Accumulating evidenee suggested that long noncoding RNAs(IncRNAs)possess a potential role in prostate cancer(PCa)diagnosis and prognosis.Rapid biochemical recurrence(BCR)is considered as a sign for clinical recurrence...Accumulating evidenee suggested that long noncoding RNAs(IncRNAs)possess a potential role in prostate cancer(PCa)diagnosis and prognosis.Rapid biochemical recurrence(BCR)is considered as a sign for clinical recurrence metastasis and PCa-specific mortality.Hence,the aim of the present study was to identify a IncRNA signature that can predict BCR of PCa accurately.Bioinformatics analysis,Kaplan-Meier analyses,Cox regression analyses,and Gene Set Enrichment Analysis(GSEA)were performed in a publicly available database with 499 PCa tissues and 52 matched normal tissues.A signature was identified.All these IncRNAs were differentially expressed between tumor and normal tissues and differentially expressed between high Gleason score and low Gleason score tissues.Furthermore,we developed a seven IncRNAs signature that can predict PCa BCR.Patients classified into low-risk group showed better BCR survival significantly than the patients in the high-risk group(hazard ratio=0.32,95%Cl:0.20-0.52,concordance index=0.63).The area under the curve was 0.68 for BCR.The signature also had good discrimination for BCR in men with Gleason 7 PCa.In conclusion,our results suggest that the seven IncRNAs signature is a new biomarker of BCR and high risk in PCa.In addition,the in dividual In cRNA warrants further study to un cover the associated mechanisms of PCa progression and the signature could be used to design direct clinical trials for adjuvant therapy.展开更多
基金This study was supported by the National Natural Science Foundation of China(No.81502192 to FNW,No.81370073 to YZ and No.81872099,81472377 and 81672544 to DWY)the Shanghai Rising Star Program(No.16QA1401100).
文摘Accumulating evidenee suggested that long noncoding RNAs(IncRNAs)possess a potential role in prostate cancer(PCa)diagnosis and prognosis.Rapid biochemical recurrence(BCR)is considered as a sign for clinical recurrence metastasis and PCa-specific mortality.Hence,the aim of the present study was to identify a IncRNA signature that can predict BCR of PCa accurately.Bioinformatics analysis,Kaplan-Meier analyses,Cox regression analyses,and Gene Set Enrichment Analysis(GSEA)were performed in a publicly available database with 499 PCa tissues and 52 matched normal tissues.A signature was identified.All these IncRNAs were differentially expressed between tumor and normal tissues and differentially expressed between high Gleason score and low Gleason score tissues.Furthermore,we developed a seven IncRNAs signature that can predict PCa BCR.Patients classified into low-risk group showed better BCR survival significantly than the patients in the high-risk group(hazard ratio=0.32,95%Cl:0.20-0.52,concordance index=0.63).The area under the curve was 0.68 for BCR.The signature also had good discrimination for BCR in men with Gleason 7 PCa.In conclusion,our results suggest that the seven IncRNAs signature is a new biomarker of BCR and high risk in PCa.In addition,the in dividual In cRNA warrants further study to un cover the associated mechanisms of PCa progression and the signature could be used to design direct clinical trials for adjuvant therapy.
