The effects of recombinant eel growth hormone (reGH).methyltestosterone (MT)and L-thyroxine (T4)on the growth of red sea bream. Pagrosomus major.were investigated.Administration of reGH to fry by immersion at 2 mg 1 f...The effects of recombinant eel growth hormone (reGH).methyltestosterone (MT)and L-thyroxine (T4)on the growth of red sea bream. Pagrosomus major.were investigated.Administration of reGH to fry by immersion at 2 mg 1 for 2 hevery 5 dsys resulted in significant increase in both weight and length.but the condition factor (CF) diminished relative to that of similarly treated controls over the 37day treatment period.Immersion in 0.1 mg:1 T4 also resulted in significant increase in both weight and length and higher survival rate of test fry compared to the controls. Immersion in MT had less effect on growth and high-dose resulted in high mortality.In the second study.injection of 2 μg reGH(gwk)caused a significant increase in the specific growth rate (SGR) of test red sea bream fingerlings relative to that of the controls during the 4-week treatment period and maintained the increasing trend over the post-treatment period (weeks 4-6).Injection of MT at a dosage of 1μg (gwk) resulted in a significant展开更多
目的:探讨灯盏乙素对L-甲状腺素(L-Thy)诱导的大鼠实验性心肌肥厚的影响及其可能作用机制。方法:将大鼠随机分为正常组、模型组、卡托普利组(25 mg.kg-1)、灯盏乙素高、中、低剂量组(100,50,25 mg.kg-1)共6组。除正常组外,其余各组连续1...目的:探讨灯盏乙素对L-甲状腺素(L-Thy)诱导的大鼠实验性心肌肥厚的影响及其可能作用机制。方法:将大鼠随机分为正常组、模型组、卡托普利组(25 mg.kg-1)、灯盏乙素高、中、低剂量组(100,50,25 mg.kg-1)共6组。除正常组外,其余各组连续10 d ip L-Thy诱导心肌肥厚性损伤,造模的同时ig相应的药物进行治疗。观察大鼠的心脏质量指数、血清天冬氨酸转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)活性、左心室心肌匀浆中胶原含量及心肌病理变化。结果:L-Thy损伤模型组全心质量指数、左心室质量指数、血清AST,LDH,CK活性、左心室胶原含量均较正常组明显升高(P<0.01),病理切片显示心肌细胞肥大,胶原增多。与模型组相比,灯盏乙素各剂量组能明显降低左心室质量指数(P<0.05);低剂量组能明显降低血清AST活性(P<0.05),中、低剂量组能明显降低LDH活性(P<0.05),灯盏乙素各剂量组均能显著降低CK活性(P<0.01或P<0.05);高剂量组能降低左心室胶原含量(P<0.05),心肌病理改变明显减轻。结论:灯盏乙素能显著抑制甲状腺素所致的大鼠心肌肥厚,对心肌具有明显的保护作用。展开更多
文摘The effects of recombinant eel growth hormone (reGH).methyltestosterone (MT)and L-thyroxine (T4)on the growth of red sea bream. Pagrosomus major.were investigated.Administration of reGH to fry by immersion at 2 mg 1 for 2 hevery 5 dsys resulted in significant increase in both weight and length.but the condition factor (CF) diminished relative to that of similarly treated controls over the 37day treatment period.Immersion in 0.1 mg:1 T4 also resulted in significant increase in both weight and length and higher survival rate of test fry compared to the controls. Immersion in MT had less effect on growth and high-dose resulted in high mortality.In the second study.injection of 2 μg reGH(gwk)caused a significant increase in the specific growth rate (SGR) of test red sea bream fingerlings relative to that of the controls during the 4-week treatment period and maintained the increasing trend over the post-treatment period (weeks 4-6).Injection of MT at a dosage of 1μg (gwk) resulted in a significant
文摘目的:探讨灯盏乙素对L-甲状腺素(L-Thy)诱导的大鼠实验性心肌肥厚的影响及其可能作用机制。方法:将大鼠随机分为正常组、模型组、卡托普利组(25 mg.kg-1)、灯盏乙素高、中、低剂量组(100,50,25 mg.kg-1)共6组。除正常组外,其余各组连续10 d ip L-Thy诱导心肌肥厚性损伤,造模的同时ig相应的药物进行治疗。观察大鼠的心脏质量指数、血清天冬氨酸转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)活性、左心室心肌匀浆中胶原含量及心肌病理变化。结果:L-Thy损伤模型组全心质量指数、左心室质量指数、血清AST,LDH,CK活性、左心室胶原含量均较正常组明显升高(P<0.01),病理切片显示心肌细胞肥大,胶原增多。与模型组相比,灯盏乙素各剂量组能明显降低左心室质量指数(P<0.05);低剂量组能明显降低血清AST活性(P<0.05),中、低剂量组能明显降低LDH活性(P<0.05),灯盏乙素各剂量组均能显著降低CK活性(P<0.01或P<0.05);高剂量组能降低左心室胶原含量(P<0.05),心肌病理改变明显减轻。结论:灯盏乙素能显著抑制甲状腺素所致的大鼠心肌肥厚,对心肌具有明显的保护作用。
