Objective: To discuss some key points about nursing in the use of DDG-3300K liver reserve function analyzer in patients at the department of infectious diseases. Method: DDG-3300K liver reserve function analyzer was a...Objective: To discuss some key points about nursing in the use of DDG-3300K liver reserve function analyzer in patients at the department of infectious diseases. Method: DDG-3300K liver reserve function analyzer was applied to 5464 patients at the department of infectious diseases. The reasons for failed detection and complications related to the detection were analyzed, and the measures for improving the nursing procedures were proposed. Result: Among the 5464 patients, the detections were successful at the first attempt in 5458 patients;2 patients had leakage of liquid;2 patients were poorly prepared, and 1 case failed because of mistaken selection of CO mode, which led to adverse drug reactions;1 case did not finish the detection due to anaphylactic shock;8 patients had nausea and 6 patients had skin rash on the four limbs and torso during the detection. Conclusion: It is necessary to formulate the nursing procedures for the use of DDG-3300K liver reserve function analyzer. Moreover, preparatory work, health education, refined nursing procedures and skillful operations are closely related to the success rate and accuracy of the detection.展开更多
In this context, we mainly study the behavior in the neighborhood of finite singular points for k-regular functions in R1^n with values in R0、n. We get a Laurent expansion of them in an open set, prove its uniqueness...In this context, we mainly study the behavior in the neighborhood of finite singular points for k-regular functions in R1^n with values in R0、n. We get a Laurent expansion of them in an open set, prove its uniqueness, give the definitions of k-poles, isolated and essential singular points and removable singularity, discuss some properties, and further obtain the residue theorems.展开更多
In this paper, we obtain the convexity of new general integral operator on some classes of k-uniformly p-valent a-convex functions of complex order. These results extend some known theorems.
For the first time,proteolysis-targeting chimeras(PROTAC)technology was utilized to achieve the isoform-selective degradation of class I phosphoinositide 3-kinases(PI3Ks)in this study.Through screening and optimizatio...For the first time,proteolysis-targeting chimeras(PROTAC)technology was utilized to achieve the isoform-selective degradation of class I phosphoinositide 3-kinases(PI3Ks)in this study.Through screening and optimization,the PROTAC molecule ZM-PI05 was identified as a selective degrader of p110αin multiple breast cancer cells.More importantly,the degrader can down-regulate p85 regulatory subunit simultaneously,thereby inhibiting the non-enzymatic functions of PI3K that are independent on p110catalytic subunits.Therefore,compared with PI3K inhibitor copanlisib,ZM-PI05 displayed the stronger anti-proliferative activity on breast cancer cells.In brief,a selective and efficient PROTAC molecule was developed to induce the degradation of p110αand concurrent reduction of p85 proteins,providing a tool compound for the biological study of PI3K-αby blocking its enzymatic and non-enzymatic functions.展开更多
The purpose of this paper is to present a general universal formula for <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;&...The purpose of this paper is to present a general universal formula for <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate survival functions for arbitrary <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 2, 3, <span style="font-family:;" "=""><span style="font-family:Verdana;">...<span style="font-family:Verdana;">, given all the univariate marginal survival functions. This universal form of <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate probability distributions was obtained by means of “dependence functions” named “joiners” in the text. These joiners determine all the involved stochastic dependencies between the underlying random variables. However, in order that the presented formula (the form) represents a legitimate survival function, some necessary and sufficient conditions for the joiners had to be found. Basically, finding those conditions is the main task of this paper. This task was successfully performed for the case <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 2 and the main results for the case <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 3 were formulated as Theorem 1 and Theorem 2 in Section 4. Nevertheless, the hypothetical conditions valid for the general <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> ≥ 4 case were also formulated in Section 3 as the (very convincing) Hypothesis. As for the sufficient conditions for both the <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:;" "=""><span style="font-family:Verdana;"> = 3 and <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> ≥ 4 cases, the full generality was not achieved since two restrictions were imposed. Firstly, we limited ourselves to the, defined in the text, “continuous cases” (when the corresponding joint density exists and is continuous), and secondly we consider positive stochastic dependencies only. Nevertheless, the class of the <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate distributions which can be constructed is very wide. The presented method of construction by means of joiners can be considered competitive to the <span style="font-family:Verdana;"><span style="font-family:Verdana;">copula<span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> methodology. As it is suggested in the paper the possibility of building a common theory of both copulae and joiners is quite possible, and the joiners may play the role of tools within the theory of copulae, and vice versa copulae may, for example, be used for finding proper joiners. Another independent feature of the joiners methodology is the possibility of constructing many new stochastic processes including stationary and Markovian.展开更多
k holomorphic functions are a type of generation of holomorphic functions.In this paper,a nonlinear boundary value problem for k holomorphic functions is primarily discussed on generalized polycylinders in C^(2).The e...k holomorphic functions are a type of generation of holomorphic functions.In this paper,a nonlinear boundary value problem for k holomorphic functions is primarily discussed on generalized polycylinders in C^(2).The existence of the solution for the problem is studied in detail with the help of the boundary properties of Cauchy type singular integral operators with a k holomorphic kernel.Furthermore,the integral representation for the solution is obtained.展开更多
In this paper. we study the average n-K width of the convolution class B_(pq)(G)(or B_(?)(G)), for which the kernel G(x) is a PF density, in the metric L_q(R)(or L_(qp)(R)) for the case 1≤q<p ≤∞, and obtain some...In this paper. we study the average n-K width of the convolution class B_(pq)(G)(or B_(?)(G)), for which the kernel G(x) is a PF density, in the metric L_q(R)(or L_(qp)(R)) for the case 1≤q<p ≤∞, and obtain some exact results.展开更多
The objective of this note is to provide some(potentially useful) integral transforms(for example, Euler, Laplace, Whittaker etc.) associated with the generalized k-Bessel function defined by Saiful and Nisar [3]. We ...The objective of this note is to provide some(potentially useful) integral transforms(for example, Euler, Laplace, Whittaker etc.) associated with the generalized k-Bessel function defined by Saiful and Nisar [3]. We have also discussed some other transforms as special cases of our main results.展开更多
For the surgical treatment of cardiovascular disease(CVD),there is a clear and unmet need in developing small-diameter(diameter<6 mm)vascular grafts.In our previous work,sulfated silk fibroin(SF)was successfully fa...For the surgical treatment of cardiovascular disease(CVD),there is a clear and unmet need in developing small-diameter(diameter<6 mm)vascular grafts.In our previous work,sulfated silk fibroin(SF)was successfully fabricated as a potential candidate for preparing vascular grafts due to the great cytocompatibility and hemocompatibility.However,vascular graft with single layer is difficult to adapt to the complex internal environment.In this work,polycaprolactone(PCL)and sulfated SF were used to fabricate bilayer vascular graft(BLVG)to mimic the structure of natural blood vessels.To enhance the biological activity of BLVG,nicorandil(NIC),an FDA-approved drug with multi-bioactivity,was loaded in the BLVG to fabricate NIC-loaded BLVG.The morphology,chemical composition and mechanical properties of NIC-loaded BLVG were assessed.The results showed that the bilayer structure of NIC-loaded BLVG endowed the graft with a biphasic drug release behavior.The in vitro studies indicated that NIC-loaded BLVG could significantly increase the proliferation,migration and antioxidation capability of endothelial cells(ECs).Moreover,we found that the potential biological mechanism was the activation of PI3K/AKT/eNOS signaling pathway.Overall,the results effectively demonstrated that NIC-loaded BLVG had a promising in vitro performance as a functional small-diameter vascular graft.展开更多
Drill wear not only affects the surface smoothness of the hole, but also influences the life of the drill. Drill wear state recognition is important in the manufacturing process, which consists of two steps： first, d...Drill wear not only affects the surface smoothness of the hole, but also influences the life of the drill. Drill wear state recognition is important in the manufacturing process, which consists of two steps： first, decomposing cutting torque components from the original signals by wavelet packet decomposition （WPD）; second, extracting wavelet coefficients of different wear states （i.e., slight, normal, or severe wear） with signal features adapting to Welch spectrum. Finally, monitoring and recognition of the feature vectors of cutting torque signal are performed by using the K-means cluster and radial basis function neural network （RBFNN）. The experiments on different tool wears of the multivariable features reveal that the results of monitoring and recognition are significant and effective.展开更多
Objective:To observe the effect of Taohong Siyu Decoction on the coagulation function and the signaling pathway of PI3K(phosphatidylinositol 3-kinase)/AKT(protein kinase B)/mTOR(mammalian target of rapamycin)after fem...Objective:To observe the effect of Taohong Siyu Decoction on the coagulation function and the signaling pathway of PI3K(phosphatidylinositol 3-kinase)/AKT(protein kinase B)/mTOR(mammalian target of rapamycin)after femoral artery anastomosis in rabbits.Methods:30 New Zealand white rabbits were divided into blank control group,model control group,papavine hydrochloride injection group and low,medium and high dose groups of Taohong Siwu decoction by random number table method,with 5 rabbits in each group.The rabbits in the model control group,papavine hydrochloride injection group and low,medium and high dose groups of Taohong Siwu decoction were treated with the femoral artery simple intermittent end-to-end suture model.After the successful modeling,the low,medium and high dose groups of Taohong Siwu decoction were given the Taohong Siwu decoction,while the model control group,the blank control group and papavine hydrochloride injection group were given the same amount of normal saline.APTT(activated partial thromboplastin time),FIB(fibrinogen)and PI3K/AKT/mTOR concentrations were measured in aural venous blood samples from six groups of rabbits 30min before operation and 1d,2D,3D and 7d after operation,respectively.Statistical analysis was conducted on the data of the six groups.Results:Compared with blank control group,APTT of model control group was significantly shortened 1d to 7d after operation(P<0.05),FIB values were significantly increased from 1d to 7d after operation(P<0.05);Compared with model control group,APTT in Taohong Siwu decoction low-dose,medium-dose and high-dose groups were significantly prolonged 1d to 7d after operation(P<0.05),FIB value of Taohong Siwu decoction medium and high dose groups decreased significantly from 1d to 7d after operation(P<0.05),the FIB value of Taohong Siwu decoction low-dose group was significantly decreased from 2d to 7d after surgery(P<0.05);Compared with papaverine hydrochloride injection group,APTT in Taohong Siwu decoction medium dose group was significantly prolonged 2d to 7d after surgery(P<0.05),APTT of Taohong Siwu decoction high-dose group was significantly prolonged on 1d to 7d after operation(P<0.05).FIB in Taohong Siwu decoction medium and high dose groups decreased significantly 1d to 7d after operation(P<0.05);Compared with the blank control group,the expression concentrations of PI3K,Akt and mTOR in serum of the model control group were significantly increased from 1d to 7d after surgery(P<0.05);Compared with the model control group,the expression levels of PI3K,Akt and mTOR in serum were significantly increased in the low dose group of Taohong Siwu decoction and Papaverine Hydrochloride Injection group on postoperative 7 days(P<0.05),Taohong Siwu decoction high-dose group was significantly increased from 1d to 7d after surgery(P<0.05),the expression concentrations of PI3K and Akt in Taohong Siwu decoction medium dose group were significantly increased from 2d to 7d after operation(P<0.05),mTOR expression levels were significantly increased from 3d to 7d after operation(P<0.05);Compared with papaverine hydrochloride injection group,the expression concentrations of PI3K,Akt and mTOR in serum of Taohong Siwu decoction medium dose group were significantly increased from 3d to 7d after operation(P<0.05),the expression concentrations of PI3K and mTOR in Taohong Siwu decoction high-dose group were significantly increased from 1d to 7d after operation(P<0.05),and the expression concentration of Akt increased significantly from 3d to 7d after operation(P<0.05).Conclusion:The Taohong Siwu decoction can improve the coagulation function of rabbit femoral artery anastomosis,prevent thrombosis,activate PI3K/Akt/mTOR signaling pathway,promote angiogenesis,and improve tissue ischemia after artery anastomosis.展开更多
Different technical conditions in the process of solid-state fermentation of red yeast rice has a certain impact on the production of acid-form and lactone form Monacolin K.When cultured in the loose rice medium,the a...Different technical conditions in the process of solid-state fermentation of red yeast rice has a certain impact on the production of acid-form and lactone form Monacolin K.When cultured in the loose rice medium,the acid form Monacolin K accounts for 50%-60%;while the acid form Monacolin K accounts for 80%-90%cultured in the consolidated rice medium.And we also found that the proportion of the acid form and lactone form Monacolin K will decrease with the increase of fermentation time.展开更多
We consider the questions connected with the approximation of a real continuous 1-periodic functions and give a new proof of the equivalence of the special Boman-Shapiro modulus of continuity with Peetre’s K-function...We consider the questions connected with the approximation of a real continuous 1-periodic functions and give a new proof of the equivalence of the special Boman-Shapiro modulus of continuity with Peetre’s K-functional. We also prove Jackson’s inequality for the approximation by trigonometric polynomials.展开更多
In this paper, we prove an analogous to a result of Erdös and Rényi and of Kelly and Oxley. We also show that there are several properties of k-balanced matroids for which there exists a threshold function.
文摘Objective: To discuss some key points about nursing in the use of DDG-3300K liver reserve function analyzer in patients at the department of infectious diseases. Method: DDG-3300K liver reserve function analyzer was applied to 5464 patients at the department of infectious diseases. The reasons for failed detection and complications related to the detection were analyzed, and the measures for improving the nursing procedures were proposed. Result: Among the 5464 patients, the detections were successful at the first attempt in 5458 patients;2 patients had leakage of liquid;2 patients were poorly prepared, and 1 case failed because of mistaken selection of CO mode, which led to adverse drug reactions;1 case did not finish the detection due to anaphylactic shock;8 patients had nausea and 6 patients had skin rash on the four limbs and torso during the detection. Conclusion: It is necessary to formulate the nursing procedures for the use of DDG-3300K liver reserve function analyzer. Moreover, preparatory work, health education, refined nursing procedures and skillful operations are closely related to the success rate and accuracy of the detection.
基金Supported by the National Natural Science Foundation of China (10471107)the Specialized Research Fund for the Doctoral Program of Higher Education of China (20060486001)
文摘In this context, we mainly study the behavior in the neighborhood of finite singular points for k-regular functions in R1^n with values in R0、n. We get a Laurent expansion of them in an open set, prove its uniqueness, give the definitions of k-poles, isolated and essential singular points and removable singularity, discuss some properties, and further obtain the residue theorems.
基金Foundation item： Supported by the Natural Science Foundation of Inner Mongolia（2009MS0113） Sup- ported by the Higher School Research Foundation of Inner Mongolia（NJzy08150）
文摘In this paper, we obtain the convexity of new general integral operator on some classes of k-uniformly p-valent a-convex functions of complex order. These results extend some known theorems.
基金supported by National Key R&D Program of China(Nos.2021YFA1302100,2021YFA1300200,2020YFE0202200)National Natural Science Foundation of China(Nos.82125034,82330115)。
文摘For the first time,proteolysis-targeting chimeras(PROTAC)technology was utilized to achieve the isoform-selective degradation of class I phosphoinositide 3-kinases(PI3Ks)in this study.Through screening and optimization,the PROTAC molecule ZM-PI05 was identified as a selective degrader of p110αin multiple breast cancer cells.More importantly,the degrader can down-regulate p85 regulatory subunit simultaneously,thereby inhibiting the non-enzymatic functions of PI3K that are independent on p110catalytic subunits.Therefore,compared with PI3K inhibitor copanlisib,ZM-PI05 displayed the stronger anti-proliferative activity on breast cancer cells.In brief,a selective and efficient PROTAC molecule was developed to induce the degradation of p110αand concurrent reduction of p85 proteins,providing a tool compound for the biological study of PI3K-αby blocking its enzymatic and non-enzymatic functions.
文摘The purpose of this paper is to present a general universal formula for <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate survival functions for arbitrary <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 2, 3, <span style="font-family:;" "=""><span style="font-family:Verdana;">...<span style="font-family:Verdana;">, given all the univariate marginal survival functions. This universal form of <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate probability distributions was obtained by means of “dependence functions” named “joiners” in the text. These joiners determine all the involved stochastic dependencies between the underlying random variables. However, in order that the presented formula (the form) represents a legitimate survival function, some necessary and sufficient conditions for the joiners had to be found. Basically, finding those conditions is the main task of this paper. This task was successfully performed for the case <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 2 and the main results for the case <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 3 were formulated as Theorem 1 and Theorem 2 in Section 4. Nevertheless, the hypothetical conditions valid for the general <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> ≥ 4 case were also formulated in Section 3 as the (very convincing) Hypothesis. As for the sufficient conditions for both the <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:;" "=""><span style="font-family:Verdana;"> = 3 and <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> ≥ 4 cases, the full generality was not achieved since two restrictions were imposed. Firstly, we limited ourselves to the, defined in the text, “continuous cases” (when the corresponding joint density exists and is continuous), and secondly we consider positive stochastic dependencies only. Nevertheless, the class of the <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate distributions which can be constructed is very wide. The presented method of construction by means of joiners can be considered competitive to the <span style="font-family:Verdana;"><span style="font-family:Verdana;">copula<span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> methodology. As it is suggested in the paper the possibility of building a common theory of both copulae and joiners is quite possible, and the joiners may play the role of tools within the theory of copulae, and vice versa copulae may, for example, be used for finding proper joiners. Another independent feature of the joiners methodology is the possibility of constructing many new stochastic processes including stationary and Markovian.
基金the NSF of China(11571089,11871191)the NSF of Henan Province(222300420397)+1 种基金the NSF of Hebei Province(A2022208007)the Key Foundation of Hebei Normal University(L2018Z01)。
文摘k holomorphic functions are a type of generation of holomorphic functions.In this paper,a nonlinear boundary value problem for k holomorphic functions is primarily discussed on generalized polycylinders in C^(2).The existence of the solution for the problem is studied in detail with the help of the boundary properties of Cauchy type singular integral operators with a k holomorphic kernel.Furthermore,the integral representation for the solution is obtained.
基金The author was supported by the National Natural Science Found of China.
文摘In this paper. we study the average n-K width of the convolution class B_(pq)(G)(or B_(?)(G)), for which the kernel G(x) is a PF density, in the metric L_q(R)(or L_(qp)(R)) for the case 1≤q<p ≤∞, and obtain some exact results.
文摘The objective of this note is to provide some(potentially useful) integral transforms(for example, Euler, Laplace, Whittaker etc.) associated with the generalized k-Bessel function defined by Saiful and Nisar [3]. We have also discussed some other transforms as special cases of our main results.
基金This work was supported by the National Natural Science Foundation of China(31771058,32071359,11421202,61227902 and 11120101001)NationalKey Technology R&D Program(2016YFC1100704,2016YFC1101101)+3 种基金International Joint Research Center of Aerospace Biotechnology and Medical Engineering from Ministry of Science and Technology of China111 Project(B13003)Research Fund for the Doctoral Program of Higher Education of China(20131102130004)Fundamental Research Funds for the Central Universities.
文摘For the surgical treatment of cardiovascular disease(CVD),there is a clear and unmet need in developing small-diameter(diameter<6 mm)vascular grafts.In our previous work,sulfated silk fibroin(SF)was successfully fabricated as a potential candidate for preparing vascular grafts due to the great cytocompatibility and hemocompatibility.However,vascular graft with single layer is difficult to adapt to the complex internal environment.In this work,polycaprolactone(PCL)and sulfated SF were used to fabricate bilayer vascular graft(BLVG)to mimic the structure of natural blood vessels.To enhance the biological activity of BLVG,nicorandil(NIC),an FDA-approved drug with multi-bioactivity,was loaded in the BLVG to fabricate NIC-loaded BLVG.The morphology,chemical composition and mechanical properties of NIC-loaded BLVG were assessed.The results showed that the bilayer structure of NIC-loaded BLVG endowed the graft with a biphasic drug release behavior.The in vitro studies indicated that NIC-loaded BLVG could significantly increase the proliferation,migration and antioxidation capability of endothelial cells(ECs).Moreover,we found that the potential biological mechanism was the activation of PI3K/AKT/eNOS signaling pathway.Overall,the results effectively demonstrated that NIC-loaded BLVG had a promising in vitro performance as a functional small-diameter vascular graft.
文摘Drill wear not only affects the surface smoothness of the hole, but also influences the life of the drill. Drill wear state recognition is important in the manufacturing process, which consists of two steps： first, decomposing cutting torque components from the original signals by wavelet packet decomposition （WPD）; second, extracting wavelet coefficients of different wear states （i.e., slight, normal, or severe wear） with signal features adapting to Welch spectrum. Finally, monitoring and recognition of the feature vectors of cutting torque signal are performed by using the K-means cluster and radial basis function neural network （RBFNN）. The experiments on different tool wears of the multivariable features reveal that the results of monitoring and recognition are significant and effective.
文摘Objective:To observe the effect of Taohong Siyu Decoction on the coagulation function and the signaling pathway of PI3K(phosphatidylinositol 3-kinase)/AKT(protein kinase B)/mTOR(mammalian target of rapamycin)after femoral artery anastomosis in rabbits.Methods:30 New Zealand white rabbits were divided into blank control group,model control group,papavine hydrochloride injection group and low,medium and high dose groups of Taohong Siwu decoction by random number table method,with 5 rabbits in each group.The rabbits in the model control group,papavine hydrochloride injection group and low,medium and high dose groups of Taohong Siwu decoction were treated with the femoral artery simple intermittent end-to-end suture model.After the successful modeling,the low,medium and high dose groups of Taohong Siwu decoction were given the Taohong Siwu decoction,while the model control group,the blank control group and papavine hydrochloride injection group were given the same amount of normal saline.APTT(activated partial thromboplastin time),FIB(fibrinogen)and PI3K/AKT/mTOR concentrations were measured in aural venous blood samples from six groups of rabbits 30min before operation and 1d,2D,3D and 7d after operation,respectively.Statistical analysis was conducted on the data of the six groups.Results:Compared with blank control group,APTT of model control group was significantly shortened 1d to 7d after operation(P<0.05),FIB values were significantly increased from 1d to 7d after operation(P<0.05);Compared with model control group,APTT in Taohong Siwu decoction low-dose,medium-dose and high-dose groups were significantly prolonged 1d to 7d after operation(P<0.05),FIB value of Taohong Siwu decoction medium and high dose groups decreased significantly from 1d to 7d after operation(P<0.05),the FIB value of Taohong Siwu decoction low-dose group was significantly decreased from 2d to 7d after surgery(P<0.05);Compared with papaverine hydrochloride injection group,APTT in Taohong Siwu decoction medium dose group was significantly prolonged 2d to 7d after surgery(P<0.05),APTT of Taohong Siwu decoction high-dose group was significantly prolonged on 1d to 7d after operation(P<0.05).FIB in Taohong Siwu decoction medium and high dose groups decreased significantly 1d to 7d after operation(P<0.05);Compared with the blank control group,the expression concentrations of PI3K,Akt and mTOR in serum of the model control group were significantly increased from 1d to 7d after surgery(P<0.05);Compared with the model control group,the expression levels of PI3K,Akt and mTOR in serum were significantly increased in the low dose group of Taohong Siwu decoction and Papaverine Hydrochloride Injection group on postoperative 7 days(P<0.05),Taohong Siwu decoction high-dose group was significantly increased from 1d to 7d after surgery(P<0.05),the expression concentrations of PI3K and Akt in Taohong Siwu decoction medium dose group were significantly increased from 2d to 7d after operation(P<0.05),mTOR expression levels were significantly increased from 3d to 7d after operation(P<0.05);Compared with papaverine hydrochloride injection group,the expression concentrations of PI3K,Akt and mTOR in serum of Taohong Siwu decoction medium dose group were significantly increased from 3d to 7d after operation(P<0.05),the expression concentrations of PI3K and mTOR in Taohong Siwu decoction high-dose group were significantly increased from 1d to 7d after operation(P<0.05),and the expression concentration of Akt increased significantly from 3d to 7d after operation(P<0.05).Conclusion:The Taohong Siwu decoction can improve the coagulation function of rabbit femoral artery anastomosis,prevent thrombosis,activate PI3K/Akt/mTOR signaling pathway,promote angiogenesis,and improve tissue ischemia after artery anastomosis.
文摘Different technical conditions in the process of solid-state fermentation of red yeast rice has a certain impact on the production of acid-form and lactone form Monacolin K.When cultured in the loose rice medium,the acid form Monacolin K accounts for 50%-60%;while the acid form Monacolin K accounts for 80%-90%cultured in the consolidated rice medium.And we also found that the proportion of the acid form and lactone form Monacolin K will decrease with the increase of fermentation time.
文摘We consider the questions connected with the approximation of a real continuous 1-periodic functions and give a new proof of the equivalence of the special Boman-Shapiro modulus of continuity with Peetre’s K-functional. We also prove Jackson’s inequality for the approximation by trigonometric polynomials.
文摘In this paper, we prove an analogous to a result of Erdös and Rényi and of Kelly and Oxley. We also show that there are several properties of k-balanced matroids for which there exists a threshold function.
