With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th...With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether they are physiological or pathological.展开更多
Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized b...Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).展开更多
When attending a symposium on private businesses on 17 February,Chinese President Xi Jinping underscored the immense opportunities within China’s private economy.He stated that the private sector enjoys broad prospec...When attending a symposium on private businesses on 17 February,Chinese President Xi Jinping underscored the immense opportunities within China’s private economy.He stated that the private sector enjoys broad prospects and great potential on the new journey in the new era,and that it is a prime time for private businesses and entrepreneurs to give full play to their capabilities.展开更多
Autophagy plays a crucial role in axon regeneration by maintaining cellular homeostasis and promoting the clearance of damaged organelles and proteins,which is essential for the growth and repair of axons.In response ...Autophagy plays a crucial role in axon regeneration by maintaining cellular homeostasis and promoting the clearance of damaged organelles and proteins,which is essential for the growth and repair of axons.In response to axonal injury,autophagy is upregulated to facilitate the removal of cellular debris and support the recycling of essential components needed for regeneration.展开更多
Symbiotic nitrogen fixation in members of the Fabaceae family is highly efficient and beneficial for global agriculture,but not all species in this family form root nodules with rhizobial bacteria.Nodulation mainly oc...Symbiotic nitrogen fixation in members of the Fabaceae family is highly efficient and beneficial for global agriculture,but not all species in this family form root nodules with rhizobial bacteria.Nodulation mainly occurs in plants belonging to the Papilionoideae and Caesalpinioideae subfamilies(Tederso0 et al.,2018;van Velzen et al.,2019).Nodulation mechanisms in Fabaceae are well studied(Yang et al.,2022),and genomic comparisons of nodulating and non-nodulating host species can provide valuable insights into the evolutionary and genetic basis of this key process.展开更多
Iread with great interest the recent article by Shin,et al.[1]the authors present an important exploration into the use of drug-coated balloon(DCB)in patients aged≥75 years,a demographic increasingly encountered in m...Iread with great interest the recent article by Shin,et al.[1]the authors present an important exploration into the use of drug-coated balloon(DCB)in patients aged≥75 years,a demographic increasingly encountered in modern cardiovascular practice.The authors conducted a retrospective analysis involving 2050 elderly patients(aged≥75 years)undergoing successful percutaneous coronary intervention(PCI).展开更多
In recent years,with the increasing attention to issues related to carbon emissions,such as carbon tariffs and government netzero carbon emission policies,carbon emissions have become an important indicator that is be...In recent years,with the increasing attention to issues related to carbon emissions,such as carbon tariffs and government netzero carbon emission policies,carbon emissions have become an important indicator that is being prioritized by governments worldwide.The Google Environmental Insights Explorer(EIE)tool has been developed to facilitate the collection and integration of data in this context.This study focuses on Tainan City and utilizes EIE to analyze greenhouse gas emissions from transportation.By using EIE,the study obtains data on greenhouse gas emissions from transportation activities in Tainan City.EIE utilizes data collected by Google and simulation functions to estimate data based on actual measurements of transportation activities.This tool saves time and resources by eliminating the need for on-site investigations while providing data that closely represent the real emissions from transportation activities in urban areas.Transportation vehicles contribute to greenhouse gas emissions in two ways:through direct combustion of fossil fuels and through the consumption of electricity in electric vehicles(EVs).The level of greenhouse gas emissions in a city’s transportation industry depends on factors such as transportation modes,fuel types,fleet age and energy efficiency,total distance traveled,and annual mileage.EIE estimates the greenhouse gas emissions from Tainan City’s transportation industry in 2022 to be 3,320,000 metric tons,including emissions from buses,motorcycles,cars,walking,railways,bicycles,and other modes of transportation.展开更多
The donkey is an important livestock species that can provide milk,meat,and skin and belongs to the family Equus.The first genome of a male donkey was sequenced and de novo assembled using a whole-genome shotgun strat...The donkey is an important livestock species that can provide milk,meat,and skin and belongs to the family Equus.The first genome of a male donkey was sequenced and de novo assembled using a whole-genome shotgun strategy(Huang et al.,2015).Subsequently,the donkey genome showed greater improvement in continuity and chromosome length than a previous assembly(Renaud et al.,2018).展开更多
Osteoarthritis(OA)is a debilitating degenerative disease affecting multiple joint tissues,including cartilage,bone,synovium,and adipose tissues.OA presents diverse clinical phenotypes and distinct molecular endotypes,...Osteoarthritis(OA)is a debilitating degenerative disease affecting multiple joint tissues,including cartilage,bone,synovium,and adipose tissues.OA presents diverse clinical phenotypes and distinct molecular endotypes,including inflammatory,metabolic,mechanical,genetic,and synovial variants.Consequently,innovative technologies are needed to support the development of effective diagnostic and precision therapeutic approaches.Traditional analysis of bulk OA tissue extracts has limitations due to technical constraints,causing challenges in the differentiation between various physiological and pathological phenotypes in joint tissues.This issue has led to standardization difficulties and hindered the success of clinical trials.Gaining insights into the spatial variations of the cellular and molecular structures in OA tissues,encompassing DNA,RNA,metabolites,and proteins,as well as their chemical properties,elemental composition,and mechanical attributes,can contribute to a more comprehensive understanding of the disease subtypes.Spatially resolved biology enables biologists to investigate cells within the context of their tissue microenvironment,providing a more holistic view of cellular function.Recent advances in innovative spatial biology techniques now allow intact tissue sections to be examined using various-omics lenses,such as genomics,transcriptomics,proteomics,and metabolomics,with spatial data.This fusion of approaches provides researchers with critical insights into the molecular composition and functions of the cells and tissues at precise spatial coordinates.Furthermore,advanced imaging techniques,including high-resolution microscopy,hyperspectral imaging,and mass spectrometry imaging,enable the visualization and analysis of the spatial distribution of biomolecules,cells,and tissues.Linking these molecular imaging outputs to conventional tissue histology can facilitate a more comprehensive characterization of disease phenotypes.This review summarizes the recent advancements in the molecular imaging modalities and methodologies for in-depth spatial analysis.It explores their applications,challenges,and potential opportunities in the field of OA.Additionally,this review provides a perspective on the potential research directions for these contemporary approaches that can meet the requirements of clinical diagnoses and the establishment of therapeutic targets for OA.展开更多
Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues,including the skeletal and immune systems.Recent studies have elucidated the intricate ...Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues,including the skeletal and immune systems.Recent studies have elucidated the intricate bidirectional interactions between these two systems.展开更多
The development of high-sloping-capacity carbons enables the creation of high-power lithium-ion batteries and capacitors(LIBs/LICs).Among the various heteroatomdoped carbon materials,hydrogen-rich carbon appears to be...The development of high-sloping-capacity carbons enables the creation of high-power lithium-ion batteries and capacitors(LIBs/LICs).Among the various heteroatomdoped carbon materials,hydrogen-rich carbon appears to be a promising candidate due to its facile synthesis and high capacity for Li^(+)storage.Nevertheless,conclusive data are still lacking to elucidate the fundamental function of the hydrogen-terminated groups(C-H configuration)in Li^(+)storage.Prof.Lian and his co-workers have utilized an ion-catalyzed self-template method to synthesize the hydrogen-rich carbon nanoribbon(HCNR)with high specific and rate capacity.展开更多
This is a correction to:Péter Borza,Varsha Rani,Csaba F Vad,Niche differentiation among facultative flter feeders:Insights from invasive Ponto-Caspian mysids,Current Zoology,2023;zoad030,https://doi.org/10.1093/c...This is a correction to:Péter Borza,Varsha Rani,Csaba F Vad,Niche differentiation among facultative flter feeders:Insights from invasive Ponto-Caspian mysids,Current Zoology,2023;zoad030,https://doi.org/10.1093/cz/zoad030 In the originally published version of this manuscript,incorrect funding project's ID number was inadvertently included in the Acknowledgements section.展开更多
DEAR EDITOR,The Laosicheng site in Yongshun County,Hunan Province,China,plays an important role in elucidating the animal population composition of the region prior to the middle Qing Dynasty(approximately 300 years a...DEAR EDITOR,The Laosicheng site in Yongshun County,Hunan Province,China,plays an important role in elucidating the animal population composition of the region prior to the middle Qing Dynasty(approximately 300 years ago).This site has yielded a substantial number of animal bones,11960 of which have been identified to the species level,serving as direct evidence of ancient animal populations(Hunan Provincial Institute of Cultural Relics and Archaeology,2018).展开更多
The InSight(Interior Exploration using Seismic Investigations,Geodesy,and Heat Transport)mission has recorded continuous ambient noise signals with many spectral peaks since its landing in 2018.The majority of these p...The InSight(Interior Exploration using Seismic Investigations,Geodesy,and Heat Transport)mission has recorded continuous ambient noise signals with many spectral peaks since its landing in 2018.The majority of these peaks are modes produced by instrumental vibrations and are associated with environmental factors,such as temperature and wind energy fluctuations.Understanding how these modes react under various conditions is crucial because it aids in identifying their origins.In this study,we analyzed the three-component spectra of InSight recordings from sols 184–738 and obtained the horizontal-to-vertical spectral ratio(HVSR,also known as H/V)curves for different time intervals.The primary modes,such as those at 3.3 and 4.1 Hz,exhibited different behaviors,suggesting diverse origins.Some modes were sensitive to low temperature and some were sensitive to high temperature.Additionally,we investigated the influence of wind and temperature on the H/V curve.The peak frequency was mainly affected by temperature,whereas the H/V value was not associated with the temperature or wind only.Characterizing these modes and elucidating their origins are significant for processing signals from InSight and can provide valuable guidance for designing future planetary seismometers.展开更多
In the context of the cultural development of the new era and the burgeoning spiritual demands of the people,there has been a remarkable surge in the proliferation of traditional Chinese cultural programs.The“Chinese...In the context of the cultural development of the new era and the burgeoning spiritual demands of the people,there has been a remarkable surge in the proliferation of traditional Chinese cultural programs.The“Chinese Festivals”series,produced by Henan TV,standing out as an engaging TV program that showcases traditional Chinese culture,has rapidly captivated a diverse audience across different age groups,creating a rich,multi-dimensional,and cross-media cultural communication ecosystem.The program strategically selects symbolic elements by systematically categorizing and organizing traditional Chinese cultural symbols to create a rich cultural space.It employs cutting-edge scientific and technological methods to enrich viewer immersion,crafting media rituals with both temporal significance and a profound sense of media ritual.This approach boosts the program’s popularity and sets a benchmark for industry innovation.By fostering an interactive narrative between mainstream media and the public,the program continuously broadens the scope of the“story world,”fostering a harmonious and structured national cultural community through the creative interpretation of traditional Chinese culture and the evocative crafting of the aesthetic sensibilities inherent in Chinese art.It is worth noting that the phenomenon of aesthetic fatigue besets the development of this serial program.To address this issue and further improve the appeal of the program,a comprehensive approach is required to develop a cohesive narrative mode for the“story world.”This involves harmonizing the interplay between artistic endeavors and technological advancements,synchronizing sensory experiences with the foundational ritualistic elements,and enhancing the effectiveness of the media communication matrix to construct a brand of media culture that has social significance,aesthetic value,and economic profits in the new era.展开更多
基金Clévio Nóbrega’s laboratory is funded by the Cure CSB projectthe Viljem Julijan Association for Children with Rare Diseases(Slovenia)+1 种基金the Algarve Biomedical Center Research Institute(ABC-Ri)funded by CRESC Algarve 2020(Operation Code:ALG-01-0145-FEDER-072586)(to CN)。
文摘With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether they are physiological or pathological.
基金supported by NEI/NIH R01 EY030513NIAMS/NIH R21-AR076035Multi-PI Team Science grant from Presbyterian Health Foundation。
文摘Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).
文摘When attending a symposium on private businesses on 17 February,Chinese President Xi Jinping underscored the immense opportunities within China’s private economy.He stated that the private sector enjoys broad prospects and great potential on the new journey in the new era,and that it is a prime time for private businesses and entrepreneurs to give full play to their capabilities.
文摘Autophagy plays a crucial role in axon regeneration by maintaining cellular homeostasis and promoting the clearance of damaged organelles and proteins,which is essential for the growth and repair of axons.In response to axonal injury,autophagy is upregulated to facilitate the removal of cellular debris and support the recycling of essential components needed for regeneration.
基金supported by the National Natural Science Foundation of China(No.32160142)Guangxi Natural Science Foundation(No.2023GXNSFDA026034)+3 种基金State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources(SKLCUSAb202302)to H.W.,the National Natural Science Foundation of China(No.32460062)to Y.L.,and 1+9 Leading the Charge with Open Competition'project of Sichuan Academy of Agricultural Sciences(1+9KJGG010)Fruit tree breeding project in Sichuan Province(2021YFYZ0023)to H.X.
文摘Symbiotic nitrogen fixation in members of the Fabaceae family is highly efficient and beneficial for global agriculture,but not all species in this family form root nodules with rhizobial bacteria.Nodulation mainly occurs in plants belonging to the Papilionoideae and Caesalpinioideae subfamilies(Tederso0 et al.,2018;van Velzen et al.,2019).Nodulation mechanisms in Fabaceae are well studied(Yang et al.,2022),and genomic comparisons of nodulating and non-nodulating host species can provide valuable insights into the evolutionary and genetic basis of this key process.
文摘Iread with great interest the recent article by Shin,et al.[1]the authors present an important exploration into the use of drug-coated balloon(DCB)in patients aged≥75 years,a demographic increasingly encountered in modern cardiovascular practice.The authors conducted a retrospective analysis involving 2050 elderly patients(aged≥75 years)undergoing successful percutaneous coronary intervention(PCI).
文摘In recent years,with the increasing attention to issues related to carbon emissions,such as carbon tariffs and government netzero carbon emission policies,carbon emissions have become an important indicator that is being prioritized by governments worldwide.The Google Environmental Insights Explorer(EIE)tool has been developed to facilitate the collection and integration of data in this context.This study focuses on Tainan City and utilizes EIE to analyze greenhouse gas emissions from transportation.By using EIE,the study obtains data on greenhouse gas emissions from transportation activities in Tainan City.EIE utilizes data collected by Google and simulation functions to estimate data based on actual measurements of transportation activities.This tool saves time and resources by eliminating the need for on-site investigations while providing data that closely represent the real emissions from transportation activities in urban areas.Transportation vehicles contribute to greenhouse gas emissions in two ways:through direct combustion of fossil fuels and through the consumption of electricity in electric vehicles(EVs).The level of greenhouse gas emissions in a city’s transportation industry depends on factors such as transportation modes,fuel types,fleet age and energy efficiency,total distance traveled,and annual mileage.EIE estimates the greenhouse gas emissions from Tainan City’s transportation industry in 2022 to be 3,320,000 metric tons,including emissions from buses,motorcycles,cars,walking,railways,bicycles,and other modes of transportation.
基金supported by the Third National Census of Livestock and Poultry Genetic Resources(K4050422227)the 2020 Scientist plus Engineer program of Shaanxi Province of Chinathe Central Guidance on Local Science and Technology Development Fund(K3030922098).
文摘The donkey is an important livestock species that can provide milk,meat,and skin and belongs to the family Equus.The first genome of a male donkey was sequenced and de novo assembled using a whole-genome shotgun strategy(Huang et al.,2015).Subsequently,the donkey genome showed greater improvement in continuity and chromosome length than a previous assembly(Renaud et al.,2018).
基金the NHMRC Investigator grant fellowship (APP1176298)the EMCR grant from the Centre for Biomedical Technologies (QUT)+4 种基金the QUT Postgraduate Research Award (QUTPRA)QUT HDR TOP-UP scholarshipQUT HDR Tuition Fee Sponsorshipfunding support from the Academy of Finland (315820)the Jane and Aatos Erkko Foundation (190001).
文摘Osteoarthritis(OA)is a debilitating degenerative disease affecting multiple joint tissues,including cartilage,bone,synovium,and adipose tissues.OA presents diverse clinical phenotypes and distinct molecular endotypes,including inflammatory,metabolic,mechanical,genetic,and synovial variants.Consequently,innovative technologies are needed to support the development of effective diagnostic and precision therapeutic approaches.Traditional analysis of bulk OA tissue extracts has limitations due to technical constraints,causing challenges in the differentiation between various physiological and pathological phenotypes in joint tissues.This issue has led to standardization difficulties and hindered the success of clinical trials.Gaining insights into the spatial variations of the cellular and molecular structures in OA tissues,encompassing DNA,RNA,metabolites,and proteins,as well as their chemical properties,elemental composition,and mechanical attributes,can contribute to a more comprehensive understanding of the disease subtypes.Spatially resolved biology enables biologists to investigate cells within the context of their tissue microenvironment,providing a more holistic view of cellular function.Recent advances in innovative spatial biology techniques now allow intact tissue sections to be examined using various-omics lenses,such as genomics,transcriptomics,proteomics,and metabolomics,with spatial data.This fusion of approaches provides researchers with critical insights into the molecular composition and functions of the cells and tissues at precise spatial coordinates.Furthermore,advanced imaging techniques,including high-resolution microscopy,hyperspectral imaging,and mass spectrometry imaging,enable the visualization and analysis of the spatial distribution of biomolecules,cells,and tissues.Linking these molecular imaging outputs to conventional tissue histology can facilitate a more comprehensive characterization of disease phenotypes.This review summarizes the recent advancements in the molecular imaging modalities and methodologies for in-depth spatial analysis.It explores their applications,challenges,and potential opportunities in the field of OA.Additionally,this review provides a perspective on the potential research directions for these contemporary approaches that can meet the requirements of clinical diagnoses and the establishment of therapeutic targets for OA.
基金supported by the National Key R&D Program of China (2021YFA1101500)Wuhan Science and Technology Bureau (2022020801020464)+1 种基金partially supported by University Grants Committee,Research Grants Council of the Hong Kong Special Administrative Region,China (14113723,N_CUHK472/22,T13-402/17-N and AoE/M-402/20)Direct Grant of CUHK (2022.042)。
文摘Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues,including the skeletal and immune systems.Recent studies have elucidated the intricate bidirectional interactions between these two systems.
基金financially supported by the National Natural Science Foundation of China(No.22209109)。
文摘The development of high-sloping-capacity carbons enables the creation of high-power lithium-ion batteries and capacitors(LIBs/LICs).Among the various heteroatomdoped carbon materials,hydrogen-rich carbon appears to be a promising candidate due to its facile synthesis and high capacity for Li^(+)storage.Nevertheless,conclusive data are still lacking to elucidate the fundamental function of the hydrogen-terminated groups(C-H configuration)in Li^(+)storage.Prof.Lian and his co-workers have utilized an ion-catalyzed self-template method to synthesize the hydrogen-rich carbon nanoribbon(HCNR)with high specific and rate capacity.
文摘This is a correction to:Péter Borza,Varsha Rani,Csaba F Vad,Niche differentiation among facultative flter feeders:Insights from invasive Ponto-Caspian mysids,Current Zoology,2023;zoad030,https://doi.org/10.1093/cz/zoad030 In the originally published version of this manuscript,incorrect funding project's ID number was inadvertently included in the Acknowledgements section.
基金supported by the National Natural Science Foundation of China(41925009,32100488)National Key R&D Program of China(2022YFE0203800)+1 种基金Chinese Academy of Sciences(YSBR-019)New Cornerstone Science Foundation through the XPLORER PRIZE。
文摘DEAR EDITOR,The Laosicheng site in Yongshun County,Hunan Province,China,plays an important role in elucidating the animal population composition of the region prior to the middle Qing Dynasty(approximately 300 years ago).This site has yielded a substantial number of animal bones,11960 of which have been identified to the species level,serving as direct evidence of ancient animal populations(Hunan Provincial Institute of Cultural Relics and Archaeology,2018).
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB 41000000).
文摘The InSight(Interior Exploration using Seismic Investigations,Geodesy,and Heat Transport)mission has recorded continuous ambient noise signals with many spectral peaks since its landing in 2018.The majority of these peaks are modes produced by instrumental vibrations and are associated with environmental factors,such as temperature and wind energy fluctuations.Understanding how these modes react under various conditions is crucial because it aids in identifying their origins.In this study,we analyzed the three-component spectra of InSight recordings from sols 184–738 and obtained the horizontal-to-vertical spectral ratio(HVSR,also known as H/V)curves for different time intervals.The primary modes,such as those at 3.3 and 4.1 Hz,exhibited different behaviors,suggesting diverse origins.Some modes were sensitive to low temperature and some were sensitive to high temperature.Additionally,we investigated the influence of wind and temperature on the H/V curve.The peak frequency was mainly affected by temperature,whereas the H/V value was not associated with the temperature or wind only.Characterizing these modes and elucidating their origins are significant for processing signals from InSight and can provide valuable guidance for designing future planetary seismometers.
基金the project“Research on the Digitalized Living Inheritance and Development of the Yellow River Cultural Gene,”a project of Humanities and Social Sciences Research of Higher Education Institutes in Henan Province(Project No.2024-ZDJH-770).
文摘In the context of the cultural development of the new era and the burgeoning spiritual demands of the people,there has been a remarkable surge in the proliferation of traditional Chinese cultural programs.The“Chinese Festivals”series,produced by Henan TV,standing out as an engaging TV program that showcases traditional Chinese culture,has rapidly captivated a diverse audience across different age groups,creating a rich,multi-dimensional,and cross-media cultural communication ecosystem.The program strategically selects symbolic elements by systematically categorizing and organizing traditional Chinese cultural symbols to create a rich cultural space.It employs cutting-edge scientific and technological methods to enrich viewer immersion,crafting media rituals with both temporal significance and a profound sense of media ritual.This approach boosts the program’s popularity and sets a benchmark for industry innovation.By fostering an interactive narrative between mainstream media and the public,the program continuously broadens the scope of the“story world,”fostering a harmonious and structured national cultural community through the creative interpretation of traditional Chinese culture and the evocative crafting of the aesthetic sensibilities inherent in Chinese art.It is worth noting that the phenomenon of aesthetic fatigue besets the development of this serial program.To address this issue and further improve the appeal of the program,a comprehensive approach is required to develop a cohesive narrative mode for the“story world.”This involves harmonizing the interplay between artistic endeavors and technological advancements,synchronizing sensory experiences with the foundational ritualistic elements,and enhancing the effectiveness of the media communication matrix to construct a brand of media culture that has social significance,aesthetic value,and economic profits in the new era.