摘要
Hepatocellular carcinoma(HCC)represents a major global health burden,ranking third as the leading cause of cancer-related mortality worldwide.This compre-hensive review examines the substantial body of evidence linking modifiable lifestyle factors to HCC pathogenesis and clinical outcomes.We systematically evaluate dietary components,alcohol consumption patterns,tobacco use,physical activity levels,and emerging factors including metabolic disorders,psychological stress,and sleep disturbances.These factors collectively influence hepatocarcino-genesis through diverse biological mechanisms,including genotoxic damage,metabolic dysregulation,chronic inflammatory responses,and gut microbiome-mediated pathways.The accumulated data underscore the urgent need to inte-grate lifestyle interventions into multidisciplinary HCC management.
基金
Supported by Chinese Academy of Medical Sciences Initiative for Innovative Medicine,No.2021-I2M-1-015
the National Natural Science Foundation of China,No.82330061 and No.82001937
the Peking Union Medical College Graduate Curriculum Informatization Development Special Fund Project,No.2024YXX004
the Science and Education Cultivation Fund of the National Cancer and Regional Medical Center of Shanxi Provincial Cancer Hospital,No.TD2023003.
