Amidst the late 19th-century influx of Chinese laborers into the Straits Settlements,few scholar-physicians engaged in transnational medical discourse,making Qing Imperial physician Li Jun(力钧)a remarkable exception....Amidst the late 19th-century influx of Chinese laborers into the Straits Settlements,few scholar-physicians engaged in transnational medical discourse,making Qing Imperial physician Li Jun(力钧)a remarkable exception.A distinguished Confucian physician,Li Jun traveled to Singapore and Penang in the 1890s,meticulously documenting his unique observations in his book,Bin Lang Yu Zhi Lue(《槟榔屿志略》The Monograph on Penang).This paper explores Li Jun’s narratives and critiques of Chinese medicine in Penang,analyzing them through the lens of his elite background and the socio-historical context of the time.By contextualizing his account within the era’s healthcare landscape,migration patterns,and colonial dynamics,the paper assesses his views on the role,practitioners,perceived strengths,and limitations of Chinese medicine as practiced overseas.Li Jun’s insightful perspective reveals complexities in the adaptation and provision of Chinese healthcare within the diaspora,highlighting its historical challenges and illuminating the interplay between medical traditions and the colonial environment at the time.展开更多
目的探讨槲皮素抑制前列腺癌的作用机制。方法应用蛋白印迹技术检查槲皮素(quercetin)对雄激素受体(androgen receptor,AR)的辅调节因子c-Jun和cAMP应答元件结合蛋白的结合蛋白[cAMP response elem entb ind ing prote in(CREB)-b ind i...目的探讨槲皮素抑制前列腺癌的作用机制。方法应用蛋白印迹技术检查槲皮素(quercetin)对雄激素受体(androgen receptor,AR)的辅调节因子c-Jun和cAMP应答元件结合蛋白的结合蛋白[cAMP response elem entb ind ing prote in(CREB)-b ind ing prote in,CBP]蛋白表达的影响;利用细胞转染技术检测c-Jun和CBP对AR功能的影响;免疫沉淀技术检验c-Jun与AR的蛋白-蛋白相互作用。结果槲皮素能够明显诱导c-Jun的高表达,高表达的c-Jun能够抑制AR的功能。槲皮素对CBP的蛋白表达水平无明显影响,而增加CBP的表达并不能逆转槲皮素对AR功能的抑制作用。免疫沉淀结果表明,c-Jun与AR存在蛋白-蛋白相互作用。结论槲皮素抑制前列腺癌的机制可能是通过c-Jun与AR的蛋白相互作用,而不是通过c-Jun竞争结合AR的辅激活因子CBP来实现的。展开更多
文摘Amidst the late 19th-century influx of Chinese laborers into the Straits Settlements,few scholar-physicians engaged in transnational medical discourse,making Qing Imperial physician Li Jun(力钧)a remarkable exception.A distinguished Confucian physician,Li Jun traveled to Singapore and Penang in the 1890s,meticulously documenting his unique observations in his book,Bin Lang Yu Zhi Lue(《槟榔屿志略》The Monograph on Penang).This paper explores Li Jun’s narratives and critiques of Chinese medicine in Penang,analyzing them through the lens of his elite background and the socio-historical context of the time.By contextualizing his account within the era’s healthcare landscape,migration patterns,and colonial dynamics,the paper assesses his views on the role,practitioners,perceived strengths,and limitations of Chinese medicine as practiced overseas.Li Jun’s insightful perspective reveals complexities in the adaptation and provision of Chinese healthcare within the diaspora,highlighting its historical challenges and illuminating the interplay between medical traditions and the colonial environment at the time.
文摘目的探讨槲皮素抑制前列腺癌的作用机制。方法应用蛋白印迹技术检查槲皮素(quercetin)对雄激素受体(androgen receptor,AR)的辅调节因子c-Jun和cAMP应答元件结合蛋白的结合蛋白[cAMP response elem entb ind ing prote in(CREB)-b ind ing prote in,CBP]蛋白表达的影响;利用细胞转染技术检测c-Jun和CBP对AR功能的影响;免疫沉淀技术检验c-Jun与AR的蛋白-蛋白相互作用。结果槲皮素能够明显诱导c-Jun的高表达,高表达的c-Jun能够抑制AR的功能。槲皮素对CBP的蛋白表达水平无明显影响,而增加CBP的表达并不能逆转槲皮素对AR功能的抑制作用。免疫沉淀结果表明,c-Jun与AR存在蛋白-蛋白相互作用。结论槲皮素抑制前列腺癌的机制可能是通过c-Jun与AR的蛋白相互作用,而不是通过c-Jun竞争结合AR的辅激活因子CBP来实现的。
