantly associated with the diagnosis of SHS,with an area under the curve of 0.77(P<.001).A score of 18.75 yielded the highest Youden Index(0.407),with a sensitivity of 60.5%and a specificity of 80.3%.Significant associations were observed between health-promoting lifestyles and qi stagnation constitution severity in an ordinal regression analysis(P<.001).Protective factors included stress management(OR:1.59),self-actualization(OR:1.57),and exercise(OR:1.36).In contrast,poorer interpersonal relationships(OR:0.79),greater health responsibilities(OR:0.86),and poorer nutrition(OR:0.91)were associated with increased severity.Conclusion:Modulating the qi stagnation constitution through lifestyle interventions may help prevent the progression of SHS to disease,which aligns with core preventive principles in traditional Chinese medicine.展开更多
This study aimed to evaluate the association of a healthy lifestyle pattern with mortality risk among patients with type 2 diabetes mellitus(T2DM).Data were derived from a prospective cohort study enrolling 13776Chine...This study aimed to evaluate the association of a healthy lifestyle pattern with mortality risk among patients with type 2 diabetes mellitus(T2DM).Data were derived from a prospective cohort study enrolling 13776Chinese patients with T2DM.A healthy lifestyle pattern was constructed based on six lifestyle factors,including smoking status,alcohol consumption,dietary habits,physical activity,sedentary time,and sleep duration.Multivariate Cox proportional hazards models were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for all-cause and cause-specific mortality.During a median follow-up of 9.78 years,2497 deaths were recorded.Compared with T2DM patients with a lifestyle pattern scoring 0–2,those scoring 5–6 had a 40%lower risk for all-cause mortality(HR=0.60,95%CI:0.52–0.69),a 33%lower risk for cardiovascular disease mortality(HR=0.67,95%CI:0.52–0.86),and a 25%lower risk for cancer mortality(HR=0.75,95%CI:0.58–0.97).Additionally,we found that the association between the lifestyle pattern and all-cause mortality risk was stronger in females than in males(P for interaction<0.05).In conclusion,adherence to a healthy lifestyle pattern is associated with a decreased risk of all-cause,cardiovascular disease,and cancer mortality.These findings have important implications for reducing premature mortality among patients with T2DM.展开更多
The national weight management campaign,part of the broader Healthy China strategy,enhances public health literacy,fosters healthy living habits,and creates supportive environments for sustained weight control.
Objective:This study aimed to examine the influence of behavioral lifestyle factors on recent episodic memory retention capacity among young-old adults(aged 60-69 years)in China.The findings provide scientific evidenc...Objective:This study aimed to examine the influence of behavioral lifestyle factors on recent episodic memory retention capacity among young-old adults(aged 60-69 years)in China.The findings provide scientific evidence to inform proactive strategies to mitigate cognitive decline risk within China’s rapidly aging population.Methods:Utilizing data from the 2022 wave of the China Family Panel Studies(CFPS),a total of 2,772 adults aged 60-69 were included in the analytical sample.Recent episodic memory retention capacity(scored 0-5 points,based on self-reported assessment)served as the dependent variable.Six categories of behavioral lifestyle indicators(including exercise frequency,sleep quality,dietary patterns,etc.)were analyzed as independent variables.Associations were assessed using multivariate ordinal logistic regression models,controlling for relevant covariates.Results:Self-reported potential impairment in recent episodic memory was identified by 47.19%of respondents.Multivariate analysis revealed significant associations between behavioral lifestyle factors and memory retention capacity.Regular exercise(OR=1.297,95%CI:1.118-1.504),meat consumption(OR=1.765,95%CI:1.393-2.237),regular reading habits(OR=1.599,95%CI:1.283-1.992),and internet use(OR=1.413,95%CI:1.217-1.641)emerged as significant protective factors.Abnormal sleep duration was detrimentally associated with retention capacity(too short:OR=0.728,95%CI:0.591-0.897;too long:OR=0.810,95%CI:0.670-0.980).Significant associations were also observed for control variables:urban residence(OR=1.270,95%CI:1.100-1.467),high school education or above(OR=1.543,95%CI:1.293-1.841),and better self-rated health status(OR=1.156,95%CI:1.089-1.227)were positively correlated with better memory retention.Conclusions:Optimal sleep duration,regular physical exercise,meat intake,habitual reading,and internet engagement positively predict self-assessed recent episodic memory retention capacity in Chinese young-old adults.These findings underscore the potential for multi-faceted lifestyle interventions to enhance cog-nitive health in aging populations.Specifically,strategies should encompass community-based sleep hygiene management,tailored nutritional interventions(especially promoting adequate protein sources like meat),enhanced digital literacy and internet accessibility programs,and the promotion of age-appropriate physical activity initiatives.Furthermore,implementing culturally responsive strategies adapted to urban-rural contexts-such as deploying“mobile cognitive health units”in rural areas and fostering digital reading platforms in urban settings-is recommended to optimize intervention effectiveness.展开更多
Background Both medication and non-medication therapies are effective approaches to control blood pressure (BP) in hypertension patients.However,the association of joint changes in antihypertensive medication use and ...Background Both medication and non-medication therapies are effective approaches to control blood pressure (BP) in hypertension patients.However,the association of joint changes in antihypertensive medication use and healthy lifestyle index (HLI)with BP control among hypertension patients is seldom reported,which needs to provide more evidence by prospective intervention studies.We examined the association of antihypertensive medication use and HLI with BP control among employees with hypertension in China based on a workplace-based multicomponent intervention program.Methods Between January 2013 and December 2014,a cluster randomized clinical trial of a workplace-based multicomponent intervention program was conducted in 60 workplaces across 20 urban areas in China.Workplaces were randomly divided into intervention (n=40) and control (n=20) groups.Basic information on employees at each workplace was collected by trained professionals,including sociodemographic characteristics,medical history,family history,lifestyle behaviors,medication status and physical measurements.After baseline,the intervention group received a 2-year intervention to achieve BP control,which included:(1) a workplace wellness program for all employees;(2) a guidelines-oriented hypertension management protocol.HLI including nonsmoking,nondrinking,adequate physical activity,weight within reference range and balanced diet,were coded on a 5-point scale (range:0-5,with higher score indicating a healthier lifestyle).Antihypertensive medication use was defined as taking drug within the last 2 weeks.Changes in HLI,antihypertensive medication use and BP control from baseline to 24 months were measured after the intervention.Results Overall,4655 employees were included (age:46.3±7.6 years,men:3547 (82.3%)).After 24 months of the intervention,there was a significant improvement in lifestyle[smoking (OR=0.65,95%CI:0.43-0.99;P=0.045),drinking (OR=0.52,95%CI:0.40-0.68;P<0.001),regular exercise (OR=3.10,95%CI:2.53-3.78;P<0.001),excessive intake of fatty food (OR=0.17,95%CI:0.06-0.52;P=0.002),restrictive use of salt (OR=0.26,95%CI:0.12-0.56;P=0.001)].Compare to employees with a deteriorating lifestyle after the intervention,those with an improved lifestyle had a higher BP control.In the intervention group,compared with employees not using antihypertensive medication,those who consistent used (OR=2.34;95%CI:1.16-4.72;P=0.017) or changed from not using to using antihypertensive medication (OR=2.24;95%CI:1.08-4.62;P=0.030) had higher BP control.Compared with those having lower HLI,participants with a same (OR=1.38;95%CI:0.99-1.93;P=0.056) or high (OR=1.79;95%CI:1.27~2.53;P<0.001) HLI had higher BP control.Those who used antihypertensive medication and had a high HLI had the highest BP control (OR=1.88;95%CI:1.32-2.67,P<0.001).Subgroup analysis also showed the consistent effect as the above.Conclusion These findings suggest that adherence to antihypertensive medication treatment and healthy lifestyle were associated with a significant improvement in BP control among employees with hypertension.展开更多
Objective:To investigate the lifestyle and myopia among primary school students in urban areas of Fujian with the context of myopia prevention and control measures,aiming to provide scientific evidence for identifying...Objective:To investigate the lifestyle and myopia among primary school students in urban areas of Fujian with the context of myopia prevention and control measures,aiming to provide scientific evidence for identifying high-risk myopia population and formulating effective intervention strategies.Methods:A cross-sectional study was conducted from October to November 2023,enrolling 811 fourth-grade students from three primary schools in three cities across Fujian.Personal information and lifestyle-related pattern were collected using customized questionnaire.Participants underwent comprehensive ophthalmic assessments including distance visual acuity tests and refractive examinations.Logistic regression analysis was used to assess the impact of lifestyle on the onset of myopia.Results:The prevalence of myopia among fourth-grade students in urban primary schools in Fujian was 46.4%.Only 25.8%students engaged in outdoor activities for more than 2 hours daily,while63.3%participated in outdoor activities during class breaks.Multivariate Logistic regression analysis revealed that outdoor activities during class breaks(OR=0.646(95%confidence interval(CI):0.473-0.881),P=0.006)and daily time spent outdoors(2-3 hours,OR=0.682(95%CI:0.466-0.993),P=0.047;more than 3 hours,OR=0.403(95%CI:0.192-0.796),P=0.01)were independent protective factors against myopia.Lifestyle significantly enhanced the predictive performance for myopia(P=0.01).Additionally,parental myopia(one parent with myopia,OR=2.247(95%CI:1.612-3.145),P<0.001;both parents with myopia,OR=4.824(95%CI:3.262-7.204),P<0.001)emerged as a key risk factor for myopia.Conclusions:There is considerable scope for improving the lifestyle of primary school students in urban areas of Fujian.Lifestyle is strongly associated with myopia onset,highlighting the need for schools and families to actively encourage students to engage in more outdoor activities and take breaks outdoors to prevent and control myopia.Students with parents,especially both parents,having myopia should be considered as a key target group for myopia prevention efforts.展开更多
Background:Obesity remains a major global health challenge,closely linked to individuals'health beliefs and lifestyle behaviors.Descriptive and relational research methods were used to ascertain the correlation be...Background:Obesity remains a major global health challenge,closely linked to individuals'health beliefs and lifestyle behaviors.Descriptive and relational research methods were used to ascertain the correlation between health beliefs and healthy lifestyle behaviors in obese individuals based on the Health Belief Model.Methods:The population of the research are obese individuals who are treated in the internal medicine clinic in a state hospital in Diyarbakır and applied to a dietitian.Based on power analysis,the study’s sample consisted of 192 obese people.The health belief model scale in obese individuals(HBMSO),the Healthy Lifestyle Behaviors Scale-II(HLBS-II),and the Personal Information Form were used to gather the data.The data was evaluated using the following methods:mean,standard deviation,linear regression analysis,Mann-Whitney U test,Kruskal-Wallis test,Shapiro Wilk and Kolmogorov Smirnov tests,post-hoc Dunn-Benferronni tests,Pearson and Spearman correlation,and others.Results:It was determined that 26.0%of obese individuals were in the 46–55 age range,63.5%were female,64.6%were married,60.4%had a BMI in the range of 30–34.9 kg/m^(2),and 42.7%partially exercised.All sub-dimensions and HBMSO sub-dimensions had statistically significant correlation with the HLBS-II total score.The linear regression analysis results used to identify the predictors of the HLBS-II total score showed that the increase in the level of education and the HBMSO“Importance of Health”sub-dimension score increased the HLBS-II total score,while not exercising and an increase in the HBMSO“Obstacle Perception”sub-dimension score decreased the HLBS-II total score.Conclusion:Individuals’health attitudes have a major impact on leading a healthy lifestyle,which is consistent with the research results.展开更多
Polycystic ovary syndrome(PCOS)is a lifelong disorder affecting reproductive,metabolic,and psychological health.A healthy lifestyle and effective weight management strategies should underpin the treatment of PCOS.This...Polycystic ovary syndrome(PCOS)is a lifelong disorder affecting reproductive,metabolic,and psychological health.A healthy lifestyle and effective weight management strategies should underpin the treatment of PCOS.This case report documents the successful management of a Chinese patient with PCOS who was overweight and presented with oligomenorrhea and persistent adiposity.The patient was diagnosed using the Rotterdam criteria.The intervention was a 2-month program involving caloric restriction(1,350 kcal/day whole-food diet),progressive exercise titration(150–180 min/week of aerobic and resistance training),mindfulness practice,and metformin initiation after confirmed insulin resistance(HOMA-IR 3.67)resulted in clinically significant body composition improvements:fat mass was reduced by 5.0 kg,visceral adipose area was reduced by 44.7 cm^(2),skeletal muscle was increased by 1.4 kg,and regular menstrual cycles(32 day interval)were restored following 5% weight loss-consistent with evidence linking this threshold to improved ovarian function.The combination of a structured lifestyle modification program with targeted pharmacotherapy offers a viable clinical approach for metabolic PCOS phenotypes,although further validation is required to ascertain long-term efficacy.展开更多
Objective:To explore the associations between income levels,employment risk,lifestyles,occupational stress,and male fertility.Methods:This cross-sectional study analyzed 294 men seeking fertility treatment at fertilit...Objective:To explore the associations between income levels,employment risk,lifestyles,occupational stress,and male fertility.Methods:This cross-sectional study analyzed 294 men seeking fertility treatment at fertility clinics in Terengganu,Pahang,and Kuala Lumpur from November 2021 to June 2023.Data were collected through structured questionnaires covering income levels,lifestyles,employment risks,occupational stress,and semen quality.Multinomial logistic regression was employed to assess predictors of semen quality,with crude and adjusted odds ratios(OR)reported.Results:The lower-income group exhibited higher odds of having abnormal semen quality compared to normal semen quality.Specifically,these participants were more likely to experience azoospermia[crude OR 6.68,95%confidence interval(CI)1.84-52.63;adjusted OR 6.26,95%CI 1.76-51.38],indicating a link between low income and infertility issues.Lifestyle factors did not show significant associations with semen abnormalities after adjustment.High employment risks had significant associations with oligozoospermia after adjustment(crude OR 5.50,95%CI 2.14-14.11;adjusted OR 5.15,95%CI 1.93-13.71),while high occupational stress was linked to asthenozoospermia(crude OR 2.26,95%CI 1.09-4.68;adjusted OR 2.25,95%CI 1.07-4.69).Conclusions:The findings underscore the influence of socioeconomic and occupational factors on male fertility,showing associations between lower income levels,high-risk occupations,and semen abnormalities.In contrast,lifestyle factors did not show significant associations with semen abnormalities after adjustment.Nevertheless,the current findings should be further confirmed through more extensive studies focusing on abnormal semen and lifestyle factors.展开更多
On the macro level,the ‘2018 Chinese Guidelines for Prevention and Treatment of Hypertension’[1] provides a detailed overview on the population strategies for hypertension prevention as well as the principles and me...On the macro level,the ‘2018 Chinese Guidelines for Prevention and Treatment of Hypertension’[1] provides a detailed overview on the population strategies for hypertension prevention as well as the principles and methods of community standardized management for hypertension control,with particular emphasis on the significance of correcting unhealthy lifestyles for the prevention and control of hypertension and its complications.?展开更多
Purpose: Public health nurses (PHNs) are required to assess the readiness of the clients and provide lifestyle counseling accordingly. The purpose of this study was to compare the lifestyle counseling provided for cli...Purpose: Public health nurses (PHNs) are required to assess the readiness of the clients and provide lifestyle counseling accordingly. The purpose of this study was to compare the lifestyle counseling provided for clients with different levels of readiness based on self-evaluations and independent assessment. Methods: Participants were PHNs with 10 years’ experience or less. Lifestyle counseling skills were measured through a simulated counseling session in a primary setting lasting up to 30 minutes, followed by a review session, where the participant provided self-evaluations, and the simulated client provided others-evaluations, of the session. The simulated clients played the role of clients at either the pre-contemplation or contemplation stage of preparedness as per the stages of behavior change theory. Results: The self-evaluation results showed that the mean scores for five of the six skill categories, are lower in the precontemplation-stage client cases than in the contemplation-stage client cases, and significantly so for two skill categories. The others-evaluations showed significantly lower mean scores for all skill categories in the precontemplation cases than in the contemplation cases. Conclusion: The PHNs and simulated clients agreed that lifestyle counseling skills were inadequate for the precontemplation cases, as compared with the contemplation cases. The lifestyle counseling skills of PHNs with less experience may not be well-adjusted to the readiness of the client, indicating difficulties in supporting less prepared clients.展开更多
基金supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Republic of Korea(NRF-2021S1A3A2A02096338).
文摘Background:In this study,we aimed to validate and test the reliability of the Yonsei lifestyle profile(YLP)in assessing multifaceted health lifestyle levels in a study population from the United States.Methods:The YLP-English version and health-promoting lifestyle profile II were administered to 100 individuals living in the United States.Concurrent validity was analyzed using Pearson's correlation coefficient,and discriminant validity was examined by comparing sex and age differences through t-tests and multiple variance analysis.Internal consistency was assessed using Cronbach'sαfor each sub-factor.Results:The YLP-English Version demonstrated concurrent validity with the Health-Promoting Lifestyle Profile II,showing consistent correlations for the total score(0.3,p<0.01)and frequency sub-factors(0.25-0.69,p<0.01).Among the satisfaction sub-factors,only nutrition showed a weak negative correlation(-0.19,p<0.01);all others were nonsignificant.Discriminant validity revealed no significant sex differences,but physical activity frequency varied across age groups.Internal consistency was high(Cronbach'sα=0.80-0.86).Conclusion:In this study,we validated the YLP-English version as a reliable instrument for assessing health-related lifestyle behaviors.The YLP uniquely captures both lifestyle frequency and satisfaction,offering a comprehensive perspective on health behaviors.Although this tool is currently most applicable in population-level studies,future research should establish clinical thresholds to enhance its utility in individualized health assessments and interventions.
基金Supported by Chinese Academy of Medical Sciences Initiative for Innovative Medicine,No.2021-I2M-1-015the National Natural Science Foundation of China,No.82330061 and No.82001937+1 种基金the Peking Union Medical College Graduate Curriculum Informatization Development Special Fund Project,No.2024YXX004the Science and Education Cultivation Fund of the National Cancer and Regional Medical Center of Shanxi Provincial Cancer Hospital,No.TD2023003.
文摘Hepatocellular carcinoma(HCC)represents a major global health burden,ranking third as the leading cause of cancer-related mortality worldwide.This compre-hensive review examines the substantial body of evidence linking modifiable lifestyle factors to HCC pathogenesis and clinical outcomes.We systematically evaluate dietary components,alcohol consumption patterns,tobacco use,physical activity levels,and emerging factors including metabolic disorders,psychological stress,and sleep disturbances.These factors collectively influence hepatocarcino-genesis through diverse biological mechanisms,including genotoxic damage,metabolic dysregulation,chronic inflammatory responses,and gut microbiome-mediated pathways.The accumulated data underscore the urgent need to inte-grate lifestyle interventions into multidisciplinary HCC management.
文摘BACKGROUND Obesity impacts 42%of United States adults and results in an estimated economic burden of nearly 1.4 trillion dollars annually.Endoscopic sleeve gastroplasty(ESG)is a United States Food and Drug Administration authorized procedure with an excellent safety,efficacy,and durability profile.The cost-effectiveness of ESG compared to lifestyle modification(LM)in real-world patients with class I-III obesity represents a critical knowledge gap.AIM To approximate the cost-effectiveness of ESG vs LM using a real-world dataset of 860 United States adults with class I-III obesity undergoing ESG.METHODS A 6-state Markov model was employed,including healthy weight,overweight,class I-III obesity,and death.The LM control group was built using transition states previously described in the literature,supplemented by expert opinion.Cycles lasted six-months in the model’s first year and twelve-months thereafter.Existing literature informed approximations of each health state utility,adverse event disutility,and incidence of obesity-associated comorbidities.One-way sensitivity and probabilistic sensitivity analyses were performed.RESULTS The base-case incremental cost-effectiveness ratio(ICER)for ESG vs LM was 5904 dollars per quality-adjusted life year(QALY).In a one-way sensitivity analysis,the utilities assigned to the three obesity classes most greatly influenced the ICER.Probabilistic sensitivity analysis estimated an increase in upper-bound ICER of 8038 dollars per QALY,well under the generally cited United States willingness to pay ratio of 100000 dollars per QALY.CONCLUSION The results of this model support that ESG is overwhelmingly cost-effective compared to LM across all obesity classes.Payors should consider expanding coverage for their members.
基金Supported by the Open Bidding for Selecting the Best Candidates for Xin’an Medicine and the Modernization of Traditional Chinese Medicine of IHM,No.2023CXMMTCM024 and No.2023CXMMTCM003the Anhui University Collaborative Innovation Project,No.GXXT-2020-025+2 种基金the Scientific Research Project of Health and Wellness in Anhui Province,No.AHWJ2023BAc10002the Anhui Province New Era Education Quality Project,No.2023gjxslt014and the Clinical and Translational Research Project of Anhui Province,No.202427b10020046.
文摘BACKGROUND Prediabetes mellitus(PDM)is receiving increasing attention as a precursor to type 2 diabetes mellitus.Lifestyle and traditional Chinese medicine(TCM)inter-ventions are effective for PDM prevention and treatment.Therefore,we con-ducted a preliminary investigation and an exploratory randomised controlled trial to assess the effects of a combined lifestyle and TCM intervention on PDM indicators.AIM To study the effectiveness of Xiaokeqing granules(XQG)and lifestyle inter-ventions in PDM participants while using metabolomics to identify potential markers.METHODS Forty PDM participants with yin deficiency syndrome with excessive heat were recruited and randomly allocated to the control(Con)group or the XQG group(20 per group).The Con group underwent lifestyle interventions,whereas the XQG group underwent lifestyle and XQG interventions.The follow-up duration was 2 months.Fasting blood glucose,2-hour postprandial glucose(2hPG),gly-cated haemoglobin A1c,fasting insulin,homeostasis model assessment-insulin resistance levels,and serum metabolomics characteristics were compared via liquid chromatography-tandem mass spectrometry analysis.RESULTS There were significant differences in 2hPG between the two groups(P<0.05)in the intention-to-treat analysis and per-protocol analysis.The intervention method used in this study was safe(P>0.05).Groenlandicine,kaempferol,isomangiferin,etc.,are the XQG constituents absorbed in the blood.N-Nervonoyl methionine and 5-hydroxy-L-tryptophan are core potential metabolomic biomarkers for the effectiveness of XQG and lifestyle interventions.HTR1A,HTR2C,SLC6A4,etc.,are the core targets of XQG and lifestyle interventions,as well as the reason for their clinical efficacy.Possible mechanistic pathways include tryptophan metabolism,pantothenate and certificate of analysis biosynthesis,lysine degradation and biosynthesis of cofactors.CONCLUSION This pilot study provides evidence that a combined XQG and lifestyle intervention can improve 2hPG in par-ticipants with PDM.The mechanism of action is related to multiple constituents,targets and pathways.
基金National Natural Science Foundation of China,No.42171295,No.42401380Outstanding Youth Science Fund of Henan Province,No.242300421144+1 种基金The Postgraduate Cultivating Innovation and Quality Improvement Action Plan of Henan University,No.SYLYC2022013Henan Science and Technology Innovation Talent Project,No.24HASTIT050。
文摘A low-carbon lifestyle presents new opportunities for sustainable urban development.While previous studies have verified the impact of the built environment and socioeconomic status(SES)on low-carbon lifestyles,they have primarily focused on direct effects.At present,there is still a lack of analysis on the interaction effects on low-carbon lifestyles,and limited attention has been given to the peer effect in low-carbon lifestyles,especially in the context of residential differentiation.Therefore,we take Zhengzhou city as the case area and first calculate the low-carbon lifestyle of 1485 families from three dimensions:low-carbon action(A),low-carbon interest(I)and low-carbon opinion(O).We then analyze the direct and interactive impacts of the built environment and SES on low-carbon lifestyles and explore the peer effect.Our findings indicate that families with higher SES have higher levels of low-carbon interest and low-carbon opinion,but relatively low levels of low-carbon action.This suggests an interest-action bias in the low-carbon lifestyles of high-SES families.POI density,road network density and accessibility positively affect low-carbon lifestyles—that is,residents living in areas with well-developed infrastructure and convenient transportation tend to be green in their daily behavior.The peer effect influences low-carbon action,interest,and opinion by 54.6%,34.9%,and 16%,respectively,indicating that the peer effect is most evident in low-carbon action.That is,the peer effect is more obvious in low-carbon action.In addition,the built environment affects the low-carbon lifestyles of different SES groups.Land-use mix positively increases low-carbon action and low-carbon interest among high-SES groups but reduces low-carbon opinion.Road network density positively affects the low-carbon action of high-SES groups and the low-carbon interest and low-carbon opinion of low-SES groups.This study explores low-carbon lifestyles from a situational perspective,providing a practical basis for policies aimed at accelerating a transition to sustainable living.
文摘Non-communicable diseases (NCDs) are on the rise worldwide and in developing countries like Botswana. Unhealthy eating habits and lack of proper nutrition knowledge cause non-communicable diseases and affect adolescents. It is in adolescence that eating habits are formed that persist till adulthood. Lifestyle interventions are needed to curb NCDs in adolescents. This paper reports the findings of a study that aimed to validate a lifestyle intervention program and its effect on food intake, physical activity, and nutrition knowledge. It was a clustered randomized control trial study conducted in four (4) junior secondary schools. There were 46 participants, 21 in the control and 25 in the intervention arm, who were blindly assigned to each arm by a statistician. Information and skills on nutrition were imparted using the Information, Motivation, and Behavioral Skills model. The program was implemented for eight (8) weeks hourly after school. A questionnaire was used to collect data pre- and post-intervention. Number, proportion, percentage, and independent t-test (mean and SD or median and IQR, p-value) were calculated using numerical and categorical data. The findings showed that the lifestyle intervention was valid, and there was a slight decrease in the intake of sweets among participants in both trial arms (p = 0.066). There was no significant difference in terms of food intake. Only a small number of participants still ate a few fruits, and there was no change in vegetable intake in both trial arms (p = 0.641). There was no change in the intake of fried foods in both trail arms (p = 0.402). Regarding nutrition knowledge, there was a slight significant difference of p = 0.079 between the trial arms. Though the effect of the lifestyle intervention program was not statistically significant, the results are promising, especially if the duration could be increased to a longer period and a larger sample size included.
文摘BACKGROUNDColorectal cancer(CRC)typically progresses from benign colorectal polyps,whichrepresent a precursor to malignancy.Identifying the factors influencing thisprogression is crucial for early intervention and prevention.Although genetic andenvironmental factors have been widely studied,the role of lifestyle factors suchas physical activity,diet,smoking,sleep,and stress remains underexplored,especially in patients with early stage CRC or polyps.Recent evidence suggeststhat lifestyle behaviors may influence cancer progression by modulating inflammatorypathways,metabolic health,and immune function.For instance,highlevels of physical activity are linked to a reduced risk of CRC development,whereas poor dietary habits,smoking,and inadequate sleep have all beenimplicated in increased cancer risk and progression.Moreover,early-stage CRCpatients,who are often asymptomatic or have minimal symptoms,may particularlybenefit from lifestyle modifications to slow disease progression andimprove overall prognosis.The gap in understanding the specific influence ofthese lifestyle factors on colorectal polyps and early stage cancer progressionunderscores the need for comprehensive studies.By assessing several modifiablelifestyle factors and their association with disease progression,clinicians canidentify practical intervention points.These interventions could ultimately reducethe need for more aggressive treatments and improve the long-term outcomes inaffected patients.AIMTo investigate the association between lifestyle factors and disease progression inpatients with colorectal polyps and early stage cancer.METHODSIn this observational study conducted from January 2022 to December 2023,werecruited 120 patients with colorectal polyps or early stage cancer from Jiangshan People's Hospital.Lifestyle factors,including physical activity,dietary patterns,smoking status,sleep quality,andstress levels,were assessed using validated questionnaires.Disease progression was evaluated using standardizedfollow-up colonoscopies and pathological examinations.Cox proportional hazards models were used to analyzethe association between lifestyle factors and disease progression after adjusting for potential confounders.RESULTSDuring the median follow-up of 18.4 months,42(35.0%)patients experienced disease progression.High levels ofphysical activity were associated with reduced progression risk[adjusted hazard ratio(HR)0.55,95%confidenceinterval(CI):0.38-0.80,P=0.002]compared to low activity levels.High adherence to a healthy dietary patternshowed similar protective effects(adjusted HR 0.62,95%CI:0.43-0.89,P=0.009).Current smoking(adjusted HR1.92,95%CI:1.35-2.73,P<0.001)and poor sleep quality(adjusted HR 1.38,95%CI:1.05-1.82,P=0.021)wereassociated with increased progression risk.The impact of lifestyle factors was particularly pronounced in patientsyounger than 60 years and those with multiple polyps at baseline.CONCLUSIONThis study demonstrated significant associations between lifestyle factors and disease progression in colorectalpolyps and early stage cancer.Physical activity,dietary patterns,smoking status,and sleep quality have emergedas key modifiable factors influencing disease progression.These findings support the integration of lifestyleassessments and modifications in the clinical management of patients with colorectal neoplasia.
基金funding via a National Breast Cancer Foundation(NBCF)Chair in Breast Cancer Prevention grant(No.EC-21-001)a National Health and Medical Research Council(NHMRC)Investigator(Leader)grant(No.1194410)supported by funding from a NBCF Investigator Initiated Research Scheme grant(No.2023/IIRS0028)。
文摘Objective:Heterogeneity in the evidence of association between lifestyle factors and breast cancer(BC)incidence hampers initiatives to modify BC risk.This overview aims to synthesise evidence from systematic reviews(SRs)to inform lifestyle-related modifications for BC prevention.Methods:We systematically searched(MEDLINE,EMBASE,and CINAHL)from January 2013 to August 2023 for SRs of the association between lifestyle factors[alcohol consumption,physical activity(PA),body mass index(BMI),smoking,breastfeeding,oral contraception(OC),hormone replacement therapy(HRT),and sedentary behavior(SB)]and BC incidence.A narrative data synthesis was performed.Results:Sixty-six SRs met the eligibility criteria.Evidence from 40 SRs indicated consistent associations between the risk of BC and postmenopausal BMI increase(relative risk increase:2%-21%),use of HRT(risk increase:23%-33%),smoking(risk increase:4%-86%),and alcohol consumption(risk increase:4%-61%).Additionally,evidence from 23 SRs suggested protective associations with PA(risk decrease:10%-39%),breastfeeding(risk decrease:9%-53%),and healthy lifestyle scores(protective about 20%-26%).However,inconsistent and/or statistically non-significant associations were found between BC incidence and premenopausal BMI increase[relative risk(RR):0.78-1.08],SB(RR:1.01-1.20),and OC use[odds ratio(OR):1.01-1.35].Conclusions:This overview identifies lifestyle factors associated with BC incidence,highlighting both harmful and protective factors.Our summary findings can support information and interventions related to modifying these factors,including limiting alcohol and smoking,or avoiding postmenopausal BMI increase and HRT.
文摘Purpose:This study aimed to provide comparative evidence on the effectiveness of various lifestyle interventions on body composition management for preschool and school-aged children.Methods:PubMed(MEDLINE),Embase,CINAHL,and Web of Science were systematically searched for this network meta-analysis.Randomized controlled studies(RCTs)that included children aged 4-12 years with no physical or mental conditions;performed at least 1 type of lifestyle intervention;reported change in body mass index(BMI),BMI z-score,or body fat percentage(BFP);and were published between January2010 and August 2023 were included.Results:The final analysis included 91 RCTs with aggregate data for 58,649 children.All interventions were categorized into single-arm approaches(physical activity,diet,and behavioral and informational support)and combined arms approaches(bicomponent and multicomponent treatment).Multicomponent treatment showed significant effectiveness on the reduction of BMI(mean deviation(MD)-0.49,95%confidence interval(95%CI):-0.88 to-0.12),BMI z-score(MD=-0.11,95%CI:-0.18 to-0.04),and BFP(MD=-1.69,95%CI:-2.97 to-0.42)compared to the usual care condition.Bicomponent treatment also significantly reduced BMI(MD=-0.28,95%CI:-0.54 to-0.04)and BMI z-score(MD=-0.07,95%CI:-0.12 to-0.02)compared to usual care.Conclusion:Interventions targeting multiple lifestyle components achieved greater reductions in children's BMI and BFP.Among single-component approaches,physical activity engagement emerged as the most effective.These findings should guide practitioners in recommending comprehensive lifestyle modifications for children.Moreover,children with higher initial BMI and body fat levels tend to exhibit more positive responses to lifestyle interventions aimed at managing obesity.
基金supported by the National Natural Science Foundation of China(T2341019)NSFC-Guangdong Joint Fund(U1132001)+9 种基金General Program of the National Natural Science Foundation of China(82174243 and 82204948)Natural Science Foundation of Guangdong Province,China(2023A1515110757)Guangzhou Science and Technology Plan Project(2024B03J1343)Major Scientific and Technological Project of Guangzhou Municipal Health Commission(20252D003)Research Project of Traditional Chinese Medicine Bureau of Guangdong Province(20241208)General project of Beijing Natural Science Foundation(7242227)Fundamental Research Funds for the Central Universities(BZY-JMZY-2022-001 and 2023-JYB-JBZD-009)High-level Key Discipline of the National Administration of Traditional Chinese Medicine-Traditional Chinese Constitutional Medicine(zyyzdxk-2023251)Major Science and Technology Special Projects in Hubei Province(2023BCA005)the Chief Scientist Research Project of Hubei Shizhen Laboratory(HSL2024SX0002).
文摘Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12-80 years.The qi stagnation constitution was assessed using the Constitution in Chinese Medicine Questionnaire.Health status was evaluated through medical records and the Subhealth Measurement Scale V1.0(SHMS V1.0).Health-promoting lifestyles were measured using the Health-Promoting Lifestyle Profile Ⅱ(HPLP-Ⅱ).Results:Of the 24159 participants,16.1%and 15.2%were classified as“always”and“sometimes”having the qi stagnation constitution,respectively.Those classified as“rarely”having the qi stagnation constitution scored higher on both the HPLP-Ⅱ and SHMS V1.0.The participants classified as“always”having the qi stagnation constitution showed a significant association with SHS or disease compared to other imbalanced constitutions.Those in the“always”category were approximately 21 times more likely to be classified as having SHS(odds ratio[OR]:21.17,95%confidence interval[CI]:15.74-28.45),whereas those in the“sometimes”category were approximately six times more likely(OR:5.89,95%CI:5.04-6.90).Accordingly,the qi stagnation constitution score was significantly associated with the diagnosis of SHS,with an area under the curve of 0.77(P<.001).A score of 18.75 yielded the highest Youden Index(0.407),with a sensitivity of 60.5%and a specificity of 80.3%.Significant associations were observed between health-promoting lifestyles and qi stagnation constitution severity in an ordinal regression analysis(P<.001).Protective factors included stress management(OR:1.59),self-actualization(OR:1.57),and exercise(OR:1.36).In contrast,poorer interpersonal relationships(OR:0.79),greater health responsibilities(OR:0.86),and poorer nutrition(OR:0.91)were associated with increased severity.Conclusion:Modulating the qi stagnation constitution through lifestyle interventions may help prevent the progression of SHS to disease,which aligns with core preventive principles in traditional Chinese medicine.
基金supported by the Jiangsu Provincial Health Commission Medical Research Project(Grant Nos.M2020085 to J.S.and H2023022 to X.F.)the Outstanding Youth Fund of Jiangsu Natural Science Foundation(Grant No.BK20230005 to D.H.)Suzhou Science and Technology Bureau Livelihood Technology-Technology Demonstration Project(Grant No.SS202010 to Y.L.)。
文摘This study aimed to evaluate the association of a healthy lifestyle pattern with mortality risk among patients with type 2 diabetes mellitus(T2DM).Data were derived from a prospective cohort study enrolling 13776Chinese patients with T2DM.A healthy lifestyle pattern was constructed based on six lifestyle factors,including smoking status,alcohol consumption,dietary habits,physical activity,sedentary time,and sleep duration.Multivariate Cox proportional hazards models were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for all-cause and cause-specific mortality.During a median follow-up of 9.78 years,2497 deaths were recorded.Compared with T2DM patients with a lifestyle pattern scoring 0–2,those scoring 5–6 had a 40%lower risk for all-cause mortality(HR=0.60,95%CI:0.52–0.69),a 33%lower risk for cardiovascular disease mortality(HR=0.67,95%CI:0.52–0.86),and a 25%lower risk for cancer mortality(HR=0.75,95%CI:0.58–0.97).Additionally,we found that the association between the lifestyle pattern and all-cause mortality risk was stronger in females than in males(P for interaction<0.05).In conclusion,adherence to a healthy lifestyle pattern is associated with a decreased risk of all-cause,cardiovascular disease,and cancer mortality.These findings have important implications for reducing premature mortality among patients with T2DM.
文摘The national weight management campaign,part of the broader Healthy China strategy,enhances public health literacy,fosters healthy living habits,and creates supportive environments for sustained weight control.
文摘Objective:This study aimed to examine the influence of behavioral lifestyle factors on recent episodic memory retention capacity among young-old adults(aged 60-69 years)in China.The findings provide scientific evidence to inform proactive strategies to mitigate cognitive decline risk within China’s rapidly aging population.Methods:Utilizing data from the 2022 wave of the China Family Panel Studies(CFPS),a total of 2,772 adults aged 60-69 were included in the analytical sample.Recent episodic memory retention capacity(scored 0-5 points,based on self-reported assessment)served as the dependent variable.Six categories of behavioral lifestyle indicators(including exercise frequency,sleep quality,dietary patterns,etc.)were analyzed as independent variables.Associations were assessed using multivariate ordinal logistic regression models,controlling for relevant covariates.Results:Self-reported potential impairment in recent episodic memory was identified by 47.19%of respondents.Multivariate analysis revealed significant associations between behavioral lifestyle factors and memory retention capacity.Regular exercise(OR=1.297,95%CI:1.118-1.504),meat consumption(OR=1.765,95%CI:1.393-2.237),regular reading habits(OR=1.599,95%CI:1.283-1.992),and internet use(OR=1.413,95%CI:1.217-1.641)emerged as significant protective factors.Abnormal sleep duration was detrimentally associated with retention capacity(too short:OR=0.728,95%CI:0.591-0.897;too long:OR=0.810,95%CI:0.670-0.980).Significant associations were also observed for control variables:urban residence(OR=1.270,95%CI:1.100-1.467),high school education or above(OR=1.543,95%CI:1.293-1.841),and better self-rated health status(OR=1.156,95%CI:1.089-1.227)were positively correlated with better memory retention.Conclusions:Optimal sleep duration,regular physical exercise,meat intake,habitual reading,and internet engagement positively predict self-assessed recent episodic memory retention capacity in Chinese young-old adults.These findings underscore the potential for multi-faceted lifestyle interventions to enhance cog-nitive health in aging populations.Specifically,strategies should encompass community-based sleep hygiene management,tailored nutritional interventions(especially promoting adequate protein sources like meat),enhanced digital literacy and internet accessibility programs,and the promotion of age-appropriate physical activity initiatives.Furthermore,implementing culturally responsive strategies adapted to urban-rural contexts-such as deploying“mobile cognitive health units”in rural areas and fostering digital reading platforms in urban settings-is recommended to optimize intervention effectiveness.
基金supported by grant 2011BAI11B01 from the Projects in the Chinese National Science and Technology Pillar Program during the 12th Five-year Plan Periodby grant 2017-I2M-1-004 from the Chinese Academy of Medical Science Innovation Fund for Medical Sciencesby the Major science and technology special plan project of Yunnan Province (202302AA310045)。
文摘Background Both medication and non-medication therapies are effective approaches to control blood pressure (BP) in hypertension patients.However,the association of joint changes in antihypertensive medication use and healthy lifestyle index (HLI)with BP control among hypertension patients is seldom reported,which needs to provide more evidence by prospective intervention studies.We examined the association of antihypertensive medication use and HLI with BP control among employees with hypertension in China based on a workplace-based multicomponent intervention program.Methods Between January 2013 and December 2014,a cluster randomized clinical trial of a workplace-based multicomponent intervention program was conducted in 60 workplaces across 20 urban areas in China.Workplaces were randomly divided into intervention (n=40) and control (n=20) groups.Basic information on employees at each workplace was collected by trained professionals,including sociodemographic characteristics,medical history,family history,lifestyle behaviors,medication status and physical measurements.After baseline,the intervention group received a 2-year intervention to achieve BP control,which included:(1) a workplace wellness program for all employees;(2) a guidelines-oriented hypertension management protocol.HLI including nonsmoking,nondrinking,adequate physical activity,weight within reference range and balanced diet,were coded on a 5-point scale (range:0-5,with higher score indicating a healthier lifestyle).Antihypertensive medication use was defined as taking drug within the last 2 weeks.Changes in HLI,antihypertensive medication use and BP control from baseline to 24 months were measured after the intervention.Results Overall,4655 employees were included (age:46.3±7.6 years,men:3547 (82.3%)).After 24 months of the intervention,there was a significant improvement in lifestyle[smoking (OR=0.65,95%CI:0.43-0.99;P=0.045),drinking (OR=0.52,95%CI:0.40-0.68;P<0.001),regular exercise (OR=3.10,95%CI:2.53-3.78;P<0.001),excessive intake of fatty food (OR=0.17,95%CI:0.06-0.52;P=0.002),restrictive use of salt (OR=0.26,95%CI:0.12-0.56;P=0.001)].Compare to employees with a deteriorating lifestyle after the intervention,those with an improved lifestyle had a higher BP control.In the intervention group,compared with employees not using antihypertensive medication,those who consistent used (OR=2.34;95%CI:1.16-4.72;P=0.017) or changed from not using to using antihypertensive medication (OR=2.24;95%CI:1.08-4.62;P=0.030) had higher BP control.Compared with those having lower HLI,participants with a same (OR=1.38;95%CI:0.99-1.93;P=0.056) or high (OR=1.79;95%CI:1.27~2.53;P<0.001) HLI had higher BP control.Those who used antihypertensive medication and had a high HLI had the highest BP control (OR=1.88;95%CI:1.32-2.67,P<0.001).Subgroup analysis also showed the consistent effect as the above.Conclusion These findings suggest that adherence to antihypertensive medication treatment and healthy lifestyle were associated with a significant improvement in BP control among employees with hypertension.
基金supported by the Science and Technology Planning Project of Guangdong Province(2023A1111120011)the Natural Science Foundation of Guangdong Province(2024A1515010801).
文摘Objective:To investigate the lifestyle and myopia among primary school students in urban areas of Fujian with the context of myopia prevention and control measures,aiming to provide scientific evidence for identifying high-risk myopia population and formulating effective intervention strategies.Methods:A cross-sectional study was conducted from October to November 2023,enrolling 811 fourth-grade students from three primary schools in three cities across Fujian.Personal information and lifestyle-related pattern were collected using customized questionnaire.Participants underwent comprehensive ophthalmic assessments including distance visual acuity tests and refractive examinations.Logistic regression analysis was used to assess the impact of lifestyle on the onset of myopia.Results:The prevalence of myopia among fourth-grade students in urban primary schools in Fujian was 46.4%.Only 25.8%students engaged in outdoor activities for more than 2 hours daily,while63.3%participated in outdoor activities during class breaks.Multivariate Logistic regression analysis revealed that outdoor activities during class breaks(OR=0.646(95%confidence interval(CI):0.473-0.881),P=0.006)and daily time spent outdoors(2-3 hours,OR=0.682(95%CI:0.466-0.993),P=0.047;more than 3 hours,OR=0.403(95%CI:0.192-0.796),P=0.01)were independent protective factors against myopia.Lifestyle significantly enhanced the predictive performance for myopia(P=0.01).Additionally,parental myopia(one parent with myopia,OR=2.247(95%CI:1.612-3.145),P<0.001;both parents with myopia,OR=4.824(95%CI:3.262-7.204),P<0.001)emerged as a key risk factor for myopia.Conclusions:There is considerable scope for improving the lifestyle of primary school students in urban areas of Fujian.Lifestyle is strongly associated with myopia onset,highlighting the need for schools and families to actively encourage students to engage in more outdoor activities and take breaks outdoors to prevent and control myopia.Students with parents,especially both parents,having myopia should be considered as a key target group for myopia prevention efforts.
文摘Background:Obesity remains a major global health challenge,closely linked to individuals'health beliefs and lifestyle behaviors.Descriptive and relational research methods were used to ascertain the correlation between health beliefs and healthy lifestyle behaviors in obese individuals based on the Health Belief Model.Methods:The population of the research are obese individuals who are treated in the internal medicine clinic in a state hospital in Diyarbakır and applied to a dietitian.Based on power analysis,the study’s sample consisted of 192 obese people.The health belief model scale in obese individuals(HBMSO),the Healthy Lifestyle Behaviors Scale-II(HLBS-II),and the Personal Information Form were used to gather the data.The data was evaluated using the following methods:mean,standard deviation,linear regression analysis,Mann-Whitney U test,Kruskal-Wallis test,Shapiro Wilk and Kolmogorov Smirnov tests,post-hoc Dunn-Benferronni tests,Pearson and Spearman correlation,and others.Results:It was determined that 26.0%of obese individuals were in the 46–55 age range,63.5%were female,64.6%were married,60.4%had a BMI in the range of 30–34.9 kg/m^(2),and 42.7%partially exercised.All sub-dimensions and HBMSO sub-dimensions had statistically significant correlation with the HLBS-II total score.The linear regression analysis results used to identify the predictors of the HLBS-II total score showed that the increase in the level of education and the HBMSO“Importance of Health”sub-dimension score increased the HLBS-II total score,while not exercising and an increase in the HBMSO“Obstacle Perception”sub-dimension score decreased the HLBS-II total score.Conclusion:Individuals’health attitudes have a major impact on leading a healthy lifestyle,which is consistent with the research results.
文摘Polycystic ovary syndrome(PCOS)is a lifelong disorder affecting reproductive,metabolic,and psychological health.A healthy lifestyle and effective weight management strategies should underpin the treatment of PCOS.This case report documents the successful management of a Chinese patient with PCOS who was overweight and presented with oligomenorrhea and persistent adiposity.The patient was diagnosed using the Rotterdam criteria.The intervention was a 2-month program involving caloric restriction(1,350 kcal/day whole-food diet),progressive exercise titration(150–180 min/week of aerobic and resistance training),mindfulness practice,and metformin initiation after confirmed insulin resistance(HOMA-IR 3.67)resulted in clinically significant body composition improvements:fat mass was reduced by 5.0 kg,visceral adipose area was reduced by 44.7 cm^(2),skeletal muscle was increased by 1.4 kg,and regular menstrual cycles(32 day interval)were restored following 5% weight loss-consistent with evidence linking this threshold to improved ovarian function.The combination of a structured lifestyle modification program with targeted pharmacotherapy offers a viable clinical approach for metabolic PCOS phenotypes,although further validation is required to ascertain long-term efficacy.
基金supported by Malaysia's Ministry of Higher Education through the Fundamental Research Grant Scheme(FRGS)under the reference code FRGS/1/2020/SS0/UMT/02/3 and vote number 59637.
文摘Objective:To explore the associations between income levels,employment risk,lifestyles,occupational stress,and male fertility.Methods:This cross-sectional study analyzed 294 men seeking fertility treatment at fertility clinics in Terengganu,Pahang,and Kuala Lumpur from November 2021 to June 2023.Data were collected through structured questionnaires covering income levels,lifestyles,employment risks,occupational stress,and semen quality.Multinomial logistic regression was employed to assess predictors of semen quality,with crude and adjusted odds ratios(OR)reported.Results:The lower-income group exhibited higher odds of having abnormal semen quality compared to normal semen quality.Specifically,these participants were more likely to experience azoospermia[crude OR 6.68,95%confidence interval(CI)1.84-52.63;adjusted OR 6.26,95%CI 1.76-51.38],indicating a link between low income and infertility issues.Lifestyle factors did not show significant associations with semen abnormalities after adjustment.High employment risks had significant associations with oligozoospermia after adjustment(crude OR 5.50,95%CI 2.14-14.11;adjusted OR 5.15,95%CI 1.93-13.71),while high occupational stress was linked to asthenozoospermia(crude OR 2.26,95%CI 1.09-4.68;adjusted OR 2.25,95%CI 1.07-4.69).Conclusions:The findings underscore the influence of socioeconomic and occupational factors on male fertility,showing associations between lower income levels,high-risk occupations,and semen abnormalities.In contrast,lifestyle factors did not show significant associations with semen abnormalities after adjustment.Nevertheless,the current findings should be further confirmed through more extensive studies focusing on abnormal semen and lifestyle factors.
文摘On the macro level,the ‘2018 Chinese Guidelines for Prevention and Treatment of Hypertension’[1] provides a detailed overview on the population strategies for hypertension prevention as well as the principles and methods of community standardized management for hypertension control,with particular emphasis on the significance of correcting unhealthy lifestyles for the prevention and control of hypertension and its complications.?
文摘Purpose: Public health nurses (PHNs) are required to assess the readiness of the clients and provide lifestyle counseling accordingly. The purpose of this study was to compare the lifestyle counseling provided for clients with different levels of readiness based on self-evaluations and independent assessment. Methods: Participants were PHNs with 10 years’ experience or less. Lifestyle counseling skills were measured through a simulated counseling session in a primary setting lasting up to 30 minutes, followed by a review session, where the participant provided self-evaluations, and the simulated client provided others-evaluations, of the session. The simulated clients played the role of clients at either the pre-contemplation or contemplation stage of preparedness as per the stages of behavior change theory. Results: The self-evaluation results showed that the mean scores for five of the six skill categories, are lower in the precontemplation-stage client cases than in the contemplation-stage client cases, and significantly so for two skill categories. The others-evaluations showed significantly lower mean scores for all skill categories in the precontemplation cases than in the contemplation cases. Conclusion: The PHNs and simulated clients agreed that lifestyle counseling skills were inadequate for the precontemplation cases, as compared with the contemplation cases. The lifestyle counseling skills of PHNs with less experience may not be well-adjusted to the readiness of the client, indicating difficulties in supporting less prepared clients.
